Article ; Online: A metabolomics footprinting approach using GC-MS to study inhibitory effects of the fungal metabolite diplopyrone C against nosocomial pathogen biofilms.
Journal of pharmaceutical and biomedical analysis
2024 Volume 243, Page(s) 116081
Abstract: Seen initially as wonder drugs, the widespread and often inappropriate use of antibiotics led to the development of microbial resistances. As a result, a true emergency has arisen, and a significant need has emerged to discover and develop new safe and ... ...
| Abstract | Seen initially as wonder drugs, the widespread and often inappropriate use of antibiotics led to the development of microbial resistances. As a result, a true emergency has arisen, and a significant need has emerged to discover and develop new safe and valuable antibiotics. The captivating chemical structure of the fungal metabolite diplopyrone C has caught our attention as an excellent candidate for a circumstantial study aimed at revealing its antimicrobial and antibiofilm activities. In this work, we describe the full analytical strategy from the isolation/identification to the evaluation of the metabolomics effect on target microorganisms of this fungal metabolite. Our results show interesting antimicrobial and antibiofilm activities of diplopyrone C against two frequently isolated nosocomial pathogens (i.e., the fungus Candida albicans and the gram-negative bacterium Klebsiella pneumoniae). Moreover, a GC-MS based metabolomics footprinting approach gave an insight into the uptake and excretion of metabolites from and into the culture medium as a response to the presence of this active substance. The workflow employed in this study is suitable to exploit natural resources for the search of lead compounds for drug development. |
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| MeSH term(s) | Humans ; Cross Infection ; Gas Chromatography-Mass Spectrometry ; Anti-Infective Agents/pharmacology ; Biofilms ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Pyrones |
| Chemical Substances | diplopyrone ; Anti-Infective Agents ; Anti-Bacterial Agents ; Pyrones |
| Language | English |
| Publishing date | 2024-03-02 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 604917-5 |
| ISSN | 1873-264X ; 0731-7085 |
| ISSN (online) | 1873-264X |
| ISSN | 0731-7085 |
| DOI | 10.1016/j.jpba.2024.116081 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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