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  1. Article ; Online: Macrophage reprogramming for therapy.

    Bart, Valentina M T / Pickering, Robert J / Taylor, Philip R / Ipseiz, Natacha

    Immunology

    2021  Volume 163, Issue 2, Page(s) 128–144

    Abstract: Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although ... ...

    Abstract Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent cutting-edge technologies have highlighted macrophages as potential targets for disease control. Macrophages play central roles in development, homeostasis and host defence, and their dysfunction and dysregulation have been implicated in the onset and pathogenesis of multiple disorders including cancer, neurodegeneration, autoimmunity and metabolic diseases. Recent advancements have led to a greater understanding of macrophage origin, diversity and function, in both health and disease. Over the last few years, a variety of strategies targeting macrophages have been developed and these open new therapeutic opportunities. Here, we review the progress in macrophage reprogramming in various disorders and discuss the potential implications and challenges for macrophage-targeted approaches in human disease.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Cell Differentiation ; Cellular Reprogramming ; Humans ; Immunotherapy/trends ; Macrophages/immunology ; Metabolic Diseases/immunology ; Metabolic Diseases/therapy ; Neoplasms/immunology ; Neoplasms/therapy ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/therapy
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.13300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; Thesis: The role of the nuclear receptor Nr4a1 as mediator of the anti-inflammatory effects of apoptotic cells

    Ipseiz, Natacha

    Die Rolle des nukleären Rezeptors Nr4a1 als Mediator der anti-inflammatorischen Effekte apoptotischer Zellen

    2014  

    Author's details von Natacha Ipseiz
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Erlangen-Nürnberg, 2014
    Database Former special subject collection: coastal and deep sea fishing

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  3. Article ; Online: The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious Conditions.

    Bohaud, Candice / Johansen, Matt D / Jorgensen, Christian / Kremer, Laurent / Ipseiz, Natacha / Djouad, Farida

    Frontiers in immunology

    2021  Volume 12, Page(s) 707856

    Abstract: Several infectious pathologies in humans, such as tuberculosis or SARS-CoV-2, are responsible for tissue or lung damage, requiring regeneration. The regenerative capacity of adult mammals is limited to few organs. Critical injuries of non-regenerative ... ...

    Abstract Several infectious pathologies in humans, such as tuberculosis or SARS-CoV-2, are responsible for tissue or lung damage, requiring regeneration. The regenerative capacity of adult mammals is limited to few organs. Critical injuries of non-regenerative organs trigger a repair process that leads to a definitive architectural and functional disruption, while superficial wounds result in scar formation. Tissue lesions in mammals, commonly studied under non-infectious conditions, trigger cell death at the site of the injury, as well as the production of danger signals favouring the massive recruitment of immune cells, particularly macrophages. Macrophages are also of paramount importance in infected injuries, characterized by the presence of pathogenic microorganisms, where they must respond to both infection and tissue damage. In this review, we compare the processes implicated in the tissue repair of non-infected
    MeSH term(s) Airway Remodeling ; Animals ; COVID-19/immunology ; Humans ; Infections ; Macrophages, Alveolar/physiology ; Mammals ; Regeneration ; SARS-CoV-2/physiology ; Wound Healing
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.707856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Macrophages During Zebrafish Injury and Tissue Regeneration Under Infectious and Non-Infectious Conditions.

    Bohaud, Candice / Johansen, Matt D / Jorgensen, Christian / Ipseiz, Natacha / Kremer, Laurent / Djouad, Farida

    Frontiers in immunology

    2021  Volume 12, Page(s) 707824

    Abstract: The future of regenerative medicine relies on our understanding of the mechanistic processes that underlie tissue regeneration, highlighting the need for suitable animal models. For many years, zebrafish has been exploited as an adequate model in the ... ...

    Abstract The future of regenerative medicine relies on our understanding of the mechanistic processes that underlie tissue regeneration, highlighting the need for suitable animal models. For many years, zebrafish has been exploited as an adequate model in the field due to their very high regenerative capabilities. In this organism, regeneration of several tissues, including the caudal fin, is dependent on a robust epimorphic regenerative process, typified by the formation of a blastema, consisting of highly proliferative cells that can regenerate and completely grow the lost limb within a few days. Recent studies have also emphasized the crucial role of distinct macrophage subpopulations in tissue regeneration, contributing to the early phases of inflammation and promoting tissue repair and regeneration in late stages once inflammation is resolved. However, while most studies were conducted under non-infectious conditions, this situation does not necessarily reflect all the complexities of the interactions associated with injury often involving entry of pathogenic microorganisms. There is emerging evidence that the presence of infectious pathogens can largely influence and modulate the host immune response and the regenerative processes, which is sometimes more representative of the true complexities underlying regenerative mechanics. Herein, we present the current knowledge regarding the paths involved in the repair of non-infected and infected wounds using the zebrafish model.
    MeSH term(s) Animals ; Fish Diseases ; Infections ; Macrophages ; Regeneration ; Zebrafish
    Language English
    Publishing date 2021-07-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.707824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: 3R Blackboard: A platform for animal and organ sharing

    Czubala, Magdalena A / Eilles, Eva / Staubi, Andreas / Ipseiz, Natacha / Vogt, Michael / Zieglowski, Leonie / Ernst, Lisa / Tolba, René H / Taylor, Philip R / Weiskirchen, Ralf

    Laboratory animals. 2022 June, v. 56, no. 3

    2022  

    Abstract: Since the embedding of the principles of the 3Rs (Replacement, Reduction and Refinement) in national and international regulations on the use of animals, scientists have been challenged to find ways to reduce the number of animals in their research. Here, ...

    Abstract Since the embedding of the principles of the 3Rs (Replacement, Reduction and Refinement) in national and international regulations on the use of animals, scientists have been challenged to find ways to reduce the number of animals in their research. Here, we present a digital platform, called ‘3R Backboard’, linked to a laboratory animal management system, which facilitates sharing of surplus biological materials from animals (e.g. tissues, organs and cells) to other research teams. Based on information provided, such as genotype, age and sex, other animal workers were able to indicate their interest in collecting specific tissues and to communicate with the person providing the animals. A short pilot study of this approach conducted in a limited academic environment presented strong evidence of its effectiveness and resulted in a notable reduction of the number of mice used. In addition, the use of 3R Blackboard led to resource saving, knowledge exchange and even establishment of new collaboration.
    Keywords animal husbandry ; genotype ; information exchange ; laboratories ; laboratory animals ; management systems
    Language English
    Dates of publication 2022-06
    Size p. 292-296.
    Publishing place SAGE Publications
    Document type Article
    ZDB-ID 391008-8
    ISSN 1758-1117 ; 0023-6772
    ISSN (online) 1758-1117
    ISSN 0023-6772
    DOI 10.1177/00236772211067456
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Therapeutic targeting of chronic kidney disease-associated DAMPs differentially contributing to vascular pathology.

    Mazzarino, Morgane / Cetin, Esra / Bartosova, Maria / Marinovic, Iva / Ipseiz, Natacha / Hughes, Timothy R / Schmitt, Claus Peter / Ramji, Dipak P / Labéta, Mario O / Raby, Anne-Catherine

    Frontiers in immunology

    2023  Volume 14, Page(s) 1240679

    Abstract: Chronic Kidney Disease (CKD) is associated with markedly increased cardiovascular (CV) morbidity and mortality. Chronic inflammation, a hallmark of both CKD and CV diseases (CVD), is believed to drive this association. Pro-inflammatory endogenous TLR ... ...

    Abstract Chronic Kidney Disease (CKD) is associated with markedly increased cardiovascular (CV) morbidity and mortality. Chronic inflammation, a hallmark of both CKD and CV diseases (CVD), is believed to drive this association. Pro-inflammatory endogenous TLR agonists, Damage-Associated Molecular Patterns (DAMPs), have been found elevated in CKD patients' plasma and suggested to promote CVD, however, confirmation of their involvement, the underlying mechanism(s), the extent to which individual DAMPs contribute to vascular pathology in CKD and the evaluation of potential therapeutic strategies, have remained largely undescribed. A multi-TLR inhibitor, soluble TLR2, abrogated chronic vascular inflammatory responses and the increased aortic atherosclerosis-associated gene expression observed in nephropathic mice, without compromising infection clearance. Mechanistically, we confirmed elevation of 4 TLR DAMPs in CKD patients' plasma, namely Hsp70, Hyaluronic acid, HMGB-1 and Calprotectin, which displayed different abilities to promote key cellular responses associated with vascular inflammation and progression of atherosclerosis in a TLR-dependent manner. These included loss of trans-endothelial resistance, enhanced monocyte migration, increased cytokine production, and foam cell formation by macrophages, the latter via cholesterol efflux inhibition. Calprotectin and Hsp70 most consistently affected these functions. Calprotectin was further elevated in CVD-diagnosed CKD patients and strongly correlated with the predictor of CV events CRP. In nephropathic mice, Calprotectin blockade robustly reduced vascular chronic inflammatory responses and pro-atherosclerotic gene expression in the blood and aorta. Taken together, these findings demonstrated the critical extent to which the DAMP-TLR pathway contributes to vascular inflammatory and atherogenic responses in CKD, revealed the mechanistic contribution of specific DAMPs and described two alternatives therapeutic approaches to reduce chronic vascular inflammation and lower CV pathology in CKD.
    MeSH term(s) Humans ; Animals ; Mice ; Renal Insufficiency, Chronic/pathology ; Alarmins ; Atherosclerosis/drug therapy ; Inflammation/metabolism ; Cardiovascular Diseases/complications ; Leukocyte L1 Antigen Complex
    Chemical Substances Alarmins ; Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1240679
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  7. Article ; Online: 3R Blackboard: A platform for animal and organ sharing.

    Czubala, Magdalena A / Eilles, Eva / Staubi, Andreas / Ipseiz, Natacha / Vogt, Michael / Zieglowski, Leonie / Ernst, Lisa / Tolba, René H / Taylor, Philip R / Weiskirchen, Ralf

    Laboratory animals

    2022  Volume 56, Issue 3, Page(s) 292–296

    Abstract: Since the embedding of the principles of the 3Rs (Replacement, Reduction and Refinement) in national and international regulations on the use of animals, scientists have been challenged to find ways to reduce the number of animals in their research. Here, ...

    Abstract Since the embedding of the principles of the 3Rs (Replacement, Reduction and Refinement) in national and international regulations on the use of animals, scientists have been challenged to find ways to reduce the number of animals in their research. Here, we present a digital platform, called '3R Backboard', linked to a laboratory animal management system, which facilitates sharing of surplus biological materials from animals (e.g. tissues, organs and cells) to other research teams. Based on information provided, such as genotype, age and sex, other animal workers were able to indicate their interest in collecting specific tissues and to communicate with the person providing the animals. A short pilot study of this approach conducted in a limited academic environment presented strong evidence of its effectiveness and resulted in a notable reduction of the number of mice used. In addition, the use of 3R Blackboard led to resource saving, knowledge exchange and even establishment of new collaboration.
    MeSH term(s) Animal Experimentation ; Animal Testing Alternatives ; Animal Welfare ; Animals ; Animals, Laboratory ; Humans ; Mice ; Pilot Projects
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 391008-8
    ISSN 1758-1117 ; 0023-6772
    ISSN (online) 1758-1117
    ISSN 0023-6772
    DOI 10.1177/00236772211067456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Article: Erratum: Effective

    Ipseiz, Natacha / Czubala, Magdalena A / Bart, Valentina M T / Davies, Luke C / Jenkins, Robert H / Brennan, Paul / Taylor, Philip R

    Molecular therapy. Methods & clinical development

    2020  Volume 19, Page(s) 375

    Abstract: This corrects the article DOI: 10.1016/j.omtm.2019.10.004.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.omtm.2019.10.004.].
    Language English
    Publishing date 2020-11-03
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2020.10.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis.

    Ipseiz, Natacha / Scholtysek, Carina / Culemann, Stephan / Krönke, Gerhard

    Swiss medical weekly

    2014  Volume 144, Page(s) w14055

    Abstract: Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis. These properties render ... ...

    Abstract Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis. These properties render them attractive targets for the therapy of various inflammatory and autoimmune diseases affecting the musculoskeletal system. This review summarises the current knowledge on the role of these families of receptors during innate and adaptive immunity as well as during the control of bone turnover and discuss the potential use of targeting these molecules during the treatment of chronic diseases such as osteoarthritis, rheumatoid arthritis and osteoporosis.
    MeSH term(s) Adaptive Immunity ; Bone Remodeling ; Bone and Bones/physiology ; Homeostasis ; Humans ; Immunity, Innate ; Inflammation/metabolism ; Liver X Receptors ; Orphan Nuclear Receptors/metabolism ; Peroxisome Proliferator-Activated Receptors/metabolism
    Chemical Substances Liver X Receptors ; Orphan Nuclear Receptors ; Peroxisome Proliferator-Activated Receptors
    Language English
    Publishing date 2014
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2014.14055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.152: Show issues Location:
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  10. Article: Effective

    Ipseiz, Natacha / Czubala, Magdalena A / Bart, Valentina M T / Davies, Luke C / Jenkins, Robert H / Brennan, Paul / Taylor, Philip R

    Molecular therapy. Methods & clinical development

    2019  Volume 16, Page(s) 21–31

    Abstract: Tissue-resident macrophages exhibit specialized phenotypes dependent on ... ...

    Abstract Tissue-resident macrophages exhibit specialized phenotypes dependent on their
    Language English
    Publishing date 2019-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2019.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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