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  1. Article ; Online: Establishment of a novel NFAT-GFP reporter platform useful for the functional avidity maturation of HLA class II-restricted TCRs.

    Fujiki, Fumihiro / Morimoto, Soyoko / Nishida, Yuya / Tanii, Satoe / Aoyama, Nao / Inatome, Miki / Inoue, Kento / Katsuhara, Akiko / Nakajima, Hiroko / Nakata, Jun / Nishida, Sumiyuki / Tsuboi, Akihiro / Oka, Yoshihiro / Oji, Yusuke / Sogo, Shinji / Sugiyama, Haruo

    Cancer immunology, immunotherapy : CII

    2023  Volume 72, Issue 7, Page(s) 2347–2356

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Humans ; Immunotherapy, Adoptive/methods ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/metabolism ; CD4-Positive T-Lymphocytes ; Neoplasms ; Antigens, Neoplasm
    Chemical Substances Receptors, Antigen, T-Cell ; Antigens, Neoplasm
    Language English
    Publishing date 2023-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-023-03420-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Identification of two distinct populations of WT1-specific cytotoxic T lymphocytes in co-vaccination of WT1 killer and helper peptides.

    Fujiki, Fumihiro / Tsuboi, Akihiro / Morimoto, Soyoko / Hashimoto, Naoya / Inatome, Miki / Nakajima, Hiroko / Nakata, Jun / Nishida, Sumiyuki / Hasegawa, Kana / Hosen, Naoki / Oka, Yoshihiro / Oji, Yusuke / Sogo, Shinji / Sugiyama, Haruo

    Cancer immunology, immunotherapy : CII

    2020  Volume 70, Issue 1, Page(s) 253–263

    Abstract: Simultaneous induction of tumor antigen-specific cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) is required for an optimal anti-tumor immune response. ... ...

    Abstract Simultaneous induction of tumor antigen-specific cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) is required for an optimal anti-tumor immune response. WT1
    MeSH term(s) Antigens, Neoplasm/immunology ; CD5 Antigens/immunology ; Cancer Vaccines/immunology ; Cell Death/immunology ; Cell Proliferation/physiology ; Cells, Cultured ; Humans ; Leukocytes, Mononuclear/immunology ; Neoplasm Recurrence, Local/immunology ; Peptides/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; Vaccination/methods ; Vaccines, Subunit/immunology ; WT1 Proteins/immunology
    Chemical Substances Antigens, Neoplasm ; CD5 Antigens ; Cancer Vaccines ; Peptides ; Vaccines, Subunit ; WT1 Proteins ; WT1 protein, human
    Language English
    Publishing date 2020-07-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 195342-4
    ISSN 1432-0851 ; 0340-7004
    ISSN (online) 1432-0851
    ISSN 0340-7004
    DOI 10.1007/s00262-020-02675-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1237: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity.

    Morimoto, Soyoko / Fujiki, Fumihiro / Kondo, Kenta / Nakajima, Hiroko / Kobayashi, Yoshiki / Inatome, Miki / Aoyama, Nao / Nishida, Yuya / Tsuboi, Akihiro / Oka, Yoshihiro / Nishida, Sumiyuki / Nakata, Jun / Hosen, Naoki / Oji, Yusuke / Sugiyama, Haruo

    Oncotarget

    2018  Volume 9, Issue 75, Page(s) 34132–34141

    Abstract: Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor antigens. Therefore, ...

    Abstract Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor antigens. Therefore, the establishment of the methodology of the efficient and precise evaluation of TCR functional avidity has been awaited. Here, we show a novel platform cell line, named 2D3, which enables the functional avidity of transduced TCRs to be evaluated efficiently and precisely. In the 2D3, the precise TCR functional avidity of transduced TCRs is easily evaluable by the expression of green fluorescent protein (GFP) reporter gene driven by nuclear factor of activated T cells (NFAT) activation via TCR signaling. Four different TCRs of HLA-A
    Language English
    Publishing date 2018-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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