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  1. Article ; Online: Letter to the editor regarding the article: comparison of obstetric to institutional antibiogram as an approach to advance antimicrobial stewardship in maternal care.

    Pérez-López, Andrés / Suleiman, Mohammed / Elamin, Nazik / Mohan, Suruchi / Imam, Omar / Tang, Patrick

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2023  Volume 36, Issue 1, Page(s) 2191774

    MeSH term(s) Female ; Pregnancy ; Humans ; Antimicrobial Stewardship ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests ; Health Facilities ; Maternal Health Services
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2023.2191774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: First report of NDM-1-producing Pseudomonas aeruginosa in the Arabian Peninsula.

    Basahel, Ali / Shurab, Nada / Sundararaju, Sathyavathi / Hasan, Mohammad Rubayet / Tsui, Kin Ming / Suleiman, Mohammed / Imam, Omar / Tang, Patrick / Pérez-López, Andrés

    Journal of global antimicrobial resistance

    2021  Volume 29, Page(s) 553–554

    MeSH term(s) Humans ; Pseudomonas Infections ; Pseudomonas aeruginosa/genetics ; beta-Lactamases/genetics
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; beta-lactamase NDM-1 (EC 3.5.2.6)
    Language English
    Publishing date 2021-12-17
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2021.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trends in fecal carriage of carbapenemase-producing Enterobacterales in children before and after the implementation of international travel restrictions in response to COVID-19.

    Pérez-López, Andrés / Hasan, Mohammad Rubayet / Sundararaju, Sathyavathi / Tsui, Clement Kin Ming / Al-Mana, Hassan Abdulla / Suleiman, Mohammed / Imam, Omar / Tang, Patrick

    Travel medicine and infectious disease

    2021  Volume 43, Page(s) 102120

    MeSH term(s) Bacterial Proteins ; COVID-19 ; Child ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/prevention & control ; Humans ; SARS-CoV-2 ; beta-Lactamases
    Chemical Substances Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2021-06-15
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2021.102120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fecal Carriage and Molecular Characterization of Carbapenemase-Producing

    Pérez-López, Andrés / Sundararaju, Sathyavathi / Tsui, Kin Ming / Al-Mana, Hassan / Hasan, Mohammad Rubayet / Suleiman, Mohammed / Al Maslamani, Eman / Imam, Omar / Roscoe, Diane / Tang, Patrick

    Microbiology spectrum

    2021  Volume 9, Issue 3, Page(s) e0112221

    Abstract: Whole-genome sequencing was used to characterize carbapenemase- ... ...

    Abstract Whole-genome sequencing was used to characterize carbapenemase-producing
    MeSH term(s) Adolescent ; Anti-Bacterial Agents ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; COVID-19 ; Child ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/genetics ; Enterobacteriaceae/isolation & purification ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Feces/chemistry ; Genotype ; Humans ; Klebsiella pneumoniae/enzymology ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Mutation ; Qatar ; Retrospective Studies ; SARS-CoV-2 ; Whole Genome Sequencing ; beta-Lactamases/chemistry ; beta-Lactamases/genetics ; beta-Lactamases/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/Spectrum.01122-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.

    Hasan, Mohammad Rubayet / Sundaram, Manu Somasundaram / Sundararaju, Sathyavathi / Tsui, Kin-Ming / Karim, Mohammed Yousuf / Roscoe, Diane / Imam, Omar / Janahi, Mohammad A / Thomas, Eva / Dobson, Simon / Tan, Rusung / Tang, Patrick / Lopez, Andres Perez

    BMC infectious diseases

    2020  Volume 20, Issue 1, Page(s) 237

    Abstract: Background: Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characterized. Here, ... ...

    Abstract Background: Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characterized. Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria.
    Case presentation: A previously healthy, six-year-old boy presented with a 45-day history of fever prior to a diagnosis of hemophagocytic lymphohistiocytosis and hemorrhagic colitis, both associated with CMV. On hospital admission, the patient was found to be colonized with multiple, multidrug-resistant (MDR) bacteria including vancomycin-resistant enterococci (VRE) and carbapenamase-producing organisms (CPO). He eventually developed respiratory, urine and bloodstream infections with highly drug-resistant, including pandrug-resistant bacteria, which could not be controlled by antibiotic treatment. Antiviral therapy also failed to contain his CMV infection and the patient succumbed to overwhelming bacterial and viral infection. Whole genome sequencing (WGS) of the MDR bacteria and metagenomic analysis of his blood sample revealed an unusual accumulation of a wide range of antimicrobial resistance mechanisms in a single patient, including antiviral resistance to ganciclovir, and resistance mechanisms to all currently available antibiotics.
    Conclusions: The case highlights both the risk of acquiring MDR superbugs and the severity of these infections in HLH patients.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Carbapenem-Resistant Enterobacteriaceae/drug effects ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Child ; Cytomegalovirus/drug effects ; Cytomegalovirus/genetics ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/virology ; Drug Resistance, Multiple, Bacterial/genetics ; Drug Resistance, Multiple, Viral ; Fatal Outcome ; Ganciclovir/adverse effects ; Ganciclovir/therapeutic use ; Genotype ; Humans ; Lymphohistiocytosis, Hemophagocytic/diagnosis ; Lymphohistiocytosis, Hemophagocytic/drug therapy ; Lymphohistiocytosis, Hemophagocytic/virology ; Male ; Sepsis/drug therapy ; Sepsis/microbiology ; Sepsis/mortality ; Vancomycin-Resistant Enterococci/drug effects ; Vancomycin-Resistant Enterococci/genetics
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Ganciclovir (P9G3CKZ4P5)
    Keywords covid19
    Language English
    Publishing date 2020-03-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-020-04966-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Peritoneal Dialysis-Associated Peritonitis Caused by

    Imam, Omar / Al-Zubaidi, Khaled / Janahi, Mohammad / Imam, Abubakr / Leghrouz, Bassil / Dobson, Simon / Sundararaju, Sathyavathi / Tsui, Kin Ming / Hasan, Mohammad Rubayet / Perez-Lopez, Andres

    Open forum infectious diseases

    2020  Volume 8, Issue 1, Page(s) ofaa579

    Abstract: Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been ... ...

    Abstract Peritoneal dialysis (PD)-associated peritonitis constitutes a major complication associated with the procedure. PD-associated peritonitis caused by nontuberculous mycobacteria, usually as a result of an infection related to the PD catheter, has been reported in adults and is associated with significant complications and poor outcome. The management of PD-associated peritonitis caused by
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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