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  1. Article ; Online: Ocular PEComas are frequently melanotic and TFE3-translocated: report of two cases including the first description of PRCC-TFE3 fusion in PEComa.

    Gao, Y / Chen, G / Chow, C / Io, I / Wong, E W N / Tsui, W M S / Lam, W Y / To, K F / Chan, J K C / Cheuk, Wah

    Virchows Archiv : an international journal of pathology

    2020  Volume 478, Issue 5, Page(s) 1025–1031

    Abstract: Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large ... ...

    Abstract Ocular perivascular epithelioid cell tumor (PEComa) is exceedingly rare. We reported two examples involving the choroid and subconjunctival tissue, respectively, in patients aged 17 and 20 years. Both tumors comprised packets and sheets of large polygonal cells with moderately pleomorphic nuclei and prominent nucleoli, traversed by delicate fibrovascular septa. Melanin pigmentation was present in one case. The tumors showed HMB45 and TFE3 immunoreactivity. TFE3 gene translocation was confirmed by FISH break-apart probes. RNA seq revealed PRCC-TFE3 and NONO-TFE3 fusions, with the former representing the first description of PRCC-TFE3 in PEComa. Critical reappraisal of the reported cases showed that ocular PEComa frequently affected young patents with melanin pigmentation, frequent TFE3 protein expression, and/or TFE3 gene translocation. No recurrence or metastasis was reported after complete excision despite the presence of cytologic atypia.
    MeSH term(s) Adolescent ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Cell Cycle Proteins/genetics ; Choroid Neoplasms/chemistry ; Choroid Neoplasms/genetics ; Choroid Neoplasms/pathology ; Choroid Neoplasms/surgery ; Eye Neoplasms/chemistry ; Eye Neoplasms/genetics ; Eye Neoplasms/pathology ; Eye Neoplasms/surgery ; Female ; Gene Fusion ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lacrimal Apparatus Diseases/genetics ; Lacrimal Apparatus Diseases/metabolism ; Lacrimal Apparatus Diseases/pathology ; Lacrimal Apparatus Diseases/surgery ; Male ; Melanins/analysis ; Neoplasm Proteins/genetics ; Perivascular Epithelioid Cell Neoplasms/chemistry ; Perivascular Epithelioid Cell Neoplasms/genetics ; Perivascular Epithelioid Cell Neoplasms/pathology ; Perivascular Epithelioid Cell Neoplasms/surgery ; RNA-Seq ; Young Adult
    Chemical Substances Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Biomarkers, Tumor ; Cell Cycle Proteins ; Melanins ; Neoplasm Proteins ; PRCC protein, human ; TFE3 protein, human
    Language English
    Publishing date 2020-07-16
    Publishing country Germany
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-020-02890-w
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  2. Article: Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges

    Nicacio, Karen J / Ióca Laura P / Fróes Adriana M / Leomil Luciana / Appolinario Luciana R / Thompson Christiane C / Thompson Fabiano L / Ferreira Antonio G / Williams David E / Andersen Raymond J / Eustaquio Alessandra S / Berlinck Roberto G. S

    Journal of natural products. 2017 Feb. 24, v. 80, no. 2

    2017  

    Abstract: Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and ... ...

    Abstract Herein we report the isolation and spectroscopic identification of fistularin-3 (1), 11-hydroxyaerothionin (2), and verongidoic acid (3), as well as the UPLC-HRMS detection of aerothionin (4), homopurpuroceratic acid B (5), purealidin L (6), and aplysinamisine II (7), from cultures of the marine bacterium Pseudovibrio denitrificans Ab134, isolated from tissues of the marine sponge Arenosclera brasiliensis. These results unambiguously demonstrate for the first time that bromotyrosine-derived alkaloids that were previously isolated only from Verongida sponges can be biosynthesized by a marine bacterium.
    Keywords Verongida ; alkaloids ; bacteria ; spectroscopy
    Language English
    Dates of publication 2017-0224
    Size p. 235-240.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021%2Facs.jnatprod.6b00838
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    Zs.A 1144: Show issues Location:
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  3. Article: Structure and Biogenesis of Roussoellatide, a Dichlorinated Polyketide from the Marine-Derived Fungus Roussoella sp. DLM33

    Ferreira, Everton L. F / Williams David E / Ióca Laura P / Morais-Urano Raquel P / Santos Mario F. C / Patrick Brian O / Elias Luciana M / Lira Simone P / Ferreira Antonio G / Passarini Michel R. Z / Sette Lara D / Andersen Raymond J / Berlinck Roberto G. S

    Organic letters. 2015 Nov. 06, v. 17, no. 21

    2015  

    Abstract: The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with [1-¹³C]acetate, [2-¹³C]acetate, and [1,2-¹³C]acetate were consistent with a ... ...

    Abstract The structure of the fungal metabolite roussoellatide (1) has been established by spectroscopic and X-ray diffraction analyses. Results from feeding experiments with [1-¹³C]acetate, [2-¹³C]acetate, and [1,2-¹³C]acetate were consistent with a biosynthetic pathway to the unprecedented skeleton of 1 involving Favorskii rearrangements in separate pentaketides, subsequently joined via an intermolecular Diels–Alder reaction.
    Keywords X-ray diffraction ; acetates ; biochemical pathways ; biogenesis ; chemical reactions ; chemical structure ; fungi ; metabolites ; polyketides ; spectroscopy
    Language English
    Dates of publication 2015-1106
    Size p. 5152-5155.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021%2Facs.orglett.5b02060
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  4. Article: Condensation of Macrocyclic Polyketides Produced by Penicillium sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway

    de Castro, Marcos V / Ióca Laura P / Williams David E / Costa Bruna Z / Mizuno Carolina M / Santos Mario F. C / de Jesus Karen / Ferreira Éverton L. F / Seleghim Mirna H. R / Sette Lara D / Pereira Filho Edenir R / Ferreira Antonio G / Gonçalves Natália S / Santos Raquel A / Patrick Brian O / Andersen Raymond J / Berlinck Roberto G. S

    Journal of natural products. 2016 June 24, v. 79, no. 6

    2016  

    Abstract: Application of a refined procedure of experimental design and chemometric analysis to improve the production of curvularin-related polyketides by a marine-derived Penicillium sp. DRF2 resulted in the isolation and identification of cyclothiocurvularins ... ...

    Abstract Application of a refined procedure of experimental design and chemometric analysis to improve the production of curvularin-related polyketides by a marine-derived Penicillium sp. DRF2 resulted in the isolation and identification of cyclothiocurvularins 6–8 and cyclosulfoxicurvularins 10 and 11, novel curvularins condensed with a mercaptolactate residue. Two additional new curvularins, 3 and 4, are also reported. The structures of the sulfur-bearing curvularins were unambiguously established by analysis of spectroscopic data and by X-ray diffraction analysis. Analysis of stable isotope feeding experiments with [U–¹³C₃¹⁵N]-l-cysteine confirmed the presence of the 2-hydroxy-3-mercaptopropanoic acid residue in 6–8 and the oxidized sulfoxide in 10 and 11. Cyclothiocurvularins A (6) and B (7) are formed by spontaneous reaction between 10,11-dehydrocurvularin (2) and mercaptopyruvate (12) obtained by transamination of cysteine. High ratios of [U–¹³C₃¹⁵N]-l-cysteine incorporation into cyclothiocurvularin B (7), the isolation of two diastereomers of cyclothiocurvularins, the lack of cytotoxicity of cyclothiocurvularin B (7) and its methyl ester (8), and the spontaneous formation of cyclothiocurvularins from 10,11-dehydrocurvularin and mercaptopyruvate provide evidence that the formation of cyclothiocurvularins may well correspond to a 10,11-dehydrocurvularin detoxification process by Penicillium sp. DRF2.
    Keywords Penicillium ; X-ray diffraction ; chemometrics ; curvularin ; cysteine ; cytotoxicity ; diastereomers ; experimental design ; fungi ; spectral analysis ; stable isotopes ; transamination
    Language English
    Dates of publication 2016-0624
    Size p. 1668-1678.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021%2Facs.jnatprod.6b00295
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    Zs.A 1144: Show issues Location:
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  5. Article: [Care of the urinary tract of patients with spinal cord injuries. A conference].

    Miyazaki, K / Io, I / Kuwabara, T / Endo, A / Kagoshima, J

    Kango gijutsu] : [Nursing technique

    1980  Volume 26, Issue 11, Page(s) 1463–1472

    MeSH term(s) Humans ; Spinal Cord Injuries/nursing ; Urinary Bladder, Neurogenic/nursing
    Language Japanese
    Publishing date 1980-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603232-1
    ISSN 0449-752X
    ISSN 0449-752X
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    Zs.B 1571: Show issues Location:
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  6. Article: Septic metastatic endophthalmitis complicating Klebsiella pneumoniae liver abscess in a non-diabetic Chinese man.

    Wong, T Y / Chiu, S I / So, M K / Tsang, M K / Lai, S T / Tse, K K / Io, I Y

    Hong Kong medical journal = Xianggang yi xue za zhi

    2001  Volume 7, Issue 3, Page(s) 303–306

    Abstract: Septic metastatic endophthalmitis is a rare but serious disease. Endophthalmitis arising from Klebsiella pneumoniae liver abscess has been reported with diabetes mellitus as a major associated condition, but is rarely seen in patients without diabetes. A ...

    Abstract Septic metastatic endophthalmitis is a rare but serious disease. Endophthalmitis arising from Klebsiella pneumoniae liver abscess has been reported with diabetes mellitus as a major associated condition, but is rarely seen in patients without diabetes. A non-diabetic patient with liver abscess complained of right eye discomfort and floaters 3 days after admission. Both blood and liver aspirate cultured Klebsiella pneumoniae. The patient was treated initially with systemic and subconjunctival antibiotics followed by intravitreal antibiotics with successful visual salvation. Previous reports from the literature showed poor visual outcome despite treatment and delayed recognition was often the cause. Clinicians should be alert to endophthalmitis whenever a patient with Klebsiella pneumoniae liver abscess complains of ocular symptoms. Urgent ophthalmological assessment should be sought.
    MeSH term(s) Endophthalmitis/microbiology ; Humans ; Klebsiella Infections ; Klebsiella pneumoniae ; Liver Abscess/complications ; Male ; Middle Aged
    Language English
    Publishing date 2001-09
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
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    Zs.A 4347: Show issues Location:
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  7. Article: Effectiveness of acetylurea in the rations of ruminants

    Sliosarau, I.K / Kbiatkouski, H.I / Hiorasimovich, IO I / Mishanin, IU.F

    1977, 4

    1977  

    Keywords livestock ; animal science ; animal nutrition
    Language Bemba
    Size p. 90-94.
    Document type Article
    Note Russian summary
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  8. Book ; Online: Joh. Jacobi Bajeri Oryktographia Norica

    Baier, Johann J / Baier, Ioann I / Baier, Joannes J / Baier, Joannes Jakob / Baier, Johann Jacob / Baierus, Io. I / Baierus, Io. Iac / Baierus, Io. Iacobus / Baierus, Ioannes I / Baierus, Ioannes Iacobus / Baierus, Ioh. Iac / Baierus, Iohannes Iacobus / Baierus, Joannes Jacobus / Baierus, Joh. Jac / Baierus, Johannes J / Baierus, Johannes Jacobus / Bajer, Joh. J / Bajer, Johann J / Bajerus, Joh. J /
    Bajerus, Joh. Jac / Bajerus, Joh. Jacobi / Bajerus, Joh. Jacobus / Bajerus, Johann J / Bajerus, Johannes J / Bajerus, Johannes Jacobus / Bayer, Johann J

    sive rerum fossilium et ad minerale regnum pertinentium, in territorio Norimbergensi ejusque vicinia observatarum succincta descriptio

    1708  

    Title variant Oryktographia Norica : sive rerum fossilium et ad minerale regnum pertinentium, in territorio Norimbergensi ejusque vicinia observatarum succincta descriptio ..
    Language Latin
    Size Online-Ressource, Ill
    Publisher Michahelles
    Publishing place Norimbergae
    Document type Book ; Online
    Database Former special subject collection: coastal and deep sea fishing

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