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  1. Article: Glycan-mediated molecular interactions in bacterial pathogenesis

    Lee, Sohyoung / Inzerillo, Sean / Lee, Gi Young / Bosire, Erick M. / Mahato, Saroj K. / Song, Jeongmin

    Trends in microbiology. 2022 Mar., v. 30, no. 3

    2022  

    Abstract: Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host–pathogen ... ...

    Abstract Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host–pathogen interactions can benefit the pathogen, host, or both. Here, we discuss (i) bacterial glycans that play a critical role in bacterial colonization and/or immune evasion, (ii) host glycans that are utilized by bacteria for pathogenesis, and (iii) bacterial and host glycans involved in immune responses against pathogens. We further discuss (iv) opportunities and challenges for transforming these research findings into more effective antibacterial strategies, and (v) technological advances in glycoscience that have helped to accelerate progress in research. These studies collectively offer valuable insights into new perspectives on antibacterial strategies that may effectively tackle the drug-resistant pathogens that are rapidly spreading globally.
    Keywords bacterial colonization ; drug resistance ; immune evasion ; pathogenesis ; pathogens ; polysaccharides
    Language English
    Dates of publication 2022-03
    Size p. 254-267.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.06.011
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/714: Show issues

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  2. Article ; Online: The Use of COVID-19 Vaccines in Patients with SLE.

    Tang, Wei / Gartshteyn, Yevgeniya / Ricker, Edd / Inzerillo, Sean / Murray, Shane / Khalili, Leila / Askanase, Anca

    Current rheumatology reports

    2021  Volume 23, Issue 11, Page(s) 79

    Abstract: Purpose of review: Three COVID-19 vaccines obtained emergency authorization from the Food and Drug Administration (FDA) and are widely used in the USA. Unfortunately, there is a paucity of evidence on the safety and efficacy of these vaccines in ... ...

    Abstract Purpose of review: Three COVID-19 vaccines obtained emergency authorization from the Food and Drug Administration (FDA) and are widely used in the USA. Unfortunately, there is a paucity of evidence on the safety and efficacy of these vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD), as these patients were excluded from all phases of vaccine development. Here we reviewed current data on COVID-19 vaccination in patients with AIIRD, with emphasis on systemic lupus erythematosus (SLE), and provided a comprehensive update on the benefits and risks of vaccination.
    Recent findings: Patients with SLE have worse immune responses following SARS-CoV-2 vaccination than healthy controls. The efficacy of the COVID-19 vaccines seems to be further reduced by immunosuppressive medications, such as glucocorticoids (GC), methotrexate (MTX), mycophenolate/mycophenolic acid (MMF), and rituximab (RTX). However, these data do not substantiate that AIIRD patients are at greater risk of disease flares or have a higher incidence of side effects following vaccination. There is no significant safety concern for the use of COVID-19 vaccines in patients with AIIRD. The benefits of vaccination far outweigh the risks in patients with AIIRD, including SLE. More data are needed to determine the necessity of a booster vaccine dose and appropriate adjustment of immunosuppressants around the administration of vaccine.
    MeSH term(s) Autoimmune Diseases ; COVID-19 ; COVID-19 Vaccines ; Humans ; Lupus Erythematosus, Systemic ; Rheumatic Diseases ; SARS-CoV-2 ; United States ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-021-01046-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Glycan-mediated molecular interactions in bacterial pathogenesis.

    Lee, Sohyoung / Inzerillo, Sean / Lee, Gi Young / Bosire, Erick M / Mahato, Saroj K / Song, Jeongmin

    Trends in microbiology

    2021  Volume 30, Issue 3, Page(s) 254–267

    Abstract: Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host-pathogen ... ...

    Abstract Glycans are expressed on the surface of nearly all host and bacterial cells. Not surprisingly, glycan-mediated molecular interactions play a vital role in bacterial pathogenesis and host responses against pathogens. Glycan-mediated host-pathogen interactions can benefit the pathogen, host, or both. Here, we discuss (i) bacterial glycans that play a critical role in bacterial colonization and/or immune evasion, (ii) host glycans that are utilized by bacteria for pathogenesis, and (iii) bacterial and host glycans involved in immune responses against pathogens. We further discuss (iv) opportunities and challenges for transforming these research findings into more effective antibacterial strategies, and (v) technological advances in glycoscience that have helped to accelerate progress in research. These studies collectively offer valuable insights into new perspectives on antibacterial strategies that may effectively tackle the drug-resistant pathogens that are rapidly spreading globally.
    MeSH term(s) Bacteria ; Host-Pathogen Interactions ; Immune Evasion ; Phagocytosis ; Polysaccharides ; Polysaccharides, Bacterial
    Chemical Substances Polysaccharides ; Polysaccharides, Bacterial
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae.

    Motley, Michael P / Diago-Navarro, Elizabeth / Banerjee, Kasturi / Inzerillo, Sean / Fries, Bettina C

    mBio

    2020  Volume 11, Issue 5

    Abstract: Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem- ... ...

    Abstract Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem-resistant
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Antibodies, Bacterial/classification ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal/classification ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Binding Sites, Antibody ; Carbapenem-Resistant Enterobacteriaceae/immunology ; Carbapenems/pharmacology ; Immunoglobulin G/classification ; Immunoglobulin G/immunology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Neutropenia ; Phagocytosis ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/prevention & control
    Chemical Substances Anti-Bacterial Agents ; Antibodies, Bacterial ; Antibodies, Monoclonal ; Carbapenems ; Immunoglobulin G
    Language English
    Publishing date 2020-09-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.02059-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Impact of Telemedicine on Rheumatology Care.

    Tang, Wei / Inzerillo, Sean / Weiner, Julia / Khalili, Leila / Barasch, Julia / Gartshteyn, Yevgeniya / Dall'Era, Maria / Aranow, Cynthia / Mackay, Meggan / Askanase, Anca

    Frontiers in medicine

    2022  Volume 9, Page(s) 876835

    Abstract: Background: The pandemic disrupted the care of patients with rheumatic diseases; difficulties in access to care and its psychological impact affected quality of life. Telemedicine as an alternative to traditional face-to-face office visits has the ... ...

    Abstract Background: The pandemic disrupted the care of patients with rheumatic diseases; difficulties in access to care and its psychological impact affected quality of life. Telemedicine as an alternative to traditional face-to-face office visits has the potential to mitigate this impact.
    Objective: To evaluate patient and provider experience with telemedicine and its effect on care.
    Methods: We surveyed patients with rheumatic diseases and their rheumatology providers. The surveys were conducted in 2020 and repeated in 2021. We assessed data on quality of care and health-related quality of life.
    Results: Hundred patients and 17 providers responded to the survey. Patients reported higher satisfaction with telemedicine in 2021 compared to 2020 (94 vs. 84%), felt more comfortable with (96 vs. 86%), expressed a stronger preference for (22 vs. 16%), and higher intention to use telemedicine in the future (83 vs. 77%); patients thought physicians were able to address their concerns. While providers' satisfaction with telemedicine increased (18-76%), 14/17 providers believed that telemedicine visits were worse than in-person visits. There were no differences in annualized office visits and admissions. Mean EQ-5D score was 0.74, lower than general population (0.87) but equivalent to a subset of patients with SLE (0.74).
    Conclusion: Our data showed a high level of satisfaction with telemedicine. The lower rheumatology provider satisfaction raises concern if telemedicine constitutes an acceptable alternative to in-person care. The stable number of office visits, admissions, and the similar quality of life to pre-pandemic level suggest effective management of rheumatic diseases using telemedicine/in-person hybrid care.
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.876835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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