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  1. Article ; Online: Interstitial 6q25 microdeletion syndrome: 46,XX,del(6)(q25.2q26).

    Inoue, Takaharu / Sato, Koichiro / Ohashi, Hirofumi / Motojima, Toshino / Takizawa, Takumi

    Pediatrics international : official journal of the Japan Pediatric Society

    2019  Volume 61, Issue 6, Page(s) 618–620

    MeSH term(s) Chromosome Deletion ; Chromosome Disorders/diagnosis ; Chromosome Disorders/genetics ; Chromosomes, Human, Pair 6 ; Female ; Humans ; Infant ; Syndrome
    Language English
    Publishing date 2019-06-13
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.13871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 848: Show issues Location:
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  2. Article ; Online: Oxidative stress induces

    Nishida, Yutaka / Yagi, Hisako / Ota, Masaya / Tanaka, Atsushi / Sato, Koichiro / Inoue, Takaharu / Yamada, Satoshi / Arakawa, Naoya / Ishige, Takashi / Kobayashi, Yasuko / Arakawa, Hirokazu / Takizawa, Takumi

    FASEB bioAdvances

    2023  Volume 5, Issue 4, Page(s) 171–181

    Abstract: Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing ... ...

    Abstract Oxidative stress increases the production of the predominant mucin MUC5AC in airway epithelial cells and is implicated in the pathogenesis of bronchial asthma and chronic obstructive pulmonary disease. Oxidative stress impairs mitochondria, releasing mitochondrial DNA into the cytoplasm and inducing inflammation through the intracytoplasmic DNA sensor STING (stimulator of interferon genes). However, the role of innate immunity in mucin production remains unknown. We aimed to elucidate the role of innate immunity in mucin production in airway epithelial cells under oxidative stress. Human airway epithelial cell line (NCI-H292) and normal human bronchial epithelial cells were used to confirm
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2022-00081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [SWITCHING BIOLOGICS LED TO GOOD CONTROL IN SEVERE CHILDHOOD ASTHMA: A CASE REPORT].

    Imai, Akira / Takizawa, Takumi / Sato, Koichiro / Inoue, Takaharu / Nishida, Yutaka / Yagi, Hisako / Arakawa, Hirokazu

    Arerugi = [Allergy

    2019  Volume 68, Issue 7, Page(s) 869–873

    Abstract: The two biologic therapies, anti-IgE (omalizumab) and anti-IL-5 antibodies (mepolizumab), are used in the treatment of severe pediatric asthma. We present here a case study of a 13-year-old girl with severe asthma who switched from omalizumab to ... ...

    Abstract The two biologic therapies, anti-IgE (omalizumab) and anti-IL-5 antibodies (mepolizumab), are used in the treatment of severe pediatric asthma. We present here a case study of a 13-year-old girl with severe asthma who switched from omalizumab to mepolizumab therapy and achieved good control over her asthma. The patient was diagnosed with asthma at one year of age and presented with poor disease control, even while taking high doses of inhaled corticosteroids (ICS). As such, she was considered to have severe persistent asthma. At 10 years old, she began omalizumab therapy which improved asthma control. However, after two years of this therapy, she manifested frequent acute exacerbations. At 12 years old, she switched to mepolizumab and has since maintained good control of asthma. Additionally, total serum IgE levels and peripheral eosinophil counts decreased. As the underlying mechanisms of omalizumab and mepolizumab therapy are distinct, it is recommended to use either one if the other proves ineffective.
    MeSH term(s) Adolescent ; Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Biological Products/therapeutic use ; Child ; Drug Substitution ; Female ; Humans ; Omalizumab/therapeutic use
    Chemical Substances Adrenal Cortex Hormones ; Antibodies, Monoclonal, Humanized ; Biological Products ; Omalizumab (2P471X1Z11) ; mepolizumab (90Z2UF0E52)
    Language Japanese
    Publishing date 2019-08-12
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 974201-3
    ISSN 0021-4884
    ISSN 0021-4884
    DOI 10.15036/arerugi.68.869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 245: Show issues Location:
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  4. Article ; Online: Expression of Leucine-rich Repeat-containing Protein 32 Following Lymphocyte Stimulation in Patients with Non-IgE-mediated Gastrointestinal Food Allergies.

    Yagi, Hisako / Sato, Koichiro / Arakawa, Naoya / Inoue, Takaharu / Nishida, Yutaka / Yamada, Satoshi / Ishige, Takashi / Yamada, Yoshiyuki / Arakawa, Hirokazu / Takizawa, Takumi

    The Yale journal of biology and medicine

    2020  Volume 93, Issue 5, Page(s) 645–655

    Abstract: The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found ... ...

    Abstract The lymphocyte stimulation test (LST) facilitates the diagnosis of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs). However, LSTs require large volumes of blood and prolonged culture durations. Recently, we found that
    MeSH term(s) Animals ; Cattle ; Cells, Cultured ; Female ; Food Hypersensitivity ; Humans ; Immunoglobulin E ; Infant ; Leucine ; Leukocytes, Mononuclear ; Lymphocyte Activation ; Membrane Proteins/metabolism
    Chemical Substances LRRC32 protein, human ; Membrane Proteins ; Immunoglobulin E (37341-29-0) ; Leucine (GMW67QNF9C)
    Language English
    Publishing date 2020-12-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200515-3
    ISSN 1551-4056 ; 0044-0086
    ISSN (online) 1551-4056
    ISSN 0044-0086
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  5. Article ; Online: Interleukin 2 receptor-α expression after lymphocyte stimulation for non-IgE-mediated gastrointestinal food allergies.

    Yagi, Hisako / Takizawa, Takumi / Sato, Koichiro / Inoue, Takaharu / Nishida, Yutaka / Yamada, Satoshi / Ishige, Takashi / Hatori, Reiko / Inoue, Takahiro / Yamada, Yoshiyuki / Arakawa, Hirokazu

    Allergology international : official journal of the Japanese Society of Allergology

    2020  Volume 69, Issue 2, Page(s) 287–289

    MeSH term(s) Allergens/immunology ; Child ; Child, Preschool ; Female ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/genetics ; Food Hypersensitivity/immunology ; Gastrointestinal Tract/immunology ; Humans ; Immunoglobulin E ; Immunologic Tests ; Infant ; Infant, Newborn ; Interleukin-2 Receptor alpha Subunit/genetics ; Lymphocyte Activation ; Male ; Milk Proteins/immunology ; RNA, Messenger
    Chemical Substances Allergens ; IL2RA protein, human ; Interleukin-2 Receptor alpha Subunit ; Milk Proteins ; RNA, Messenger ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Letter
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2019.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5248: Show issues Location:
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  6. Article ; Online: Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants.

    Yagi, Hisako / Takizawa, Takumi / Sato, Koichiro / Inoue, Takaharu / Nishida, Yutaka / Ishige, Takashi / Tatsuki, Maiko / Hatori, Reiko / Kobayashi, Yasuko / Yamada, Yoshiyuki / Arakawa, Hirokazu

    Allergology international : official journal of the Japanese Society of Allergology

    2018  Volume 68, Issue 2, Page(s) 178–184

    Abstract: Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations.: Methods: Grading scales of the ... ...

    Abstract Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations.
    Methods: Grading scales of the severity of non-IgE-GI-FAs according to extra-GI symptoms, such as poor weight gain, as well as systemic symptoms, including fever and shock, were developed and retrospectively applied to patients with non-IgE-GI-FAs. The relationship between the severity of non-IgE-GI-FAs and both clinical and laboratory findings were examined.
    Results: Elevation of C-reactive protein levels and a decrease in total protein and albumin were observed in accordance with allergy severity. In an endoscopic examination, inflammatory findings were confirmed in large areas of the colonic mucosa in case of higher severity levels, and infiltration of inflammatory cells other than eosinophils was found in the severest grade. Extensively hydrolyzed milk or amino acid-based milk was required for all patients with the severest grade. In addition, the timing of acquiring tolerance tended to be late for this grade.
    Conclusions: Classification and determination of the severity of non-IgE-GI-FAs in neonates and infants may not only contribute to elucidation of the pathogenesis but may also be useful in the clinical setting.
    MeSH term(s) C-Reactive Protein/analysis ; Colon/pathology ; Endoscopy ; Female ; Food Hypersensitivity/blood ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/diet therapy ; Food Hypersensitivity/pathology ; Humans ; Immunoglobulin E/blood ; Infant ; Infant, Newborn ; Intestinal Mucosa/pathology ; Male ; Severity of Illness Index
    Chemical Substances Immunoglobulin E (37341-29-0) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2018-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2018.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5248: Show issues Location:
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  7. Article: Assimilation of metal ions bound to porphyrins or porphyrin-peptides by vibrio vulnificus, a human pathogen inhabiting estuarine and marine environments.

    Miyoshi, Shin-ichi / Sasaki, Tomoko / Kaku, Nahoko / Inoue, Takaharu / Uozumi, Natsuki / Maehara, Yoko / Nakao, Hiroshi

    Biocontrol science

    2010  Volume 15, Issue 1, Page(s) 1–6

    Abstract: Vibrio vulnificus, a ubiquitous microorganism in aquatic environments, causes serious septicemia to the immunocompromised host. In addition to protoheme, this species can utilize Fe-TCPP [ferric tetrakis (4-carboxyphenyl) porphine] as an iron source. In ... ...

    Abstract Vibrio vulnificus, a ubiquitous microorganism in aquatic environments, causes serious septicemia to the immunocompromised host. In addition to protoheme, this species can utilize Fe-TCPP [ferric tetrakis (4-carboxyphenyl) porphine] as an iron source. In the present study, heme c bound covalently to the protein in cytochrome c, as well as the Fe-TCPP complex formed with a nanopeptide with a high affinity, was found to be useful iron sources for V. vulnificus. This bacterium was also revealed to use Zn-TCPP as a single zinc source. However, other metalloporphyrins such as Mn-TCPP and Pt-TCPP delayed the bacterial growth in the broth containing Fe-TCPP, suggesting interference in the iron assimilation. These results indicate that V. vulnificus may acquire metal ions from both free and peptide-bound metalloporphyrins.
    MeSH term(s) Cytochromes c/metabolism ; Geologic Sediments ; Metalloporphyrins/metabolism ; Vibrio vulnificus/growth & development ; Vibrio vulnificus/metabolism
    Chemical Substances Metalloporphyrins ; iron 5,10,15,20-tetrakis-4-carboxyphenylporphyrin ; zinc(II) tetrakis(4-carboxyphenyl)porphine (27647-84-3) ; Cytochromes c (9007-43-6)
    Language English
    Publishing date 2010-03-24
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1414347-1
    ISSN 1884-0205 ; 1342-4815
    ISSN (online) 1884-0205
    ISSN 1342-4815
    DOI 10.4265/bio.15.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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