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Book ; Online: Computational Fluid Dynamics

Ionescu, Adela

Basic Instruments and Applications in Science

2018

Keywords	Computer modelling & simulation ; cfd, climate change, optimization, heat transfer, 3d printing, genetic algorithm
Language	English
Size	1 electronic resource (410 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030647191
ISBN	9789535140641 ; 9535140647
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Sudden Cardiac Arrest in a Youth with Multiple Arrhythmic Substrates.

Ainsworth, James / Ionescu, Adrian

Case reports in critical care

2024 Volume 2024, Page(s) 6054468

Abstract: Background: Mitral valve prolapse (MVP) is a common condition with an estimated prevalence of 1-3%, in which there is systolic displacement of a morphologically redundant mitral valve towards the left atrium. Mitral annular disjunction (MAD) is a ... ...

Abstract	Background: Mitral valve prolapse (MVP) is a common condition with an estimated prevalence of 1-3%, in which there is systolic displacement of a morphologically redundant mitral valve towards the left atrium. Mitral annular disjunction (MAD) is a separation of the MV attachment with the left ventricle, with hypermobility of the leaflets, and with systolic "curling" of the basal LV (left ventricle) myocardium. It is frequently associated with MVP and may confer an increased arrhythmic risk. Conclusions: This report describes the clinical dilemma of identifying and treating a patient with multiple potential causes of cardiac arrest. Despite being relatively common, the clinical significance of MAD is still uncertain and the extent to which it may be linked with complications such as ventricular arrhythmias and sudden cardiac death. MAD appears to confer an increased risk of ventricular arrhythmias, particularly when associated with MVP, particularly nonsustained VT.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2927720-6
ISSN	2090-6439 ; 2090-6420
ISSN (online)	2090-6439
ISSN	2090-6420
DOI	10.1155/2024/6054468
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Model-Based ISO 14971 Risk Management of EEG-Based Medical Devices.

Yakymets, N / Zanetti, R / Ionescu, A / Atienza, D

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2023 Volume 2023, Page(s) 1–7

Abstract: Risk management (RM) is a key component of the development of modern medical devices (MD) to achieve acceptable functional safety and pass the regulatory process. The emerging availability of various techniques, languages, and tools that use model-based ... ...

Abstract	Risk management (RM) is a key component of the development of modern medical devices (MD) to achieve acceptable functional safety and pass the regulatory process. The emerging availability of various techniques, languages, and tools that use model-based system engineering (MBSE) promises to facilitate the development and analysis of complex MD. In this paper, we show how to integrate RM principles and activities recommended in ISO 14971 medical standard into an MBSE-driven MD development process. We propose a method and framework capable of modeling essential RM concepts and performing RM and safety analysis in the early stages of the MD development life cycle. The framework extends OMG RAAML (Object Management Group Risk Analysis and Assessment Modeling Language) to the medical domain according to ISO 14971. We illustrate our approach using a case study of the e-Glass system developed for real-time EEG-based subject monitoring with the intended use of stress monitoring.Clinical Relevance-This facilitates the MD certification process by semi-automation of RM based on ISO 14971 and obtaining safe MD by design.
MeSH term(s)	Risk Management ; Risk Assessment ; Electroencephalography
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC40787.2023.10340131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: It needs more than a myocardial infarction to start exercising: the CoLaus|PsyCoLaus prospective study.

Flammer, François / Paraschiv-Ionescu, Anisoara / Marques-Vidal, Pedro

BMC cardiovascular disorders

2024 Volume 24, Issue 1, Page(s) 102

Abstract: Background: Increased physical activity (PA) is recommended after an acute coronary event to prevent recurrences. Whether patients with acute coronary event actually increase their PA has not been assessed using objective methods such as accelerometer. ... ...

Abstract	Background: Increased physical activity (PA) is recommended after an acute coronary event to prevent recurrences. Whether patients with acute coronary event actually increase their PA has not been assessed using objective methods such as accelerometer. We aimed to assess the subjectively and objectively measured physical activity (PA) levels of patients before and after an acute coronary event. Methods: Data from the three follow-up surveys of a prospective study conducted in Lausanne, Switzerland. Self-reported PA was assessed by questionnaire in the first (2009-2012) and second (2014-2017) follow-ups. Objective PA was assessed by a wrist-worn accelerometer in the second and third (2018-2021) follow-ups. Participants who developed an acute coronary event between each survey period were considered as eligible. PA levels were compared before and after the event, and changes in PA levels were also compared between participants who developed an acute event with three gender and age-matched healthy controls. Results: For self-reported PA, data from 43 patients (12 women, 64 ± 9 years) were used. No differences were found for all PA levels expressed in minutes/day before and after the event: moderate PA, median and [interquartile range] 167 [104-250] vs. 153 [109-240]; light PA: 151 [77-259] vs. 166 [126-222], and sedentary behaviour: 513 [450-635] vs. 535 [465-642] minutes/day. Comparison with gender- and age-matched healthy controls showed no differences regarding trends in reported PA. For accelerometer-assessed PA, data from 32 patients (16 women, 66 ± 9 years) were used. No differences were found for all PA levels expressed in minutes/day before and after the event: moderate PA: 159 [113-189] vs. 141 [111-189]; light PA: 95.8 [79-113] vs. 95.9 [79-117], and sedentary behaviour: 610 [545-659] vs. 602 [540-624]. Regarding the comparison with gender- and age-matched healthy controls, controls had an increase in accelerometer-assessed sedentary behaviour as % of day: multivariable adjusted average standard error 2.7 ± 0.6, while no increase was found for cases: 0.1 ± 1.1; no differences were found for the other PA levels. Conclusion: Patients do not seem to change their PA levels after a first coronary event. Our results should be confirmed in larger samples.
MeSH term(s)	Humans ; Female ; Prospective Studies ; Exercise ; Surveys and Questionnaires ; Self Report ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Accelerometry
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-024-03755-9
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Article ; Online: Misunderstood and underappreciated: A critical review of mental health advocacy and activism in low- and middle-income countries.

Ionescu, Alma / Mannell, Jenevieve / Vaughan, Megan / Burgess, Rochelle

Health policy and planning

2024

Abstract: Mental health advocacy and activism have been highlighted as important in the effort towards creating environments for better mental health. However, relevant research in low- and middle-income (LMIC) settings remains limited and lacks critical ... ...

Abstract	Mental health advocacy and activism have been highlighted as important in the effort towards creating environments for better mental health. However, relevant research in low- and middle-income (LMIC) settings remains limited and lacks critical exploration. We seek to contribute to filling this gap by exploring driving factors behind mental health advocacy and activism efforts in LMIC settings. This review uses a critically informed thematic analysis using conceptual frameworks of productive power to analyse peer-reviewed articles on mental health advocacy or activism over the last twenty years. We suggest that the current body of research is marred by superficial explorations of activism and advocacy, partly due to a lack of cohesion around definitions. Based on our findings, we suggest a conceptual framework to guide deeper explorations of mental health advocacy and activism. This framework identifies Legitimacy, Context, and Timing as the main dimensions to consider in understanding activism and advocacy efforts. The fact that they remain misunderstood and underappreciated creates missed opportunities for meaningful inclusion of lived experience in policy decisions and limits our understanding of how communities envision and enact change.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	632896-9
ISSN	1460-2237 ; 0268-1080
ISSN (online)	1460-2237
ISSN	0268-1080
DOI	10.1093/heapol/czae016
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Article ; Online: Microfluidic Neuromuscular Co-culture System for Tracking Cell-to-Cell Transfer and Axonal Transport of Labeled Proteins.

Ionescu, Ariel / Perlson, Eran

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2431, Page(s) 145–161

Abstract: The molecular communication mechanisms within the Motor Neurons (MN) distant axon and its soma, as well as between MN and their neighboring cells and extracellular environment are of keen interest for our understanding of neurodevelopment and ... ...

Abstract	The molecular communication mechanisms within the Motor Neurons (MN) distant axon and its soma, as well as between MN and their neighboring cells and extracellular environment are of keen interest for our understanding of neurodevelopment and neurodegenerative diseases. One tool that has significantly improved our ability to study such processes with high spatiotemporal resolution is microfluidic devices. Here we describe a step-by-step guide to the neuromuscular co-culturing procedure and demonstrate how to track trophic factors transmission from muscle-to-neuron and their transport along the axons.
MeSH term(s)	Axonal Transport ; Axons/metabolism ; Coculture Techniques ; Microfluidics/methods ; Muscles/metabolism
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1990-2_7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Walking and running cadence estimation using a single trunk-fixed accelerometer for daily physical activities assessment.

Prigent, G / Barthelet, E / Aminian, K / Paraschiv-Ionescu, A

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2022 Volume 2022, Page(s) 3645–3648

Abstract: Accurate assessment of the type, duration, and intensity of physical activity (PA) in daily life is considered very important because of the close relationship between PA level, health, and well-being. Therefore, the assessment of PA using lightweight ... ...

Abstract	Accurate assessment of the type, duration, and intensity of physical activity (PA) in daily life is considered very important because of the close relationship between PA level, health, and well-being. Therefore, the assessment of PA using lightweight wearable sensors has gained interest in recent years. In particular, the use of activity monitors could help to measure the health-related effects of specific PA interventions. Our study, named as Run4Vit, focuses on evaluating the acute and longterm effects of an eight-week running intervention on PA behaviour and vitality. To achieve this goal, we developed an algorithm to detect running and estimate instantaneous cadence using a single trunk-fixed accelerometer. Cadence was computed using time and frequency domain approaches. Validation was performed over a wide range of locomotion speeds using an open-source gait database. Across all subjects, the cadence estimation algorithms achieved a mean bias and precision of - 0.01 ± 0.69 steps/min for the temporal method and 0.02 ± 1.33 steps/min for the frequency method. The running detection algorithm demonstrated very good performance, with an accuracy of 98% and a precision superior to 99%. These algorithms could be used to extract metrics related to the multiple dimensions of PA, and provide reliable outcome measures for the Run4Vit longitudinal running intervention program. Clinical Relevance- This work aims at validating a multi-dimensional physical activity (PA) classification algorithm for assessing the acute and long-term effects of eight weeks running intervention on PA behaviours and vitality.
MeSH term(s)	Accelerometry/methods ; Exercise ; Fitness Trackers ; Gait ; Humans ; Walking
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC48229.2022.9871713
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Article ; Online: Looking for answers far away from the soma-the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS.

Ionescu, Ariel / Altman, Topaz / Perlson, Eran

Molecular neurodegeneration

2023 Volume 18, Issue 1, Page(s) 35

Abstract: Axon degeneration and Neuromuscular Junction (NMJ) disruption are key pathologies in the fatal neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). Despite accumulating evidence that axons and NMJs are impacted at a very early stage of the ... ...

Abstract	Axon degeneration and Neuromuscular Junction (NMJ) disruption are key pathologies in the fatal neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS). Despite accumulating evidence that axons and NMJs are impacted at a very early stage of the disease, current knowledge about the mechanisms leading to their degeneration remains elusive. Cytoplasmic mislocalization and accumulation of the protein TDP-43 are considered key pathological hallmarks of ALS, as they occur in ~ 97% of ALS patients, both sporadic and familial. Recent studies have identified pathological accumulation of TDP-43 in intramuscular nerves of muscle biopsies collected from pre-diagnosed, early symptomatic ALS patients. These findings suggest a gain of function for TDP-43 in axons, which might facilitate early NMJ disruption. In this review, we dissect the process leading to axonal TDP-43 accumulation and phosphorylation, discuss the known and hypothesized roles TDP-43 plays in healthy axons, and review possible mechanisms that connect TDP-43 pathology to the axon and NMJ degeneration in ALS.
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/metabolism ; Axons/metabolism ; DNA-Binding Proteins/metabolism ; Neurodegenerative Diseases/metabolism ; Neuromuscular Junction
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2244557-2
ISSN	1750-1326 ; 1750-1326
ISSN (online)	1750-1326
ISSN	1750-1326
DOI	10.1186/s13024-023-00623-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Repeated echocardiographic imaging of aortic stenosis: Real-life lessons.

Bray, Jonathan J H / Ionescu, Adrian

Echocardiography (Mount Kisco, N.Y.)

2021 Volume 38, Issue 11, Page(s) 1854–1859

Abstract: Background: Timing of aortic valve intervention is dependent on the accuracy and reproducibility of echocardiographic (ECHO) parameters. We aimed to assess haemodynamic subsets of aortic stenosis (AS), their change over time, and variability of ECHO ... ...

Abstract	Background: Timing of aortic valve intervention is dependent on the accuracy and reproducibility of echocardiographic (ECHO) parameters. We aimed to assess haemodynamic subsets of aortic stenosis (AS), their change over time, and variability of ECHO parameters. Method: This retrospective, longitudinal study compared sequential ECHO over 15 months to identify concordant or discordant aortic valve area (AVA) and mean pressure gradient (MPG) in order to determine the real world variability of echocardiographic indices. Results: We included 143 patients with a mean age of 76.0 years. The median length of time between studies was 112 days (IQR 38-208). Initially, participants were classified as 9 (6.4%) mild, 47 (33.6%) moderate, and 84 (60.0%%) severe AS. In 80 (55.9%) AVA and MPG were concordant; stroke volume index (SVi) was < 35 mL/m Conclusion: Almost half of patients with AS have valve area/gradient discordance. Variations in LVOT diameter measurement commensurate with clinical practice reclassified AS severity in up to two-third of cases. Change in AS severity should only be accepted following careful scrutiny of all available ECHO data.
MeSH term(s)	Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve Stenosis/diagnostic imaging ; Echocardiography ; Humans ; Longitudinal Studies ; Reproducibility of Results ; Retrospective Studies ; Severity of Illness Index ; Stroke Volume
Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.15222
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Article: Developmental Dysplasia of the Hip: How Many Risk Factors Are Needed?

Ionescu, Adelina / Dragomirescu, Mihai-Codrut / Herdea, Alexandru / Ulici, Alexandru

Children (Basel, Switzerland)

2023 Volume 10, Issue 6

Abstract: Developmental dysplasia of the hip (DDH) is a progressive condition that lacks clear diagnostic and management protocols, due to insufficient data. While some advocate for universal screening, others recommend using risk factors as landmarks. In this ... ...

Abstract	Developmental dysplasia of the hip (DDH) is a progressive condition that lacks clear diagnostic and management protocols, due to insufficient data. While some advocate for universal screening, others recommend using risk factors as landmarks. In this study, we aimed to assess the risk factors associated with DDH incidence among a large population. We conducted a retrospective single-center multifactorial study between January 2019 and March 2022, including 3720 children who were investigated anamnestically, clinically, and through an ultrasound scan. We classified them into two groups: the control group with 3300 healthy children and the study group with 420 newborns diagnosed with DDH. Our analysis identified several risk factors associated with DDH, including gender, prematurity, non-vertex birth presentation, oligohydramnios, gestational diabetes, maternal hypertension, family history, associated deformities, and swaddling. We found that every DDH patient had at least two risk factors. Based on our findings, we recommend that children who present two or more risk factors for DDH be mandatorily evaluated sonographically, as well as children with clinical signs. DDH screening is recommended for each newborn for the long-term benefits of early detection and treatment.
Language	English
Publishing date	2023-05-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10060968
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