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Article ; Online: Disseminated genitourinary histoplasmosis in a patient with AIDS with negative urine antigen testing.

Joseph, Candice Theodora / Feely, Michael / Iovine, Nicole

BMJ case reports

2021 Volume 14, Issue 11

Abstract: Disseminated histoplasmosis is a life-threatening condition in immunocompromised patients. The majority of healthy persons have benign disease not requiring treatment. However, in persons living with HIV, mortality is high and accurate diagnosis is ... ...

Abstract	Disseminated histoplasmosis is a life-threatening condition in immunocompromised patients. The majority of healthy persons have benign disease not requiring treatment. However, in persons living with HIV, mortality is high and accurate diagnosis is paramount. We present a case of a 48-year-old HIV-positive woman who presented with haematuria and flank pain. She had a history of recurrent urinary tract infection and nephrolithiasis with obstructive hydronephrosis. During cystoscopy, a bladder lesion was found. Pathological evaluation demonstrated abundant intracellular organisms with apparent budding. Subsequent urine histoplasma antigen was negative. Given the high index of suspicion for histoplasmosis based on the surgical pathology findings and epidemiological history, the patient was started immediately on antifungal therapy. One week later, PCR results of the bladder lesion confirmed the presence of
MeSH term(s)	Acquired Immunodeficiency Syndrome ; Body Fluids ; Female ; Histoplasma ; Histoplasmosis/complications ; Histoplasmosis/diagnosis ; Histoplasmosis/drug therapy ; Humans ; Immunocompromised Host ; Middle Aged
Language	English
Publishing date	2021-11-12
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-243375
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Article ; Online: In Silico Prediction of the Mechanism of Action of Pyriproxyfen and 4'-OH-Pyriproxyfen against

Spaggiari, Giulia / Iovine, Nadia / Cozzini, Pietro

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: Background: Poisoning from pesticides can be extremely hazardous for non-invasive species, such as bees, and humans causing nearly 300,000 deaths worldwide every year. Several pesticides are recognized as endocrine disruptors compounds that alter the ... ...

Abstract	Background: Poisoning from pesticides can be extremely hazardous for non-invasive species, such as bees, and humans causing nearly 300,000 deaths worldwide every year. Several pesticides are recognized as endocrine disruptors compounds that alter the production of the normal hormones mainly by acting through their interaction with nuclear receptors (NRs). Among the insecticides, one of the most used is pyriproxyfen. As analogous to the juvenile hormone, the pyriproxyfen acts in the bee's larval growth and creates malformations at the adult organism level. Methods: This work aims to investigate the possible negative effects of pyriproxyfen and its metabolite, the 4'-OH-pyriproxyfen, on human and bee health. We particularly investigated the mechanism of binding of pyriproxyfen and its metabolite with ultraspiracle protein/ecdysone receptor (USP-EcR) dimer of Results: The results revealed that pyriproxyfen and its metabolite, the 4'-OH- pyriproxyfen, stabilize each dimer and resulted in stronger binders than the natural ligands. Conclusion: We demonstrated the endocrine interference of two pesticides and explained their possible mechanism of action. Furthermore, in vitro studies should be carried out to evaluate the biological effects of pyriproxyfen and its metabolite.
MeSH term(s)	Amino Acid Sequence ; Animals ; Bees/drug effects ; Bees/metabolism ; Computer Simulation ; Humans ; Insecticides/pharmacology ; Juvenile Hormones/metabolism ; Larva/drug effects ; Larva/metabolism ; Pyridines/pharmacology ; Receptors, Cytoplasmic and Nuclear/metabolism ; Receptors, Steroid/metabolism
Chemical Substances	Insecticides ; Juvenile Hormones ; Pyridines ; Receptors, Cytoplasmic and Nuclear ; Receptors, Steroid ; ecdysone receptor ; pyriproxyfen (3Q9VOR705O)
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147751
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Article ; Online: Brincidofovir for disease progression due to suspected tecovirimat resistance in association with advanced HIV.

Harrison, Iris / DeSear, Kathryn / Santevecchi, Barbara A / Venugopalan, Veena / Cherabuddi, Kartikeya / Iovine, Nicole / Radhakrishnan, Nila

International journal of STD & AIDS

2024 , Page(s) 9564624241238813

Abstract: A man with advanced HIV presented with verrucous plaques 2-3 months after initial mpox infection. He received two courses of tecovirimat without resolution of initial mpox lesions and development of new lesions raising concern for resistance. He was ... ...

Abstract	A man with advanced HIV presented with verrucous plaques 2-3 months after initial mpox infection. He received two courses of tecovirimat without resolution of initial mpox lesions and development of new lesions raising concern for resistance. He was treated with two doses of brincidofovir and demonstrated improvement 6 months later.
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624241238813
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Article ; Online: Association between lipid profiles and viral respiratory infections in human sputum samples.

Humes, Sara T / Iovine, Nicole / Prins, Cindy / Garrett, Timothy J / Lednicky, John A / Coker, Eric S / Sabo-Attwood, Tara

Respiratory research

2022 Volume 23, Issue 1, Page(s) 177

Abstract: Background: Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insights regarding the development and progression of ... ...

Abstract	Background: Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insights regarding the development and progression of priority respiratory infections. We hypothesized that select clusters of lipids in human sputum would be associated with specific viral infections (Influenza (H1N1, H3N2) or Rhinovirus). Methods: Lipid identification and semi-quantitation was determined with liquid chromatography and high-resolution mass spectrometry in induced sputum from individuals with confirmed respiratory infections (influenza (H1N1, H3N2) or rhinovirus). Clusters of lipid species and associations between lipid profiles and the type of respiratory viral agent was determined using Bayesian profile regression and multinomial logistic regression. Results: More than 600 lipid compounds were identified across the sputum samples with the most abundant lipid classes identified as triglycerides (TG), phosphatidylethanolamines (PE), phosphatidylcholines (PC), Sphingomyelins (SM), ether-PC, and ether-PE. A total of 12 lipid species were significantly different when stratified by infection type and included acylcarnitine (AcCar) (10:1, 16:1, 18:2), diacylglycerols (DG) (16:0_18:0, 18:0_18:0), Lysophosphatidylcholine (LPC) (12:0, 20:5), PE (18:0_18:0), and TG (14:1_16:0_18:2, 15:0_17:0_19:0, 16:0_17:0_18:0, 19:0_19:0_19:0). Cluster analysis yielded three clusters of lipid profiles that were driven by just 10 lipid species (TGs and DGs). Cluster 1 had the highest levels of each lipid species and the highest prevalence of influenza A H3 infection (56%, n = 5) whereas cluster 3 had lower levels of each lipid species and the highest prevalence of rhinovirus (60%; n = 6). Using cluster 3 as the reference group, the crude odds of influenza A H3 infection compared to rhinovirus in cluster 1 was significantly (p = 0.047) higher (OR = 15.00 [95% CI: 1.03, 218.29]). After adjustment for confounders (smoking status and pulmonary comorbidities), the odds ratio (OR) became only marginally significant (p = 0.099), but the magnitude of the effect estimate was similar (OR = 16.00 [0.59, 433.03]). Conclusions: In this study, human sputum lipid profiles were shown to be associated with distinct types of viral infection. Better understanding the relationship between respiratory infections of global importance and lipids contributes to advancing knowledge of pathogenesis of infections including identifying populations with increased susceptibility and developing effective therapeutics and biomarkers of health status.
MeSH term(s)	Bayes Theorem ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H3N2 Subtype ; Influenza, Human ; Lysophosphatidylcholines ; Phosphatidylcholines ; Pneumonia ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Rhinovirus ; Sputum ; Virus Diseases/diagnosis ; Virus Diseases/epidemiology
Chemical Substances	Lysophosphatidylcholines ; Phosphatidylcholines
Language	English
Publishing date	2022-07-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-022-02091-w
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Article ; Online: Evaluation of patient risk factors for infection with carbapenem-resistant Enterobacteriaceae.

Predic, Marko / Delano, John P / Tremblay, Elizabeth / Iovine, Nicole / Brown, Scott / Prins, Cindy

American journal of infection control

2020 Volume 48, Issue 9, Page(s) 1028–1031

Abstract: Background: To evaluate risk factors for infection or colonization with carbapenem-resistant Enterobacteriaceae (CRE) to develop an algorithm for targeted CRE screening.: Methods: We conducted a case-control study of 50 CRE-positive cases and 100 CRE- ...

Abstract	Background: To evaluate risk factors for infection or colonization with carbapenem-resistant Enterobacteriaceae (CRE) to develop an algorithm for targeted CRE screening. Methods: We conducted a case-control study of 50 CRE-positive cases and 100 CRE-negative controls to identify risk factors that were significant for CRE infection or colonization. The setting was at an acute care academic hospital. Patients who tested positive for CRE or other microbiological laboratory tests during the study period were included. We reviewed medical records of 50 patients who were CRE-positive and 100 matched controls who had a non-CRE culture at a similar anatomic site within the closest time period to the case's culture date. Risk factors were assessed using logistic regression with SAS 9.4, observing the 95% confidence interval (CI) to determine significance. Results: Significant risk factors for CRE infection or colonization included the use of fluoroquinolones (odds ratio [OR], 3.75; 95% CI, 1.35, 10.38) and cephalosporins (OR, 2.37; 95% CI, 1.17, 4.86). In addition, undergoing an invasive procedure with a scope device was also a significant risk factor for our participants (OR, 4.57; 95% CI, 1.31, 16.02). Significance of these risk factors varied within the community-acquired and hospital-acquired cases. Conclusions: Our results suggest that exposure to certain antimicrobials and invasive procedures with a scope device (endoscopic retrograde cholangiopancreatography, duodenal endoscope) are risk factors for CRE. The findings of significant differences in antimicrobials received highlight the necessity to understand antimicrobial stewardship in the development of CRE colonization and infection. Along with antibiotics, inaccessibility to components within scope devices may be increasing the risk of CRE spread.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenem-Resistant Enterobacteriaceae ; Carbapenems/pharmacology ; Case-Control Studies ; Enterobacteriaceae Infections/drug therapy ; Enterobacteriaceae Infections/epidemiology ; Humans ; Risk Factors
Chemical Substances	Anti-Bacterial Agents ; Carbapenems
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2019.11.025
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Zs.A 1773: Show issues

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Article ; Online: Use of therapeutic drug monitoring to characterize cefepime-related neurotoxicity.

Venugopalan, Veena / Casaus, Danielle / Kainz, Leonie / Slaton, Cara N / Hurst, Natalie / Bruzzone, Maria / Hu, Calvin / Sword, Gabriel / Cherabuddi, Kartikeya / Iovine, Nicole / Liu, Jiajun / Scheetz, Marc H / Rhodes, Nathaniel / Maranchick, Nicole / Peloquin, Charles A / Klinker, Kenneth / Alshaer, Mohammad H

Pharmacotherapy

2022 Volume 43, Issue 1, Page(s) 6–14

Abstract: Study objectives: Data evaluating cefepime thresholds associated with neurotoxicity remain limited. The objectives of this study were to evaluate the incidence of cefepime-related neurotoxicity (CRN) in patients with plasma cefepime concentrations, ... ...

Abstract	Study objectives: Data evaluating cefepime thresholds associated with neurotoxicity remain limited. The objectives of this study were to evaluate the incidence of cefepime-related neurotoxicity (CRN) in patients with plasma cefepime concentrations, assess the relationship between cefepime exposure and CRN, investigate clinical factors associated with CRN, and describe electroencephalogram (EEG) abnormalities in CRN. Design: This was a retrospective study of adult inpatients admitted between 2016 and 2018 who received cefepime therapeutic drug monitoring (TDM). Potential CRN cases were identified utilizing a standard definition. The primary outcomes of the study were to determine the incidence of CRN and evaluate the relationship between cefepime trough concentrations, the average daily AUC, and neurotoxicity. Bayesian posteriors were generated for each patient using a cefepime pharmacokinetic (PK) model, and the mean daily area under the concentration-time curve (AUC) was calculated. Multiple regression was performed to assess the association between CRN, cefepime PK, and clinical predictors of neurotoxicity. Main results: Four hundred eighty-one patients with 503 hospital encounters received cefepime TDM and were included in the analysis. The incidence of CRN was 4.4% (22/503). Patients with CRN had a higher incidence of renal dysfunction, hypertension, and diabetes mellitus compared to patients without CRN (non-NT). The mean cefepime trough concentration was significantly greater in the CRN patients than in the non-NT group (61.8 ± 33.7 vs. 30 ± 27.7 mg/L, respectively, p = 0.0002). Cefepime trough concentration and renal dysfunction were independently associated with increased risk of CRN in the adjusted multiple regression model. Moderate generalized slowing of the background rhythm was the most common EEG pattern associated with CRN. Delaying cefepime TDM greater than 72 h after the initiation of cefepime was associated with a 3-fold increased risk of CRN. Conclusion: Cefepime should be used cautiously in hospitalized patients with renal dysfunction due to the risk of neurotoxicity. Dose optimization utilizing TDM early in cefepime treatment may minimize adverse effects and improve patient safety.
MeSH term(s)	Adult ; Humans ; Cefepime/adverse effects ; Cefepime/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Drug Monitoring ; Retrospective Studies ; Bayes Theorem ; Neurotoxicity Syndromes/epidemiology ; Neurotoxicity Syndromes/etiology ; Kidney Diseases/chemically induced
Chemical Substances	Cefepime (807PW4VQE3) ; Anti-Bacterial Agents
Language	English
Publishing date	2022-12-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.2744
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

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Article ; Online: Hypopituitarism in Neurocritical Patients: A Case Report.

Iovino, Michele / Iovine, Nicola / Mondillo, Fiorentino / Guastamacchia, Edoardo / Licchelli, Brunclla / Giagulli, Vito A / Triggiani, Vincenzo

Endocrine, metabolic & immune disorders drug targets

2015 Volume 16, Issue 1, Page(s) 28–31

Abstract: Background: Besides changes in pituitary hormones secretion observed during the acute phase of stroke as an adaptive response to injury or an effect of drugs, a true hypopituitarism due to ischemic and/or hemorrhagic damage at the hypothalamus and/or ... ...

Abstract	Background: Besides changes in pituitary hormones secretion observed during the acute phase of stroke as an adaptive response to injury or an effect of drugs, a true hypopituitarism due to ischemic and/or hemorrhagic damage at the hypothalamus and/or pituitary gland can develop after a stroke. Case report: We report a case of a 72-year-old woman showing clinical signs and laboratory data suggesting a secondary adrenal insufficiency following a recent acute brain ischemia. Cortisone therapy significantly improved this pituitary dysfunction. Conclusions: Clinicians must pay attention to the hypothalamic-pituitary axis in neurocritical patients because hormonal replacement therapy may be life-saving.
MeSH term(s)	Aged ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Female ; Humans ; Hypopituitarism/complications ; Hypopituitarism/diagnostic imaging
Language	English
Publishing date	2015-09-28
Publishing country	United Arab Emirates
Document type	Case Reports ; Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530315666150930121912
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Article ; Online: Amiodarone-induced SIADH: two cases report.

Iovino, Michele / Iovine, Nicola / Petrosino, Antonio / Licchelli, Brunella / Giagulli, Vito A / Iacoviello, Massimo / Guastamacchia, Edoardo / Triggiani, Vincenzo

Endocrine, metabolic & immune disorders drug targets

2014 Volume 14, Issue 2, Page(s) 123–125

Abstract: Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule ...

Abstract	Amiodarone-induced SIADH is a rare but serious side effect of this drug. We report two cases of mild hyponatremia, observed in the last five years, and discuss the role played by age, sex and dose of amiodarone as well as the influence that this molecule may have on aquaporin-2 water channel expression in the renal collecting ducts.
MeSH term(s)	Aged ; Amiodarone/administration & dosage ; Amiodarone/adverse effects ; Arrhythmias, Cardiac/drug therapy ; Dose-Response Relationship, Drug ; Humans ; Inappropriate ADH Syndrome/chemically induced ; Male
Chemical Substances	Amiodarone (N3RQ532IUT)
Language	English
Publishing date	2014-04-06
Publishing country	United Arab Emirates
Document type	Case Reports ; Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530314666140407111410
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Article ; Online: Sevelamer carbonate markedly reduces levothyroxine absorption.

Iovino, Michele / Iovine, Nicola / Petrosino, Alfanso / Giagulli, Vito A / Licchelli, Brunella / Guastamacchia, Edoardo / Triggiani, Vincenzo

Endocrine, metabolic & immune disorders drug targets

2014 Volume 14, Issue 3, Page(s) 206–209

Abstract: We report the case of a young woman affected by hypothyroidism due to Hashimoto's thyroiditis, previously well compensated with a full replacement therapy (150 mcg/day of levothyroxine), presenting a clinical picture of myxedema, with a TSH=650 mU/L. Two ...

Abstract	We report the case of a young woman affected by hypothyroidism due to Hashimoto's thyroiditis, previously well compensated with a full replacement therapy (150 mcg/day of levothyroxine), presenting a clinical picture of myxedema, with a TSH=650 mU/L. Two years earlier she had started a dialysis treatment because of a chronic renal failure and had been under treatment for the last 18 months with sevelamer carbonate, a phosphate binder. No improvement of clinical conditions nor reduction in TSH serum levels was observed even on increasing the dose of levothyroxine up to 300 mcg/day, whereas euthyroidism finally restored by administering the first morning dose of sevelamer carbonate at least 4 hours after levothyroxine administration. This case shows that sevelamer carbonate, in analogy with what has been already reported for sevelamer hydrochloride, can interfere with levothyroxine absorption leading to a condition of hypothyroidism in patients previously well compensated with a given replacement dose.
MeSH term(s)	Adult ; Drug Administration Schedule ; Drug Interactions ; Female ; Hashimoto Disease/drug therapy ; Hashimoto Disease/metabolism ; Humans ; Intestinal Absorption/drug effects ; Myxedema/chemically induced ; Polyamines/administration & dosage ; Polyamines/adverse effects ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/metabolism ; Renal Insufficiency, Chronic/therapy ; Sevelamer ; Thyroxine/pharmacokinetics ; Thyroxine/therapeutic use
Chemical Substances	Polyamines ; Sevelamer (9YCX42I8IU) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2014-09-02
Publishing country	United Arab Emirates
Document type	Case Reports ; Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530314666140902151804
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Article ; Online: Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.

Berger, Jeffrey S / Neal, Matthew D / Kornblith, Lucy Z / Gong, Michelle N / Reynolds, Harmony R / Cushman, Mary / Althouse, Andrew D / Lawler, Patrick R / McVerry, Bryan J / Kim, Keri S / Baumann Kreuziger, Lisa / Solomon, Scott D / Kosiborod, Mikhail N / Berry, Scott M / Bochicchio, Grant V / Contoli, Marco / Farkouh, Michael E / Froess, Joshua D / Gandotra, Sheetal /

JAMA network open

2023 Volume 6, Issue 5, Page(s) e2314428

Abstract: Importance: Platelet activation is a potential therapeutic target in patients with COVID-19.: Objective: To evaluate the effect of P2Y12 inhibition among critically ill patients hospitalized for COVID-19.: Design, setting, and participants: This ... ...

Abstract	Importance: Platelet activation is a potential therapeutic target in patients with COVID-19. Objective: To evaluate the effect of P2Y12 inhibition among critically ill patients hospitalized for COVID-19. Design, setting, and participants: This international, open-label, adaptive platform, 1:1 randomized clinical trial included critically ill (requiring intensive care-level support) patients hospitalized with COVID-19. Patients were enrolled between February 26, 2021, through June 22, 2022. Enrollment was discontinued on June 22, 2022, by the trial leadership in coordination with the study sponsor given a marked slowing of the enrollment rate of critically ill patients. Intervention: Participants were randomly assigned to receive a P2Y12 inhibitor or no P2Y12 inhibitor (usual care) for 14 days or until hospital discharge, whichever was sooner. Ticagrelor was the preferred P2Y12 inhibitor. Main outcomes and measures: The primary outcome was organ support-free days, evaluated on an ordinal scale that combined in-hospital death and, for participants who survived to hospital discharge, the number of days free of cardiovascular or respiratory organ support up to day 21 of the index hospitalization. The primary safety outcome was major bleeding, as defined by the International Society on Thrombosis and Hemostasis. Results: At the time of trial termination, 949 participants (median [IQR] age, 56 [46-65] years; 603 male [63.5%]) had been randomly assigned, 479 to the P2Y12 inhibitor group and 470 to usual care. In the P2Y12 inhibitor group, ticagrelor was used in 372 participants (78.8%) and clopidogrel in 100 participants (21.2%). The estimated adjusted odds ratio (AOR) for the effect of P2Y12 inhibitor on organ support-free days was 1.07 (95% credible interval, 0.85-1.33). The posterior probability of superiority (defined as an OR > 1.0) was 72.9%. Overall, 354 participants (74.5%) in the P2Y12 inhibitor group and 339 participants (72.4%) in the usual care group survived to hospital discharge (median AOR, 1.15; 95% credible interval, 0.84-1.55; posterior probability of superiority, 80.8%). Major bleeding occurred in 13 participants (2.7%) in the P2Y12 inhibitor group and 13 (2.8%) in the usual care group. The estimated mortality rate at 90 days for the P2Y12 inhibitor group was 25.5% and for the usual care group was 27.0% (adjusted hazard ratio, 0.96; 95% CI, 0.76-1.23; P = .77). Conclusions and relevance: In this randomized clinical trial of critically ill participants hospitalized for COVID-19, treatment with a P2Y12 inhibitor did not improve the number of days alive and free of cardiovascular or respiratory organ support. The use of the P2Y12 inhibitor did not increase major bleeding compared with usual care. These data do not support routine use of a P2Y12 inhibitor in critically ill patients hospitalized for COVID-19. Trial registration: ClinicalTrials.gov Identifier: NCT04505774.
MeSH term(s)	Humans ; Male ; Middle Aged ; COVID-19 ; Critical Illness/therapy ; Hemorrhage ; Hospital Mortality ; Ticagrelor/therapeutic use ; Purinergic P2Y Receptor Agonists/therapeutic use
Chemical Substances	Ticagrelor (GLH0314RVC) ; Purinergic P2Y Receptor Agonists
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.14428
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