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Article ; Online: JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes.

Ogawa, Shuhei / Ishii, Takashi / Otani, Takahito / Inai, Yuko / Matsuura, Takashi / Inai, Tetsuichiro

2024 Volume 161, Issue 4, Page(s) 345–357

Abstract: ... c-Jun ... ...

Abstract	c-Jun NH
MeSH term(s)	Cell Adhesion/genetics ; Desmoglein 3/genetics ; Desmoglein 3/metabolism ; Keratinocytes/metabolism ; MAP Kinase Signaling System
Chemical Substances	Desmoglein 3
Language	English
Publishing date	2024-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-023-02264-8
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Article: A patient with pleuroparenchymal fibroelastosis carrying a novel

Hidaka, Kouko / Inai, Tetsuichiro / Kosho, Tomoki / Yamaguchi, Tomomi / Kawabata, Yoshinori / Inai, Yuko / Imamura, Shogo / Sanada, Sakiko

Respiratory medicine case reports

2023 Volume 44, Page(s) 101870

Abstract: Pleuroparenchymal fibroelastosis is a recently recognized clinical entity characterized by interstitial pneumonia with proliferating elastin in the upper lung regions. Pleuroparenchymal fibroelastosis is categorized as idiopathic or reported depending on ...

Abstract	Pleuroparenchymal fibroelastosis is a recently recognized clinical entity characterized by interstitial pneumonia with proliferating elastin in the upper lung regions. Pleuroparenchymal fibroelastosis is categorized as idiopathic or reported depending on the coexistent initiating factors; however, congenital contractural arachnodactyly, which is caused by abnormal production of elastin based on a mutation in the
Language	English
Publishing date	2023-05-13
Publishing country	England
Document type	Case Reports
ZDB-ID	2666110-X
ISSN	2213-0071
ISSN	2213-0071
DOI	10.1016/j.rmcr.2023.101870
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Article ; Online: Risk factors for postoperative pneumonia according to examination findings before surgery under general anesthesia.

Inai, Yuko / Nomura, Yoshiaki / Takarada, Tohru / Hanada, Nobuhiro / Wada, Naohisa

Clinical oral investigations

2020 Volume 24, Issue 10, Page(s) 3577–3585

Abstract: Objective: This study was performed to determine the risk factors associated with postoperative complications after surgery under general anesthesia according to respiratory function test results and oral conditions.: Materials and methods: ... ...

Abstract	Objective: This study was performed to determine the risk factors associated with postoperative complications after surgery under general anesthesia according to respiratory function test results and oral conditions. Materials and methods: Preoperative examination data were collected for 471 patients who underwent surgery under general anesthesia at the Medical Hospital of Kyusyu University. Respiratory function tests, oral examinations, and perioperative oral management were performed in all patients. The incidence of and risk factors for postoperative complications were investigated. Classification and regression tree analyses were performed to investigate the risk factors for postoperative complications. Results: Among the 471 patients, 11 developed postoperative pneumonia, 10 developed postoperative respiratory symptoms, and 10 developed postoperative fever. The most important risk factor for pneumonia was edentulism. Age, the Brinkman index, and head and neck surgery were also revealed as important risk factors for pneumonia. The O'Leary plaque control record (initial visit) was an important risk factor for postoperative respiratory symptoms. With respect to postoperative fever, a Hugh-Jones classification of grade > 1 was the most important risk factor; edentulism and a Brinkman index of > 642.5 were also found to be risk factors. Conclusion: In addition to respiratory function tests, oral examinations may be important for the prediction of postoperative complications. Additionally, improved oral hygiene may be effective in preventing postoperative respiratory complications. Clinical relevance: Risk factors for postoperative complications should be comprehensively evaluated using both respiratory function tests and oral findings.
MeSH term(s)	Anesthesia, General ; Humans ; Incidence ; Pneumonia/etiology ; Postoperative Complications ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2020-02-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-020-03230-7
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Article ; Online: Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes.

Ishikawa, Shoko / Nikaido, Misaki / Otani, Takahito / Ogata, Kayoko / Iida, Hiroshi / Inai, Yuko / Tamaoki, Sachio / Inai, Tetsuichiro

Microscopy (Oxford, England)

2022 Volume 71, Issue 3, Page(s) 152–160

Abstract: Retinoic acid (RA) plays an important role in epithelial homeostasis and influences the morphology, proliferation, differentiation and permeability of epithelial cells. Mouse keratinocytes, K38, reconstituted non-keratinized stratified epithelium in ... ...

Abstract	Retinoic acid (RA) plays an important role in epithelial homeostasis and influences the morphology, proliferation, differentiation and permeability of epithelial cells. Mouse keratinocytes, K38, reconstituted non-keratinized stratified epithelium in three-dimensional (3D) cultures with serum, which contains retinol (a source of RA), but the morphology was different from in vivo epithelium. The formed epithelium was thick, with loosened cell-cell contacts. Here, we investigated whether the inhibition of RA receptor (RAR)/retinoid X receptor (RXR)-mediated signaling by an RXR antagonist, HX 531, improved K38 3D cultures in terms of morphology and intercellular junctions. The epithelium formed by 0.5 μM HX531 was thin, and the intercellular space was narrowed because of the restoration of the layer-specific distribution of desmoglein (DSG)-1, DSG3 and plakoglobin (PG). Moreover, the levels of desmosomal proteins and tight junction proteins, including DSG1, DSG2, DSG3, PG, claudin (CLDN)-1 and CLDN4 increased, but the adherens junction protein, E-cadherin, did not show any change. Furthermore, CLDN1 was recruited to occludin-positive cell-cell contacts in the superficial cells and transepithelial electrical resistance was increased. Therefore, K38 3D cultures treated with 0.5 μM HX531 provides a useful in vitro model to study intercellular junctions in the non-keratinized epithelium.
MeSH term(s)	Animals ; Benzoates/pharmacology ; Biphenyl Compounds/pharmacology ; Cell Culture Techniques, Three Dimensional ; Desmosomal Cadherins/metabolism ; Keratinocytes/cytology ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Mice ; Permeability ; Retinoid X Receptors/antagonists & inhibitors ; Retinoid X Receptors/metabolism
Chemical Substances	Benzoates ; Biphenyl Compounds ; Desmosomal Cadherins ; Retinoid X Receptors ; diazepinylbenzoic acid
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2707496-1
ISSN	2050-5701 ; 2050-5698
ISSN (online)	2050-5701
ISSN	2050-5698
DOI	10.1093/jmicro/dfac007
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Article ; Online: Factors That Influence the Judgment of Oral Management Necessity in Preoperative Oral Screening.

Kai, Nanami / Tsukamoto, Yoko / Urabe, Kaoru / Tani, Asuka / Inai, Yuko / Okadome, Asako / Kashiwazaki, Haruhiko / Mizutani, Shinsuke / Wada, Naohisa

International journal of environmental research and public health

2021 Volume 18, Issue 22

Abstract: Oral management during the perioperative period is important to prevent the development of postoperative complications. However, there are no unified systems to examine the oral status of patients and very few studies have focused on preoperative oral ... ...

Abstract	Oral management during the perioperative period is important to prevent the development of postoperative complications. However, there are no unified systems to examine the oral status of patients and very few studies have focused on preoperative oral screening. In this study, we examined the oral status of patients who underwent oral screening at a University Hospital. A total of 1173 patients who underwent oral screening for perioperative management from April 2020 to July 2021 were enrolled. The subjects' medical data were retrospectively extracted from the dental records, and finally, the data of 1081 patients aged ≥20 years were analyzed. Oral screening based on seven categories was performed by dentists or dental hygienists. Our cumulative results determined whether patients required oral management during the perioperative period. "Poor oral hygiene" was the most frequent category (24%) of all oral categories examined. Logistic analysis revealed that tooth mobility had the highest odds ratio (21.476; 95% confidence interval: 11.462-40.239;
MeSH term(s)	Humans ; Judgment ; Odds Ratio ; Perioperative Period ; Postoperative Complications ; Retrospective Studies
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182212236
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Article ; Online: Effect of Mucosal Brushing on the Serum Levels of C-Reactive Protein for Patients Hospitalized with Acute Symptoms.

Nakahodo, Naoko / Nomura, Yoshiaki / Oshiro, Takumi / Otsuka, Ryoko / Kakuta, Erika / Okada, Ayako / Inai, Yuko / Takei, Noriko / Hanada, Nobuhiro

Medicina (Kaunas, Lithuania)

2020 Volume 56, Issue 10

Abstract: This study was based in a hospital setting. Patients with acute symptoms face a life-threatening crisis and often have systemic complications during the convalescence stage. During the acute stage, oral function does not work and oral hygiene status ... ...

Abstract	This study was based in a hospital setting. Patients with acute symptoms face a life-threatening crisis and often have systemic complications during the convalescence stage. During the acute stage, oral function does not work and oral hygiene status deteriorates. A gauze or sponge brush is generally used to wipe the oral cavity; however, this process does not clean the oral cavity enough. Effective oral care requires better methods. Patients participating in this study were all hospitalized by ambulance and with acute symptoms. During the convalescence stage, patients were assigned application of mucosal brushing or wiping by gauze or sponge brush by order of hospitalization. The effects were evaluated by the number of bacteria on the tongue surface, serum C-reactive protein (CRP) and body temperature. Changes in bacterial count, body temperature, and CRP were effectively reduced in the mucosal brushing group compared to the wiping by gauze or sponge brush group. Based on mixed effect modeling, the coefficient of mucosal brushing for CRP was -2.296 and for body temperature was -0.067 and statistically significant. This simple method can effectively prevent systemic complication of inpatients with deteriorated oral conditions. This method may also be effective for the elderly in nursing homes or perioperative oral-care management.
MeSH term(s)	C-Reactive Protein/analysis ; Critical Illness ; Humans ; Mouth Mucosa ; Mucous Membrane ; Tongue ; Toothbrushing
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2020-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina56100549
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Article ; Online: The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium.

Miyazono, Shoji / Otani, Takahito / Ogata, Kayoko / Kitagawa, Norio / Iida, Hiroshi / Inai, Yuko / Matsuura, Takashi / Inai, Tetsuichiro

Histochemistry and cell biology

2020 Volume 153, Issue 4, Page(s) 225–237

Abstract: Keratinocytes take up serum-derived retinol (vitamin A) and metabolize it to all-trans-retinoic acid (atRA), which binds to the nuclear retinoic acid receptor (RAR). We previously reported that serum-affected keratinocyte differentiation and function; ... ...

Abstract	Keratinocytes take up serum-derived retinol (vitamin A) and metabolize it to all-trans-retinoic acid (atRA), which binds to the nuclear retinoic acid receptor (RAR). We previously reported that serum-affected keratinocyte differentiation and function; namely, it inhibited keratinization, decreased loricrin (LOR) and claudin (CLDN) 1 expression, increased keratin (K) 4 and CLDN4 levels, and reduced paracellular permeability in three-dimensional (3D) cultures of mouse keratinocytes (COCA). Contrarily, RAR inhibition reversed these changes. Here, we aimed to examine whether atRA exerted the same effects as serum, and whether it was involved in the differential oral mucosa keratinization among animal species. Porcine oral mucosal keratinocytes, which form non-keratinized epithelium in vivo, established keratinized epithelium in 3D cultures. Both mouse and porcine sera induced non-keratinized epithelium at 0.1% in COCA 3D cultures. Although atRA caused the same changes as serum, its effective concentration differed. atRA inhibited keratinization at 0.1 nM and 1 nM in porcine or human keratinocytes and COCA, respectively. Furthermore, atRA upregulated CLDN7 in the cytoplasm but not in cell-cell contacts. These atRA-induced changes were reverted by RAR inhibition. The results indicate that serum-induced changes are probably due to the effect of serum-derived atRA, and that mouse keratinocytes require higher atRA concentrations to suppress keratinization than porcine and human keratinocytes. We propose that the lower susceptibility of mouse keratinocytes to atRA, rather than a lower retinol concentration, is a possible reason for the keratinization of mouse oral mucosal epithelium.
MeSH term(s)	Animals ; Benzoates/pharmacology ; Cells, Cultured ; Epithelium/drug effects ; Epithelium/metabolism ; Esophageal Mucosa/drug effects ; Esophageal Mucosa/metabolism ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratins/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Mouth Mucosa/drug effects ; Mouth Mucosa/metabolism ; Stilbenes/pharmacology ; Swine ; Tretinoin/antagonists & inhibitors ; Tretinoin/pharmacology
Chemical Substances	4-(2-(5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl)ethen-1-yl)benzoic acid ; Benzoates ; Stilbenes ; Tretinoin (5688UTC01R) ; Keratins (68238-35-7)
Language	English
Publishing date	2020-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-020-01845-1
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Article ; Online: Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3.

Kitagawa, Norio / Inai, Yuko / Higuchi, Yoshinori / Iida, Hiroshi / Inai, Tetsuichiro

Histochemistry and cell biology

2014 Volume 142, Issue 4, Page(s) 389–399

Abstract: Epidermal keratinocytes proliferate in the basal layer, differentiate, migrate through the spinous layer, granular layer and cornified layer, and finally are peeled off from the surface of skin with layer-specific expression of differentiation markers, ... ...

Abstract	Epidermal keratinocytes proliferate in the basal layer, differentiate, migrate through the spinous layer, granular layer and cornified layer, and finally are peeled off from the surface of skin with layer-specific expression of differentiation markers, including cytokeratins and cell-cell junction proteins such as desmogleins. Basal cells express CK5, CK14 and Ki67. In contrast, the suprabasal cells in the spinous and granular layers express CK1 and CK10 without Ki67. Inhibition of c-Jun NH2-terminal protein kinase (JNK) in HaCaT cells, a human epidermal keratinocyte cell line, induced the formation of tight junctions, which occurs in the granular layer in vivo. These cells lost their expression of CK5 and CK17, exhibited decreased expression of desmoglein 3 and had no Ki67 labeling in the nucleus. These results suggest that inhibition of JNK causes HaCaT cells to differentiate from basal- and spinous-like cells to granular-like cells. The inhibition of JNK in HaCaT cells provides a useful in vitro model system to study the differentiation of epidermal keratinocytes.
MeSH term(s)	Anthracenes/chemistry ; Anthracenes/pharmacology ; Cells, Cultured ; Desmoglein 3/biosynthesis ; Desmoglein 3/deficiency ; Down-Regulation/drug effects ; Humans ; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors ; JNK Mitogen-Activated Protein Kinases/metabolism ; Keratin-17/biosynthesis ; Keratin-17/deficiency ; Keratin-5/biosynthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Structure-Activity Relationship ; Tight Junctions/drug effects ; Tight Junctions/metabolism
Chemical Substances	Anthracenes ; DSG3 protein, human ; Desmoglein 3 ; Keratin-17 ; Keratin-5 ; Protein Kinase Inhibitors ; pyrazolanthrone (1TW30Y2766) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2014-04-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1222930-1
ISSN	1432-119X ; 0301-5564 ; 0948-6143
ISSN (online)	1432-119X
ISSN	0301-5564 ; 0948-6143
DOI	10.1007/s00418-014-1219-9
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Article ; Online: Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage.

Hama, Susumu / Takahashi, Kanako / Inai, Yuko / Shiota, Kanako / Sakamoto, Ryota / Yamada, Asako / Tsuchiya, Hiroyuki / Kanamura, Kiyoshi / Yamashita, Eiji / Kogure, Kentaro

Journal of pharmaceutical sciences

2012 Volume 101, Issue 8, Page(s) 2909–2916

Abstract: Astaxanthin (Asx) would be expected to prevent ultraviolet (UV)-induced skin damage, as it is regarded as a potent antioxidative carotenoid in biological membranes. However, it is difficult to administer Asx topically to skin because of its poor water ... ...

Abstract	Astaxanthin (Asx) would be expected to prevent ultraviolet (UV)-induced skin damage, as it is regarded as a potent antioxidative carotenoid in biological membranes. However, it is difficult to administer Asx topically to skin because of its poor water solubility. In this study, we attempted to solve this problem by preparing liposomes containing Asx (Asx-lipo), which were dispersible in the water phase, and therefore, suitable for topical application to the skin. Asx-lipo was shown to have potent scavenging ability against chemiluminescence-dependent singlet oxygen production in the water phase. When Asx-lipo was applied to skin before UV exposure, UV-induced skin thickening was prevented. Interestingly, collagen reduction induced by UV exposure was also prevented by preadministration of Asx-lipo. In addition, topical administration of Asx-lipo containing cationic lipid inhibited melanin production in skin exposed to UV. Consequently, we succeeded in preventing UV-induced skin damage using a topical application of a liposomal formulation containing Asx.
MeSH term(s)	Administration, Topical ; Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Iontophoresis ; Liposomes/chemistry ; Male ; Melanins/metabolism ; Mice ; Mice, Hairless ; Singlet Oxygen/metabolism ; Skin/drug effects ; Skin/metabolism ; Skin/pathology ; Skin/radiation effects ; Skin Pigmentation/drug effects ; Skin Pigmentation/radiation effects ; Ultraviolet Rays ; Xanthophylls/administration & dosage ; Xanthophylls/pharmacology
Chemical Substances	Antioxidants ; Liposomes ; Melanins ; Xanthophylls ; Singlet Oxygen (17778-80-2) ; astaxanthine (8XPW32PR7I)
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1002/jps.23216
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