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Article ; Online: Experimental investigation of an Air Source Heat Pump

Tălpigă Mugurel Florin / Iordache Florin / Mandric Eugen

E3S Web of Conferences, Vol 85, p

2019 Volume 01011

Abstract: An experimental investigation were driven to catch all working parameters of an Air Source Heat Pump such as temperature differences between refrigerant working states and evaporator respectively condenser environment temperatures. Heat Pump compressor ... ...

Abstract	An experimental investigation were driven to catch all working parameters of an Air Source Heat Pump such as temperature differences between refrigerant working states and evaporator respectively condenser environment temperatures. Heat Pump compressor were monitored to know inlet and outlet refrigerant temperatures to build working diagram of the heat pump in heating configuration. At condenser, a plate heat exchanger is used to discharge the energy from refrigerant to water, liquid used in secondary circuit. Heat exchanger temperatures of refrigerant and water were monitored to drive the working diagram of the heat exchanger equipment. Current consumption of Heat Pump were registered together with heat exchanger secondary circuit temperature differences and his water flow to estimate Seasonal Performance Factor during experiment.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Numerical approach regarding functional and design optimization for a residential building daily hot water system composed by heat pump and auxiliary source

Talpiga Mugurel Florin / Mandric Eugen / Iordache Florin

E3S Web of Conferences, Vol 111, p

2019 Volume 01060

Abstract: In this paper is presented the physical model and mathematical approach which describe the equation system used in system calibration and design optimization. The system proposed for study is built from heat pump, for energy demand delivery, together ... ...

Abstract	In this paper is presented the physical model and mathematical approach which describe the equation system used in system calibration and design optimization. The system proposed for study is built from heat pump, for energy demand delivery, together with auxiliary heating source to face in all low temperature days, when heat pump work at maximum load but the required demand for daily hot water by the building inhabitants is higher. The paper present few of the common used systems in market for which the mathematical equation system will be proposed to come in help designers for in simulation and cost optimization. Simulation of proposed design is realized and results are delivered. The system construction, is optimized by comparison study of design and simulation data for each system type proposed. The comparison study is used for cost estimation of system and energy balance.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Energy analysis of a CHP plant with internal combustion engines, for a district heating system, based on the information from the annual database

Mărcuş Gabriel / Iordache Vlad / Iordache Florin / Ilie Anica

E3S Web of Conferences, Vol 85, p

2019 Volume 01012

Abstract: Building a model for consumption, production and efficiency of a combined heat and power (CHP) system can bring important data for planning and management activity of such a technological system. The results of this study will show the overall efficiency ...

Abstract	Building a model for consumption, production and efficiency of a combined heat and power (CHP) system can bring important data for planning and management activity of such a technological system. The results of this study will show the overall efficiency of a real cogeneration plant over a year. The study is based on the information from the daily database of an economic operator, during 2012. The CHP plant, having reciprocating internal combustion engines (RICE) as prime movers, provides the thermal energy to the district heating system of a city from Romania with 129,368 habitants. RICE are operating in simultaneous mode or in partial load. The numerical model reveals the behavior of the daily thermal, electrical and global efficiency, accordingly to the partial load. The model was applied in both calculation assumptions: using the lower heating value and the higher heating value of the natural gas. A statistical analysis of efficiencies of the CHP plant was made. Was performed the statistical analysis of the database efficiency (also called real efficiency) with the global efficiency calculated by the model (also called modelled efficiency). Linear and multiple regression equations explain the variance of the real efficiency and of the modelled global efficiency.
Keywords	Environmental sciences ; GE1-350
Subject code	660
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Numerical approach regarding functional and design optimization for a residential building heating system composed by heat pump and auxiliary

Talpiga Mugurel Florin / Mandric Eugen / Iordache Florin

E3S Web of Conferences, Vol 111, p

2019 Volume 01069

Abstract	In this paper is presented the physical model and mathematical approach which describe the equation system used in system calibration and design optimization. The system proposed for study is built from heat pump, for energy demand delivery, together with auxiliary heating source to face in all low temperature days, when heat pump work at maximum load but the required demand by the building is higher. The paper present few of the common used systems in market for which the mathematical equation system will be proposed to come in help designers for in simulation and cost optimization. Simulation of proposed design is realized and results are delivered. The system construction, is optimized by comparison study of design and simulation data for each system type proposed. The comparison study is used for cost estimation of system and energy balance.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PCR Array Profiling of miRNA Expression Involved in the Differentiation of Amniotic Fluid Stem Cells toward Endothelial and Smooth Muscle Progenitor Cells.

Iordache, Florin / Petcu, Adriana Ionescu / Pisoschi, Aurelia Magdalena / Stanca, Loredana / Geicu, Ovidiu Ionut / Bilteanu, Liviu / Curuțiu, Carmen / Amuzescu, Bogdan / Serban, Andreea Iren

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: Differentiation of amniotic fluid stem cells (AFSCs) into multiple lineages is controlled by epigenetic modifications, which include DNA methylation, modifications of histones, and the activity of small noncoding RNAs. The present study investigates the ... ...

Abstract	Differentiation of amniotic fluid stem cells (AFSCs) into multiple lineages is controlled by epigenetic modifications, which include DNA methylation, modifications of histones, and the activity of small noncoding RNAs. The present study investigates the role of miRNAs in the differentiation of AFSCs and addresses how their unique signatures contribute to lineage-specific differentiation. The miRNA profile was assessed in AFSCs after 4 weeks of endothelial and muscular differentiation. Our results showed decreased expression of five miRNAs (miR-18a-5p, miR-125b-5p, miR-137, miR-21-5p, and let-7a) and increased expression of twelve miRNAs (miR-134-5p, miR-103a-3p, let-7i-5p, miR-214-3p, let-7c-5p, miR-129-5p, miR-210-3p, let-7d-5p, miR-375, miR-181-5p, miR-125a-5p, and hsa-let-7e-5p) in endothelial progenitor cells (EPCs) compared with undifferentiated AFSCs. AFSC differentiation into smooth muscle revealed notable changes in nine out of the 84 tested miRNAs. Among these, three miRNAs (miR-18a-5p, miR-137, and sa-miR-21-5p) were downregulated, while six miRNAs (miR-155-5p, miR-20a-5p, let-7i-5p, hsa-miR-134-5p, hsa-miR-214-3p, and hsa-miR-375) exhibited upregulation. Insights from miRNA networks promise future advancements in understanding and manipulating endothelial and muscle cell dynamics. This knowledge has the potential to drive innovation in areas like homeostasis, growth, differentiation, and vascular function, leading to breakthroughs in biomedical applications and therapies.
MeSH term(s)	Amniotic Fluid ; Satellite Cells, Skeletal Muscle ; MicroRNAs/genetics ; Muscle, Smooth ; Polymerase Chain Reaction
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-12-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010302
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predicting Pregnancy Outcome in Dairy Cows: The Role of IGF-1 and Progesterone.

Constantin, Nicolae Tiberiu / Bercea-Strugariu, Cezar Mihai / Bîrțoiu, Dragoș / Posastiuc, Florin Petrișor / Iordache, Florin / Bilteanu, Liviu / Serban, Andreea Iren

Animals : an open access journal from MDPI

2023 Volume 13, Issue 10

Abstract: The purpose of this study was to determine the link between insulin-like growth factor 1 (IGF-1), progesterone (PROG), non-esterified fatty acids (NEFAs), β-hydroxybutyrate (BHB), and glucose (GLU) and pregnancy probability after the first artificial ... ...

Abstract	The purpose of this study was to determine the link between insulin-like growth factor 1 (IGF-1), progesterone (PROG), non-esterified fatty acids (NEFAs), β-hydroxybutyrate (BHB), and glucose (GLU) and pregnancy probability after the first artificial insemination (AI) and during the first 100 days in milk (DIM), during the critical transition period. We determined levels of serum IGF-1, PROG, NEFA, BHB, and GLU in Holstein dairy cows via ELISA, using blood samples collected 7 days before parturition (DAP) until 21 days postparturition (DPP). The group was split into cows diagnosed pregnant at 100 DIM (PREG) and those that did not conceive at 100 and 150 DIM (NPREG). Serum IGF-1 and PROG median levels at 7 DAP were significantly higher in PREG vs. NPREG (
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13101579
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Article ; Online: Editorial: Nanobiomaterials for Improving Stem Cell Applications in Tissue Engineering and Regenerative Medicine.

Iordache, Florin / Grumezescu, Alexandru Mihai

Current stem cell research & therapy

2017 Volume 12, Issue 2, Page(s) 88

MeSH term(s)	Animals ; Biocompatible Materials/chemistry ; Humans ; Nanostructures/chemistry ; Regenerative Medicine ; Stem Cells/cytology ; Tissue Engineering
Chemical Substances	Biocompatible Materials
Language	English
Publishing date	2017-03-02
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2251937-3
ISSN	2212-3946 ; 1574-888X
ISSN (online)	2212-3946
ISSN	1574-888X
DOI	10.2174/1574888X1202161216184150
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Article ; Online: Comprehensive and critical view on the anti-inflammatory and immunomodulatory role of natural phenolic antioxidants.

Pisoschi, Aurelia Magdalena / Iordache, Florin / Stanca, Loredana / Cimpeanu, Carmen / Furnaris, Florin / Geicu, Ovidiu Ionut / Bilteanu, Liviu / Serban, Andreea Iren

European journal of medicinal chemistry

2023 Volume 265, Page(s) 116075

Abstract: The immune response encompasses innate and adaptive immunity, each with distinct and specific activities. The innate immune system is constituted by phagocytic cells, macrophages, monocytes and neutrophils, the cascade system, and different classes of ... ...

Abstract	The immune response encompasses innate and adaptive immunity, each with distinct and specific activities. The innate immune system is constituted by phagocytic cells, macrophages, monocytes and neutrophils, the cascade system, and different classes of receptors such as toll-like receptors that are exploited by the innate immune cells. The adaptive immune system is antigen-specific, encompassing memory lymphocytes and the corresponding specific receptors. Inflammation is understood as an activation of different signaling pathways such as toll-like receptors or nuclear factor kappa-light-chain-enhancer of activated B cells, with an increase in nitric oxide, inflammatory cytokines and chemokines. Increased oxidative stress has been identified as main source of chronic inflammation. Phenolic antioxidants modulate the activities of lymphocytes and macrophages by impacting cytokines and nitric oxide release, exerting anti-inflammatory effect. The nuclear-factor kappa-light-chain-enhancer of activated B cells signaling pathway and the mitogen-activated protein kinase pathway are targeted, alongside an increase in nuclear factor erythroid 2-related factor mediated antioxidant response, triggering the activity of antioxidant enzymes. The inhibitive potential on phospholipase A2, cyclooxygenase and lipoxygenase in the arachidonic acid pathway, and the subsequent reduction in prostaglandin and leukotriene generation, reveals the potential of phenolics as inflammation antagonists. The immunomodulative potential encompasses the capacity to interfere with proinflammatory cytokine synthesis and with the expression of the corresponding genes. A diet rich in antioxidants can result in prevention of inflammation-related pathologies. More investigations are necessary to establish the role of these antioxidants in therapy. The appropriate delivery system and the prooxidant effects exhibited at large doses, or in the presence of heavy metal cations should be regarded.
MeSH term(s)	Humans ; Antioxidants/pharmacology ; Antioxidants/metabolism ; NF-kappa B/metabolism ; Nitric Oxide ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism ; Inflammation/drug therapy ; Toll-Like Receptors ; Immunity ; Lipopolysaccharides
Chemical Substances	Antioxidants ; NF-kappa B ; Nitric Oxide (31C4KY9ESH) ; Anti-Inflammatory Agents ; Cytokines ; Toll-Like Receptors ; Lipopolysaccharides
Language	English
Publishing date	2023-12-21
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.116075
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Composition-Based Risk Estimation of Mycotoxins in Dry Dog Foods

Geicu, Ovidiu Ionut / Bilteanu, Liviu / Stanca, Loredana / Ionescu Petcu, Adriana / Iordache, Florin / Pisoschi, Aurelia Magdalena / Serban, Andreea Iren

Foods. 2022 Dec. 25, v. 12, no. 1

2022

Abstract: The risk of mycotoxins co-occurrence in extrusion-produced dry foods increases due to their composition based on various grains and vegetables. This study aimed to validate a risk estimation for the association between ingredients and the ELISA-detected ... ...

Abstract	The risk of mycotoxins co-occurrence in extrusion-produced dry foods increases due to their composition based on various grains and vegetables. This study aimed to validate a risk estimation for the association between ingredients and the ELISA-detected levels of DON, FUM, ZEA, AFs, T2, and OTA in 34 dry dog food products. The main ingredients were corn, beet, and oil of different origins (of equal frequency, 79.41%), rice (67.6%), and wheat (50%). DON and FUM had the strongest positive correlation (0.635, p = 0.001). The presence of corn in the sample composition increased the median DON and ZEA levels, respectively, by 99.45 μg/kg and 65.64 μg/kg, p = 0.011. In addition to DON and ZEA levels, integral corn presence increased the FUM median levels by 886.61 μg/kg, p = 0.005. For corn gluten flour-containing samples, DON, FUM, and ZEA median differences still existed, and OTA levels also differed by 1.99 μg/kg, p < 0.001. Corn gluten flour presence was strongly associated with DON levels > 403.06 μg/kg (OR = 38.4, RR = 9.90, p = 0.002), FUM levels > 1097.56 μg/kg (OR = 5.56, RR = 1.45, p = 0.048), ZEA levels > 136.88 μg/kg (OR = 23.00, RR = 3.09, p = 0.002), and OTA levels > 3.93 μg/kg (OR = 24.00, RR = 3.09, p = 0.002). Our results suggest that some ingredients or combinations should be avoided due to their risk of increasing mycotoxin levels.
Keywords	beets ; corn ; corn gluten ; dogs ; flour ; mycotoxins ; oils ; pet foods ; rice ; risk ; risk estimate ; wheat
Language	English
Dates of publication	2022-1225
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12010110
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Predicting Pregnancy Outcome in Dairy Cows: The Role of IGF-1 and Progesterone

Constantin, Nicolae Tiberiu / Bercea-Strugariu, Cezar Mihai / Bîrțoiu, Dragoș / Posastiuc, Florin Petrișor / Iordache, Florin / Bilteanu, Liviu / Serban, Andreea Iren

Animals. 2023 May 09, v. 13, no. 10

2023

Abstract	The purpose of this study was to determine the link between insulin-like growth factor 1 (IGF-1), progesterone (PROG), non-esterified fatty acids (NEFAs), β-hydroxybutyrate (BHB), and glucose (GLU) and pregnancy probability after the first artificial insemination (AI) and during the first 100 days in milk (DIM), during the critical transition period. We determined levels of serum IGF-1, PROG, NEFA, BHB, and GLU in Holstein dairy cows via ELISA, using blood samples collected 7 days before parturition (DAP) until 21 days postparturition (DPP). The group was split into cows diagnosed pregnant at 100 DIM (PREG) and those that did not conceive at 100 and 150 DIM (NPREG). Serum IGF-1 and PROG median levels at 7 DAP were significantly higher in PREG vs. NPREG (p = 0.029), the only statistically significant differences across the subgroups. At 7 DAP, IGF-1 levels within the initial group showed a strong negative correlation with PROG (r = −0.693; p = 0.006), while for the PREG subgroup, the IGF-1 levels exhibited a very strong positive correlation with GLU (r = 0.860; p = 0.011) and NEFA (r = 0.872; p = 0.013). IGF-1 and PROG levels detected at 7 DAP may be useful to predict pregnancy at 100 DIM. The positive correlation of NEFA and GLU levels during the transition period demonstrates that the initial group is not in NEB; thus, the NEFA level was not a decisive factor for reproduction success.
Keywords	Holstein ; artificial insemination ; blood serum ; glucose ; insulin-like growth factor I ; milk ; parturition ; pregnancy outcome ; probability ; progesterone
Language	English
Dates of publication	2023-0509
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13101579
Database	NAL-Catalogue (AGRICOLA)

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