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  1. Article ; Online: Implications of solid waste dumps on the microplastic abundance in groundwater in Kollam, India.

    Priya, K L / Iqbal, Shabana / Archana, A R / Gopika, B / Mina, Michi / Haddout, S / M Madhu, Athul

    Journal of environmental management

    2023  Volume 348, Page(s) 119224

    Abstract: Water pollution caused by microplastics has garnered increasing attention in recent years due to its potential ecological and human health risks. However, there are very limited studies and a general lack of consensus regarding the presence and negative ... ...

    Abstract Water pollution caused by microplastics has garnered increasing attention in recent years due to its potential ecological and human health risks. However, there are very limited studies and a general lack of consensus regarding the presence and negative impacts of microplastics in groundwater. Due to their small size, microplastics can easily be transported at surface as well as subsurface levels, potentially reaching the groundwater table and contaminating the groundwater system This contamination is expected to occur more rapidly in landfill areas and other locations where plastic waste is dumped. In this study, we examined well water samples collected from areas near various dumping sites to assess the abundance and characteristics of microplastics. An average of 12 items/L of microplastics were found in groundwater wells near eight dumping sites in Kollam Corporation. The predominant shape of microplastics in the groundwater samples was fibres, followed by flakes, with black being the predominant colour. The areal extent of solid waste dumping was observed to have an influence on the abundance of microplastics. Additionally, the pH of groundwater near heavy dumping sites was found to be in the acidic range, indicating the intrusion of leachate from dumps into groundwater. The study revealed that the leachate from solid waste dumps is the primary source of microplastics in groundwater. Furthermore, a risk assessment of the microplastic pollution was carried out using an index namely Microplastic Pollution Index and the areas of high risks were identified. The locations having heavy solid waste dumping and those near coastal areas were observed to be at high risk, thereby indicating that both the leachate from dumps and sea water intrusion can cause higher microplastic pollution risk in the groundwater system. The findings of this study are expected to support managers in formulating and implementing effective solid waste management plans to mitigate microplastic pollution in the groundwater system.
    MeSH term(s) Humans ; Solid Waste/analysis ; Microplastics ; Refuse Disposal ; Plastics ; Environmental Monitoring ; Water Pollutants, Chemical/analysis ; Groundwater ; Waste Disposal Facilities ; India ; Water Pollution
    Chemical Substances Solid Waste ; Microplastics ; Plastics ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.119224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and safety of aromatase inhibitors in early breast cancer.

    Ozair, Sundus / Iqbal, Shabana

    Expert opinion on drug safety

    2008  Volume 7, Issue 5, Page(s) 547–558

    Abstract: Background: Third-generation aromatase inhibitors (AIs) are surfacing as the standard adjuvant treatment for postmenopausal women with hormone receptor positive breast cancer over tamoxifen but their long-term effects are still under investigation.: ... ...

    Abstract Background: Third-generation aromatase inhibitors (AIs) are surfacing as the standard adjuvant treatment for postmenopausal women with hormone receptor positive breast cancer over tamoxifen but their long-term effects are still under investigation.
    Objective: In the light of current information, what factors should health practitioners take into consideration when prescribing AIs to patients?
    Methods: Results of several randomized controlled adjuvant clinical trials were reviewed to assess the efficacy of treatment and their subprotocols focusing on quality of life and skeletal health to highlight the safety concerns.
    Conclusion: To prevent early recurrences, AIs should be considered as the upfront hormonal treatment of choice. They are also recommended for use as a switching strategy after 2-3 years of tamoxifen and as extended adjuvant treatment after 5 years of tamoxifen. The adverse events experienced are manageable and overall quality of life is not compromised; however, bone density must be monitored for patients at risk and appropriate bone-protection supplements need to be taken.
    MeSH term(s) Aromatase Inhibitors/adverse effects ; Aromatase Inhibitors/therapeutic use ; Bone Density/drug effects ; Breast Neoplasms/drug therapy ; Drug Monitoring/methods ; Female ; Humans ; Neoplasms, Hormone-Dependent/drug therapy ; Postmenopause ; Quality of Life ; Randomized Controlled Trials as Topic ; Time Factors
    Chemical Substances Aromatase Inhibitors
    Language English
    Publishing date 2008-08-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1517/14740338.7.5.547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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