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  1. Article: Timely synergic surgical and radiological aggressiveness improves perioperative mortality after hemorrhagic complication in Whipple procedure.

    Chierici, Andrea / Intotero, Marcello / Granieri, Stefano / Paleino, Sissi / Flocchini, Giovanni / Germini, Alessandro / Cotsoglou, Christian

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2020  Volume 20, Issue 4, Page(s) 387–390

    MeSH term(s) Aged ; Ampulla of Vater/surgery ; Angiography ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Signet Ring Cell/pathology ; Carcinoma, Signet Ring Cell/surgery ; Embolization, Therapeutic ; Hepatic Artery/injuries ; Hepatic Artery/surgery ; Humans ; Male ; Pancreatectomy ; Pancreatic Fistula/diagnosis ; Pancreatic Fistula/etiology ; Pancreatic Fistula/therapy ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Pancreaticoduodenectomy/adverse effects ; Patient Care Team ; Postoperative Hemorrhage/diagnostic imaging ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/therapy ; Prosthesis Implantation ; Radiography, Interventional/adverse effects ; Radiography, Interventional/methods ; Recurrence ; Reoperation ; Splenectomy ; Stents ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/methods ; Vascular System Injuries/diagnosis ; Vascular System Injuries/etiology ; Vascular System Injuries/therapy
    Language English
    Publishing date 2020-12-10
    Publishing country Singapore
    Document type Case Reports ; Letter
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/j.hbpd.2020.12.003
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  2. Article ; Online: Acute pulmonary embolism in patients presenting pulmonary deterioration after hospitalisation for non-critical COVID-19.

    Polo Friz, Hernan / Gelfi, Elia / Orenti, Annalisa / Motto, Elena / Primitz, Laura / Donzelli, Tino / Intotero, Marcello / Scarpazza, Paolo / Vighi, Giuseppe / Cimminiello, Claudio / Boracchi, Patrizia

    Internal medicine journal

    2021  Volume 51, Issue 8, Page(s) 1236–1242

    Abstract: Background: Emerging evidence suggests an association between COVID-19 and acute pulmonary embolism (APE).: Aims: To assess the prevalence of APE in patients hospitalised for non-critical COVID-19 who presented clinical deterioration, and to ... ...

    Abstract Background: Emerging evidence suggests an association between COVID-19 and acute pulmonary embolism (APE).
    Aims: To assess the prevalence of APE in patients hospitalised for non-critical COVID-19 who presented clinical deterioration, and to investigate the association of clinical and biochemical variables with a confirmed diagnosis of APE in these subjects.
    Methods: All consecutive patients admitted to the internal medicine department of a general hospital with a diagnosis of non-critical COVID-19, who performed a computer tomography pulmonary angiography (CTPA) for respiratory deterioration in April 2020, were included in this retrospective cohort study.
    Results: Study populations: 41 subjects, median (interquartile range) age: 71.7 (63-76) years, CPTA confirmed APE = 8 (19.51%, 95% confidence interval (CI): 8.82-34.87%). Among patients with and without APE, no significant differences were found with regards symptoms, comorbidities, treatment, Wells score and outcomes. The optimal cut-off value of d-dimer for predicting APE was 2454 ng/mL, sensitivity (95% CI): 63 (24-91), specificity: 73 (54-87), positive predictive value: 36 (13-65), negative predictive value: 89 (71-98) and AUC: 0.62 (0.38-0.85). The standard and age-adjusted d-dimer cut-offs, and the Wells score ≥2 did not associate with confirmed APE, albeit a cut-off value of d-dimer = 2454 ng/mL showed an relative risk: 3.21; 95% CI: 0.92-13.97; P = 0.073. Heparin at anticoagulant doses was used in 70.73% of patients before performing CTPA.
    Conclusion: Among patients presenting pulmonary deterioration after hospitalisation for non-critical COVID-19, the prevalence of APE is high. Traditional diagnostic tools to identify high APE pre-test probability patients do not seem to be clinically useful. These results support the use of a high index of suspicion for performing CTPA to exclude or confirm APE as the most appropriate diagnostic approach in this clinical setting.
    MeSH term(s) Aged ; COVID-19 ; Fibrin Fibrinogen Degradation Products ; Hospitalization ; Humans ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/epidemiology ; Retrospective Studies ; SARS-CoV-2
    Chemical Substances Fibrin Fibrinogen Degradation Products
    Language English
    Publishing date 2021-04-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15307
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  3. Article ; Online: One-year pulmonary impairment after severe COVID-19: a prospective, multicenter follow-up study.

    Faverio, Paola / Luppi, Fabrizio / Rebora, Paola / D'Andrea, Gabriele / Stainer, Anna / Busnelli, Sara / Catalano, Martina / Modafferi, Giuseppe / Franco, Giovanni / Monzani, Anna / Galimberti, Stefania / Scarpazza, Paolo / Oggionni, Elisa / Betti, Monia / Oggionni, Tiberio / De Giacomi, Federica / Bini, Francesco / Bodini, Bruno Dino / Parati, Mara /
    Bilucaglia, Luca / Ceruti, Paolo / Modina, Denise / Harari, Sergio / Caminati, Antonella / Intotero, Marcello / Sergio, Pietro / Monzillo, Giuseppe / Leati, Giovanni / Borghesi, Andrea / Zompatori, Maurizio / Corso, Rocco / Valsecchi, Maria Grazia / Bellani, Giacomo / Foti, Giuseppe / Pesci, Alberto

    Respiratory research

    2022  Volume 23, Issue 1, Page(s) 65

    Abstract: Background: Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 12-month from discharge.: ... ...

    Abstract Background: Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 12-month from discharge.
    Methods: In this multicentre, prospective, observational study, patients hospitalised for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support ("oxygen only", "continuous positive airway pressure (CPAP)" and "invasive mechanical ventilation (IMV)") and followed up at 12 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6 min walking test, high resolution CT (HRCT) scan, and modified Medical Research Council (mMRC) dyspnea scale were collected.
    Results: Out of 287 patients hospitalized with SARS-CoV-2 pneumonia and followed up at 1 year, DLCO impairment, mainly of mild entity and improved with respect to the 6-month follow-up, was observed more frequently in the "oxygen only" and "IMV" group (53% and 49% of patients, respectively), compared to 29% in the "CPAP" group. Abnormalities at chest HRCT were found in 46%, 65% and 80% of cases in the "oxygen only", "CPAP" and "IMV" group, respectively. Non-fibrotic interstitial lung abnormalities, in particular reticulations and ground-glass attenuation, were the main finding, while honeycombing was found only in 1% of cases. Older patients and those requiring IMV were at higher risk of developing radiological pulmonary sequelae. Dyspnea evaluated through mMRC scale was reported by 35% of patients with no differences between groups, compared to 29% at 6-month follow-up.
    Conclusion: DLCO alteration and non-fibrotic interstitial lung abnormalities are common after 1 year from hospitalization due to SARS-CoV-2 pneumonia, particularly in older patients requiring higher ventilatory support. Studies with longer follow-ups are needed.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Female ; Follow-Up Studies ; Hospitalization ; Humans ; Lung Diseases/diagnosis ; Lung Diseases/therapy ; Lung Diseases/virology ; Male ; Middle Aged ; Oxygen Inhalation Therapy ; Prospective Studies ; Respiration, Artificial ; Respiratory Function Tests ; Time Factors
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-022-01994-y
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  4. Article: Large iatrogenic pseudoaneurysm of the posterior tibial artery treated with sonographically guided thrombin injection.

    Corso, Rocco / Carrafiello, Gianpaolo / Intotero, Marcello / Solcia, Marco

    AJR. American journal of roentgenology

    2003  Volume 180, Issue 5, Page(s) 1479–1480

    MeSH term(s) Aged ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/drug therapy ; Aneurysm, False/etiology ; Aneurysm, False/pathology ; Hemostatics/administration & dosage ; Humans ; Iatrogenic Disease ; Injections ; Male ; Thrombin/administration & dosage ; Tibial Arteries/diagnostic imaging ; Tibial Arteries/injuries ; Ultrasonography
    Chemical Substances Hemostatics ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2003-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/ajr.180.5.1801479
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  5. Article: Ingested medications reteined in the colon.

    Carrafiello, Gianpaolo / Intotero, Marcello / Vimercati, Franco / Corso, Rocco / Vanzulli, Angelo

    La Radiologia medica

    2002  Volume 104, Issue 5-6, Page(s) 490–493

    MeSH term(s) Adenocarcinoma/complications ; Aged ; Colonic Neoplasms/complications ; Diagnosis, Differential ; Drug-Related Side Effects and Adverse Reactions ; Female ; Foreign Bodies/diagnostic imaging ; Humans ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Radiography
    Language Italian
    Publishing date 2002-11
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
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  6. Article: Occlusion of postcatheterisation femoral pseudoaneurysms with percutaneous thrombin injection under ultrasound guidance.

    Corso, Rocco / Rampoldi, Antonio / Riolo, Franco / Carrafiello, Gianpaolo / Solcia, Marco / Intotero, Marcello / Vanzulli, Angelo

    La Radiologia medica

    2004  Volume 108, Issue 4, Page(s) 385–393

    Abstract: Purpose: The incidence of iatrogenic femoral artery pseudoaneurysms is reported to occur in 1-7% by of all percutaneous catheterisations. These pseudoaneurysms are traditionally treated by ultrasound-guided compression or surgical repair. We report our ... ...

    Abstract Purpose: The incidence of iatrogenic femoral artery pseudoaneurysms is reported to occur in 1-7% by of all percutaneous catheterisations. These pseudoaneurysms are traditionally treated by ultrasound-guided compression or surgical repair. We report our experience in sealing postcatheterization femoral pseudoaneurysms with percutaneous thrombin injection under colour-Doppler ultrasound guidance.
    Materials and methods: Since June 2000 we have consecutively treated 31 pseudoaneurysms in 30 patients, (14 males and 16 females, age range 45 to 81 years); in one patient the pseudoaneurysm was bilateral. All patients had a clinical diagnosis of postcatheterization femoral pseudoaneurysm, later confirmed by colour-Doppler ultrasonography. We injected a bovine thrombin solution percutaneously at a concentration of 1000 U/mL using 21-22 gauge needles under colour Doppler ultrasound guidance. All patients underwent clinical and colour-Doppler US examination before, during and 24 hours after the procedure and were followed up after 1 and 3 months.
    Results: The primary success rate was 83.8%. Complete and persistent occlusion of the pseudoaneurysm was achieved in less than 20 seconds by administering an average dose of 880 U of thrombin (0.8 mL of solution). In 5 cases (16.1%) reperfusion of the pseudoaneurysm was observed within 24 hours. These patients underwent a repeat procedure. The final result was successful in 96.7% of patients (30 of 31 cases). No thromboembolic complication was observed. Only 22.5% of patients reported a heat sensation in the treated limb, which resolved spontaneously within minutes.
    Conclusions: The percutaneous injection of thrombin under ultrasound colour-Doppler guidance should be regarded as the first choice treatment for postcatheterization femoral pseudoaneurysms, owing to its simplicity, safety, effectiveness and inexpensiveness.
    MeSH term(s) Aged ; Aged, 80 and over ; Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aneurysm, False/therapy ; Catheterization, Peripheral/adverse effects ; Female ; Femoral Artery ; Humans ; Injections ; Male ; Middle Aged ; Thrombin/administration & dosage ; Ultrasonography, Doppler, Color ; Ultrasonography, Interventional
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language Italian
    Publishing date 2004-10
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
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