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  1. AU="Imen Ben Mustapha"
  2. AU="Verloo, Henk"
  3. AU="Tal, Yuval"
  4. AU="Oehrl, Simon"
  5. AU="Canty-Laird, E G"
  6. AU="Renart, Eduard Gibert"
  7. AU="Guiducci, Laura"
  8. AU=Chaudhry Imtiaz A
  9. AU="Baoqing Sun"
  10. AU="Pereira, A A"
  11. AU="Graff, Nicholas R"
  12. AU=Jones Jana E
  13. AU=Takabayashi Akinobu
  14. AU="Paratz, Jennifer D"
  15. AU="Schulte, Kevin L."
  16. AU="Hu, Guanqun"
  17. AU="Li, Jin-Yan"
  18. AU="Stonsaovapak, Siriporn"
  19. AU="Trétarre, Brigitte"

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  1. Artikel ; Online: In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines

    Sondes Haddad-Boubaker / Houcemeddine Othman / Rabeb Touati / Kaouther Ayouni / Marwa Lakhal / Imen Ben Mustapha / Kais Ghedira / Maher Kharrat / Henda Triki

    BMC Bioinformatics, Vol 22, Iss 1, Pp 1-

    evidence of a possible putative protective effect

    2021  Band 14

    Abstract: Abstract Background Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against ... ...

    Abstract Abstract Background Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools. Results A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19. Conclusions Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions.
    Schlagwörter SARS-CoV-2 ; BCG ; OPV ; MMR ; Immunogenicity ; Vaccine ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: A founder mutation underlies a severe form of phosphoglutamase 3 (PGM3) deficiency in Tunisian patients

    Ben-Khemis, Leila / Najla Mekki / Imen Ben-Mustapha / Karen Rouault / Fethi Mellouli / Monia Khemiri / Mohamed Bejaoui / Leila Essaddam / Saayda Ben-Becher / Lamia Boughamoura / Saida Hassayoun / Meriem Ben-Ali / Mohamed-Ridha Barbouche

    Molecular Immunology. 2017,

    2017  

    Abstract: Phosphoglucomutase 3 (PGM3) protein catalyzes the conversion of N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6-P) to N-acetyl-D-glucosamine-1-phosphate (GlcNAc-1-P), which is required for the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) ...

    Abstract Phosphoglucomutase 3 (PGM3) protein catalyzes the conversion of N-acetyl-D-glucosamine-6-phosphate (GlcNAc-6-P) to N-acetyl-D-glucosamine-1-phosphate (GlcNAc-1-P), which is required for the synthesis of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) an important precursor for protein glycosylation. Mutations in PGM3 gene have been recently shown to underlie a new congenital disorder of glycosylation often associated to elevated IgE. Herein, we report twelve PGM3 deficient patients. They belong to three highly consanguineous families, originating from a rural district in the west central Tunisia. The patient’s clinical phenotype is characterized by severe respiratory and cutaneous infections as well as developmental delay and severe mental retardation. Fourteen patients died in early infancy before diagnosis supporting the severity of the clinical phenotype.Laboratory findings revealed elevated IgE, CD4 lymphopenia and impaired T cell proliferation in most patients. Genetic analysis showed the presence, of a unique homozygous mutation (p.Glu340del) in PGM3 gene leading to reduced PGM3 abundance. Segregating analysis using fifteen polymorphic markers overlapping PGM3 gene showed that all patients inherited a common homozygous haplotype encompassing 10-Mb on chromosome 6. The founder mutational event was estimated to have occurred approximately 100 years ago.To date, (p.Glu340del) mutation represents the first founder mutation identified in PGM3 gene. These findings will facilitate the development of preventive approaches through genetic counselling and prenatal diagnosis in the affected families.
    Schlagwörter N-acetylglucosamine ; T-lymphocytes ; cell proliferation ; chromosomes ; congenital abnormalities ; counseling ; genes ; genetic analysis ; glycosylation ; haplotypes ; homozygosity ; immunoglobulin E ; infancy ; inheritance (genetics) ; mutation ; patients ; phenotype ; phosphoglucomutase ; uridine diphosphate ; Tunisia
    Sprache Englisch
    Umfang p. .
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2017.06.248
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel: Activation induced cytidine deaminase mutant (AID-His130Pro) from Hyper IgM 2 patient retained mutagenic activity on SHM artificial substrate

    Ouadani, Hanen / Imen Ben-Mustapha / Meriem Ben-ali / Beya Larguèche / Tihana Jovanic / Sylvie Garcia / Benoit Arcangioli / Houda Elloumi-Zghal / Dahmani Fathallah / Mongia Hachicha / Hatem Masmoudi / François Rougeon / Mohamed-Ridha Barbouche

    Molecular Immunology. 2016 Nov., v. 79

    2016  

    Abstract: Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper IgM 2 syndrome where both CSR ... ...

    Abstract Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper IgM 2 syndrome where both CSR and SHM or only CSR are affected. Indeed, triggering either of the two mechanisms requires the DNA deamination activity of AID. Besides, different domains of AID may be differentially involved in CSR and SHM through their interaction with specific cofactors. Herein, we studied the AID-induced SHM activity of the AID-His130Pro mutant identified in a patient with Hyper IgM 2 syndrome. AID mutagenic activity was monitored by the reversion of nonsense mutations of the EGFP gene assessed by flow cytometry. We found that the His130Pro mutation, which affects CSR, preserves AID mutagenic activity. Indeed, the His130 residue is located in a putative specific CSR region in the APOBEC-like domain, known to involve CSR specific cofactors that probably play a major role in AID physiological activities.
    Schlagwörter DNA ; cytidine deaminase ; deamination ; flow cytometry ; genes ; immune response ; immunoglobulin M ; mutagenicity ; mutants ; nonsense mutation ; patients ; preserves
    Sprache Englisch
    Erscheinungsverlauf 2016-11
    Umfang p. 77-82.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2016.09.025
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 166: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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