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Article ; Online: Monitoring adrenal insufficiency through salivary steroids: a pilot study.

Tucci, Lorenzo / Fanelli, Flaminia / Improta, Ilaria / Bissi, Valentina / Lena, Claudia / Galante, Greta / Mezzullo, Marco / Magagnoli, Matteo / Lalumera, Anna Bianca / Colombin, Giacomo / Coscia, Kimberly / Rotolo, Laura / Vicennati, Valentina / Pagotto, Uberto / Di Dalmazi, Guido

European journal of endocrinology

2024 Volume 190, Issue 4, Page(s) 327–337

Abstract: Background: Various glucocorticoid replacement therapies (GRTs) are available for adrenal insufficiency (AI). However, their effectiveness in restoring glucocorticoid rhythm and exposure lacks adequate biochemical markers. We described the diurnal ... ...

Abstract	Background: Various glucocorticoid replacement therapies (GRTs) are available for adrenal insufficiency (AI). However, their effectiveness in restoring glucocorticoid rhythm and exposure lacks adequate biochemical markers. We described the diurnal salivary cortisol (SalF) and cortisone (SalE) rhythm among different GRTs and analysed the associations between saliva-derived parameters and life quality questionnaires. Methods: Control subjects (CSs, n = 28) and AI patients receiving hydrocortisone (HC, n = 9), cortisone acetate (CA, n = 23), and dual-release hydrocortisone once (DRHC-od, n = 10) and twice a day (DRHC-td, n = 6) collected 9 saliva samples from 07:00 to 23:00. Patients compiled Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, and Addison disease-specific quality-of-life questionnaires. SalE and SalF were measured by liquid chromatography-mass spectrometry. Exposure was monitored using SalE for HC and DRHC and SalF for CA. Area under the curve (AUC) was computed. Different GRTs were compared by Z-scores calculated from saliva-derived parameters. Questionnaire results predictors were evaluated with multiple regression analysis. Results: Compared with controls, all GRTs resulted in glucocorticoid overexposure in the morning. Hydrocortisone, CA, and DRHC-td caused overexposure also in afternoon and evening. Compared with other treatments, CA determined increased Z-score-07:00 (P < .001), DRHC-td determined increased Z-score-AUC07:00→14:00 (P = .007), and DRHC-od induced lower Z-score-AUC14:00→23:00 (P = .015). Z-scores-AUC14:00→16:00 ≥ .619 best predicted questionnaire scores. Conclusions: None of the GRTs mimics normal glucocorticoid rhythmicity and exposure. SalE, SalF, and Z-score may be useful markers for monitoring and comparing different GRTs. Excess glucocorticoid in early afternoon best associated with depressive symptoms and worse life and sleep quality.
MeSH term(s)	Humans ; Glucocorticoids/adverse effects ; Hydrocortisone/analysis ; Pilot Projects ; Adrenal Insufficiency/chemically induced ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/drug therapy ; Cortisone/therapeutic use ; Cortisone/analysis ; Saliva/chemistry
Chemical Substances	Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ) ; Cortisone (V27W9254FZ)
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1183856-5
ISSN	1479-683X ; 0804-4643
ISSN (online)	1479-683X
ISSN	0804-4643
DOI	10.1093/ejendo/lvae037
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Article: Characterization of a New Dry Drill-Milling Process of Carbon Fibre Reinforced Polymer Laminates.

Caggiano, Alessandra / Improta, Ilaria / Nele, Luigi

Materials (Basel, Switzerland)

2018 Volume 11, Issue 8

Abstract: Carbon Fibre Reinforced Polymer (CFRP) composites are widely used in aerospace applications that require severe quality parameters. To simplify the assembly operations and reduce the associated costs, the current trend in industry is to optimize the ... ...

Abstract	Carbon Fibre Reinforced Polymer (CFRP) composites are widely used in aerospace applications that require severe quality parameters. To simplify the assembly operations and reduce the associated costs, the current trend in industry is to optimize the drilling processes. However, the machining of CFRP composites is very challenging compared with metals, and several defect types can be generated by drilling. The emerging process of orbital drilling can greatly reduce the defects associated with the traditional drilling of CFRP, but it is a more complex process requiring careful process parameters selection and it does not allow for the complete elimination of the thrust force responsible for delamination damage. As an alternative to traditional and orbital drilling, this work presents a new hole making process, where the hole is realized by a combination of drilling and peripheral milling performed using the same cutting tool following a novel tool path strategy. An original tool design principle is proposed to realize a new drill-milling tool, made of a first drilling and a subsequent milling portion. Two different tool configurations are experimentally tested to evaluate the performance of the newly-conceived combined drill-milling process. This process is quick and easy, and the experimental results show an improvement in the drilled hole quality.
Language	English
Publishing date	2018-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma11081470
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Article ; Online: Physical Activity and Type 2 Diabetes: In Search of a Personalized Approach to Improving β-Cell Function.

Di Murro, Emanuela / Di Giuseppe, Gianfranco / Soldovieri, Laura / Moffa, Simona / Improta, Ilaria / Capece, Umberto / Nista, Enrico Celestino / Cinti, Francesca / Ciccarelli, Gea / Brunetti, Michela / Gasbarrini, Antonio / Pontecorvi, Alfredo / Giaccari, Andrea / Mezza, Teresa

Nutrients

2023 Volume 15, Issue 19

Abstract: Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are fundamental non-pharmacological components of T2DM therapy. Exercise interventions are strongly ... ...

Abstract	Type 2 diabetes mellitus (T2DM) is one of the most widespread diseases worldwide. Lifestyle interventions, including diet and physical activity (PA), are fundamental non-pharmacological components of T2DM therapy. Exercise interventions are strongly recommended for people with or at risk of developing or already with overt diabetes, but adherence to PA guidelines in this population is still challenging. Furthermore, the heterogeneity of T2DM patients, driven by differing residual β-cell functionality, as well as the possibility of practicing different types and intensities of PA, has led to the need to develop tailored exercise and training plans. Investigations on blood glucose variation in response to exercise could help to clarify why individuals do not respond in the same way to PA, and to guide the prescription of personalized treatments. The aim of this review is to offer an updated overview of the current evidence on the effects of different regimens and modalities of PA regarding glucose sensing and β-cell secretory dynamics in individuals with prediabetes or T2DM, with a special focus on β-cell function.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Exercise ; Prediabetic State/therapy ; Diet ; Blood Glucose
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-09-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15194202
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Article ; Online: Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports.

Moffa, Simona / Improta, Ilaria / Rocchetti, Sandro / Mezza, Teresa / Giaccari, Andrea

Nutrition (Burbank, Los Angeles County, Calif.)

2018 Volume 57, Page(s) 1–4

Abstract: Objectives: Insulin autoimmune syndrome (IAS) or Hirata disease is a rare cause of autoimmune hypoglycemia with apparent high insulin levels and anti-insulin autoantibodies and was first described by Hirata in Japan in 1970. IAS cases are usually ... ...

Abstract	Objectives: Insulin autoimmune syndrome (IAS) or Hirata disease is a rare cause of autoimmune hypoglycemia with apparent high insulin levels and anti-insulin autoantibodies and was first described by Hirata in Japan in 1970. IAS cases are usually related to exposure to sulfhydryl-containing drugs, which stimulate the production of insulin autoantibodies. Among sulfhydryl-containing compounds, alpha lipoic acid (ALA) has recently emerged as a cause of IAS. After the first observations of ALA-induced IAS were reported in Japan in 2006, an increasing number of cases related to ALA administration have been described. An Italian group recently reported on six cases of IAS of which one was associated with HLA-DRB104:06 and the remaining five with HLA-DRB104:03. This suggests that the latter is potentially involved in the genetic susceptibility of people of European descent to IAS. Methods: Here, we describe two new cases of IAS in women that were triggered by ALA. Results: Both cases are associated with HLA-DRB104:03 and confirm the evidence that HLA-DRB104:03 rather than HLA-DRB104:06 is specifically related to IAS susceptibility in Europeans. Conclusions:* Case reports of ALA-induced hypoglycemic episodes highlight the need for greater care in prescribing ALA supplementation as well as the identification of specific and personalized therapeutic targets.
MeSH term(s)	Aged ; Aged, 80 and over ; Antioxidants/adverse effects ; Autoimmune Diseases/blood ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/drug therapy ; Dietary Supplements/adverse effects ; Female ; Glucocorticoids/therapeutic use ; Humans ; Hypoglycemia/blood ; Hypoglycemia/chemically induced ; Hypoglycemia/drug therapy ; Insulin/blood ; Insulin/immunology ; Insulin Antibodies/blood ; Insulin Antibodies/immunology ; Prednisone/therapeutic use ; Syndrome ; Thioctic Acid/adverse effects ; Thioctic Acid/blood ; Thioctic Acid/immunology
Chemical Substances	Antioxidants ; Glucocorticoids ; Insulin ; Insulin Antibodies ; Thioctic Acid (73Y7P0K73Y) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2018-05-25
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639259-3
ISSN	1873-1244 ; 0899-9007
ISSN (online)	1873-1244
ISSN	0899-9007
DOI	10.1016/j.nut.2018.04.010
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Article ; Online: Cognitive dysfunctions in occipital lobe epilepsy compared to temporal lobe epilepsy.

Santangelo, Gabriella / Trojano, Luigi / Vitale, Carmine / Improta, Ilaria / Alineri, Irma / Meo, Roberta / Bilo, Leonilda

Journal of neuropsychology

2015 Volume 11, Issue 2, Page(s) 277–290

Abstract: Objective: To compare cognitive profiles of occipital lobe epilepsy (OLE) and temporal lobe epilepsy (TLE) and to investigate whether impairment of visuospatial functions is a specific deficit of OLE.: Method: Eighteen patients with OLE, 18 patients ... ...

Abstract	Objective: To compare cognitive profiles of occipital lobe epilepsy (OLE) and temporal lobe epilepsy (TLE) and to investigate whether impairment of visuospatial functions is a specific deficit of OLE. Method: Eighteen patients with OLE, 18 patients with TLE, and 18 controls underwent a neuropsychological battery assessing memory, visuospatial functions, and frontal/executive functions. Results: Multivariate analysis evidenced poorer performance of patients with TLE and patients with OLE relative to controls on tasks assessing verbal and non-verbal long-term memory, frontal functions, and visuospatial functions. Patients with OLE had poorer performance than patients with TLE on visuospatial tasks, whereas patients with TLE performed worse than patients with OLE on verbal long-term memory test. Discriminant analysis identified two canonical discriminant functions: The first explained 53.3% of the variance, and the second explained 46.7% of the variance. The first function included verbal and non-verbal memory tests distinguishing controls from both OLE and TLE, whereas the second factor including a visuoconstructional test distinguished OLE from TLE and controls. Conclusions: The results demonstrate that visuoconstructional dysfunction is related to OLE and support the idea that alterations of occipito-parietal stream may be specific to patients with OLE.
MeSH term(s)	Adult ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Epilepsies, Partial/complications ; Epilepsy, Temporal Lobe/complications ; Executive Function/physiology ; Female ; Humans ; Male ; Memory/physiology ; Memory Disorders/etiology ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; Visual Perception/physiology ; Young Adult
Language	English
Publishing date	2015-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2380753-2
ISSN	1748-6653 ; 1748-6645
ISSN (online)	1748-6653
ISSN	1748-6645
DOI	10.1111/jnp.12085
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Article ; Online: Patterns in ano-rectal dose maps and the risk of late toxicity after prostate IMRT.

Onjukka, Eva / Fiorino, Claudio / Cicchetti, Alessandro / Palorini, Federica / Improta, Ilaria / Gagliardi, Giovanna / Cozzarini, Cesare / Degli Esposti, Claudio / Gabriele, Pietro / Valdagni, Riccardo / Rancati, Tiziana

Acta oncologica (Stockholm, Sweden)

2019 Volume 58, Issue 12, Page(s) 1757–1764

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Anal Canal/radiation effects ; Dose Fractionation, Radiation ; Fecal Incontinence/etiology ; Gastrointestinal Hemorrhage/etiology ; Humans ; Male ; Prospective Studies ; Prostatic Neoplasms/radiotherapy ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Rectal Diseases/etiology ; Rectum/radiation effects ; Risk
Language	English
Publishing date	2019-07-12
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	896449-x
ISSN	1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
ISSN (online)	1651-226X
ISSN	0349-652X ; 0284-186X ; 1100-1704
DOI	10.1080/0284186X.2019.1635267
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Article ; Online: Body Constraints on Motor Simulation in Autism Spectrum Disorders.

Conson, Massimiliano / Hamilton, Antonia / De Bellis, Francesco / Errico, Domenico / Improta, Ilaria / Mazzarella, Elisabetta / Trojano, Luigi / Frolli, Alessandro

Journal of autism and developmental disorders

2016 Volume 46, Issue 3, Page(s) 1051–1060

Abstract: Developmental data suggested that mental simulation skills become progressively dissociated from overt motor activity across development. Thus, efficient simulation is rather independent from current sensorimotor information. Here, we tested the impact ... ...

Abstract	Developmental data suggested that mental simulation skills become progressively dissociated from overt motor activity across development. Thus, efficient simulation is rather independent from current sensorimotor information. Here, we tested the impact of bodily (sensorimotor) information on simulation skills of adolescents with Autism Spectrum Disorders (ASD). Typically-developing (TD) and ASD participants judged laterality of hand images while keeping one arm flexed on chest or while holding both arms extended. Both groups were able to mentally simulate actions, but this ability was constrained by body posture more in ASD than in TD adolescents. The strong impact of actual body information on motor simulation implies that simulative skills are not fully effective in ASD individuals.
MeSH term(s)	Adolescent ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/psychology ; Child ; Female ; Functional Laterality/physiology ; Hand/physiology ; Humans ; Male ; Motor Activity/physiology ; Photic Stimulation/methods ; Posture/physiology ; Psychomotor Performance/physiology ; Reaction Time/physiology ; Young Adult
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-015-2652-x
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Article ; Online: Neuropsychological profile of adult patients with nonsymptomatic occipital lobe epilepsies.

Bilo, Leonilda / Santangelo, Gabriella / Improta, Ilaria / Vitale, Carmine / Meo, Roberta / Trojano, Luigi

Journal of neurology

2012 Volume 260, Issue 2, Page(s) 445–453

Abstract: To explore the neuropsychological and neurobehavioral profile in adult patients affected by nonsymptomatic (cryptogenic and idiopathic) occipital lobe epilepsy (OLE), with normal intelligence, we enrolled 20 adult patients with nonsymptomatic OLE and 20 ... ...

Abstract	To explore the neuropsychological and neurobehavioral profile in adult patients affected by nonsymptomatic (cryptogenic and idiopathic) occipital lobe epilepsy (OLE), with normal intelligence, we enrolled 20 adult patients with nonsymptomatic OLE and 20 age-, sex-, and education-matched healthy subjects. All participants underwent neuropsychiatric assessment scales, and standardized neuropsychological tests tapping memory, executive functions, constructional, visuospatial and visuoperceptual skills. After Bonferroni correction for multiple comparisons, patients performed significantly worse than controls on several tests tapping complex visuospatial skills and frontal lobe functions. The analysis of single patients' performance revealed that a significantly higher number of OLE patients achieved age- and education-adjusted pathological scores on three tests (Benton Judgment of Line Orientation Test, Freehand Copying of Drawings Test, color-word interference task of Stroop test) with respect to controls. Patients did not differ from control subjects on neuropsychiatric aspects. The direct comparison between OLE subtypes showed that cryptogenetic OLE patients tended to achieve lower scores than idiopathic OLE patients on most tests, but no difference between the two groups was fully significant. In summary, patients with nonsymptomatic OLE can be affected by clinically relevant impairments in selected neuropsychological domains: complex visuospatial skills and executive functions. It could be speculated that frontal and visuospatial cognitive deficits might be the result of epileptic activity spreading within a neural network that includes structures far beyond the occipital lobe.
MeSH term(s)	Adolescent ; Adult ; Behavioral Symptoms/etiology ; Case-Control Studies ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Electroencephalography ; Epilepsies, Partial/complications ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Statistics as Topic ; Statistics, Nonparametric ; Young Adult
Language	English
Publishing date	2012-08-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-012-6650-z
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Article ; Online: Impulse control disorders induced by rasagiline as adjunctive therapy for Parkinson's disease: report of 2 cases.

Vitale, Carmine / Santangelo, Gabriella / Erro, Roberto / Errico, Domenico / Manganelli, Fiore / Improta, Ilaria / Moccia, Marcello / Barone, Paolo

Parkinsonism & related disorders

2013 Volume 19, Issue 4, Page(s) 483–484

MeSH term(s)	Aged ; Antiparkinson Agents/therapeutic use ; Disruptive, Impulse Control, and Conduct Disorders/chemically induced ; Humans ; Indans/adverse effects ; Male ; Middle Aged ; Neuroprotective Agents/adverse effects ; Parkinson Disease/drug therapy
Chemical Substances	Antiparkinson Agents ; Indans ; Neuroprotective Agents ; rasagiline (003N66TS6T)
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2012.11.008
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Article ; Online: Baseline status and dose to the penile bulb predict impotence 1 year after radiotherapy for prostate cancer.

Cozzarini, Cesare / Rancati, Tiziana / Badenchini, Fabio / Palorini, Federica / Avuzzi, Barbara / Degli Esposti, Claudio / Girelli, Giuseppe / Improta, Ilaria / Vavassori, Vittorio / Valdagni, Riccardo / Fiorino, Claudio

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2016 Volume 192, Issue 5, Page(s) 297–304

Abstract: Aim: To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer.: Patients and methods: In a multi-centric prospective study, the International Index of Erectile Function (IIEF) questionnaire-based potency of 91 ... ...

Title translation	Baseline-Status und Dosis auf den Bulbus penis als Prädiktoren für Impotenz ein Jahr nach Radiotherapie bei Prostatakrebs.
Abstract	Aim: To assess the predictors of the onset of impotence 1 year after radiotherapy for prostate cancer. Patients and methods: In a multi-centric prospective study, the International Index of Erectile Function (IIEF) questionnaire-based potency of 91 hormone-naïve and potent patients (IIEF1-5 > 11 before radiotherapy) was assessed. At the time of this analysis, information on potency 1 year after treatment was available for 62 of 91 patients (42 treated with hypofractionation: 2.35-2.65 Gy/fr, 70-74.2 Gy; 20 with conventional fractionation: 74-78 Gy). Prospectively collected individual information and Dmax/Dmean to the penile bulb were available; the corresponding 2 Gy-equivalent values (EQD2_max/EQD2_mean) were also considered. Predictors of 1‑year impotency were assessed through uni- and multi-variable backward logistic regression: The best cut-off values discriminating between potent and impotent patients were assessed by ROC analyses. The discriminative power of the models and goodness-of-fit were measured by AUC analysis and the Hosmer-Lemeshow (H&L) test. Results: At 1‑year follow-up, 26 of 62 patients (42 %) became impotent. The only predictive variables were baseline IIEF1-5 values (best cut-off baseline IIEF1-5 ≥ 19), Dmax ≥ 68.5 Gy and EQD2_max ≥ 74.2 Gy. The risk of 1‑year impotence may be predicted by a two-variable model including baseline IIEF1-5 (OR: 0.80, p = 0.003) and EQD2_max ≥ 74.2 Gy (OR: 4.1, p = 0.022). The AUC of the model was 0.77 (95% CI: 0.64-0.87, p = 0.0007, H&L: p = 0.62). The 1‑year risk of impotency after high-dose radiotherapy in potent men depends on the EQD2_max to the penile bulb and on baseline IIEF1-5 values. Conclusion: A significant reduction in the risk may be expected mainly when sparing the bulb in patients with no/mild baseline impotency (IIEF1-5 > 17).
MeSH term(s)	Aged ; Aged, 80 and over ; Comorbidity ; Erectile Dysfunction/diagnosis ; Erectile Dysfunction/epidemiology ; Follow-Up Studies ; Humans ; Italy/epidemiology ; Longitudinal Studies ; Male ; Middle Aged ; Outcome Assessment (Health Care)/methods ; Penis/radiation effects ; Prevalence ; Prognosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/radiotherapy ; Radiation Exposure/analysis ; Radiation Injuries/diagnosis ; Radiation Injuries/epidemiology ; Radiotherapy Dosage ; Regression Analysis ; Reproducibility of Results ; Risk Assessment/methods ; Sensitivity and Specificity ; Treatment Outcome
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-016-0964-1
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