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  1. Article: Profiling of

    Mahdi, Ismail / Imbimbo, Paola / Annaz, Hassan / Bakrim, Widad Ben / Sahri, Nihad / Alaoui, Asmae / Monti, Daria Maria / Sobeh, Mansour

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1338482

    Abstract: Petroselinum ... ...

    Abstract Petroselinum sativum
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1338482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture

    Liberti, Davide / Imbimbo, Paola / Giustino, Enrica / D’Elia, Luigi / Silva, Mélanie / Barreira, Luísa / Monti, Daria Maria

    Antioxidants. 2023 Jan. 31, v. 12, no. 2

    2023  

    Abstract: Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced ... ...

    Abstract Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga Porphyridium cruentum (CCALA415). In vitro and cell-based assays were performed to assess the biological activities of these compounds. The s-EPSs, owing to the presence of sulfate groups, showed biocompatibility on immortalized eukaryotic cell lines and a high antioxidant activity on cell-based systems. PE showed powerful antioxidant activity both in vitro and on cell-based systems, but purification is mandatory for its safe use. Finally, both molecules showed anti-inflammatory activity comparable to that of ibuprofen and helped tissue regeneration. Thus, the isolated molecules from microalgae represent an excellent source of antioxidants to be used in different fields.
    Keywords Porphyridium cruentum ; anti-inflammatory activity ; antioxidant activity ; antioxidants ; biocompatibility ; eukaryotic cells ; exopolysaccharides ; ibuprofen ; microalgae ; phycoerythrin ; sulfates ; tissue repair
    Language English
    Dates of publication 2023-0131
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020337
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Shedding Light on the Hidden Benefit of

    Liberti, Davide / Imbimbo, Paola / Giustino, Enrica / D'Elia, Luigi / Silva, Mélanie / Barreira, Luísa / Monti, Daria Maria

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced ... ...

    Abstract Microalgae can represent a reliable source of natural compounds with different activities. Here, we evaluated the antioxidant and anti-inflammatory activity of sulfated exopolysaccharides (s-EPSs) and phycoerythrin (PE), two molecules naturally produced by the red marine microalga
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Steric hindrance and charge influence on the cytotoxic activity and protein binding properties of diruthenium complexes.

    Terán, Aarón / Ferraro, Giarita / Imbimbo, Paola / Sánchez-Peláez, Ana E / Monti, Daria Maria / Herrero, Santiago / Merlino, Antonello

    International journal of biological macromolecules

    2023  Volume 253, Issue Pt 1, Page(s) 126666

    Abstract: Paddlewheel diruthenium complexes are being used as metal-based drugs. It has been proposed that their charge and steric properties determine their selectivity towards proteins. Here, we explore these parameters using the first water-soluble diruthenium ... ...

    Abstract Paddlewheel diruthenium complexes are being used as metal-based drugs. It has been proposed that their charge and steric properties determine their selectivity towards proteins. Here, we explore these parameters using the first water-soluble diruthenium complex bearing two formamidinate ligands, [Ru
    MeSH term(s) Humans ; Protein Binding ; Metals
    Chemical Substances Metals
    Language English
    Publishing date 2023-09-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.126666
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Chemical profiling and dermatological and anti-aging properties of

    Mahdi, Ismail / Imbimbo, Paola / Ortaakarsu, Ahmet Buğra / Adhiambo Ochieng, Melvin / Ben Bakrim, Widad / Drissi, Badr Eddine / Ibrahim, Mohammed Auwal / Abdelfattah, Mohamed A O / Mahmoud, Mona F / Monti, Daria Maria / Sobeh, Mansour

    Frontiers in molecular biosciences

    2024  Volume 10, Page(s) 1331059

    Abstract: The phytoconstituents of the aqueous extract ... ...

    Abstract The phytoconstituents of the aqueous extract from
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1331059
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  6. Article: Towards green extraction methods from microalgae learning from the classics

    Imbimbo, Paola / D’Elia, Luigi / Liberti, Davide / Olivieri, Giuseppe / Monti, Daria Maria

    Applied microbiology and biotechnology. 2020 Nov., v. 104, no. 21

    2020  

    Abstract: Microalgae started receiving attention as producers of third generation of biofuel, but they are rich in many bioactive compounds. Indeed, they produce many molecules endowed with benefic effects on human health which are highly requested in the market. ... ...

    Abstract Microalgae started receiving attention as producers of third generation of biofuel, but they are rich in many bioactive compounds. Indeed, they produce many molecules endowed with benefic effects on human health which are highly requested in the market. Thus, it would be important to fractionate algal biomass into its several high-value compounds: this represents the basis of the microalgal biorefinery approach. Usually, conventional extraction methods have been used to extract a single class of molecules, with many side effects on the environment and on human health. The development of a green downstream platform could help in obtaining different class of molecules with high purity along with low environmental impact. This review is focused on technical advances that have been performed, from classic methods to the newest and green ones. Indeed, it is fundamental to set up new procedures that do not affect the biological activity of the extracted molecules. A comparative analysis has been performed among the conventional methods and the new extraction techniques, i.e., switchable solvents and microwave-assisted and compressed fluid extractions.
    Keywords biofuels ; biomass ; biorefining ; biotechnology ; environmental impact ; human health ; markets ; microalgae ; microbiology ; microwave treatment
    Language English
    Dates of publication 2020-11
    Size p. 9067-9077.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    Note NAL-AP-2-clean ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-020-10839-x
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 79/727: Show issues

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  7. Article ; Online: Halo complexes of gold(I) containing glycoconjugate carbene ligands: synthesis, characterization, cytotoxicity and interaction with proteins and DNA model systems.

    Annunziata, Alfonso / Ferraro, Giarita / Cucciolito, Maria Elena / Imbimbo, Paola / Tuzi, Angela / Monti, Daria Maria / Merlino, Antonello / Ruffo, Francesco

    Dalton transactions (Cambridge, England : 2003)

    2022  Volume 51, Issue 27, Page(s) 10475–10485

    Abstract: New neutral carbene complexes of gold(I) [Au(Im-Me)X] (X = Cl, Au1; X = Br, Au2; X = I, Au3) have been synthesized and fully characterized by different techniques, including NMR and UV-vis absorption spectroscopy and single crystal X-ray diffraction. The ...

    Abstract New neutral carbene complexes of gold(I) [Au(Im-Me)X] (X = Cl, Au1; X = Br, Au2; X = I, Au3) have been synthesized and fully characterized by different techniques, including NMR and UV-vis absorption spectroscopy and single crystal X-ray diffraction. The carbene ligand Im-Me is decorated with a glucoside fragment
    MeSH term(s) Animals ; Cattle ; DNA ; Glycoconjugates/pharmacology ; Gold/chemistry ; Ligands ; Methane/analogs & derivatives ; Models, Molecular
    Chemical Substances Glycoconjugates ; Ligands ; carbene (2465-56-7) ; Gold (7440-57-5) ; DNA (9007-49-2) ; Methane (OP0UW79H66)
    Language English
    Publishing date 2022-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt00423b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of Auranofin Loading within Ferritin Nanocages.

    Lucignano, Rosanna / Pratesi, Alessandro / Imbimbo, Paola / Monti, Daria Maria / Picone, Delia / Messori, Luigi / Ferraro, Giarita / Merlino, Antonello

    International journal of molecular sciences

    2022  Volume 23, Issue 22

    Abstract: Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages using ... ...

    Abstract Auranofin (AF), a gold(I) compound that is currently used for the treatment of rheumatoid arthritis and is in clinical trials for its promising anticancer activity, was encapsulated within the human H-chain and the horse spleen ferritin nanocages using the alkaline disassembly/reassembly protocol. The aim of the work was to highlight possible differences in their drug loading capacity and efficacy. The drug-loaded ferritins were characterized via UV-vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy to assess AF encapsulation and to define the exact amount of gold atoms trapped in the Ft cavity. The crystal structures allowed us to define the nature of AF interaction with both ferritins and to identify the gold binding sites. Moreover, the biological characterization let us to obtain preliminary information on the cytotoxic effect of AF when bound to the human H-chain.
    MeSH term(s) Animals ; Humans ; Antineoplastic Agents/chemistry ; Auranofin/chemistry ; Auranofin/pharmacology ; Binding Sites ; Ferritins/chemistry ; Ferritins/metabolism ; Gold/chemistry ; Horses ; Nanoparticle Drug Delivery System/chemistry ; Nanoparticle Drug Delivery System/pharmacology
    Chemical Substances Antineoplastic Agents ; Auranofin (3H04W2810V) ; Ferritins (9007-73-2) ; Gold (7440-57-5) ; Nanoparticle Drug Delivery System
    Language English
    Publishing date 2022-11-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232214162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impact of Hydrophobic Chains in Five-Coordinate Glucoconjugate Pt(II) Anticancer Agents.

    Annunziata, Alfonso / Imbimbo, Paola / Cucciolito, Maria Elena / Ferraro, Giarita / Langellotti, Vincenzo / Marano, Alessandra / Melchiorre, Massimo / Tito, Gabriella / Trifuoggi, Marco / Monti, Daria Maria / Merlino, Antonello / Ruffo, Francesco

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: This study describes new platinum(II) cationic five-coordinate complexes ( ...

    Abstract This study describes new platinum(II) cationic five-coordinate complexes (
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Crystallography, X-Ray ; Dimethyl Sulfoxide ; DNA ; Hydrophobic and Hydrophilic Interactions ; Muramidase ; Platinum Compounds/chemistry ; Platinum Compounds/pharmacology
    Chemical Substances Antineoplastic Agents ; carbene (2465-56-7) ; Dimethyl Sulfoxide (YOW8V9698H) ; DNA (9007-49-2) ; ethylene (91GW059KN7) ; Muramidase (EC 3.2.1.17) ; Platinum Compounds
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An Alternative Exploitation of

    Imbimbo, Paola / D'Elia, Luigi / Corrado, Iolanda / Alvarez-Rivera, Gerardo / Marzocchella, Antonio / Ibáñez, Elena / Pezzella, Cinzia / Branco Dos Santos, Filipe / Monti, Daria Maria

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Microalgal biomass represents a very interesting biological feedstock to be converted into several high-value products in a biorefinery approach. In this study, the ... ...

    Abstract Microalgal biomass represents a very interesting biological feedstock to be converted into several high-value products in a biorefinery approach. In this study, the cyanobacterium
    MeSH term(s) Synechocystis/metabolism ; Polyhydroxyalkanoates/metabolism
    Chemical Substances Polyhydroxyalkanoates
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28073144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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