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  1. Article ; Online: Reappraisal of a second examination after standard colonoscopy withdrawal in the proximal colon: Retroflex or forward view?

    Imai, Kenichiro

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2022  Volume 34, Issue 4, Page(s) 741–743

    MeSH term(s) Colon/diagnostic imaging ; Colon/pathology ; Colonic Neoplasms/diagnosis ; Colonic Polyps/diagnosis ; Colonoscopy ; Humans
    Language English
    Publishing date 2022-03-18
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14272
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    Zs.A 3854: Show issues Location:
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  2. Article: [Development of a Novel Simple Electrophysiological Study During Atrial Fibrillation Surgery:the Methods of Identifying AFs Where Pulmonary Vein Isolation is Effective].

    Imai, Katsuhiko / Hiraoka, Toshifumi

    Kyobu geka. The Japanese journal of thoracic surgery

    2024  Volume 77, Issue 1, Page(s) 43–49

    Abstract: Background & aim: Surgical procedure for chronic atrial tiburillation (Af) associated with organic cardiac disease is still superior, but atrial potential mapping has rarely been performed for these patients. An epicardial mapping is necessary to ... ...

    Abstract Background & aim: Surgical procedure for chronic atrial tiburillation (Af) associated with organic cardiac disease is still superior, but atrial potential mapping has rarely been performed for these patients. An epicardial mapping is necessary to elucidate the electrophysiology of Af as a disease, and to verify whether interventions are correctly performed to establish surgical treatment. We report the development of a new method that enables simple and immediate intraoperative decisions electrophysiologically.
    Methods & results: To realize real-time epi-atrial mapping, we planned to apply the mapping system (ExTRa Mapping System), which is already clinically applied during catheter ablation in Japan, for potential acquisition analysis. We developed an epicardial probe (20-point spiral electrode, 25 mm in diameter) that is compatible with the ExTRa mapping system. Using these electrodes, 5-second continuous recordings were made at 12 right atrial (RA) and 7 left atrial (LA) areas, covering the entire atrial surface, to confirm the existence and distribution of multiple wavelets and their central rotors (Ro). Both atria were mapped in 3 patients with chronic Af with mitral valve disease who underwent open heart surgery through a median sternotomy (mean age 73 years, 3 males). Ro was clearly expressed on the monitor display which can be observed by operator in real time.
    Discussion & conclusion: The system we have developed made it possible to observe Ro, which electrically characterize chronic Af, including their distribution in real time. The development of electrophysiologically- supported theoretical Af surgery can be expected through the accumulation of cases, detailed potential analysis, and verification of the placement of the isolation line and surgical results.
    MeSH term(s) Male ; Humans ; Aged ; Atrial Fibrillation/surgery ; Pulmonary Veins/surgery ; Heart Atria/surgery ; Heart Valve Diseases/surgery ; Cardiac Surgical Procedures/methods ; Catheter Ablation/methods ; Treatment Outcome
    Language Japanese
    Publishing date 2024-03-11
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 11: Show issues Location:
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  3. Article ; Online: Anything you don't know is invisible to your eyes: Educational interventions for serrated polyps can increase their detection.

    Imai, Kenichiro

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2021  Volume 34, Issue 1, Page(s) 75–76

    Language English
    Publishing date 2021-07-14
    Publishing country Australia
    Document type Editorial
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14071
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  4. Article ; Online: Gastrointestinal: Unusual pathology of an anorectal lesion mimicking a benign laterally spreading tumor.

    Ashizawa, H / Imai, K / Shimoda, T

    Journal of gastroenterology and hepatology

    2023  Volume 38, Issue 10, Page(s) 1681

    MeSH term(s) Humans ; Neoplasms ; Gastrointestinal Tract ; Intestine, Large
    Language English
    Publishing date 2023-06-13
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16253
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    Zs.MO 299: Show issues

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  5. Book: Development of new molecular tumor markers for diagnosis and therapy

    Imai, Kohzoh

    abstracts ; October 5 - 9, 2008, Tokyo, Japan

    (Meeting of the International Society of Oncology and BioMarkers, ISOBM ; 36 ; Tumor biology ; 29, Suppl. 1)

    2008  

    Author's details organizers K. Imai
    Series title Meeting of the International Society of Oncology and BioMarkers, ISOBM ; 36
    Tumor biology ; 29, Suppl. 1
    The ... congress of the International Society of Oncology and BioMarkers, ISOBM
    Collection The ... congress of the International Society of Oncology and BioMarkers, ISOBM
    Language English
    Size 99 S.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT015778333
    ISBN 978-3-8055-8997-0 ; 3-8055-8997-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1598 -29,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  6. Article ; Online: Parity-based assessment of anemia and iron deficiency in pregnant women.

    Imai, Kimitoshi

    Taiwanese journal of obstetrics & gynecology

    2020  Volume 59, Issue 6, Page(s) 838–841

    Abstract: Objective: This study aimed to separately evaluate the prevalence of anemia and iron deficiency in nulliparous and multiparous women.: Materials and methods: We retrospectively examined data of women who delivered in our clinic from January 2016 to ... ...

    Abstract Objective: This study aimed to separately evaluate the prevalence of anemia and iron deficiency in nulliparous and multiparous women.
    Materials and methods: We retrospectively examined data of women who delivered in our clinic from January 2016 to December 2018. Inclusion criteria were delivery occurring at ≥36 weeks and singleton pregnancy. Pregnant women with severe medical disorders were excluded. We estimated complete blood count (CBC) and serum ferritin (SF) in the first trimester and only CBC in the late second trimester. Data of nulliparas and multiparas were analyzed separately. Statistically significance was set at p < 0.05.
    Results: Totally, 481 nulliparas and 603 and multiparas were enrolled. Mean hemoglobin values in the first trimester were 12.6 ± 1.0 and 12.4 ± 1.0 g/dl (p < 0.001), while median SF values were 42.7 (12.2, 108.2) and 27.7 (8.0, 72.6) ng/ml (p < 0.001) in nulliparas and multiparas, respectively. Hemoglobin in the late second trimester was 11.2 ± 0.9 and 10.7 ± 1.0 g/dl (p < 0.001) in nulliparas and multiparas, respectively. Low ferritin levels (SF < 12 ng/ml) were more frequently found in multiparas than in nulliparas (111/603 vs. 46/481, p < 0.001, Odds ratio [OR] = 2.13). Anemia in the first trimester (hemoglobin<11.0 g/dl) was found in 3.5% (17/481) and 8.8% (53/603) (p < 0.001; OR, 2.63), while that in late second trimester (hemoglobin<10.5) was observed in 21.0% (101/481) and 36.3% (219/603) (p < 0.001, OR = 2.15) nulliparas and multiparas, respectively. Non-anemic women (hemoglobin level ≥11.0) with low ferritin levels (SF < 12 ng/ml) in the first trimester showed higher rate of anemia development in the second trimester than those with both normal hemoglobin and ferritin levels, irrespective of parity (51.3% [19/37] vs. 16.2% [69/427], p < 0.001 in nulliparas and 76.9% [60/78] vs. 26.5% [125/472], p < 0.001 in multiparas].
    Conclusion: Anemia and low SF levels occurred more commonly in multiparous than in nulliparas. Further, low SF was a risk factor for anemia development in later pregnancy.
    MeSH term(s) Adult ; Anemia/blood ; Anemia/etiology ; Anemia, Iron-Deficiency/blood ; Anemia, Iron-Deficiency/etiology ; Female ; Ferritins/blood ; Hemoglobins/analysis ; Humans ; Iron/blood ; Iron/deficiency ; Parity ; Pregnancy ; Pregnancy Complications/blood ; Pregnancy Complications/etiology ; Pregnancy Trimesters/blood ; Retrospective Studies ; Risk Factors
    Chemical Substances Hemoglobins ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-11-17
    Publishing country China (Republic : 1949- )
    Document type Evaluation Study ; Journal Article
    ISSN 1875-6263
    ISSN (online) 1875-6263
    DOI 10.1016/j.tjog.2020.09.010
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  7. Article ; Online: Analysis of the Interaction Between HIV and Periodontopathic Bacteria That Reactivates HIV Replication in Latently Infected Cells.

    Imai, Kenichi

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2210, Page(s) 207–214

    Abstract: The acquired immunodeficiency syndrome (AIDS) pandemic caused by the human immunodeficiency virus (HIV) is a major global health concern affecting 38 million people worldwide. HIV gene expression is the major determinant of the rate of viral replication ... ...

    Abstract The acquired immunodeficiency syndrome (AIDS) pandemic caused by the human immunodeficiency virus (HIV) is a major global health concern affecting 38 million people worldwide. HIV gene expression is the major determinant of the rate of viral replication leading to the progression of AIDS. The persistence of cellular reservoirs of HIV proviruses, despite prolonged treatment with antiretroviral drugs, represents the main obstacle preventing the eradication of HIV. Epigenetic silencing by histone deacetylase (HDAC) contributes to maintaining HIV transcriptional latency. However, the mechanism of the switch from latency to full HIV replication is unknown. HIV infection and antiretroviral treatment or a combination of both contribute to a higher incidence and severity of periodontitis. Periodontopathic bacteria such as Porphyromonas gingivalis and Fusobacterium nucleatum produce high concentrations of butyric acid, which strongly inhibit HDAC, indicating that periodontitis may mediate the reactivation of HIV replication. Here we describe a stepwise protocol for analyzing HIV reactivation by periodontal pathogens. However, the experiments using HIV requires BSL3 containment, making it difficult to handle HIV in dentistry. Therefore, we present an experimental method using cell lines latently infected with HIV.
    MeSH term(s) Cell Culture Techniques/methods ; Cell Line ; Enzyme-Linked Immunosorbent Assay/methods ; Fusobacterium nucleatum/physiology ; Gene Expression Regulation, Viral ; HIV Infections/complications ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Immunoblotting/methods ; Microbial Interactions ; Periodontitis/complications ; Periodontitis/microbiology ; Polymerase Chain Reaction/methods ; Porphyromonas gingivalis/physiology ; Virus Activation ; Virus Latency ; Virus Replication
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0939-2_20
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  8. Article ; Online: Medical application of the monoclonal antibody SKM9-2 against sialylated HEG1, a new precision marker for malignant mesothelioma.

    Tsuji, Shoutaro / Imai, Kohzoh

    Proceedings of the Japan Academy. Series B, Physical and biological sciences

    2023  Volume 99, Issue 2, Page(s) 39–47

    Abstract: Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleural cavity. Pathologically distinguishing MPM from other pleural lesions is often difficult. We searched for marker antigens to facilitate the pathological diagnosis of MPM and found ... ...

    Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleural cavity. Pathologically distinguishing MPM from other pleural lesions is often difficult. We searched for marker antigens to facilitate the pathological diagnosis of MPM and found useful markers for the pathological detection of malignant mesothelioma. Among them, the anti-mesothelioma monoclonal antibody SKM9-2, which was isolated as a clone binding to specimens of MPM (but not to specimens of lung adenocarcinoma) by immunohistochemical screening, showed higher specificity and sensitivity than traditional mesothelioma markers. SKM9-2 recognizes both sialylated O-glycans and peptide sequences in HEG1, and its glycan modifications are specific to mesothelioma. New effective treatments for MPM are needed because the prognosis of patients with MPM is usually poor. SKM9-2 can be used as a seed for next-generation antibody drugs with strong cytotoxic activities. In this review, we have summarized our research on antibody development for MPM diagnosis and treatment.
    MeSH term(s) Humans ; Mesothelioma, Malignant ; Antibodies, Monoclonal/therapeutic use ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Mesothelioma/diagnosis ; Mesothelioma/drug therapy ; Mesothelioma/metabolism ; Antineoplastic Agents ; Membrane Proteins
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents ; HEG1 protein, human ; Membrane Proteins
    Language English
    Publishing date 2023-02-11
    Publishing country Japan
    Document type Review ; Journal Article
    ZDB-ID 161781-3
    ISSN 1349-2896 ; 0386-2208
    ISSN (online) 1349-2896
    ISSN 0386-2208
    DOI 10.2183/pjab.99.003
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  9. Article ; Online: HISTOCHEMICAL AND ELECTRON MICROSCOPIC OBSERVATIONS ON THE STEROID HORMONE-SECRETING CELLS IN THE TESTIS OF THE JAPANESE RED-BELLIED NEWT, CYNOPS PYRRHOGASTER PYRRHOGASTER.

    Imai, Katsutoshi / Tanaka, Shigeyasu

    Development, growth & differentiation

    2023  Volume 20, Issue 2, Page(s) 151–167

    Abstract: The testis of the Japanese red-bellied newt, Cynops pyrrhogaster pyrrhogaster, caught in the middle of May was investigated in order to demonstrate the presence of steroid hormone (SH)-secreting cells, by means of histochemical and electron microscopic ... ...

    Abstract The testis of the Japanese red-bellied newt, Cynops pyrrhogaster pyrrhogaster, caught in the middle of May was investigated in order to demonstrate the presence of steroid hormone (SH)-secreting cells, by means of histochemical and electron microscopic techniques. The newt testis is divided into two main parts of spermatogenetic stages. The anterior part is immature and consists of many seminal cysts containing spermatogonia and spermatocytes. The posterior part is mature and made up of many cysts containing mature spermatozoa and glandular tissue. Histochemical studies revealed Δ
    Language English
    Publishing date 2023-06-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 280433-5
    ISSN 1440-169X ; 0012-1592
    ISSN (online) 1440-169X
    ISSN 0012-1592
    DOI 10.1111/j.1440-169X.1978.00151.x
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    Zs.A 194: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Suppression of Krüppel-like factor 5 basal expression by CREB1 binding to far distal element.

    Mihara, Nozomi / Imai, Kazushi

    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

    2023  Volume 45, Issue 1, Page(s) 81–94

    Abstract: Background: Krüppel-like factor 5 (KLF5) is a transcription factor regulating the proliferation and differentiation of epithelial cells, and its uncontrolled expression is closely associated with carcinoma progression. Sp3 binding to the minimal ... ...

    Abstract Background: Krüppel-like factor 5 (KLF5) is a transcription factor regulating the proliferation and differentiation of epithelial cells, and its uncontrolled expression is closely associated with carcinoma progression. Sp3 binding to the minimal essential region (MER) of KLF5 gene is critical for KLF5 basal expression, but the expression control mechanism is unknown.
    Objective: This study aimed to identify a regulatory region for KLF5 basal expression and the binding protein in carcinoma cells by analyzing the promoter upstream region.
    Methods: Reporter assays determined the silencer region. The protein binding to the region was identified by database analysis and ChIP assay. The protein mediating the interaction between the region and the MER was confirmed through chromosome conformation capture (3 C) on ChIP assay. The effects of the protein on KLF5 expression were analyzed using qRT-PCR and western blot.
    Results: Reporter assay localized the 425-region from upstream KLF5 gene as the silencer. Database analysis and ChIP assay found CREB1 binding to the 425-region. CREB1 siRNA or mutation of CREB1-binding site in the 425-region increased luciferase activities and decreased the binding to 425-region. 3 C on ChIP assay showed that CREB1 mediated interaction of the 425-region and the MER. CREB1 overexpression decreased endogenous KLF5 expression and luciferase activity.
    Conclusions: The 425-region is the silencer of KLF5 basal expression, and CREB1 binding suppresses the expression.
    MeSH term(s) Humans ; Carcinoma ; Cell Differentiation ; Cyclic AMP Response Element-Binding Protein/genetics ; Kruppel-Like Transcription Factors/genetics ; Luciferases
    Chemical Substances CREB1 protein, human ; Cyclic AMP Response Element-Binding Protein ; Kruppel-Like Transcription Factors ; Luciferases (EC 1.13.12.-) ; KLF5 protein, human
    Language English
    Publishing date 2023-09-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605825-5
    ISSN 1423-0380 ; 0289-5447 ; 1010-4283
    ISSN (online) 1423-0380
    ISSN 0289-5447 ; 1010-4283
    DOI 10.3233/TUB-230017
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