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  1. Article ; Online: Gender difference of geographic distribution of physicians in Japan: three-point analysis of 1994, 2004 and 2014.

    Kimura, Kazuki / Inoue, Kazuo / Ando, Takahito / Ito, Masanori

    BMC health services research

    2023  Volume 23, Issue 1, Page(s) 1404

    Abstract: Background: Japan's medical education system produces 9,000 graduates annually. Despite the government's implementation of several strategies, including increasing the number of doctors trained, the country still struggles with a shortage of physicians ... ...

    Abstract Background: Japan's medical education system produces 9,000 graduates annually. Despite the government's implementation of several strategies, including increasing the number of doctors trained, the country still struggles with a shortage of physicians in rural areas. This study examined this issue, focusing on gender and considering years of physician experience, demographic and geographic factors.
    Methods: We analyzed the Physician Census from 1994, 2004, and 2014, examining data on physicians' gender and the number of years since licensure. To correct the impact of municipal mergers, the analysis was aligned with the number of municipalities in 2014 (1741). We examined data from each physician (gender and years of medical experience) and analyzed the demographic and geographic distribution trend using Spearman correlation coefficients. We then used the Gini coefficient to evaluate the distribution change of physicians based on gender and years of experience.
    Results: The number of physicians increased 1.29-fold over the 20-year observation period (1.23-fold for male physicians and 2.17-fold for female physicians), and the percentage of female physicians increased from 13.4% to 20.4%. We found that 87.7% of physicians were concentrated in the top 1/3 municipalities in terms of population. The number of female physicians was higher at 91.8% compared to 86.8% for male physicians. The Gini coefficients were lower for veteran physicians of both sexes than for younger physicians. The Gini coefficient for all physicians was 0.315-0.298-0.298 (male physicians: 0.311-0.289-0.283, female physicians: 0.394-0.385-0.395) The Gini coefficients for female compared to male physicians were higher in all age groups, showing that The distribution of female physicians is skewed toward urban areas.
    Conclusion: Female physicians are less distributed in rural areas than male physicians. In addition, despite the fact that the number of female physicians has increased more than male physicians over the past 20 years, the geographic ubiquity of female physicians has not improved. Since the trend of increasing the number of female physicians is expected to continue in the future, it is necessary to take some measures, such as providing a work-life balance suitable for female physicians.
    MeSH term(s) Humans ; Male ; Female ; Japan/epidemiology ; Sex Factors ; Physicians ; Physicians, Women ; Education, Medical
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-023-10258-4
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  2. Article ; Online: Association of the past epidemic of Mycobacterium tuberculosis with mortality and incidence of COVID-19.

    Inoue, Kazuo / Kashima, Saori

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0253169

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a remarkable and varying impact in every country, inciting calls for broad attention. Recently, the Bacillus ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a remarkable and varying impact in every country, inciting calls for broad attention. Recently, the Bacillus Calmette-Guérin (BCG) vaccination has been regarded as a potential candidate to explain this difference. Herein, we hypothesised that the past epidemic of Mycobacterium tuberculosis (M. tuberculosis) may act as a latent explanatory factor for the worldwide differences seen in COVID-19 impact on mortality and incidence. We compared two indicators of past epidemic of M. tuberculosis, specifically, incidence (90 countries in 1990) and mortality (28 countries in 1950), with the mortality and incidence of COVID-19. We determined that an inverse relationship existed between the past epidemic indicators of M. tuberculosis and current COVID-19 impact. The rate ratio of the cumulative COVID-19 mortality per 1 million was 2.70 (95% confidence interval [CI]: 1.09-6.68) per 1 unit decrease in the incidence rate of tuberculosis (per 100,000 people). The rate ratio of the cumulative COVID-19 incidence per 1 million was 2.07 (95% CI: 1.30-3.30). This association existed even after adjusting for potential confounders (rate of people aged 65 over, diabetes prevalence, the mortality rate from cardiovascular disease, and gross domestic product per capita), leading to an adjusted rate ratio of COVID-19 mortality of 2.44, (95% CI: 1.32-4.52) and a COVID-19 incidence of 1.31 (95% CI: 0.97-1.78). After latent infection, Mycobacterium survives in the human body and may continue to stimulate trained immunity. This study suggests a possible mechanism underlying the region-based variation in the COVID-19 impact.
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0253169
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  3. Article ; Online: Lower range of serum uric acid level increases risk of rapid decline of kidney function in young and middle-aged adults: the Yuport Medical Checkup Center Study.

    Ueda, Hitomi / Inoue, Kazuo / Seki, Reiko / Nemoto, Yoshikazu / Terawaki, Hiroyuki

    Clinical and experimental nephrology

    2023  Volume 27, Issue 5, Page(s) 435–444

    Abstract: Background: The effect of low serum uric acid (sUA) levels on kidney function is unclear. This study aimed to clarify the relationship between low sUA levels and the rapid decline in kidney function.: Methods: We examined the relationship between sUA ...

    Abstract Background: The effect of low serum uric acid (sUA) levels on kidney function is unclear. This study aimed to clarify the relationship between low sUA levels and the rapid decline in kidney function.
    Methods: We examined the relationship between sUA levels and kidney function decline in health check-up examinees. A total of 10,547 participants were enrolled using data from the Yuport Medical Checkup Center Study between 1998 and 2002 for baseline and data from 2002 to 2006 as the follow-up period in Japan. According to sUA level (mg/dL), we classified the participants into the following six groups: (1) 2.0-2.9 (n = 247), (2) 3.0-3.9 (n = 1457), (3) 4.0-4.9 (n = 2883), (4) 5.0-5.9 (n = 2899), (5) 6.0-6.9 (n = 2010), and (6) 7.0-7.9 (n = 1,051). The relationship between sUA level and rapid decline in estimated glomerular filtration rate (ΔeGFR ≥ 3 mL/min/1.73 m
    Results: During study period (5.4 ± 1.6 years), the incidence of rapid eGFR decline for the respective sUA groups (2.0-2.9, 3.0-3.9, 4.0-4.9, 5.0-5.9, 6.0-6.9, 7.0-7.9) were as follows: 4.5%, 4.0%, 2.4%, 3.3%, 3.1%, 3.4%. The crude and adjusted odds ratios (OR) for rapid eGFR decline were significantly higher in the 2.0-2.9 (OR:1.93 and 1.86) and 3.0-3.9 (OR:1.72 and 1.73) groups than in the 4.0-4.9 groups (reference). Stratified analysis of age differences revealed that the detrimental effect of low sUA was not evident in older adults (age ≥ 65 years).
    Conclusion: A lower normal sUA level is related to an increased risk for a rapid decline in kidney function.
    MeSH term(s) Middle Aged ; Humans ; Aged ; Uric Acid ; Risk Factors ; Glomerular Filtration Rate ; Kidney Function Tests ; Kidney ; Renal Insufficiency, Chronic
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-02-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-023-02318-0
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  4. Article ; Online: Low creatinine levels in diabetes mellitus among older individuals: the Yuport Medical Checkup Center Study.

    Kashima, Saori / Inoue, Kazuo / Matsumoto, Masatoshi

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 15167

    Abstract: Oric id: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and ... ...

    Abstract Oric id: 0000-0002-3401-8191. It is unknown whether the interrelationship between diabetes and muscle loss is affected by ageing. Therefore, the serum creatinine levels, an indicator of muscle mass, were compared between older people with diabetes and those without diabetes, using a cross-sectional dataset from the Yuport Medical Checkup Center Study. We classified 6133 participants without kidney dysfunction into three age-groups: early-elderly (65-69 years), middle-elderly (70-74 years), and late-elderly (≥ 75 years). The association between diabetes and the lowest creatinine level, defined as less than or equal to the 25 percentile of serum creatinine, was evaluated in each age group, by calculating the odds ratio (OR) using logistic regression. Serum creatinine levels increased with ageing in the participants, and these trends were markedly observed in the non-diabetic group. Late-elderly people with diabetes were significantly more likely to have low creatinine levels than those without diabetes, with adjusted ORs 2.50 (95% CI 1.99-4.50) in men and 2.88 (95% CI 1.47-5.64) in women. Ageing modified the effect of their diabetes status towards a lower creatinine level (p for interactions between the diabetic status and age-groups were 0.01 in men and 0.05 in women, respectively). Ageing may thus accelerate the loss of muscle mass in people with diabetes.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging/blood ; Aging/pathology ; Creatinine/blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/pathology ; Female ; Humans ; Logistic Models ; Male ; Muscle, Skeletal/pathology ; Odds Ratio ; Sarcopenia/blood ; Sarcopenia/complications ; Sarcopenia/pathology ; Tokyo
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-94441-9
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  5. Article ; Online: Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD36.

    Tsuzuki, Satoshi / Kimoto, Yusaku / Marui, Keita / Lee, Shinhye / Inoue, Kazuo / Sasaki, Tsutomu

    Bioscience, biotechnology, and biochemistry

    2022  Volume 86, Issue 4, Page(s) 509–518

    Abstract: The cluster of differentiation 36 (CD36) is a transmembrane receptor expressed in various cells and has diverse lipid ligands. The expression of CD36 in the murine olfactory epithelium and its ability to recognize certain species of fatty aldehydes, a ... ...

    Abstract The cluster of differentiation 36 (CD36) is a transmembrane receptor expressed in various cells and has diverse lipid ligands. The expression of CD36 in the murine olfactory epithelium and its ability to recognize certain species of fatty aldehydes, a class of odor-active volatile compounds, have suggested a role for this receptor in the capture of specific odorants in the nasal cavity of mammals. However, the spectrum of CD36-recognizable volatile compounds is poorly understood. In this study, we employed our recently devised assay with fluorescently labeled peptides as probes (fluorescence intensity assay) and identified distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of CD36 (eg dodecyl and tetradecyl acetates). The present findings demonstrate the utility of our assay for the discovery of novel CD36 ligands and support the notion that the receptor functions as a captor of volatile compounds in the mammalian olfactory system.
    MeSH term(s) Acetates ; Amino Acids ; Animals ; CD36 Antigens/metabolism ; Fluorescence ; Mammals/metabolism ; Mice ; Odorants
    Chemical Substances Acetates ; Amino Acids ; CD36 Antigens
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbac018
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  6. Article ; Online: Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.

    Kawarasaki, Satoko / Sawazaki, Honami / Iijima, Hiroaki / Takahashi, Haruya / Nomura, Wataru / Inoue, Kazuo / Kawada, Teruo / Goto, Tsuyoshi

    European journal of pharmacology

    2023  Volume 947, Page(s) 175682

    Abstract: In the treatment of type 2 diabetes mellitus (T2DM), comprehensive management of multiple risk factors, such as blood glucose, body weight, and lipids, is important to prevent disease progression. Although the combination of dipeptidyl peptidase-4 (DPP-4) ...

    Abstract In the treatment of type 2 diabetes mellitus (T2DM), comprehensive management of multiple risk factors, such as blood glucose, body weight, and lipids, is important to prevent disease progression. Although the combination of dipeptidyl peptidase-4 (DPP-4) inhibitor and sodium-glucose co-transporter 2 (SGLT2) inhibitor is often used clinically, the effects of this combination, other than glucose metabolism, have yet to be thoroughly investigated. In this study, we evaluated the effects of combined treatment with a DPP-4 inhibitor, teneligliptin, and an SGLT2 inhibitor, canagliflozin, on the body weight and lipid metabolism in high-fat diet (HFD)-induced obese mice. We found that monotherapy with teneligliptin or canagliflozin showed suppressive effects on high-fat diet-induced body weight gain and reduced inguinal white adipose tissue (iWAT) mass, and combined treatment additively reduced body weight gain and iWAT mass. Teneligliptin significantly increased oxygen consumption during the light phase, and this effect was preserved in the combined treatment. The combined treatment did not alter the mRNA expression levels of thermogenesis-related genes in adipose tissue but showed the tendency to additively induce mRNA of fatty acid oxidation-related genes in brown adipose tissue and tended to additively decrease mRNA of fatty acid synthesis-related genes in iWAT and liver tissues. These results suggest that combined treatment with teneligliptin and canagliflozin additively suppresses HFD-induced body weight gain with increasing oxygen consumption and modulating the expression of lipid metabolism-related genes. This combination therapy may provide effective body weight management for patients with T2DM and obesity.
    MeSH term(s) Mice ; Animals ; Canagliflozin/pharmacology ; Canagliflozin/therapeutic use ; Diabetes Mellitus, Type 2/metabolism ; Lipid Metabolism ; Diet, High-Fat/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Weight Gain ; Body Weight ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; RNA, Messenger/metabolism ; Fatty Acids ; Gene Expression
    Chemical Substances Canagliflozin (0SAC974Z85) ; 3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine ; Sodium-Glucose Transporter 2 Inhibitors ; Hypoglycemic Agents ; Dipeptidyl-Peptidase IV Inhibitors ; RNA, Messenger ; Fatty Acids
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175682
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  7. Book: Vagaler Herztonus und Herzfrequenz unter dem Einfluss von Injektionsanaesthetika

    Inoue, Kazuo

    e. Studie an narkotisierten Katzen

    (ANAESTHESIOLOGIE UND INTENSIVMEDIZIN ; 155)

    1983  

    Author's details K. Inoue
    Series title ANAESTHESIOLOGIE UND INTENSIVMEDIZIN ; 155
    Anaesthesiologie und Intensivmedizin
    Collection Anaesthesiologie und Intensivmedizin
    Keywords ANESTHESIA, INTRAVENOUS / ADVERSE EFFECTS ; HEART / INNERVATION ; HEART RATE / DRUG EFFECTS ; Injektionsanästhetikum ; Herzfrequenz ; Katze ; Herztonus ; Injektionsnarkose ; Vagus ; Herz ; Injektionsanaesthetika
    Subject Felis catus ; Felis silvestris domestica ; Hauskatze ; Nervus vagus ; Herzrhythmus ; Herzrate ; Herzschlagfolge ; Herzschlagfrequenz
    Language German
    Size 39 S.
    Publisher Springer
    Publishing place Berlin
    Document type Book
    HBZ-ID HT002441672
    ISBN 3-540-12031-9 ; 0-387-12031-9 ; 978-3-540-12031-5 ; 978-0-387-12031-7
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: White Blood Cell Count and C-Reactive Protein Independently Predicted Incident Diabetes: Yuport Medical Checkup Center Study.

    Kashima, Saori / Inoue, Kazuo / Matsumoto, Masatoshi / Akimoto, Kimihiko

    Endocrine research

    2019  Volume 44, Issue 4, Page(s) 127–137

    Abstract: ... ...

    Abstract Aim
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Biomarkers/blood ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Datasets as Topic ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Incidence ; Leukocyte Count ; Leukocytes/cytology ; Leukocytes/pathology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Tokyo ; Young Adult
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2019-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 605823-1
    ISSN 1532-4206 ; 0743-5800
    ISSN (online) 1532-4206
    ISSN 0743-5800
    DOI 10.1080/07435800.2019.1589494
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  9. Article ; Online: A milk-derived pentapeptide reduces blood pressure in advanced hypertension in a CCK system-dependent manner.

    Koyama, Daiki / Sasai, Masaki / Matsumura, Shigenobu / Inoue, Kazuo / Ohinata, Kousaku

    Food & function

    2020  Volume 11, Issue 11, Page(s) 9489–9494

    Abstract: We recently found that a peptide that activates the cholecystokinin (CCK) system effectively reduces blood pressure in spontaneously hypertensive rats (SHR) after the development of hypertension, after which hypotensive drugs are sometimes less effective. ...

    Abstract We recently found that a peptide that activates the cholecystokinin (CCK) system effectively reduces blood pressure in spontaneously hypertensive rats (SHR) after the development of hypertension, after which hypotensive drugs are sometimes less effective. In this study, we investigated the vasorelaxation and antihypertensive effects of a peptide derived from a milk protein in SHR with advanced hypertension. The vasorelaxing activity was measured using the mesenteric artery isolated from SHR and the systemic blood pressure was measured by the tail-cuff method. KFWGK was released from bovine serum albumin (BSA) and the model peptide after subtilisin digestion. KFWGK relaxed the mesenteric artery and this vasorelaxation activity was inhibited by lorglumide, an antagonist of the CCK1 receptor. KFWGK more potently relaxed the artery from advanced-stage SHR than that from early-stage SHR. Orally administered KFWGK exhibited potent and long-lasting antihypertensive effects in SHR after the development of hypertension (the minimum effective dose was 5 μg kg-1). The KFWGK-induced antihypertensive effects were also blocked by a CCK antagonist, suggesting that it activates the CCK system. In conclusion, KFWGK, a CCK-dependent vasorelaxant peptide, exhibited potent antihypertensive effects in SHR after the development of hypertension.
    MeSH term(s) Administration, Oral ; Animals ; Antihypertensive Agents/administration & dosage ; Antihypertensive Agents/pharmacology ; Blood Pressure/drug effects ; Cholecystokinin/metabolism ; Dose-Response Relationship, Drug ; Male ; Mesenteric Arteries/drug effects ; Milk/chemistry ; Peptides/administration & dosage ; Peptides/pharmacology ; Rats ; Rats, Inbred SHR ; Vasodilation/drug effects
    Chemical Substances Antihypertensive Agents ; Peptides ; Cholecystokinin (9011-97-6)
    Language English
    Publishing date 2020-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d0fo01122c
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  10. Article ; Online: Serum Alanine Transaminase as a Predictor of Type 2 Diabetes Incidence: The Yuport Prospective Cohort Study.

    Hatano, Yu / Inoue, Kazuo / Kashima, Saori / Matsumoto, Masatoshi / Akimoto, Kimihiko

    The Tohoku journal of experimental medicine

    2020  Volume 251, Issue 3, Page(s) 183–191

    Abstract: Prior studies have shown an association between the incidence of diabetes with liver enzymes, such as alanine transaminase (ALT). Liver fibrosis scores, such as the Fibrosis-4 index which indicates chronic liver damage, were also associated with diabetes ...

    Abstract Prior studies have shown an association between the incidence of diabetes with liver enzymes, such as alanine transaminase (ALT). Liver fibrosis scores, such as the Fibrosis-4 index which indicates chronic liver damage, were also associated with diabetes development. However, no literature compared predictive accuracy between ALT and Fibrosis-4 index. Thus, we aimed to determine it, and to assess its association using inverse probability of treatment weighting. This was a non-concurrent prospective cohort study of 9,748 subjects without diabetes receiving Yuport Health Checkup in Japan between 1998 and 2006. ALT was categorized into three groups: the highest ALT group (men ≥ 30 U/L and women ≥ 20 U/L), the middle (men ≥ 20 and < 30 U/L, and women ≥ 14 and < 20 U/L), and the lowest (men < 20 U/L and women < 14 U/L). The primary outcome was the new onset of diabetes. The area under the receiver operating characteristic curves (AUC) of ALT for predicting the diabetes development was higher than that of any other markers of liver damage. The AUC for ALT was 0.71, while that for the Fibrosis-4 index was 0.51 (p < 0.001 for the difference between the AUCs). The highest and middle ALT groups had a significantly higher incidence of diabetes than the lowest group: adjusted relative risk 1.79 [95% confidence interval (CI): 1.29, 2.58], and 1.64 [95% CI: 1.17, 2.38] respectively. Of the various indicators of liver function, ALT is likely to be the most accurate and associated predictor of diabetes development.
    MeSH term(s) Adult ; Aged ; Alanine Transaminase/blood ; Algorithms ; Area Under Curve ; Biomarkers ; Cohort Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Hepatitis/blood ; Hepatitis/complications ; Humans ; Incidence ; Japan/epidemiology ; Liver Function Tests ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; Risk Assessment
    Chemical Substances Biomarkers ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2020-07-15
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 123477-8
    ISSN 1349-3329 ; 0040-8727
    ISSN (online) 1349-3329
    ISSN 0040-8727
    DOI 10.1620/tjem.251.183
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