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  1. Article: Subcutaneous delivery of immune checkpoint inhibitors: new route replacing intravenous administration?

    Inoue, Yusuke

    Translational lung cancer research

    2024  Volume 13, Issue 4, Page(s) 947–951

    Language English
    Publishing date 2024-04-18
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-24-63
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  2. Article ; Online: Radiation Dose Management in Computed Tomography: Introduction to the Practice at a Single Facility.

    Inoue, Yusuke

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 3, Page(s) 955–966

    Abstract: Although the clinical benefits of computed tomography (CT) are undoubtedly high, radiation doses received by patients are also relatively high; therefore, radiation dose management is mandatory to optimize CT radiation doses and prevent excessive ... ...

    Abstract Although the clinical benefits of computed tomography (CT) are undoubtedly high, radiation doses received by patients are also relatively high; therefore, radiation dose management is mandatory to optimize CT radiation doses and prevent excessive radiation events. This article describes CT dose management practice at a single facility. Many imaging protocols are used in CT depending on the clinical indications, scan region, and CT scanner; thus, managing the protocols is the first step for optimization. The appropriateness of the radiation dose for each protocol and scanner is verified, while answering whether the dose is the minimum to obtain diagnostic-quality images. Moreover, examinations with exceptionally high doses are identified, and the cause and clinical validity of the high dose are assessed. Daily imaging practice should follow standardized procedures, avoiding operator-dependent errors, and information required for radiation dose management should be recorded at each examination. The imaging protocols and procedures are reviewed for continuous improvement based on regular dose analysis and multidisciplinary team collaboration. The participation of many staff members in the dose management process is expected to contribute to promoting radiation safety through increased staff awareness.
    MeSH term(s) Humans ; Radiation Dosage ; Tomography, X-Ray Computed/adverse effects ; Tomography, X-Ray Computed/methods ; Tomography Scanners, X-Ray Computed
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9030078
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  3. Article ; Online: Relationship Between High Organ Donation Rates and COVID-19 Vaccination Coverage.

    Inoue, Yusuke

    Frontiers in public health

    2022  Volume 10, Page(s) 855051

    Abstract: Background: Besides attaining the goal of self-protection, the rollout of vaccination programs also encourages altruistic practices. Therefore, the progress in vaccination against coronavirus disease (COVID-19) in each country may be related to the ... ...

    Abstract Background: Besides attaining the goal of self-protection, the rollout of vaccination programs also encourages altruistic practices. Therefore, the progress in vaccination against coronavirus disease (COVID-19) in each country may be related to the prevalence of cooperative and altruistic practices in health care. I hypothesized that in countries where organ donation is popular, individuals would exhibit a greater tendency to become vaccinated.
    Methods: I examined the correlation between the level of progress of COVID-19 vaccination and the status of organ donation just before the pandemic in Organization for Economic Co-operation and Development (OECD) countries. Publicly available statistical information on the progress of immunization and organ donation was used. Univariate and multivariate analyses were conducted to examine common drivers of immunization and organ donation.
    Results: In OECD countries, progress in vaccination was found to be significantly correlated with the status of organ donation in each country. This relationship was stable after the summer (September 1: Pearson's
    Conclusions: Progress in COVID-19 vaccination and organ donation status for transplantation have similar trends, and both may involve people's trust in medical personnel and public health systems. Similar to the efforts to obtain organ donors, governments around the world need to take further steps to ensure that vaccination programs are supported by people's trust and sense of solidarity.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Tissue and Organ Procurement ; Vaccination ; Vaccination Coverage
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-04-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.855051
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  4. Article ; Online: Radiation Dose Modulation of Computed Tomography Component in Positron Emission Tomography/Computed Tomography.

    Inoue, Yusuke

    Seminars in nuclear medicine

    2021  Volume 52, Issue 2, Page(s) 157–166

    Abstract: In oncology practice, the CT component of PET/CT may be used for attenuation correction, lesion localization, and CT diagnosis, and significantly enhances the clinical benefit of PET. However, acquisition of CT covering the whole body increases radiation ...

    Abstract In oncology practice, the CT component of PET/CT may be used for attenuation correction, lesion localization, and CT diagnosis, and significantly enhances the clinical benefit of PET. However, acquisition of CT covering the whole body increases radiation dose and consequently the risk of cancer induction, and optimization should be pursued. In CT, radiation dose is a major determinant of image quality, and is mainly adjusted by modulation of tube current. Automatic exposure control (AEC) is widely used for tube current modulation, and increases tube current in a large patient and in strongly attenuating regions of a given patient to preserve image quality despite strong X-ray attenuation. Radiation dose determined by AEC depends on various factors, such as the type of AEC software, scout imaging direction, arm positioning, and patient centering. Because radiation dose reduction increases image noise and may degrade clinical utility, image quality should be assessed together with radiation dose in the process of optimization. Clinical demands for image quality vary largely depending on the aim of the CT component, with lower quality being sufficient for lesion localization than for CT diagnosis. Therefore, optimal radiation dose differs according to the aim. Determining optimal dose is a somewhat subjective and difficult task, and use of the diagnostic reference level, determined based on national or regional survey, is recommended to recognize need for optimization. The volume CT dose index and dose-length product are used as indices of CT radiation dose, and effective dose may also be calculated for comparison of stochastic effects among different radiation sources and among different imaging procedures. Wide coverage from the head to the lower extremities causes problems in estimating these indices in whole-body PET/CT. CT definitely enhances clinical benefits of PET but simultaneously increases potential detriments due to radiation exposure. In the era of hybrid imaging, nuclear medicine practitioners should be aware of the technology and radiation dose management of CT.
    MeSH term(s) Humans ; Multimodal Imaging/methods ; Phantoms, Imaging ; Positron Emission Tomography Computed Tomography/methods ; Radiation Dosage ; Tomography, X-Ray Computed/adverse effects
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2021.11.009
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  5. Article: Teratorn

    Inoue, Yusuke / Takeda, Hiroyuki

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1158023

    Abstract: Mobile genetic elements (e.g., transposable elements and plasmids) and viruses display significant diversity with various life cycles, but how this diversity emerges remains obscure. We previously reported a novel and giant (180 kb long) mobile element, ...

    Abstract Mobile genetic elements (e.g., transposable elements and plasmids) and viruses display significant diversity with various life cycles, but how this diversity emerges remains obscure. We previously reported a novel and giant (180 kb long) mobile element,
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1158023
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  6. Article: Teratorn

    Inoue, Yusuke / Takeda, Hiroyuki

    Zoological science

    2023  Volume 40, Issue 2, Page(s) 83–90

    Abstract: Herpesviruses are a large family of DNA viruses infecting vertebrates and invertebrates, and are important pathogens in the field of aquaculture. In general, herpesviruses do not have the ability to integrate into the host genomes since they do not have ... ...

    Abstract Herpesviruses are a large family of DNA viruses infecting vertebrates and invertebrates, and are important pathogens in the field of aquaculture. In general, herpesviruses do not have the ability to integrate into the host genomes since they do not have a chromosomal integration step in their life cycles. Recently, we identified a novel group of herpesviruses, "
    MeSH term(s) Animals ; Phylogeny ; Herpesviridae/genetics ; DNA Transposable Elements ; Fishes/genetics
    Chemical Substances DNA Transposable Elements
    Language English
    Publishing date 2023-04-12
    Publishing country Japan
    Document type Review ; Journal Article
    ZDB-ID 2038883-4
    ISSN 2212-3830 ; 0289-0003
    ISSN (online) 2212-3830
    ISSN 0289-0003
    DOI 10.2108/zs220069
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  7. Article ; Online: Factors that Lead to Stagnation in Direct Patient Reporting of Adverse Drug Reactions: An Opinion Survey of the General Public and Physicians in Japan.

    Kitabayashi, Aki / Inoue, Yusuke

    Therapeutic innovation & regulatory science

    2022  Volume 56, Issue 4, Page(s) 616–624

    Abstract: Objective: Data collection from patients regarding adverse drug reactions (ADRs) in Japan have greatly stagnated. To examine the factors underlying this stagnation, we investigated the awareness of and opinions about the direct ADR reporting system ... ...

    Abstract Objective: Data collection from patients regarding adverse drug reactions (ADRs) in Japan have greatly stagnated. To examine the factors underlying this stagnation, we investigated the awareness of and opinions about the direct ADR reporting system among the general public and physicians.
    Methods: We conducted questionnaire surveys of general citizens and physicians throughout Japan and included the following topics: (1) awareness of the direct patient ADR reporting system, (2) attitude toward this system, (3) reasons for negative opinions of this system, (4) awareness of the physician ADR reporting system, and (5) respondent demographics.
    Results: Responses were received from 845 citizens and 300 physicians. Most citizens (83.7%) were unaware of the direct patient ADR reporting system. While many citizens supported the idea of the system, 26.7% expressed negative/hesitant opinions. Prominent reasons for negative/hesitant opinions included the patient burden for reporting their own ADRs and expectations that physicians would make reports. Among the general public, the physician reporting system was better known (43.6%). In contrast, many physicians were aware of the direct patient ADR reporting system (65.0%). However, only 46.7% of physicians had supported this system; prominent reasons for disapproval included skepticism toward patients' judgment and the regulatory authorities' assessment.
    Conclusion: Our survey suggests that stagnation in the reporting system is affected by the attitudes of the general public and physicians. In addition to government measures to improve awareness and eliminate reporting hurdles, the involvement of medical staff in patient reporting needs to be improved.
    MeSH term(s) Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions ; Health Knowledge, Attitudes, Practice ; Humans ; Japan ; Pharmacovigilance ; Physicians
    Language English
    Publishing date 2022-03-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2708397-4
    ISSN 2168-4804 ; 2168-4790
    ISSN (online) 2168-4804
    ISSN 2168-4790
    DOI 10.1007/s43441-022-00397-x
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  8. Article ; Online: Anisotropic cell growth and cell wall structure in lenticular cell of Valonia utricularis (Ulvophyceae)

    Mine, Ichiro / Inoue, Yūsuke / Yamamoto, Takuji / Sekida, Satoko

    Phycological Research. 2023 July, v. 71, no. 3 p.166-171

    2023  

    Abstract: During cell division of the giant‐celled green alga, Valonia utricularis, a lenticular cell is newly formed, which grows from disc‐shaped to globular to obovoid. During the early developmental stages of growth, the cell surface shows a remarkable outward ...

    Abstract During cell division of the giant‐celled green alga, Valonia utricularis, a lenticular cell is newly formed, which grows from disc‐shaped to globular to obovoid. During the early developmental stages of growth, the cell surface shows a remarkable outward protrusion. In the present study, the anisotropy of cell growth, i.e. the difference between cell surface extension in meridional and radial orientation, was investigated by analyzing the movement of the surface markers in a living cell. Growth was isotropic around the cell zenith but of two different kinds of anisotropic growth in other regions; radial extension was dominant in cell periphery and meridional extension in intermediate regions between zenith and periphery. Moreover, local orientation of cellulose microfibrils was observed on the inner surface of the cell wall during different stages of early development in lenticular cell using an atomic force microscope. Cellulose microfibrils showed meridional orientation overall and this phenomenon was most remarkable in the periphery of the cell, suggesting the possibility of cellulose microfibrils promoting radial extension of cells by suppressing meridional extension of cell wall.
    Keywords Valonia ; anisotropy ; atomic force microscopy ; cell division ; cell growth ; cell walls ; cellulose microfibrils ; early development ; isotropy ; research
    Language English
    Dates of publication 2023-07
    Size p. 166-171.
    Publishing place John Wiley & Sons Australia, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2020835-2
    ISSN 1440-1835 ; 1322-0829
    ISSN (online) 1440-1835
    ISSN 1322-0829
    DOI 10.1111/pre.12520
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  9. Article ; Online: Haemolytic uraemic syndrome managed with subtotal colectomy.

    Adachi, Toshiyuki / Inoue, Yusuke / Okada, Satomi / Eguchi, Susumu

    BMJ case reports

    2023  Volume 16, Issue 9

    Abstract: A man in his early 70s was transferred to our hospital due to rapid decline in renal function and inflammation throughout the colon, indicating severe ischaemic enteritis. On the day following the start of intensive care, a stool specimen tested positive ...

    Abstract A man in his early 70s was transferred to our hospital due to rapid decline in renal function and inflammation throughout the colon, indicating severe ischaemic enteritis. On the day following the start of intensive care, a stool specimen tested positive for verotoxin, and haemolytic uraemic syndrome (HUS) was diagnosed. On the same day, his vital signs deteriorated suddenly, and emergency surgery was performed due to the possibility of intestinal necrosis and perforation. Severe inflammation extending to the serosal surface of the whole colon was observed, but there was no obvious intestinal necrosis or perforation. Advanced mucosal necrosis of the entire colon suggested sepsis due to bacterial translocation, and subtotal colectomy was performed to remove the infection source. Postoperative management was successful. This case demonstrates the importance of considering HUS in patients with severe renal dysfunction and bloody stools, as well as the significance of colectomy in such patients.
    MeSH term(s) Humans ; Male ; Colectomy ; Colon ; Hemolytic-Uremic Syndrome/complications ; Hemolytic-Uremic Syndrome/diagnosis ; Hemolytic-Uremic Syndrome/surgery ; Inflammation ; Intestinal Diseases ; Necrosis ; Vascular Diseases ; Aged
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256585
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  10. Article ; Online: Coronavirus Disease and the Shared Emotion of Blaming Others: Reviewing Media Opinion Polls During the Pandemic.

    Inoue, Yusuke / Okita, Taketoshi

    Journal of epidemiology

    2021  Volume 31, Issue 7, Page(s) 453–455

    MeSH term(s) COVID-19/epidemiology ; COVID-19/psychology ; Humans ; Mass Media ; Pandemics ; Public Opinion
    Language English
    Publishing date 2021-05-25
    Publishing country Japan
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1442118-5
    ISSN 1349-9092 ; 0917-5040
    ISSN (online) 1349-9092
    ISSN 0917-5040
    DOI 10.2188/jea.JE20210169
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