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  1. AU="Imad, Nasser"
  2. AU="Batiridou, Agapi L"
  3. AU="Segal, Matt"
  4. AU="Russell E. Lewis"
  5. AU="Kietselaer, Bas"
  6. AU="Edelson, Brian T"
  7. AU="Elliott, Bruce M"
  8. AU="Pérez, René"
  9. AU="Lourdes Diaz Rodriguez"
  10. AU="Choi, Kai Chow"
  11. AU="Brandolini, Jury"
  12. AU="Yom, Jina"
  13. AU="Sue Casey"
  14. AU="Arimura, Takashi"
  15. AU="Kizilkilic, Osman"

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  1. Artikel ; Online: Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells

    Giacomo Canesin / Linda Feldbrügge / Guangyan Wei / Lubica Janovicova / Monika Janikova / Eva Csizmadia / Juliana Ariffin / Andreas Hedblom / Zachary T. Herbert / Simon C. Robson / Peter Celec / Kenneth D. Swanson / Imad Nasser / Yury V. Popov / Barbara Wegiel

    iScience, Vol 25, Iss 9, Pp 104983- (2022)

    2022  

    Abstract: Summary: Activation of resident macrophages (Mϕ) and hepatic stellate cells is a key event in chronic liver injury. Mice with heme oxygenase-1 (HO-1; Hmox1)-deficient Mϕ (LysM-Cre:Hmox1flfl) exhibit increased inflammation, periportal ductular reaction, ... ...

    Abstract Summary: Activation of resident macrophages (Mϕ) and hepatic stellate cells is a key event in chronic liver injury. Mice with heme oxygenase-1 (HO-1; Hmox1)-deficient Mϕ (LysM-Cre:Hmox1flfl) exhibit increased inflammation, periportal ductular reaction, and liver fibrosis following bile duct ligation (BDL)-induced liver injury and increased pericellular fibrosis in NASH model. RiboTag-based RNA-sequencing profiling of hepatic HO-1-deficient Mϕ revealed dysregulation of multiple genes involved in lipid and amino acid metabolism, regulation of oxidative stress, and extracellular matrix turnover. Among these genes, ligand of numb-protein X1 (LNX1) expression is strongly suppressed in HO-1-deficient Mϕ. Importantly, HO-1 and LNX1 were expressed by hepatic Mϕ in human biliary and nonbiliary end-stage cirrhosis. We found that Notch1 expression, a downstream target of LNX1, was increased in LysM-Cre:Hmox1flfl mice. In HO-1-deficient Mϕ treated with heme, transient overexpression of LNX1 drives M2-like Mϕ polarization. In summary, we identified LNX1/Notch1 pathway as a downstream target of HO-1 in liver fibrosis.
    Schlagwörter Biological sciences ; Human physiology ; Cell biology ; Stem cells research ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  2. Artikel: A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.

    Pita-Juarez, Yered / Karagkouni, Dimitra / Kalavros, Nikolaos / Melms, Johannes C / Niezen, Sebastian / Delorey, Toni M / Essene, Adam L / Brook, Olga R / Pant, Deepti / Skelton-Badlani, Disha / Naderi, Pourya / Huang, Pinzhu / Pan, Liuliu / Hether, Tyler / Andrews, Tallulah S / Ziegler, Carly G K / Reeves, Jason / Myloserdnyy, Andriy / Chen, Rachel /
    Nam, Andy / Phelan, Stefan / Liang, Yan / Amin, Amit Dipak / Biermann, Jana / Hibshoosh, Hanina / Veregge, Molly / Kramer, Zachary / Jacobs, Christopher / Yalcin, Yusuf / Phillips, Devan / Slyper, Michal / Subramanian, Ayshwarya / Ashenberg, Orr / Bloom-Ackermann, Zohar / Tran, Victoria M / Gomez, James / Sturm, Alexander / Zhang, Shuting / Fleming, Stephen J / Warren, Sarah / Beechem, Joseph / Hung, Deborah / Babadi, Mehrtash / Padera, Robert F / MacParland, Sonya A / Bader, Gary D / Imad, Nasser / Solomon, Isaac H / Miller, Eric / Riedel, Stefan / Porter, Caroline B M / Villani, Alexandra-Chloé / Tsai, Linus T-Y / Hide, Winston / Szabo, Gyongyi / Hecht, Jonathan / Rozenblatt-Rosen, Orit / Shalek, Alex K / Izar, Benjamin / Regev, Aviv / Popov, Yury / Jiang, Z Gordon / Vlachos, Ioannis S

    bioRxiv : the preprint server for biology

    2022  

    Abstract: The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial ... ...

    Abstract The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial transcriptomic profiling of livers from 17 COVID-19 decedents. We identified hepatocytes positive for SARS-CoV-2 RNA with an expression phenotype resembling infected lung epithelial cells. Integrated analysis and comparisons with healthy controls revealed extensive changes in the cellular composition and expression states in COVID-19 liver, reflecting hepatocellular injury, ductular reaction, pathologic vascular expansion, and fibrogenesis. We also observed Kupffer cell proliferation and erythrocyte progenitors for the first time in a human liver single-cell atlas, resembling similar responses in liver injury in mice and in sepsis, respectively. Despite the absence of a clinical acute liver injury phenotype, endothelial cell composition was dramatically impacted in COVID-19, concomitantly with extensive alterations and profibrogenic activation of reactive cholangiocytes and mesenchymal cells. Our atlas provides novel insights into liver physiology and pathology in COVID-19 and forms a foundational resource for its investigation and understanding.
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2022.10.27.514070
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

    Pita-Juarez, Yered / Karagkouni, Dimitra / Kalavros, Nikolaos / Melms, Johannes C. / Niezen, Sebastian / Delorey, Toni M. / Essene, Adam L / Brook, Olga R. / Pant, Deepti / Skelton-Badlani, Disha / Naderi, Pourya / Huang, Pinzhu / Pan, Liuliu / Hether, Tyler / Andrews, Tallulah S. / Ziegler, Carly G.K. / Reeves, Jason / Myloserdnyy, Andriy / Chen, Rachel /
    Nam, Andy / Phelan, Stefan / Liang, Yan / Amin, Amit Dipak / Biermann, Jana / Hibshoosh, Hanina / Veregge, Molly / Kramer, Zachary / Jacobs, Christopher / Yalcin, Yusuf / Phillips, Devan / Slyper, Michal / Subramanian, Ayshwarya / Ashenberg, Orr / Bloom-Ackermann, Zohar / Tran, Victoria M. / Gomez, James / Sturm, Alexander / Zhang, Shuting / Fleming, Stephen J. / Warren, Sarah / Beechem, Joseph / Hung, Deborah / Babadi, Mehrtash / Padera, Robert F. / MacParland, Sonya A. / Bader, Gary D. / Imad, Nasser / Solomon, Isaac H. / Miller, Eric / Riedel, Stefan / Porter, Caroline B.M. / Villani, Alexandra-Chloé / Tsai, Linus T.-Y. / Hide, Winston / Szabo, Gyongyi / Hecht, Jonathan / Rozenblatt-Rosen, Orit / Shalek, Alex K. / Izar, Benjamin / Regev, Aviv / Popov, Yury / Jiang, Z. Gordon / Vlachos, Ioannis S.

    bioRxiv

    Abstract: The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial ... ...

    Abstract The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial transcriptomic profiling of livers from 17 COVID-19 decedents. We identified hepatocytes positive for SARS-CoV-2 RNA with an expression phenotype resembling infected lung epithelial cells. Integrated analysis and comparisons with healthy controls revealed extensive changes in the cellular composition and expression states in COVID-19 liver, reflecting hepatocellular injury, ductular reaction, pathologic vascular expansion, and fibrogenesis. We also observed Kupffer cell proliferation and erythrocyte progenitors for the first time in a human liver single-cell atlas, resembling similar responses in liver injury in mice and in sepsis, respectively. Despite the absence of a clinical acute liver injury phenotype, endothelial cell composition was dramatically impacted in COVID-19, concomitantly with extensive alterations and profibrogenic activation of reactive cholangiocytes and mesenchymal cells. Our atlas provides novel insights into liver physiology and pathology in COVID-19 and forms a foundational resource for its investigation and understanding.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Verlag Cold Spring Harbor Laboratory
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2022.10.27.514070
    Datenquelle COVID19

    Volltext online

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    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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