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  1. Article ; Online: Acute Pulmonary Embolism and Immunity in Animal Models.

    Imiela, Anna M / Mikołajczyk, Tomasz P / Guzik, Tomasz J / Pruszczyk, Piotr

    Archivum immunologiae et therapiae experimentalis

    2024  Volume 72, Issue 1

    Abstract: Venous thromboembolism, encompassing acute pulmonary embolism (APE) and deep vein thrombosis (DVT), is a potentially fatal disease with complex pathophysiology. Traditionally, the Virchow triad provided a framework for understanding the pathogenic ... ...

    Abstract Venous thromboembolism, encompassing acute pulmonary embolism (APE) and deep vein thrombosis (DVT), is a potentially fatal disease with complex pathophysiology. Traditionally, the Virchow triad provided a framework for understanding the pathogenic contributors to thrombus formation, which include endothelial dysfunction, alterations in blood flow and blood hypercoagulability. In the last years, it has become apparent that immunity plays a central role in thrombosis, interacting with classical prothrombotic mechanisms, oxidative stress and vascular factors. Thrombosis amplifies inflammation, and exaggerated inflammatory processes can trigger thrombosis mainly due to the activation of leukocytes, platelets, and endothelial cells. APE-related endothelium injury is a major trigger for immune system activation. Endothelium is also a key component mediating inflammatory reaction and it is relevant to maintain vascular permeability. Exaggerated right ventricular wall stress and overload, with coexisting systemic hypotension and hypoxemia, result in myocardial injury and necrosis. Hypoxia, tissue factor activation and cytokine storm are engaged in the thrombo-inflammatory processes. Thrombus development is characterized by inflammatory state vascular wall caused mainly by an early extravasation of leukocytes and intense selectins and cytokines production. Nevertheless, immunity of DVT is well described, little is known about potential chemokine and cellular differences between thrombus that develops in the vein and thrombus that detaches and lodges in the pulmonary circulation being a cause of APE. There is a paucity of data considering inflammatory state in the pulmonary artery wall during an acute episode of pulmonary embolism. The main aim of this review is to summarize the knowledge of immunity in acute phase of pulmonary embolism in experimental models.
    MeSH term(s) Animals ; Endothelial Cells ; Pulmonary Embolism/complications ; Thrombosis/complications ; Inflammation ; Models, Animal ; Hominidae
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.2478/aite-2024-0003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 393: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Acidic urine as a novel risk factor for diuretic resistance and worse in‑hospital prognosis in patients with acute heart failure.

    Imiela, Tomasz / Imiela, Anna M / Karczmarewicz, Grzegorz / Budaj, Andrzej

    Polish archives of internal medicine

    2021  Volume 131, Issue 10

    MeSH term(s) Diuretics/therapeutic use ; Heart Failure/drug therapy ; Hospital Mortality ; Hospitals ; Humans ; Prognosis ; Retrospective Studies ; Risk Factors
    Chemical Substances Diuretics
    Language English
    Publishing date 2021-07-02
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: The Vulnerable Elders Survey-13 scale is superior to the simplified Pulmonary Embolism Score Index in predicting 3-month postdischarge mortality in elderly survivors of acute pulmonary embolism.

    Imiela, Anna M / Kozak-Szkopek, Elżbieta / Szymańska, Monika / Wdowiak, Katarzyna / Dzikowska-Diduch, Olga / Żuk-Łapan, Aleksandra / Pruszczyk, Andrzej / Bukalska, Izabela / Niewczas, Karolina / Machowski, Michał / Ou-Pokrzewińska, Aisha / Pruszczyk, Piotr

    Polish archives of internal medicine

    2024  Volume 134, Issue 4

    Abstract: Introduction: Acute pulmonary embolism (APE) is the most serious manifestation of venous thromboembolism. The simplified Pulmonary Embolism Severity Index (sPESI) is employed for prediction of 30-day mortality in APE. The Vulnerable Elders Survey (VES- ... ...

    Abstract Introduction: Acute pulmonary embolism (APE) is the most serious manifestation of venous thromboembolism. The simplified Pulmonary Embolism Severity Index (sPESI) is employed for prediction of 30-day mortality in APE. The Vulnerable Elders Survey (VES-13) is used to identify participants at a risk of health impairment.
    Objectives: We aimed to compare the VES-13 and sPESI scales for prediction of 3-month mortality inelderly patients hospitalized for APE.
    Patients and methods: All patients with APE were managed according to the European Society of Cardiology (ESC) guidelines and followed up for at least 3 months after discharge. Clinical evaluation of all patients involved the Charlson Comorbidity Index (CCI) and biochemical tests. The patients with VES-13 score equal to or above 3 (VES-13≥3) were evaluated with comprehensive geriatric assessment (CGA).
    Results: A total of 164 patients met the inclusion criteria. There were significantly fewer men in the VES-13≥3 than the VES-13<3 group (34% vs 54.5%; P <0.01). The patients in the VES-13≥3 group had lower median (interquartile range [IQR]) body mass index and higher sPESI score than those in the VES-13<3 group (25.6 [21.8-28.4] kg/m2 vs 28 [25.3-31] kg/m2; P = 0.001 and 2 [1-2] points vs 1 [0-1] point; P <0.001, respectively). There were no differences in APE severity according to the ESC stratification and CCI. Logistic regression analysis identified the VES-13 score as a significant independent risk factor for 3-month mortality.
    Conclusions: The VES-13 score is a better tool than sPESI for predicting 3-month mortality. Geriatric survivors of APE characterized with VES-13≥3 points should be closely monitored after discharge. The Norton Scale Score in a combination with the VES-13 may be useful in predicting 3-month mortality among numerous tests used in the CGA.
    MeSH term(s) Humans ; Male ; Aged ; Female ; Pulmonary Embolism/mortality ; Pulmonary Embolism/diagnosis ; Aged, 80 and over ; Geriatric Assessment/methods ; Severity of Illness Index ; Survivors ; Patient Discharge
    Language English
    Publishing date 2024-01-11
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 360: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Altered monocytic phenotypes are linked to a hypertension form: A clinical observational study.

    Imiela, Anna M / Siedliński, Mateusz / Dobrowolski, Piotr / Pręgowska-Chwała, Barbara / Kabat, Marek / Oliveira Silva, Renee Nazare / Koshy, Ankita Maria / Wróbel, Aleksandra / Cendrowska-Demkow, Iwona / Januszewicz, Magdalena / Januszewicz, Andrzej / Prejbisz, Aleksander / Mikołajczyk, Tomasz P

    Kardiologia polska

    2022  Volume 80, Issue 3, Page(s) 346–349

    MeSH term(s) Humans ; Hypertension ; Monocytes ; Phenotype
    Language English
    Publishing date 2022-02-07
    Publishing country Poland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.33963/KP.a2022.0036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 598: Show issues Location:
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    Zs.MO 474: Show issues

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  5. Article ; Online: Th17/Treg imbalance in patients with primary hyperaldosteronism and resistant hypertension.

    Imiela, Anna M / Mikołajczyk, Tomasz P / Siedliński, Mateusz / Dobrowolski, Piotr / Konior-Rozlachowska, Anna / Wróbel, Aleksandra / Biernat-Kałuża, Edyta / Januszewicz, Magdalena / Guzik, Bartłomiej / Guzik, Tomasz J / Januszewicz, Andrzej / Prejbisz, Aleksander

    Polish archives of internal medicine

    2021  Volume 132, Issue 3

    Abstract: Introduction: Inflammation plays a pivotal role in blood pressure regulation. Data on experimental models of hypertension and hypertensive patients reflect the imbalance between T regulatory (Treg) and Th17 effector cells (Th17).: Objectives: The aim ...

    Abstract Introduction: Inflammation plays a pivotal role in blood pressure regulation. Data on experimental models of hypertension and hypertensive patients reflect the imbalance between T regulatory (Treg) and Th17 effector cells (Th17).
    Objectives: The aim of this study was to quantify peripheral blood Treg lymphocytes and Th17 subsets in individuals with primary hyperaldosteronism (PHA) and resistant hypertension (RHT) presenting with elevated blood pressure levels and augmented cardiovascular risk when compared with normotensive controls (CTRL).
    Patients and methods: Twenty CTRL participants, 21 patients with PHA, and 20 patients with RHT were enrolled. Plasma renin and angiotensin II, serum aldosterone concentration, ambulatory blood pressure monitoring (ABPM), echocardiography, clinical data, and phenotype of peripheral blood cells were assessed.
    Results: There were no statistically significant differences in terms of age and sex between the groups. Similar systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels in ABPM were observed in individuals with PHA and RHT. PHA patients had lower angiotensin II and 4‑fold higher aldosterone concentrations than CTRL patients. Both, PHA and RHT were associated with cardiac hypertrophy and coronary artery disease. RHT patients presented a significantly higher CD4+IL‑17A+ T cell number when compared with PHA and CTRL ones. The number of CD4+CD25+FOXP3+ T cells did not differ between patients with secondary hypertension and normotensive controls. Finally, positive correlations between the data on 24 h SBP and the content of CD4+IL‑17A+ and CD4+CD25+FOXP3+ in the PHA were found.
    Conclusions: Elevated 24 h SBP in PHA was associated with the increased numbers of CD4+IL‑17 and CD4+CD25+FOXP3+ T cells.
    MeSH term(s) Aldosterone ; Angiotensin II ; Blood Pressure Monitoring, Ambulatory ; Forkhead Transcription Factors/genetics ; Humans ; Hyperaldosteronism/complications ; Hypertension ; Interleukin-17 ; T-Lymphocytes, Regulatory
    Chemical Substances Forkhead Transcription Factors ; Interleukin-17 ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2021-12-10
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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