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  1. Article ; Online: Use of cigarettes and heated tobacco products during pregnancy and maternal-fetal outcomes: a retrospective, monocentric study.

    Incognito, Giosuè Giordano / Grassi, Laura / Palumbo, Marco

    Archives of gynecology and obstetrics

    2023  Volume 309, Issue 5, Page(s) 1981–1989

    Abstract: Purpose: To compare the effects of using heated tobacco products (HTP) or traditional cigarettes (C) on maternal and neonatal outcomes.: Methods: This is a retrospective, monocentric study conducted at San Marco Hospital from July 2021 to July 2022. ... ...

    Abstract Purpose: To compare the effects of using heated tobacco products (HTP) or traditional cigarettes (C) on maternal and neonatal outcomes.
    Methods: This is a retrospective, monocentric study conducted at San Marco Hospital from July 2021 to July 2022. We compared a cohort of pregnant patients who smoked HTP (HS), with pregnant women smoking cigarettes (CS), ex-smoker (ES) and non-smoker (NS) pregnant women. Biochemistry, ultrasound, and neonatal evaluations were performed.
    Results: In total, 642 women were enrolled, of which 270 were NS, 114 were ES, 120 were CS, and 138 were HS. CS had the greatest weight gain and had more difficulty getting pregnant. Smokers and ES experienced more frequently threats of preterm labor, miscarriages, temporary hypertensive spikes, and higher rates of cesarean sections. Preterm delivery was more associated with CS and HS groups. CS and HS had lower awareness of the risks to which the mother and the fetus are exposed. CS were more likely to be depressed and anxious. Biochemical parameters did not show significant differences between the groups. CS had the greatest difference in days between the gestational age calculated based on the last menstrual period and the one based on the actual ultrasound age. The average percentile newborn weight range of CS was lower, as well as the mean 1st minute and the 5th minute Apgar scores.
    Conclusion: The comparison of the data obtained between CS and HS underlines the greater danger of C. Nevertheless, we do not recommend HTP because the maternal-fetal outcomes are not superimposable to the NS outcomes.
    MeSH term(s) Infant, Newborn ; Pregnancy ; Female ; Humans ; Retrospective Studies ; Tobacco Products/adverse effects ; Smoking/adverse effects ; Fetus ; Cesarean Section
    Language English
    Publishing date 2023-06-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07101-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.55: Show issues Location:
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  2. Article ; Online: Rate of Vaginal Cuff Dehiscence When Using Vicryl (Poliglactyn 910) Compared to PDS (Polydioxanone) for Vaginal Cuff Closure in Laparoscopic Hysterectomy.

    Cannone, Francesco Giuseppe / Cormaci, Livia / Ettore, Carla / Gulino, Ferdinando Antonio / Incognito, Giosuè Giordano / Benvenuto, Domenico / Ettore, Giuseppe

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 1

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Pregnancy ; Female ; Humans ; Polydioxanone/therapeutic use ; Polyglactin 910/therapeutic use ; Prospective Studies ; Retrospective Studies ; Laparoscopy/adverse effects ; Hysterectomy/adverse effects
    Chemical Substances Polydioxanone (31621-87-1) ; Polyglactin 910 (34346-01-5)
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60010090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  3. Article: Correlation of the HPV 16 Genotype Persistence in Women Undergoing LEEP for CIN3 with the Risk of CIN2+ Relapses in the First 18 Months of Follow-Up: A Multicenter Retrospective Study.

    Bruno, Maria Teresa / Valenti, Gaetano / Ruggeri, Zaira / Incognito, Giosuè Giordano / Coretti, Paola / Montana, Giuseppe Dario / Panella, Marco Marzio / Mereu, Liliana

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 5

    Abstract: Objective: Specific hr-HPV genotypes have different natural histories and different oncogenic capacity. This study aimed to investigate the risk of CIN2+ recurrence of the individual genotypes and evaluate how the duration of HPV persistence influences ... ...

    Abstract Objective: Specific hr-HPV genotypes have different natural histories and different oncogenic capacity. This study aimed to investigate the risk of CIN2+ recurrence of the individual genotypes and evaluate how the duration of HPV persistence influences the risk of developing recurrent 16 cervical dysplasia of high grade (CIN2+).
    Methods: Data from patients with persistent HPV infection after primary conization were retrospectively extracted. Kaplan-Meier proportional hazards models were used to evaluate associations between the duration of HPV persistence and the risk of developing recurrent CIN2+. Kruskal-Wallis testing with Dunn's multiple comparison test was used to test whether there was a statistically significant difference in the time to development of tumor recurrences between different genotypes.
    Results: Overall, 333 patients met the inclusion criteria. In 285 cases the HPV infection was persistent, in 48 cases (18%) it was transient, i.e., different genotypes after LEEP. Overall were diagnosed 39 relapses (13.7%), 79.5% (31/39 cases) were due to genotype 16, 20.5% (8/39) were linked to the other genotypes. Persistence of genotype 16 showed a 7-fold increased risk of developing a CIN2+ relapse, OR = 7.08 (95%CI: 3.12-16.08). Furthermore, the majority of relapses (38/39) occurred within 24 months of persistence with a cut-off represented by 18 months (
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14050509
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  4. Article: The Coexistence of Cervical Intraepithelial Neoplasia (CIN3) and Adenocarcinoma In Situ (AIS) in LEEP Excisions Performed for CIN3.

    Bruno, Maria Teresa / Valenti, Gaetano / Cassaro, Nazario / Palermo, Ilenia / Incognito, Giosuè Giordano / Cavallaro, Antonino Giovanni / Sgalambro, Francesco / Panella, Marco Marzio / Mereu, Liliana

    Cancers

    2024  Volume 16, Issue 5

    Abstract: The purpose of this study was to evaluate the incidence of AIS and AC in the histological cone of women treated for CIN3. Furthermore, through the study of the specific HR HPV genotypes, we obtained more information on the possible different nature ... ...

    Abstract The purpose of this study was to evaluate the incidence of AIS and AC in the histological cone of women treated for CIN3. Furthermore, through the study of the specific HR HPV genotypes, we obtained more information on the possible different nature between the single CIN3 lesion and the CIN3 coexisting with the glandular lesion.
    Methods: A sample of 414 women underwent LEEP for CIN3. The study sample consisted of 370 women with a CIN3 lesion alone and 44 women with a CIN3 lesion coexisting with AIS or adenocarcinoma. We studied the individual HR HPV genotypes and their frequency in the two groups under study. Furthermore, the therapeutic results and follow-ups for the population were studied on the entire study sample.
    Results: In patients with a single CIN3 lesion, 11 high-risk genotypes were detected; in patients with CIN3 associated with AIS or AC, only 4 different genotypes were detected (16, 18, 45, 33). Overall, the frequency of HPV 18 was significantly higher in CIN3 coexisting with AIS compared to solitary CIN3 lesions, χ2 = 27.73 (
    Conclusion: A relatively high rate (10.7%) of AIS-AC was found in women treated for CIN3. Our study confirms the multifocal biological nature of the CIN3 lesion coexisting with AIS compared to the single CIN3 lesion. All this justifies the different treatments to which CIN3 lesions coexisting with AIS are addressed; in fact, the latter are treated with hysterectomy, while CIN3 is treated with conization alone.
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050847
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  5. Article ; Online: Challenges in the diagnosis and management of Robert's uterus: Systematic review and case presentation.

    Gulino, Ferdinando Antonio / Occhipinti, Sara / Ettore, Carla / Incognito, Giosuè Giordano / Russo, Emanuele / Cannone, Francesco Giuseppe / Ettore, Giuseppe

    Journal of clinical ultrasound : JCU

    2024  

    Abstract: Robert's uterus is a rare Müllerian duct anomaly (MDA) characterized by complete asymmetric septum dividing uterine cavity into two non-communicating parts. This study offers insights into diagnosing and management of this condition in a young patient, ... ...

    Abstract Robert's uterus is a rare Müllerian duct anomaly (MDA) characterized by complete asymmetric septum dividing uterine cavity into two non-communicating parts. This study offers insights into diagnosing and management of this condition in a young patient, and a systematic literature review. The review included 19 studies from 2013 to 2023. 11.4% of women reported a history of miscarriage and 5.7% primary infertility. Dysmenorrhea was the most frequent symptom (54.3%), and 14.3% of patients had a coexisting endometriosis. The surgical interventions most commonly combine laparoscopic and hysteroscopic techniques. Robert's uterus requires heightened clinical awareness for early diagnosis, particularly in young women.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 189393-2
    ISSN 1097-0096 ; 0091-2751
    ISSN (online) 1097-0096
    ISSN 0091-2751
    DOI 10.1002/jcu.23675
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1186: Show issues Location:
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  6. Article ; Online: Correlation of sexual desire with sexual hormone binding globulin and free androgen index in women using combined contraceptives.

    Caruso, Salvatore / Caruso, Giuseppe / Iraci Sareri, Marco / Di Guardo, Federica / Incognito, Giosuè Giordano / Palumbo, Marco

    The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

    2024  , Page(s) 1–6

    Abstract: Purpose: To correlate the sexual desire levels with sexual hormone binding globulin and free androgen index in women taking different types of hormonal contraceptives (HCs) containing ethinylestradiol (EE), oestradiol valerate (E2V), 17β-oestradiol (E2), ...

    Abstract Purpose: To correlate the sexual desire levels with sexual hormone binding globulin and free androgen index in women taking different types of hormonal contraceptives (HCs) containing ethinylestradiol (EE), oestradiol valerate (E2V), 17β-oestradiol (E2), or estetrol (E4), combined or in phasic formulation with different progestogens having antiandrogenic properties.
    Methods: Three hundred and sixty-seven women (age range 18-46) participated in the study. SHBG and total testosterone (TT) were measured, and the Free Androgen Index (FAI) was calculated. The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) questionnaires were used to assess sexual function and distress, respectively.
    Results: The highest SHBG values and the lowest FAIs were obtained of women on HCs containing EE than those of women on HCs containing E2V/17β E2 or E4 (
    Conclusions: A minority of women using HCs with EE might experience a decreased sexual desire. This was not observed in women on HCs containing E2V, 17 E2, or E4. To avoid HC discontinuation, due to sexual desire reduction, HCs having minor antiandrogenic effects could be taken into consideration.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397560-2
    ISSN 1473-0782 ; 1362-5187
    ISSN (online) 1473-0782
    ISSN 1362-5187
    DOI 10.1080/13625187.2024.2332302
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4819: Show issues Location:
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  7. Article: Letrozole and Ovarian Hyperstimulation Syndrome (OHSS): A Promising Prevention Strategy.

    Di Guardo, Federica / Lello, Chiara / Incognito, Giosuè Giordano / Bruno, Maria Teresa / Palumbo, Marco

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Ovarian Hyperstimulation Syndrome (OHSS) is an uncommon but serious complication occurring in patients undergoing ovarian stimulation. It is characterized by ovarian enlargement, nausea, vomiting, abdominal pain/distension, and reduction in urine output. ...

    Abstract Ovarian Hyperstimulation Syndrome (OHSS) is an uncommon but serious complication occurring in patients undergoing ovarian stimulation. It is characterized by ovarian enlargement, nausea, vomiting, abdominal pain/distension, and reduction in urine output. However, OHSS may rarely evolve into a life-threatening condition with ascites, hemoconcentration and hypercoagulability. Prevention of OHSS consists of an integrated approach that associates behavioral aspects with administration of pharmacological compounds. Among drugs used to manage OHSS, Letrozole has recently been proposed as an effective option for prevention of the syndrome. However, despite the promising findings reported by several studies, to date Letrozole is not yet officially mentioned in the guidelines for "Prevention and Treatment of moderate and severe ovarian hyperstimulation syndrome". In this scenario, the current study discusses Letrozole approaches scientifically available to prevent OHSS.
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020614
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  8. Article ; Online: Meningioma in the third trimester of pregnancy: A case report.

    Ettore, Carla / Zambrotta, Elisa / Gulino, Ferdinando Antonio / Incognito, Giosuè Giordano / Cannone, Francesco Giuseppe / Ettore, Giuseppe

    Case reports in women's health

    2023  Volume 39, Page(s) e00541

    Abstract: Meningiomas are rare benign tumors during pregnancy. They can put both the mother and the fetus at risk because rapid changes in size may occur. The study reports a case of olfactory groove meningioma in a 34-year-old pregnant woman with visual ... ...

    Abstract Meningiomas are rare benign tumors during pregnancy. They can put both the mother and the fetus at risk because rapid changes in size may occur. The study reports a case of olfactory groove meningioma in a 34-year-old pregnant woman with visual impairment, anosmia, and dysgeusia that increased in severity during the 29th week of gestation. Magnetic resonance imaging showed an olfactory groove meningioma. The patient underwent a preterm cesarean section to avoid the worsening of the clinical condition due to intracranial compression phenomena. A computed tomography scan of the brain supported the diagnosis. The surgical intervention occurred on the third day after delivery. The clinical course was uneventful and the chiasmal syndrome improved in the following 2 months. Meningiomas in pregnancy may present unique challenges and have a wide array of clinical presentations. Management of maternal meningiomas can be complex and requires a multidisciplinary approach. The treatment decision largely depends on the size and location of the tumor, the presence of symptoms, gestational age, and fetal well-being. Further research is needed to enhance the understanding of the underlying mechanisms and improve management approaches for this rare condition.
    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2023.e00541
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  9. Article: Scar Pregnancy: A Rare, but Challenging, Obstetric Condition.

    Granese, Roberta / Gulino, Ferdinando Antonio / Incognito, Giosuè Giordano / Martinelli, Canio / Cianci, Stefano / Ercoli, Alfredo

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Scar pregnancy is a rare and potentially life-threatening condition that occurs when an embryo implants and grows within a previous cesarean section scar or other uterine scars [ ... ]. ...

    Abstract Scar pregnancy is a rare and potentially life-threatening condition that occurs when an embryo implants and grows within a previous cesarean section scar or other uterine scars [...].
    Language English
    Publishing date 2023-06-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12123975
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  10. Article: Ultrasonographic Prenatal Diagnosis: Unveiling the Path to Improved Antenatal Care.

    Granese, Roberta / Gulino, Ferdinando Antonio / Incognito, Giosuè Giordano / Cianci, Stefano / Martinelli, Canio / Ercoli, Alfredo

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: The realm of prenatal diagnosis has witnessed remarkable advancements in recent years, primarily due to the widespread use of ultrasonography [ ... ]. ...

    Abstract The realm of prenatal diagnosis has witnessed remarkable advancements in recent years, primarily due to the widespread use of ultrasonography [...].
    Language English
    Publishing date 2023-07-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134450
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