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  1. Article ; Online: Diagnosis and treatment of adult hypophosphatasia: Still a big challenge?

    Inoue, Daisuke

    Osteoporosis and sarcopenia

    2024  Volume 10, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2024-03-16
    Publishing country Netherlands
    Document type Editorial
    ISSN 2405-5263
    ISSN (online) 2405-5263
    DOI 10.1016/j.afos.2024.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [Development of Prediction System for Drug Absorption after Intranasal Administration Incorporating Physiologic Functions of Nose -Estimation of in Vivo Drug Permeation through Nasal Mucosa Using in Vitro Membrane Permeability].

    Inoue, Daisuke

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2021  Volume 141, Issue 11, Page(s) 1235–1240

    Abstract: The nasal drug application has drawn much attention as the strategy for the delivery route of many drug modalities such as the poorly absorbed drugs, peptides, nucleic acid, and central nervous system drugs. The absorption of drug after intranasal (IN) ... ...

    Abstract The nasal drug application has drawn much attention as the strategy for the delivery route of many drug modalities such as the poorly absorbed drugs, peptides, nucleic acid, and central nervous system drugs. The absorption of drug after intranasal (IN) application depends on the nasal residence time of applied drug, affected by mucociliary clearance (MC). MC is a decisive factor in the nasal absorption of drug. We describe the establishment of in vitro evaluation system of nasal MC via the moving velocity of a marker particle on nasal mucosa, and the development of the pharmacokinetic model to which in vitro parameters on nasal MC was incorporated to enable the prediction of drug absorption after IN application. Moreover, the pharmacokinetics of norfloxacin after IN application was investigated using MC-modified rats pretreated with MC modulators. Nasal absorption fluctuated due to changes in the nasal residence time of drug in response to changes in MC. The prediction system enables quantitative evaluation of changes in drug absorption associated with MC fluctuations. In addition, for a precise prediction system for drug absorption after IN application from the drug absorption model, the relationships between in vitro drug permeability through Calu-3 layers, in vivo transnasal permeation of drug and in vivo bioavailability after IN application were evaluated. The significant correlations between these parameters were obtained, suggesting that transnasal permeability and drug absorption after IN application can be predicted from in vitro membrane permeability.
    MeSH term(s) Administration, Intranasal ; Animals ; Biological Availability ; Cell Membrane Permeability ; Forecasting ; In Vitro Techniques ; Models, Biological ; Mucociliary Clearance ; Nasal Absorption ; Nasal Mucosa/metabolism ; Norfloxacin/administration & dosage ; Norfloxacin/pharmacokinetics ; Pharmacokinetics ; Rats
    Chemical Substances Norfloxacin (N0F8P22L1P)
    Language Japanese
    Publishing date 2021-10-15
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.21-00151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  3. Article: Eosinophilic variant of chromophobe renal cell carcinoma metastasizing to the liver: Diagnostic pitfall.

    Inoue, Daisuke / Oura, Shoji

    Radiology case reports

    2023  Volume 18, Issue 10, Page(s) 3504–3508

    Abstract: An 82-year-old man developed a hypervascular renal tumor, 2 cm in size, and multiple liver tumors. Liver tumors had obscured tumor margins on ultrasonography. Positron emission tomography/computed tomography (PET/CT) showed no areas of avid radiotracer ... ...

    Abstract An 82-year-old man developed a hypervascular renal tumor, 2 cm in size, and multiple liver tumors. Liver tumors had obscured tumor margins on ultrasonography. Positron emission tomography/computed tomography (PET/CT) showed no areas of avid radiotracer uptake in the liver. Routine pathological examination failed to demonstrate tumor cells in 9 tissue samples obtained from repeated core needle biopsies. Even a frozen section of the liver segment 8 tumor further failed to prove malignant cells, and an additive frozen section of the liver section 2 tumor finally proved atypical cells growing in tubular and solid fashions with eosinophilic cytoplasm. Tumors showed expansive growth patterns, were in direct contact with normal liver cells, had abundant micro-vessels, had only sparse hyalinized septa, and had no pale cells. Immunostaining revealed the tumor cells to be positive for CD10, CD117, and E-cadherin and negative for CK7, and PAX8, leading to the diagnosis of metastatic chromophobe renal cell carcinoma (chRCC) in the liver. Arginase-1 immunostaining clearly demarcated the boundary between the chRCC cells and normal hepatic cells. Diagnostic physicians should note that chRCCs are of low-grade malignancy despite their abundant intra-tumoral blood flow and can often pose imaging and pathologic diagnostic difficulties.
    Language English
    Publishing date 2023-07-27
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Ulcer-forming colon cancer can develop cavity-forming metastatic lung tumors.

    Inoue, Daisuke / Oura, Shoji

    Radiology case reports

    2023  Volume 19, Issue 2, Page(s) 519–522

    Abstract: A 67-year-old man with abdominal pain and vomiting was referred to our hospital for the treatment of ileus. Enhanced computed tomography (CT) showed marked dilatation of the ileum and a presumed cecal tumor. After the intestinal decompression using ... ...

    Abstract A 67-year-old man with abdominal pain and vomiting was referred to our hospital for the treatment of ileus. Enhanced computed tomography (CT) showed marked dilatation of the ileum and a presumed cecal tumor. After the intestinal decompression using nasogastric tube, a colonoscopy showed a type 3 tumor in the cecum. Endoscopic biopsy pathologically showed atypical cells growing in a cribriform fashion, leading to the diagnosis of cecal cancer. Staging CT showed multiple lung nodules either in a solid or a cavity-forming fashion and a presumed peritoneal disseminating lesion. Smaller lung nodules tended to show a solid pattern and larger ones a cavity-forming pattern. On diagnostic laparoscopic operation, a frozen section of the resected peritoneal lesion proved peritoneal dissemination. The patient, therefore, underwent palliative colectomy with functional anastomosis followed by thoracoscopic resection of one cavity-forming lung nodule for the accurate evaluation of the disease spread. Pathologic study showed marked tumor tip deciduation of cecal cancer and interminglement of necrotic tissue and exfoliated cancer cell clusters in the cavity of the metastatic lung tumor. Oncologists should note that ulcer-forming colon cancer can develop metastatic lung tumors in a cavity-forming fashion. Co-presence of small solid nodules and large cavity-forming ones suggests metastatic lung tumors from ulcer-forming colon cancer.
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Sequential treatment of osteoporosis with anti-sclerostin.]

    Inoue, Daisuke

    Clinical calcium

    2019  Volume 29, Issue 3, Page(s) 363–369

    Abstract: Romosozumab is a humanized anti-sclerostin monoclonal antibody that has just been approved for the treatment of osteoporosis in Japan. Romosozumab causes both transient stimulation of bone formation and continuous suppression of resorption, thereby ... ...

    Abstract Romosozumab is a humanized anti-sclerostin monoclonal antibody that has just been approved for the treatment of osteoporosis in Japan. Romosozumab causes both transient stimulation of bone formation and continuous suppression of resorption, thereby increasing bone mineral density and decreasing fracture incidence. Because the effect of romosozumab is reversible, sequential therapy with anti-resorptives after romosozumab will be necessary. This overview summarizes the results of ARCH study demonstrating superior efficacy of romosozumab compared to alendronate and effect of sequential therapy with alendronate. Possible adverse effect of romosozumab on cardiovascular diseases will also be discussed.
    MeSH term(s) Aged ; Alendronate/administration & dosage ; Antibodies, Monoclonal/administration & dosage ; Bone Density ; Bone Density Conservation Agents/administration & dosage ; Drug Administration Schedule ; Female ; Humans ; Japan ; Osteoporosis, Postmenopausal/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Antibodies, Monoclonal ; Bone Density Conservation Agents ; romosozumab (3VHF2ZD92J) ; Alendronate (X1J18R4W8P)
    Language Japanese
    Publishing date 2019-02-27
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI 10.20837/4201903363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6536: Show issues Location:
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  6. Article: [Rickets/Osteomalacia. Action of FGF23.]

    Inoue, Daisuke

    Clinical calcium

    2018  Volume 28, Issue 10, Page(s) 1335–1342

    Abstract: FGF23 is an "endocrine FGF" mainly secreted by osteocytes. FGF23 exerts its action through binding to an FGF receptor isoform, FGFR1c, using α-Klotho as a co-receptor. The main physiological function of FGF23 is to suppress phosphate reabsorption and ... ...

    Abstract FGF23 is an "endocrine FGF" mainly secreted by osteocytes. FGF23 exerts its action through binding to an FGF receptor isoform, FGFR1c, using α-Klotho as a co-receptor. The main physiological function of FGF23 is to suppress phosphate reabsorption and active vitamin D production in the proximal tubule of the kidney, thereby lowering serum concentration of inorganic phosphate. In recent years, however, FGF23 has been shown to contribute to various pathological processes including cardiac hypertrophy via a distinct mode of action in a Klotho-independent manner. This review summarizes such pleiotropic actions of FGF23.
    MeSH term(s) Cardiomegaly ; Fibroblast Growth Factors/physiology ; Glucuronidase ; Humans ; Kidney Tubules, Proximal/physiology ; Osteomalacia ; Phosphates/blood ; Rickets ; Vitamin D/biosynthesis
    Chemical Substances Phosphates ; Vitamin D (1406-16-2) ; Fibroblast Growth Factors (62031-54-3) ; fibroblast growth factor 23 (7Q7P4S7RRE) ; Glucuronidase (EC 3.2.1.31)
    Language Japanese
    Publishing date 2018-09-27
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa181013351342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Learning beyond-pairwise interactions enables the bottom-up prediction of microbial community structure.

    Ishizawa, Hidehiro / Tashiro, Yosuke / Inoue, Daisuke / Ike, Michihiko / Futamata, Hiroyuki

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 7, Page(s) e2312396121

    Abstract: Understanding the assembly of multispecies microbial communities represents a significant challenge in ecology and has wide applications in agriculture, wastewater treatment, and human healthcare domains. Traditionally, studies on the microbial community ...

    Abstract Understanding the assembly of multispecies microbial communities represents a significant challenge in ecology and has wide applications in agriculture, wastewater treatment, and human healthcare domains. Traditionally, studies on the microbial community assembly focused on analyzing pairwise relationships among species; however, neglecting higher-order interactions, i.e., the change of pairwise relationships in the community context, may lead to substantial deviation from reality. Herein, we have proposed a simple framework that incorporates higher-order interactions into a bottom-up prediction of the microbial community assembly and examined its accuracy using a seven-member synthetic bacterial community on a host plant, duckweed. Although the synthetic community exhibited emergent properties that cannot be predicted from pairwise coculturing results, our results demonstrated that incorporating information from three-member combinations allows the acceptable prediction of the community structure and actual interaction forces within it. This reflects that the occurrence of higher-order effects follows consistent patterns, which can be predicted even from trio combinations, the smallest unit of higher-order interactions. These results highlight the possibility of predicting, explaining, and understanding the microbial community structure from the bottom-up by learning interspecies interactions from simple beyond-pairwise combinations.
    MeSH term(s) Humans ; Microbial Interactions ; Microbiota ; Ecology ; Bacteria
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2312396121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  8. Article ; Online: Potential of Predatory Bacteria to Colonize the Duckweed Microbiome and Change Its Structure: A Model Study Using the Obligate Predatory Bacterium, Bacteriovorax sp. HI3.

    Inoue, Daisuke / Nakamura, So / Sugiyama, Tomomi / Ike, Michihiko

    Microbes and environments

    2023  Volume 38, Issue 3

    Abstract: Modifying the duckweed microbiome is a major challenge for enhancing the effectiveness of duckweed-based wastewater treatment and biomass production technologies. We herein examined the potential of the exogenous introduction of predatory bacteria to ... ...

    Abstract Modifying the duckweed microbiome is a major challenge for enhancing the effectiveness of duckweed-based wastewater treatment and biomass production technologies. We herein examined the potential of the exogenous introduction of predatory bacteria to change the duckweed microbiome. Bacteriovorax sp. HI3, a model predatory bacterium, colonized the core of the Lemna microbiome, and its predatory behavior changed the microbiome structure, which correlated with colonization density. These results reveal that bacterial predatory interactions may be important drivers that shape the duckweed microbiome, suggesting their potential usefulness in modifying the microbiome.
    MeSH term(s) Araceae/microbiology ; Microbiota/genetics ; Proteobacteria/genetics ; Water Purification ; Wastewater/microbiology ; Genome, Bacterial ; Bacteriolysis
    Chemical Substances Wastewater
    Language English
    Publishing date 2023-08-28
    Publishing country Japan
    Document type Journal Article
    ISSN 1347-4405
    ISSN (online) 1347-4405
    DOI 10.1264/jsme2.ME23040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Efficacy of zoledronic acid for osteoporosis:evidence from studies abroad.]

    Inoue, Daisuke

    Clinical calcium

    2017  Volume 27, Issue 2, Page(s) 247–255

    Abstract: Zoledronic acid is a nitrogen-containing bisphosphonate that has the strongest and the most persistent anti-resorptive activity. Once-yearly zoledronic acid has recently been approved for the treatment of osteoporosis in Japan. This overview summarizes ... ...

    Abstract Zoledronic acid is a nitrogen-containing bisphosphonate that has the strongest and the most persistent anti-resorptive activity. Once-yearly zoledronic acid has recently been approved for the treatment of osteoporosis in Japan. This overview summarizes abundant evidence of zoledronic acid, obtained from studies abroad, for its efficacy for postmenopausal, male and glucocorticoid-induced osteoporosis.
    MeSH term(s) Biomarkers/analysis ; Bone Density/drug effects ; Bone Density Conservation Agents/therapeutic use ; Clinical Trials as Topic ; Diphosphonates/therapeutic use ; Humans ; Imidazoles/therapeutic use ; Osteoporosis/drug therapy ; Osteoporosis/physiopathology ; Osteoporosis/prevention & control ; Secondary Prevention
    Chemical Substances Biomarkers ; Bone Density Conservation Agents ; Diphosphonates ; Imidazoles ; zoledronic acid (6XC1PAD3KF)
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1702247255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: [Divergent functions of the calcium-sensing receptor other than regulation ofmineral metabolism.]

    Inoue, Daisuke

    Clinical calcium

    2017  Volume 27, Issue 4, Page(s) 499–505

    Abstract: The calcium-sensing receptor(CaSR)is a G protein-coupled membrane receptor that binds extracellular Ca2+and other cations as a ligand. CaSR is expressed in parathyroid glands at the highest level and plays a critical role in the regulation of ... ...

    Abstract The calcium-sensing receptor(CaSR)is a G protein-coupled membrane receptor that binds extracellular Ca2+and other cations as a ligand. CaSR is expressed in parathyroid glands at the highest level and plays a critical role in the regulation of extracellular calcium. CaSR is also expressed by a wide variety of tissues other than calcium metabolic organs. In this overview, divergent roles of CaSR in inflammasome as well as various tissues including intestines, lungs, neurons and endocrine pancreas will be briefly summarized.
    MeSH term(s) Animals ; Calcium/metabolism ; Humans ; Inflammasomes/metabolism ; Intestines/metabolism ; Ligands ; Receptors, Calcium-Sensing/metabolism ; Signal Transduction
    Chemical Substances Inflammasomes ; Ligands ; Receptors, Calcium-Sensing ; Calcium (SY7Q814VUP)
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2386417-5
    ISSN 0917-5857
    ISSN 0917-5857
    DOI CliCa1704499505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6536: Show issues Location:
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