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Article ; Online: Quality of Life of Cancer Patients during Chemotherapy in Indonesia

Dyah A. Perwitasari / Fredrick D. Purba / Susan F. Candradewi / Haafizah Dania / Lalu Muhammad Irham / Imaniar Noor Faridah / Bayu P. Septiantoro

International Journal of Clinical Practice, Vol

A Comparison of EORTC QLQ-C30 and EQ-5D-5L, Based on Patients’ Characteristics

2023 Volume 2023

Abstract: One of the important outcomes to define the success of cancer treatment is the health-related quality of life (HRQoL) that can be measured using generic and/or specific instruments. Our study aims to define the cancer patients’ HRQoL in some hospitals in ...

Abstract	One of the important outcomes to define the success of cancer treatment is the health-related quality of life (HRQoL) that can be measured using generic and/or specific instruments. Our study aims to define the cancer patients’ HRQoL in some hospitals in Indonesia as measured by the European Organization for Research and Treatment for Cancer (EORTC QLQ-C30) and the EQ-5D-5L, to define the differences of cancer patients’ HRQoL referring to patients’ characteristics, and to explore determinants of cancer patients’ HRQoL. We recruited 451 cancer patients using a cross-sectional design in two referral hospitals in Central Java, Indonesia, using the purposive sampling technique. All subjects, recruited from July 2020 to October 2021, met the inclusion criteria, namely, adult patients diagnosed with cancers in all stages who willingly participated in the study. The Indonesian value set was used to obtain the EQ-5D-5L index score. We further analyzed the data based on cancer stages and compared two questionnaires using independent t test. We highlighted that most of the cancer patients are female (69.4%), young (86%), and at advanced stages of cancer (54.1%). The physical and role functions and global health status of the cancer patients are poor, and the most severe symptom is fatigue. Moreover, most of them experience severe pain and perform daily activities with difficulties. Some patients’ characteristics show significant influences on the HRQoL domains in both questionnaires (p<0.05). Interestingly, both of the questionnaires have shown significant correlations between similar domains and revealed the poor HRQoL of advanced cancer patients (p<0.05). Our study finds that cancer patients still have poor HRQoL in some domains. We suggest to the health providers that they apply education and psychological intervention to increase their HRQoL.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: POLA PENGGUNAAN ANTIBIOTIK POST OPERASI PADA PASIEN YANG MENJALANI OPERASI GASTROINTESTINAL

Imaniar Noor Faridah

Pharmaciana, Vol 3, Iss 2, Pp 51-

2013 Volume 55

Abstract: Gastrointestinal surgery is a surgery that has a high risk of the incidence of surgical wound infection (ILO). Surgical wound infection is the result of bacterial contamination when the operation happens. The purpose of this study was to determine the ... ...

Abstract	Gastrointestinal surgery is a surgery that has a high risk of the incidence of surgical wound infection (ILO). Surgical wound infection is the result of bacterial contamination when the operation happens. The purpose of this study was to determine the pattern of post operative antibiotics usage in patients undergone gastrointestinal surgery at PKU Muhammadiyah Hospital in Bantul. The result of this study was expected to be useful as a source of information on patterns of post operative antibiotics that used, as well as for a base for next studies. This study was a descriptive non-experimental research that prospectively held at PKU Muhammadiyah Bantul Yogyakarta Hospital. Subjects for this study were all patients who had undergone gastrointestinal surgery, which hospitalized at PKU Muhammadiyah Bantul Yogyakarta Hospital and met the inclusion criteria. As for the inclusion criteria in this study i.e., patients who have undergone gastrointestinal surgery, patients undergo hospitalization, as well as patients that use antibiotics for ILO's prevention. The data analyzed was data of patterns on antibiotics usage that used to prevent ILO incident. Based on this study showed that the usage of the most widely used post operative antibiotics is a combination of Ceftriaxon and Cefadroxil as many as 28 patients (47,46%). Intravenous antibiotics that mostly used is Ceftriaxon as many as 43 patients (6,29%), whereas for the most of oral antibiotics is Cefradoxil as many as 45 patients (76,27%).
Keywords	Gastrointestinal surgery ; antibiotics ; surgical wound infection ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	616 ; 610
Language	Indonesian
Publishing date	2013-11-01T00:00:00Z
Publisher	Universitas Ahmad Dahlan
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations

Imaniar Noor Faridah / Haafizah Dania / Rita Maliza / Wan-Hsuan Chou / Wen-Hung Wang / Yen-Hsu Chen / Dyah Aryani Perwitasari / Wei-Chiao Chang

Diagnostics, Vol 13, Iss 21, p

2023 Volume 3365

Abstract: Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings ... ...

Abstract	Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings from a previous genome-wide association study (GWAS) demonstrated that variations in the major histocompatibility complex (MHC) class I chain-related B ( MICB ) and the phospholipase C epsilon 1 ( PLCE1 ) genes were related to DSS in a Vietnamese population. This study investigated associations of variations in MICB (rs3132468) and PLCE1 (rs3740360, rs3765524) with dengue severity and thrombocytopenia in both the Indonesian and Taiwanese populations. We sampled 160 patients from the Indonesian population and 273 patients from the Taiwanese population. None of the patients had DSS in the Taiwanese population. Based on age demographics, we found that dengue is more prevalent among younger individuals in the Indonesian population, whereas it has a greater impact on adults in the Taiwanese population. Our results showed the association between MICB rs3132468 and DSS. In addition, an association was identified between PLCE1 rs3740360 and DHF in secondary dengue in Indonesian patients. However, there is no association of MICB or PLCE1 variants with thrombocytopenia. This study highlights the value of genetic testing, which might be included in the clinical pathway for specific patients who can be protected from severe dengue.
Keywords	severe dengue ; MICB ; PLCE1 ; single-nucleotide polymorphism (SNP) ; Medicine (General) ; R5-920
Subject code	616 ; 610
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The use of genomic variants to drive drug repurposing for chronic hepatitis B

Lalu Muhammad Irham / Wirawan Adikusuma / Dyah Aryani Perwitasari / Haafizah Dania / Rita Maliza / Imaniar Noor Faridah / Ichtiarini Nurullita Santri / Yohane Vincent Abero Phiri / Rocky Cheung

Biochemistry and Biophysics Reports, Vol 31, Iss , Pp 101307- (2022)

2022

Abstract: Background: One of the main challenges in personalized medicine is to establish and apply a large number of variants from genomic databases into clinical diagnostics and further facilitate genome-driven drug repurposing. By utilizing biological chronic ... ...

Abstract	Background: One of the main challenges in personalized medicine is to establish and apply a large number of variants from genomic databases into clinical diagnostics and further facilitate genome-driven drug repurposing. By utilizing biological chronic hepatitis B infection (CHB) risk genes, our study proposed a systematic approach to use genomic variants to drive drug repurposing for CHB. Method: The genomic variants were retrieved from the Genome-Wide Association Study (GWAS) and Phenome-Wide Association Study (PheWAS) databases. Then, the biological CHB risk genes crucial for CHB progression were prioritized based on the scoring system devised with five strict functional annotation criteria. A score of ≥ 2 were categorized as the biological CHB risk genes and further shed light on drug target genes for CHB treatments. Overlapping druggable targets were identified using two drug databases (DrugBank and Drug-Gene Interaction Database (DGIdb)). Results: A total of 44 biological CHB risk genes were screened based on the scoring system from five functional annotation criteria. Interestingly, we found 6 druggable targets that overlapped with 18 drugs with status of undergoing clinical trials for CHB, and 9 druggable targets that overlapped with 20 drugs undergoing preclinical investigations for CHB. Eight druggable targets were identified, overlapping with 25 drugs that can potentially be repurposed for CHB. Notably, CD40 and HLA-DPB1 were identified as promising targets for CHB drug repurposing based on the target scores. Conclusion: Through the integration of genomic variants and a bioinformatic approach, our findings suggested the plausibility of CHB genomic variant-driven drug repurposing for CHB.
Keywords	Bioinformatics ; Chronic hepatitis B ; Drug repurposing ; Genomic variants ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dynamic Changes of Platelet and Factors Related Dengue Haemorrhagic Fever

Imaniar Noor Faridah / Haafizah Dania / Yen-Hsu Chen / Woro Supadmi / Barkah Djaka Purwanto / Mochammad Junaidy Heriyanto / Mahda Adil Aufa / Wei-Chiao Chang / Dyah Aryani Perwitasari

Diagnostics, Vol 12, Iss 950, p

A Retrospective Study in Indonesian

2022 Volume 950

Abstract: Dengue is a viral infection caused by the dengue virus (DENV). Dengue infection is a self-limited acute febrile illness caused by four serotypes of DENV (DENV-1~4). Early recognition of high-risk patients would be helpful to reduce mortality rates and ... ...

Abstract	Dengue is a viral infection caused by the dengue virus (DENV). Dengue infection is a self-limited acute febrile illness caused by four serotypes of DENV (DENV-1~4). Early recognition of high-risk patients would be helpful to reduce mortality rates and prevent severe dengue. Our study aimed to identify factors related to dengue hemorrhagic fever (DHF) based on admission-day data, and further to understand the distribution of biochemical laboratory data in dengue patients. This retrospective study was conducted in hospitals in Yogyakarta city, Indonesia, and involved febrile patients who were admitted to the hospital with a diagnosis of dengue during 2018 and 2020. Logistic regression models were used to identify variables related to DHF. In this study, 1087 patients were included as suspected dengue patients, among them 468 had dengue fever (DF) and 619 had DHF. Over half of the DHF patients were males (55.9%) with an average age of 17.9 years, and with a secondary infection (71.3%). By a multivariate analysis, on-admission laboratory data of thrombocytopenia and hemoglobin showed significant association with DHF. Furthermore, DHF patients had significantly prolonged hospitalizations compared to DF patients. In conclusion, on-admission platelet counts and hemoglobin laboratory data are useful as predictors of DHF especially for suspected dengue patients with the limitations of diagnostic tests.
Keywords	dengue hemorrhagic fever ; platelet ; risk factor ; Medicine (General) ; R5-920
Subject code	616 ; 610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Profile of medication variations and dose adjustment to diabetes mellitus patients’ response in PKU Muhammadiyah hospital and Panti Rapih hospital period October–December 2014

Imaniar Noor Faridah / Dyah Aryani Perwitasari / Desty Kusumaningsih / Riana Prastiwi Handayani

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), Vol 9, Iss 1, Pp 39-

2018 Volume 45

Abstract: Background: Diabetes mellitus patients may have a different response to similar medication. Therefore, individualized treatment and monitoring of the therapy is needed to ensure the patients’ response. Alternative medication or dose adjustment should be ... ...

Abstract	Background: Diabetes mellitus patients may have a different response to similar medication. Therefore, individualized treatment and monitoring of the therapy is needed to ensure the patients’ response. Alternative medication or dose adjustment should be considered in order to achieve the therapeutic goal. Objective: The aim of this study was to find out patients’ response to medication variation or dose adjustment. Methods: This study used descriptive design in PKU Muhammadiyah Hospital and Panti Rapih hospital period October-December 2014. Participants are all patients who got pharmacological therapy for treatment of diabetes mellitus type 2, including oral antidiabetics and/ insulin and met the inclusion criteria. The response of therapy was checked 2 times, during check-in and check-out. Results: Analysis of response variation showed that individualized response existed, in which positive response occurred in 10 patients and the other had a negative response. The changes were dose adjustment and medication alteration or medication addition. From 6 patients who needed medication adjusment, 5 patients had a positive response, and others had a negative response. Whereas from 6 patients whose dosage or medication was not changed, 5 of them had a positive response while one had a negative response. Conclusion: Individualized treatment is needed to achieve a therapeutic goal. Individualized treatment can be done through dose adjustment and medication alteration, or medications addition.
Keywords	Medication response ; hospital ; diabetes mellitus ; Medicine ; R
Language	English
Publishing date	2018-04-01T00:00:00Z
Publisher	Faculty of Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hubungan kualitas hidup dan persepsi pasien tentang penyakit diabetes mellitus tipe 2 dengan komplikasi

Setiyo Budi Santoso / Dyah Aryani Perwitasari / Imaniar Noor Faridah / A.A. Kaptein

Pharmaciana, Vol 7, Iss 1, Pp 33-

2017 Volume 40

Abstract: Quality of life (QoL) was developed as one of outcome measured for type 2 diabetes mellitus (T2DM) patients. The QoL may decrease due to its complications. QoL may also relate to illness perceptions. This study aims to assess the impact of illness ... ...

Abstract	Quality of life (QoL) was developed as one of outcome measured for type 2 diabetes mellitus (T2DM) patients. The QoL may decrease due to its complications. QoL may also relate to illness perceptions. This study aims to assess the impact of illness perceptions on QoL in T2DM patient with complications. A cross sectional study was carried out at the Internist Departement of PKU Muhammadiyah Hospital, Bantul, Yogyakarta, on July-September 2015. Short Form 36 questionnaire was used to assess QoL and The Brief-Illness Perceptions Questionnaire was used for measuring subject’s illness perceptions. Analysis of T-test and one way Anova to determine differences of QoL and illness perceptions among baseline (gender, age, education, occupation, plasma glucose, blood pressure, and duration of diabetes) and influence the illness perceptions on Qol. Fifty on T2DM patient with complications were studied. Subjects with low education level have worse physical role than subjects with middle and high education (p=0.049). The positive illness perceptions can increase the value of the QoL on physical role (p=0.032), vitality (p=0.032) mental health (p=0.001), social function (p=0.037). This findings suggest that education level and illness perceptions are associated with quality of life.
Keywords	type 2 diabetes mellitus with complications ; quality of life ; SF-36 ; ilness perceptions ; B-IPQ ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	360
Language	Indonesian
Publishing date	2017-06-01T00:00:00Z
Publisher	Universitas Ahmad Dahlan
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The knowledge of COVID-19 treatments, behaviors, and attitudes of providing the information on COVID-19 treatments

Dyah Aryani Perwitasari / Imaniar Noor Faridah / Haafizah Dania / Lolita Lolita / Lalu Muhammad Irham / Muthia Dewi Marthilia Alim / Maratun Shoaliha / Mochammad Junaidy Heriyanto

Journal of Education and Health Promotion, Vol 10, Iss 1, Pp 235-

Perspectives of pharmacy students

2021 Volume 235

Abstract: BACKGROUND: Increasing community awareness about the transmission and treatment of COVID-19 will stop the spread of the virus. Pharmacy students are the potential facilitator to give community education about COVID-19 treatment. The objective of this ... ...

Abstract	BACKGROUND: Increasing community awareness about the transmission and treatment of COVID-19 will stop the spread of the virus. Pharmacy students are the potential facilitator to give community education about COVID-19 treatment. The objective of this study is to evaluate the pharmacy students' knowledge of COVID-19 treatment, behavior, and attitude of providing the information about COVID-19 treatment. MATERIALS AND METHODS: We conducted cross-sectional study, recruiting 429 pharmacy students from three schools of pharmacy in Indonesia. The questionnaire about the knowledge of COVID-19 treatment, behavior, and attitude of providing the information on COVID-19 treatment met the validity and reliability criteria. We defined the proportion of knowledge, behavior, and attitude of the students using SPSS® version 22. RESULTS: Most of the students are in the earlier years (46.63%), female (84.15%), find the information about COVID-19 from many sources of media (85.08%) including scientific articles and know information about COVID-19 transmission around their life area (76.46%). The students' knowledge about antiviral and plasma convalescent is good (>70%), the positive behaviors are related to the COVID-19 treatment information regarding to the antiviral and the provision of Vitamin C (>50%), and the positive attitude are related to giving information about the use of avigan®, plasma convalescent, chloroquine, hydroxychloroquine, and immunomodulator (>50%). CONCLUSIONS: As a future pharmacist, the knowledge of pharmacy students about COVID-19 treatment needs to be improved since earlier years. Furthermore, using the good knowledge about COVID-19 treatment, the positive behavior and attitude of providing information of the students, the community behavior and attitude will be improved. The high year students have a tendency for the good knowledge and positive behavior and attitude of providing the information.
Keywords	attitude ; behavior ; covid-19 treatment ; knowledge ; pharmacy ; Special aspects of education ; LC8-6691 ; Public aspects of medicine ; RA1-1270
Subject code	302
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PENGARUH UMUR DAN PENYAKIT PENYERTA TERHADAP RESIKO INFEKSI LUKA OPERASI PADA PASIEN BEDAH GASTROINTESTINAL

Imaniar Noor Faridah / Tri Murti Andayani / Inayati Inayati

Pharmaciana, Vol 2, Iss 2, Pp 187-

2012 Volume 194

Abstract: Surgical Site Infection/SSI is the result of the contamination of bacteria which enter the body during surgery. High risk of SSI is occured in gastrointestinal surgery and influenced by the characteristics of the patients such as age and comorbidity ... ...

Abstract	Surgical Site Infection/SSI is the result of the contamination of bacteria which enter the body during surgery. High risk of SSI is occured in gastrointestinal surgery and influenced by the characteristics of the patients such as age and comorbidity since they deal with immunity system of the body. The research was aimed to identity the influence of age and comorbidity to the high risk of SSI in gastrointestinal surgery patients. The research was a cross sectional research conducted prospectively at PKU Muhammadiyah Hospital Yogyakarta from January to March 2012. The research subjects were all inpatients undergoing gastrointestinal surgery, having visible surgical site and using antibiotic to prevent surgical site infection. There are 68 patients in the research. Data that were analyzed comprised the characteristics of patients such as age and congenital disease to the risk of surgical site infection. The result of this research indicated that 2 patients (2,94%) suffering SSI. Based on the age, SSI happened to 2 patients in the age range of 41-60 years old. However, based on the statistical result, there was no correlation between age and the existence of SSI (p>0.05). SSI also occured in 2 patients with comorbidity. However, there was correlation between the existence of comorbidity and SSI (p<0.05).
Keywords	Surgical site infection ; gastrointestinal surgery ; characteristics of patients ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Subject code	616
Language	Indonesian
Publishing date	2012-11-01T00:00:00Z
Publisher	Universitas Ahmad Dahlan
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of UBE3C Variants with Reduced Kidney Function in Patients with Diabetic Kidney Disease

Ying-Chun Chen / Mei-Yi Wu / Zhi-Lei Yu / Wan-Hsuan Chou / Yi-Ting Lai / Chih-Chin Kao / Imaniar Noor Faridah / Mai-Szu Wu / Wei-Chiao Chang

Journal of Personalized Medicine, Vol 10, Iss 210, p

2020 Volume 210

Abstract: Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) and the most common variant of end-stage renal disease (ESRD) globally. The economic burden of ESRD treatment with dialysis is ... ...

Abstract	Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) and the most common variant of end-stage renal disease (ESRD) globally. The economic burden of ESRD treatment with dialysis is substantial. The incidence and prevalence of ESRD in Taiwan remain the highest worldwide. Therefore, identifying genetic factors affecting kidney function would have valuable clinical implications. We performed microarray experiments and identified that ubiquitin protein ligase E3C ( UBE3C ) is differentially expressed in two DKD patient groups with extreme (low and high) urine protein-to-creatinine ratios. A follow-up genotyping study was performed in a larger group to investigate any specific variants of UBE3C associated with DKD. A total of 263 patients were included in the study, comprising 172 patients with DKD and 91 control subjects (patients with DM without chronic kidney disease (CKD)). Two UBE3C variants (rs3802129(AA) and rs7807(CC)) were determined to be associated with reduced kidney function. The haplotype analysis revealed that rs3802129/rs3815217 (block 1) with A/G haplotype and rs8101/rs7807 (block 2) with T/C haplotype were associated with higher risks of CKD phenotypes. These findings suggest a clinical role of UBE3C variants in DKD risk.
Keywords	diabetic kidney disease ; UBE3C ; genetic polymorphism ; Medicine ; R
Subject code	616 ; 610
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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