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  1. Article ; Online: Human CRB1 and CRB2 form homo- and heteromeric protein complexes in the retina.

    Stehle, Isabel F / Imventarza, Joel A / Woerz, Franziska / Hoffmann, Felix / Boldt, Karsten / Beyer, Tina / Quinn, Peter Mj / Ueffing, Marius

    Life science alliance

    2024  Volume 7, Issue 6

    Abstract: Crumbs homolog ... ...

    Abstract Crumbs homolog 1
    MeSH term(s) Animals ; Humans ; Zebrafish/genetics ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Retina/metabolism ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/metabolism ; Leber Congenital Amaurosis/genetics ; Leber Congenital Amaurosis/metabolism ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Carrier Proteins/metabolism
    Chemical Substances Membrane Proteins ; CRB1 protein, human ; Eye Proteins ; Nerve Tissue Proteins ; CRB2 protein, human ; Carrier Proteins
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Upregulation of retinal VEGF and connexin 43 in murine nonarteritic anterior ischemic optic neuropathy induced with 577 nm laser.

    Rangel, Barbara / Mesentier-Louro, Louise A / Lowe, Lauryn L / Shariati, Ali Mohammad / Dalal, Roopa / Imventarza, Joel A / Liao, Yaping Joyce

    Experimental eye research

    2022  Volume 225, Page(s) 109139

    Abstract: Nonarteritic anterior ischemic optic neuropathy (NAION) is a common acute optic neuropathy and cause of irreversible vision loss in those older than 50 years of age. There is currently no effective treatment for NAION and the biological mechanisms ... ...

    Abstract Nonarteritic anterior ischemic optic neuropathy (NAION) is a common acute optic neuropathy and cause of irreversible vision loss in those older than 50 years of age. There is currently no effective treatment for NAION and the biological mechanisms leading to neuronal loss are not fully understood. Promising novel targets include glial cells activation and intercellular communication mediated by molecules such as gap junction protein Connexin 43 (Cx43), which modulate neuronal fate in central nervous system disorders. In this study, we investigated retinal glial changes and neuronal loss following a novel NAION animal model using a 577 nm yellow laser. We induced unilateral photochemical thrombosis using rose bengal at the optic nerve head vasculature in adult C57BL/6 mice using a 577 nm laser and performed morphometric analysis of the retinal structure using serial in vivo optical coherence tomography (OCT) and histology for glial and neuronal markers. One day after experimental NAION, in acute phase, OCT imaging revealed peripapillary thickening of the retinal ganglion cell complex (GCC, baseline: 79.5 ± 1.0 μm, n = 8; NAION: 93.0 ± 2.5 μm, n = 8, P < 0.01) and total retina (baseline: 202.9 ± 2.4 μm, n = 8; NAION: 228.1 ± 6.8 μm, n = 8, P < 0.01). Twenty-one days after ischemia, at a chronic phase, there was significant GCC thinning (baseline 78.3 ± 2.1 μm, n = 6; NAION: 72.2 ± 1.9 μm, n = 5, P < 0.05), mimicking human disease. Examination of molecular changes in the retina one day after ischemia revealed that NAION induced a significant increase in retinal VEGF levels (control: 2319 ± 195, n = 5; NAION: 4549 ± 683 gray mean value, n = 5, P < 0.05), which highly correlated with retinal thickness (r = 0.89, P < 0.05). NAION also led to significant increase in mRNA level for Cx43 (Gj1a) at day 1 (control: 1.291 ± 0.38; NAION: 3.360 ± 0.58 puncta/mm
    MeSH term(s) Adult ; Mice ; Humans ; Animals ; Optic Neuropathy, Ischemic/diagnosis ; Vascular Endothelial Growth Factor A ; Connexin 43/genetics ; Up-Regulation ; Mice, Inbred C57BL ; Retina/pathology ; Tomography, Optical Coherence/methods ; Lasers ; Disease Models, Animal
    Chemical Substances Vascular Endothelial Growth Factor A ; Connexin 43
    Language English
    Publishing date 2022-06-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2022.109139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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