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Article ; Online: Eosinophilic esophagitis with donut-shaped thickened esophageal mucosa on computed tomography.

Tasaki, Yuko / Obata, Misato / Inoue, Mika / Sakazume, Sinobu / Ohta, Kazuhide

Pediatrics international : official journal of the Japan Pediatric Society

2023 Volume 65, Issue 1, Page(s) e15639

MeSH term(s)	Humans ; Eosinophilic Esophagitis/diagnostic imaging ; Esophageal Mucosa/diagnostic imaging ; Tomography
Language	English
Publishing date	2023-10-06
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.15639
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Article: The Accuracy of Ankle Eccentric Torque Control Explains Dynamic Postural Control During the Y-Balance Test.

Nozu, Shojiro / Johnson, Kristin A / Tanaka, Tsukasa / Inoue, Mika / Nishio, Hirofumi / Takazawa, Yuji

International journal of sports physical therapy

2023 Volume 18, Issue 5, Page(s) 1113–1122

Abstract: Background: The Y-Balance Test (YBT), especially the posteromedial (PM) reach direction (PM-YBT), is able to identify dynamic postural control deficits in those who have ankle instability. However, there still exists a need to understand how ... ...

Abstract	Background: The Y-Balance Test (YBT), especially the posteromedial (PM) reach direction (PM-YBT), is able to identify dynamic postural control deficits in those who have ankle instability. However, there still exists a need to understand how sensorimotor function at the ankle explains the performance during the PM-YBT. Hypothesis/purpose: The purpose of this study was to determine whether the ability to accurately control eccentric ankle torque explained PM-YBT performance. It was hypothesized that eccentric dorsiflexion/plantarflexion torque control would be positively related to the maximum reach distance (MRD) of PM-YBT. Study design: Cross-sectional study. Methods: Twelve healthy subjects performed the PM-YBT, maximum voluntary isometric contractions (MVIC) for both dorsiflexion and plantarflexion muscle strength, and then the torque control testing of the ankle. The torque control testing provided a target torque level on a screen in front of the subject and passive rotations of the ankle joint in the sagittal plane at 10 deg/sec between plantarflexion to dorsiflexion. Subjects were then instructed to eccentrically contract the dorsiflexors and plantar flexors to generate torque while the ankle joint rotated. The accuracy of torque control during eccentric dorsiflexion and plantarflexion by calculating absolute errors, the area between the target torque and the produced torque were evaluated. Tibialis anterior and soleus muscle activities were simultaneously recorded during testing. A step-wise linear regression model was used to determine the best model predicted the MRD of the PM-YBT (PM-MRD). Results: A step-wise linear regression developed a model explaining only eccentric dorsiflexion torque control predicted higher PM-MRD score (R Conclusion: The accuracy of torque control during eccentric dorsiflexion predicts better performance in the PM-YBT. Level of evidence: 3b.
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628664-6
ISSN	2159-2896
ISSN	2159-2896
DOI	10.26603/001c.87760
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Article ; Online: Normal values for pediatric urinary biochemistry in early infancy.

Ohta, Kazuhide / Fujiki, Takuma / Yokoyama, Tadafumi / Maeda, Shinji / Inoue, Mika / Sakazume, Shinobu

Irish journal of medical science

2023 Volume 192, Issue 5, Page(s) 2507–2511

Abstract: Background: Urinary levels of N-acetyl-β-D-glucosaminidase (NAG), α1-microglobulin (α1-MG), and β2-microglobulin (β2-MG) are measured as markers of renal tubular damage. We previously determined normal values for these urine biochemical examinations in ... ...

Abstract	Background: Urinary levels of N-acetyl-β-D-glucosaminidase (NAG), α1-microglobulin (α1-MG), and β2-microglobulin (β2-MG) are measured as markers of renal tubular damage. We previously determined normal values for these urine biochemical examinations in healthy children over 3 years old. However, the values are not applicable to children younger than 2 years old, and children less than 1 year old, in particular, seem to show very high levels for all these markers. Hence, as normal values for children below 2 years old remain unclear, we determined the normal values for urinary biochemical markers in this age group. Material and methods: Fresh urine samples were obtained from 293 healthy children (from newborns to 2-year-old children). All the samples were subjected to normal urinalysis. NAG, α1-MG, β2-MG, and creatinine (Cr) levels in extracted samples were measured immediately in the central laboratory at Kanazawa Medical Center. Results: The normal values for each biomarker in children below 2 years of age were determined. Additionally, urinary α1-MG levels were observed to decrease most rapidly with age, almost reaching the level at ≥ 3 years by 6 months after birth. Conclusion: Renal tubular function can be evaluated in children < 3 years old using the normal values. Further, the most stable and useful urinary marker from early infancy seems to be urinary α1-MG.
MeSH term(s)	Humans ; Child ; Infant ; Infant, Newborn ; Child, Preschool ; Reference Values ; Acetylglucosaminidase/urine ; Biomarkers/urine ; Creatinine/urine
Chemical Substances	Acetylglucosaminidase (EC 3.2.1.52) ; Biomarkers ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2023-02-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-023-03296-8
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Article ; Online: Two cases of 22q11.2 deletion syndrome with decreased serum calcium during recovery following thyrotoxicosis.

Hiroshima, Shota / Taniguchi, Chihiro / Inoue, Mika / Sone, Hirohito / Nagasaki, Keisuke

Congenital anomalies

2022 Volume 62, Issue 6, Page(s) 254–255

MeSH term(s)	Humans ; DiGeorge Syndrome/diagnosis ; DiGeorge Syndrome/genetics ; Calcium ; Chromosome Deletion ; Thyrotoxicosis/diagnosis ; Chromosomes, Human, Pair 22
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-08-15
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	228664-6
ISSN	1741-4520 ; 0037-2285 ; 0914-3505
ISSN (online)	1741-4520
ISSN	0037-2285 ; 0914-3505
DOI	10.1111/cga.12486
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Article ; Online: [Object Detection Model Utilizing Deep Learning to Identify Retained Surgical Gauze in the Body on Postoperative Radiography: Phantom Study].

Tanuma, Takao / Kobayashi, Tatsuaki / Takaya, Eichi / Suzuki, Daigo / Inoue, Mika / Yoshikawa, Tatsuo / Kobayashi, Yasuyuki

Nihon Hoshasen Gijutsu Gakkai zasshi

2021 Volume 77, Issue 8, Page(s) 821–827

Abstract: Purpose: Foreign bodies such as a surgical gauze can be retained in the body after surgery and in some cases cannot be detected by postoperative radiography. The aim of this study was to develop an object detection model capable of postsurgical ... ...

Abstract	Purpose: Foreign bodies such as a surgical gauze can be retained in the body after surgery and in some cases cannot be detected by postoperative radiography. The aim of this study was to develop an object detection model capable of postsurgical detection of retained gauze in the body. The object detection model used deep learning using abdominal radiographs, and a phantom study was performed to evaluate the ability of the model to automatically detect retained surgical gauze. Materials and methods: The object detection model was constructed using a Single Shot MultiBox Detector (SSD) 300. In total, 268 abdominal phantom images were used: 180 gauze images were used as training data, 20 gauze images were used as validation data, and an additional 34 gauze images and 34 nongauze images were used as test data. To evaluate the performance of the object detection model, a confusion matrix was created and the accuracy and sensitivity were calculated. Result: True-positive (TP) rate, true-negative (TN) rate, false-positive (FP) rate, and false-negative (FN) rate were 0.92, 1.00, 0.00, and 0.08, respectively. Accuracy was 0.96, and sensitivity was 0.92. Conclusion: The object detection model could detect surgical gauze on abdominal phantom images with a high accuracy and sensitivity.
MeSH term(s)	Deep Learning ; Foreign Bodies/diagnostic imaging ; Humans ; Radiography ; Radiography, Abdominal
Language	Japanese
Publishing date	2021-08-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2269092-X
ISSN	1881-4883 ; 0369-4305
ISSN (online)	1881-4883
ISSN	0369-4305
DOI	10.6009/jjrt.2021_JSRT_77.8.821
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Article ; Online: Human Malformation Syndromes of Defective GLI: Opposite Phenotypes of 2q14.2 (GLI2) and 7p14.2 (GLI3) Microdeletions and a GLIA/R Balance Model.

Niida, Yo / Inoue, Mika / Ozaki, Mamoru / Takase, Etsuko

Cytogenetic and genome research

2018 Volume 153, Issue 2, Page(s) 56–65

Abstract: GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 ...

Abstract	GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 (7p14.1) mutations cause different syndromes. Here, we present 2 distinctive cases with a chromosomal microdeletion in one of these genes. Patient 1 is a 14-year-old girl with Culler-Jones syndrome. She manifested short stature, cleft palate, and mild intellectual/social disability caused by a 6.6-Mb deletion of 2q14.1q14.3. Patient 2 is a 2-year-old girl with Greig cephalopolysyndactyly contiguous gene deletion syndrome. She manifested macrocephaly, preaxial polysyndactyly, psychomotor developmental delay, cerebral cavernous malformations, and glucose intolerance due to a 6.2-Mb deletion of 7p14.1p12.3 which included GLI3, GCK, and CCM2. Each patient manifests a different phenotype which is associated with different functions of each GLI gene and different effects of the chromosomal contiguous gene deletion. We summarize the phenotypic extent of GLI2/3 syndromes in the literature and determine that these 2 syndromes manifest opposite features to a certain extent, such as midface hypoplasia or macrocephaly, and anterior or posterior side of polydactyly. We propose a GLIA/R balance model that may explain these findings.
MeSH term(s)	Abnormalities, Multiple/genetics ; Acrocephalosyndactylia/genetics ; Adolescent ; Child, Preschool ; Chromosomes, Human, Pair 2/genetics ; Chromosomes, Human, Pair 2/ultrastructure ; Chromosomes, Human, Pair 7/genetics ; Chromosomes, Human, Pair 7/ultrastructure ; Cleft Palate/genetics ; Dwarfism/genetics ; Female ; Glucose Intolerance/genetics ; Hedgehog Proteins/physiology ; Hemangioma, Cavernous, Central Nervous System/genetics ; Humans ; Intellectual Disability/genetics ; Karyotyping ; Models, Biological ; Morphogenesis/genetics ; Nerve Tissue Proteins/deficiency ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/physiology ; Nuclear Proteins/deficiency ; Nuclear Proteins/genetics ; Nuclear Proteins/physiology ; Oligonucleotide Array Sequence Analysis ; Phenotype ; Sequence Deletion ; Signal Transduction/genetics ; Syndrome ; Zinc Finger Protein Gli2/deficiency ; Zinc Finger Protein Gli2/genetics ; Zinc Finger Protein Gli2/physiology ; Zinc Finger Protein Gli3/deficiency ; Zinc Finger Protein Gli3/genetics ; Zinc Finger Protein Gli3/physiology
Chemical Substances	GLI2 protein, human ; GLI3 protein, human ; Hedgehog Proteins ; Nerve Tissue Proteins ; Nuclear Proteins ; SHH protein, human ; Zinc Finger Protein Gli2 ; Zinc Finger Protein Gli3
Language	English
Publishing date	2018-01-04
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2087824-2
ISSN	1424-859X ; 1424-8581
ISSN (online)	1424-859X
ISSN	1424-8581
DOI	10.1159/000485227
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Article ; Online: Age-based prediction of uncuffed tracheal tube size in children to prevent inappropriately large tube selection: a retrospective analysis.

Hanamoto, Hiroshi / Maegawa, Hiroharu / Inoue, Mika / Oyamaguchi, Aiko / Kudo, Chiho / Niwa, Hitoshi

BMC anesthesiology

2019 Volume 19, Issue 1, Page(s) 141

Abstract: Background: This study aims to validate our previously reported prediction technique for uncuffed tracheal tube (TT) sizes in children younger than 2 years of age based on a calculated outer diameter (OD: Methods: We included patients younger than 2 ... ...

Abstract	Background: This study aims to validate our previously reported prediction technique for uncuffed tracheal tube (TT) sizes in children younger than 2 years of age based on a calculated outer diameter (OD Methods: We included patients younger than 2 years of age who underwent oral surgery under general anesthesia with tracheal intubation between July 2011 and December 2016 at the Osaka University Dental Hospital. The OD of the actual TT and the age in days were extracted from anesthesia records. Agreement rates, estimated numbers of required tubes, and size reduction frequencies were compared to obtain recommended OD (OD Results: The agreement rates for an OD Conclusions: Because the size reduction frequency is lower despite a slightly higher number of required TTs, selecting an OD
MeSH term(s)	Anesthesia, General ; Child, Preschool ; Equipment Design ; Female ; Humans ; Infant ; Infant, Newborn ; Intubation, Intratracheal/instrumentation ; Male ; Oral Surgical Procedures ; Regression Analysis ; Retrospective Studies
Language	English
Publishing date	2019-08-07
Publishing country	England
Document type	Journal Article ; Validation Study
ISSN	1471-2253
ISSN (online)	1471-2253
DOI	10.1186/s12871-019-0818-3
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Article: Human Malformation Syndromes of Defective ; : Opposite Phenotypes of 2q14.2 ( ; ) and 7p14.2 ( ; ) Microdeletions and a GLIA/R Balance Model

Niida, Yo / Inoue, Mika / Ozaki, Mamoru / Takase, Etsuko

Cytogenetic and Genome Research

2018 Volume 153, Issue 2, Page(s) 56–65

Institution	Division of Clinical Genetics, Multidisciplinary Medical Center, Kanazawa Medical University Hospital, and Division of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada, and Department of Pediatrics, National Hospital Organization Kanazawa Medical Center, Kanazawa, Japan
Abstract	GLI family zinc finger proteins are transcriptional effectors of the sonic hedgehog signaling pathway. GLI regulates gene expression and repression at various phases of embryonic morphogenesis. In humans, 4 GLI genes are known, and GLI2 (2q14.2) and GLI3 (7p14.1) mutations cause different syndromes. Here, we present 2 distinctive cases with a chromosomal microdeletion in one of these genes. Patient 1 is a 14-year-old girl with Culler-Jones syndrome. She manifested short stature, cleft palate, and mild intellectual/social disability caused by a 6.6-Mb deletion of 2q14.1q14.3. Patient 2 is a 2-year-old girl with Greig cephalopolysyndactyly contiguous gene deletion syndrome. She manifested macrocephaly, preaxial polysyndactyly, psychomotor developmental delay, cerebral cavernous malformations, and glucose intolerance due to a 6.2-Mb deletion of 7p14.1p12.3 which included GLI3GCK, and CCM2. Each patient manifests a different phenotype which is associated with different functions of each GLI gene and different effects of the chromosomal contiguous gene deletion. We summarize the phenotypic extent of GLI2/3 syndromes in the literature and determine that these 2 syndromes manifest opposite features to a certain extent, such as midface hypoplasia or macrocephaly, and anterior or posterior side of polydactyly. We propose a GLIA/R balance model that may explain these findings.
Keywords	Greig cephalopolysyndactyly syndrome ; Pallister-Hall syndrome ; SNP array ; Sonic hedgehog pathway ; Contiguous gene deletion syndrome ; Culler-Jones syndrome ; GLI family zinc finger protein
Language	English
Publishing date	2018-01-04
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Article
ZDB-ID	2087824-2
ISSN	1424-859X ; 1424-8581
ISSN (online)	1424-859X
ISSN	1424-8581
DOI	10.1159/000485227
Database	Karger publisher's database

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Article ; Online: Mandibular advancement impairs swallowing ability more than head extension but less than mouth opening in the supine position.

Hanamoto, Hiroshi / Togawa, Eriko / Maegawa, Hiroharu / Yokoe, Chizuko / Inoue, Mika / Oyamaguchi, Aiko / Kudo, Chiho / Niwa, Hitoshi

Scientific reports

2019 Volume 9, Issue 1, Page(s) 20179

Abstract: Mandibular advancement in the supine position may influence swallowing during dental treatment under intravenous sedation. This study investigated the influence of mandibular advancement in the supine position on swallowing ability, compared with head ... ...

Abstract	Mandibular advancement in the supine position may influence swallowing during dental treatment under intravenous sedation. This study investigated the influence of mandibular advancement in the supine position on swallowing ability, compared with head extension and mouth opening. The water swallowing test was performed in 13 healthy, awake, supine, adult subjects under four head and mandibular positions. An electromyogram of the suprahyoid muscles was recorded; the duration and peak amplitude were examined. A greater volume of water remained in the mouth during mouth opening and mandibular advancement relative to the neutral position; the volume in the mandibular advancement position was larger and smaller than that in the head extension position and during mouth opening, respectively. The duration of the electromyogram in the head extension position was longer than that in the mandibular advancement position, without differences in the amplitude. Thus, swallowing ability in the supine position was more impaired with mandibular advancement, relative to neutral and head extension positions, but less than that observed with mouth opening. Although unconfirmed by electromyogram, our findings suggest that head extension might improve airway patency by reducing the impairment of swallowing ability compared with mandibular advancement.
MeSH term(s)	Adult ; Cephalometry ; Electromyography ; Female ; Head/physiology ; Humans ; Male ; Mandibular Advancement/adverse effects ; Middle Aged ; Mouth/physiology ; Movement ; Supine Position ; Young Adult
Language	English
Publishing date	2019-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-56843-8
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Article ; Online: Anaphylaxis with delayed appearance of skin manifestations during general anesthesia: two case reports.

Hanamoto, Hiroshi / Kozu, Fumi / Oyamaguchi, Aiko / Inoue, Mika / Yokoe, Chizuko / Niwa, Hitoshi

BMC research notes

2017 Volume 10, Issue 1, Page(s) 308

Abstract: Background: Anaphylaxis is difficult to diagnose in the absence of skin or mucosal signs and symptoms. We report two cases of anaphylaxis under general anesthesia, in which the initial presentation was in the form of respiratory signs, followed by skin ... ...

Abstract	Background: Anaphylaxis is difficult to diagnose in the absence of skin or mucosal signs and symptoms. We report two cases of anaphylaxis under general anesthesia, in which the initial presentation was in the form of respiratory signs, followed by skin manifestations 10-15 min later. Diagnosis of anaphylaxis was delayed because skin symptoms were absent early on in the presentation. Case presentation: In the first case, a 23-year-old male patient with jaw deformity was scheduled to undergo maxillary alveolar osteotomy. After intubation, auscultation indicated a sudden decrease in breath sounds, together with severe hypotension. Approximately 10 min later, flushing of the skin and urticaria on the thigh appeared and spread widely throughout the body. In the second case, a 21-year-old female patient with jaw deformity was scheduled to undergo maxillomandibular osteotomy. Twenty minutes after the start of dextran infusion, her lungs suddenly became difficult to ventilate, and oxygen saturation decreased to 90%. Approximately 15 min later, flushing of the skin and urticaria were observed. Conclusion: In both cases, there was a time lag between the appearance of respiratory and skin symptoms, which resulted in a delay in the diagnosis, and hence, treatment of anaphylaxis. Our experience highlights the fact that it is difficult to diagnose anaphylaxis under general anesthesia.
Language	English
Publishing date	2017-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-017-2624-7
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