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Article ; Online: Correlation of sexual desire with sexual hormone binding globulin and free androgen index in women using combined contraceptives.

Caruso, Salvatore / Caruso, Giuseppe / Iraci Sareri, Marco / Di Guardo, Federica / Incognito, Giosuè Giordano / Palumbo, Marco

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception

2024 , Page(s) 1–6

Abstract: Purpose: To correlate the sexual desire levels with sexual hormone binding globulin and free androgen index in women taking different types of hormonal contraceptives (HCs) containing ethinylestradiol (EE), oestradiol valerate (E2V), 17β-oestradiol (E2), ...

Abstract	Purpose: To correlate the sexual desire levels with sexual hormone binding globulin and free androgen index in women taking different types of hormonal contraceptives (HCs) containing ethinylestradiol (EE), oestradiol valerate (E2V), 17β-oestradiol (E2), or estetrol (E4), combined or in phasic formulation with different progestogens having antiandrogenic properties. Methods: Three hundred and sixty-seven women (age range 18-46) participated in the study. SHBG and total testosterone (TT) were measured, and the Free Androgen Index (FAI) was calculated. The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) questionnaires were used to assess sexual function and distress, respectively. Results: The highest SHBG values and the lowest FAIs were obtained of women on HCs containing EE than those of women on HCs containing E2V/17β E2 or E4 ( Conclusions: A minority of women using HCs with EE might experience a decreased sexual desire. This was not observed in women on HCs containing E2V, 17 E2, or E4. To avoid HC discontinuation, due to sexual desire reduction, HCs having minor antiandrogenic effects could be taken into consideration.
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1397560-2
ISSN	1473-0782 ; 1362-5187
ISSN (online)	1473-0782
ISSN	1362-5187
DOI	10.1080/13625187.2024.2332302
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Article ; Online: Randomized study on the effectiveness of nomegestrol acetate plus 17β-estradiol oral contraceptive versus dienogest oral pill in women with suspected endometriosis‑associated chronic pelvic pain.

Caruso, Salvatore / Cianci, Antonio / Iraci Sareri, Marco / Panella, Marco / Caruso, Giuseppe / Cianci, Stefano

BMC women's health

2022 Volume 22, Issue 1, Page(s) 146

Abstract: Background: To evaluate the effects of a combined oral contraceptive containing 1.5 mg 17b-estradiol (E2) and 2.5 mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on ... ...

Abstract	Background: To evaluate the effects of a combined oral contraceptive containing 1.5 mg 17b-estradiol (E2) and 2.5 mg nomegestrol acetate (NOMAC) or 2 mg/daily dienogest (DNG) oral progestin on endometriosis-associated chronic pelvic pain (CPP) and on the quality of life (QoL) and sexual function, by a randomized study design. Methods: The E2/NOMAC group and DNG group included 99 and 98 women, respectively. The levels of CPP were measured by the visual analogic scale (VAS). The QoL scores were investigated by the Short Form-36 questionnaire (SF-36). Finally, sexual function was studied using the Female Sexual Function Index (FSFI), while sexual distress was studied by the Female Sexual Distress Scale (FSDS). The study had 3, 6 and 12-month follow-ups. Results: The intra-group analysis showed an improvement of the VAS score from baseline to the 12-month follow-up in the women of both groups (p < 0.001). The inter-group comparison showed a similar improvement of CPP (p = 0.06). Women on DNG had better SF-36 somatic (p < 0.01) and FSFI scores (p < 0.006) than women on E2/NOMAC at the 6- and 12-month follow-ups. Conclusions: The results support the efficacy of both hormonal treatments, even if DNG was more effective than E2/NOMAC in a limited intergroup comparison.
MeSH term(s)	Chronic Pain/complications ; Chronic Pain/etiology ; Contraceptives, Oral, Combined/therapeutic use ; Endometriosis/complications ; Endometriosis/drug therapy ; Estradiol/pharmacology ; Estradiol/therapeutic use ; Female ; Humans ; Male ; Megestrol ; Nandrolone/analogs & derivatives ; Nandrolone/therapeutic use ; Norpregnadienes ; Pelvic Pain/complications ; Pelvic Pain/etiology ; Quality of Life
Chemical Substances	Contraceptives, Oral, Combined ; Norpregnadienes ; dienogest (46M3EV8HHE) ; Estradiol (4TI98Z838E) ; Nandrolone (6PG9VR430D) ; nomegestrol acetate (83J78V5W05) ; Megestrol (EA6LD1M70M)
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-022-01737-7
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Article: Incidental Diagnosis of Pseudomyxoma Peritonei: A Case Report.

Sarpietro, Giuseppe / Iraci Sareri, Marco / Bonanno, Giulia Maria / Matarazzo, Maria Grazia / Cianci, Antonio

Cureus

2022 Volume 14, Issue 3, Page(s) e23425

Abstract: Pseudomyxoma peritonei (PMP) is a rare clinical condition characterized by disseminating gelatinous ascites within the peritoneal cavity with mucinous implants on peritoneal surfaces. We present the case of a patient incidentally diagnosed after ... ...

Abstract	Pseudomyxoma peritonei (PMP) is a rare clinical condition characterized by disseminating gelatinous ascites within the peritoneal cavity with mucinous implants on peritoneal surfaces. We present the case of a patient incidentally diagnosed after laparoscopy: definitive diagnosis after the histological examination was PMP. A 37-year-old female patient with a medical history of infertility and mild pelvic pain was found to have several collections in the pelvis and an amount of free fluid into the Douglas pouch at ultrasound examination. The patient underwent laparoscopic surgical exploration. Peritoneal biopsies and appendectomy were performed. Histological examination was about a low-grade appendiceal mucinous tumor limited to the mucosa without submucosal infiltration with perforation of the wall and deposit of periappendicular acellular mucin. The patient was discharged in good health and referred to an oncological peritoneal center where cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) were performed. In conclusion, PMP is an uncommon disease within the abdomen, characterized by a mucinous tumor that produces progressive mucinous ascites. It is characterized by various non-specific symptoms and signs and difficult imaging diagnoses. Histological diagnosis is a determinant to establish the therapy that can differ significantly, depending on the stage of the disease.
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23425
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Article ; Online: Clear cell degeneration associated with endometriosis of abdominal wall after cesarean section: A case report and systematic review of literature.

Ferrari, Federico / Valenti, Gaetano / Forte, Sara / Ardighieri, Laura / Iraci Sareri, Marco / Barra, Fabio / Sartori, Enrico / Odicino, Franco

The journal of obstetrics and gynaecology research

2021 Volume 47, Issue 4, Page(s) 1243–1252

Abstract: Aim: The scar of cesarean section (CS) is the most common site of abdominal wall endometriosis (AWE), whose tumor degeneration has been reported in an increasing number of cases; the most frequent histological type is clear cell carcinoma (CCC).: ... ...

Abstract	Aim: The scar of cesarean section (CS) is the most common site of abdominal wall endometriosis (AWE), whose tumor degeneration has been reported in an increasing number of cases; the most frequent histological type is clear cell carcinoma (CCC). Methods: We conducted a systematic research of the literature, collecting data regarding the evidence on tumor degeneration from AWE after CS. Moreover, we reported a case of clear cell borderline tumor (CCBT) originating from AWE. Results: We included data of 37 patients with diagnosis of CCC. The average time between the last CS and the diagnosis of CCC was around 15 years. Overall, 26.0% and 73.9% patients received exclusive local abdominal resection of the lesion and additional surgery, respectively. Lymph nodes involvement was detected in 26.0 % patients and adjuvant chemotherapy was administered in 52.0 % cases. During follow-up period, 15.2% patients died of disease, 32.6% had no evidence of disease, and 17.4% recurred. We diagnosed a CCBT arose in a patients with AWE and a personal history of several surgical procedures for endometriosis, a CS and a subsequent transverse laparotomy. We performed an open bilateral ovariectomy and a large excision of the endometriotic abdominal lesion. Conclusion: Tumor degeneration from AWE seems to be a real occurrence with an increasing number of events. Considering the lack of risk factors and diagnostic instruments for tumor degeneration, the removal of AWE localization could be advisable, even though there was long average time between the trigger surgery and the tumor finding.
MeSH term(s)	Abdominal Wall/surgery ; Cesarean Section/adverse effects ; Cicatrix/pathology ; Endometriosis/pathology ; Endometriosis/surgery ; Female ; Humans ; Neoplasm Recurrence, Local/pathology ; Pregnancy ; Retrospective Studies
Language	English
Publishing date	2021-01-13
Publishing country	Australia
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.14635
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Article ; Online: The role of hysteroscopy in reproductive surgery: Today and tomorrow.

Riemma, Gaetano / Vitale, Salvatore Giovanni / Manchanda, Rahul / Rathore, Aayushi / Török, Péter / De Angelis, Carlo / Urman, Bulent / Iraci Sareri, Marco / La Verde, Marco / Carugno, Jose / De Franciscis, Pasquale / Tesarik, Jan

Journal of gynecology obstetrics and human reproduction

2022 Volume 51, Issue 4, Page(s) 102350

Abstract: During the last decades, the number of couples with reproductive issues has substantially increased. Many different factors are implicated in reproductive failure, including uterine factors. Endometrial pathologies, such as endometrial polyps, ... ...

Abstract	During the last decades, the number of couples with reproductive issues has substantially increased. Many different factors are implicated in reproductive failure, including uterine factors. Endometrial pathologies, such as endometrial polyps, hyperplasia, endometritis, and Mullerian anomalies, can also hinder embryo implantation. Hysteroscopy remains the gold standard for the evaluation and treatment of intrauterine pathology. Over the last few years, advances in hysteroscopic instrumentations and surgical techniques have significantly evolved, the refinement in technology, miniaturization of instruments, and improved image quality have rendered hysteroscopy a more patient and user-friendly procedure that has enhanced its use in reproductive medicine. Nowadays, hysteroscopy is essential in the evaluation and treatment of women with infertility. This article underscores the major technological breakthroughs achieved over the last few years with emphasis on the role of artificial intelligence, augmented reality, and 3D hysteroscopy, which can set new benchmarks in hysteroscopy applied to reproductive medicine.
MeSH term(s)	Artificial Intelligence ; Endometrium/pathology ; Female ; Humans ; Hysteroscopy/methods ; Pregnancy ; Uterine Diseases/pathology ; Uterine Diseases/surgery ; Uterus/abnormalities ; Uterus/surgery
Language	English
Publishing date	2022-02-26
Publishing country	France
Document type	Journal Article ; Review
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2022.102350
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Article ; Online: Sirenomelia with oligodactylia: early ultrasonographic and hysteroscopic embryoscopic diagnosis during the first trimester of gestation.

Clemente, Claudia Maria / Farina, Marco / Cianci, Antonio / Iraci Sareri, Marco

Fetal diagnosis and therapy

2010 Volume 28, Issue 1, Page(s) 43–45

Abstract: The case we describe reports the early sonographic findings of sirenomelia with oligodactylia at 9 weeks of gestation by transvaginal two-dimensional color Doppler ultrasonography imaging and its confirmation by hysteroscopic embryoscopy at 12 weeks to ... ...

Abstract	The case we describe reports the early sonographic findings of sirenomelia with oligodactylia at 9 weeks of gestation by transvaginal two-dimensional color Doppler ultrasonography imaging and its confirmation by hysteroscopic embryoscopy at 12 weeks to further characterize the findings. The embryo showed increased nuchal translucency and fused lower limbs with a large intra-abdominal vessel and two-vessel umbilical cords. The pregnancy was terminated by medical abortion induction after the patient viewed the embryoscopic images. Diagnosis is commonly made later in the second trimester of pregnancy, oligohydramnios being a warning signal, which usually makes the diagnosis difficult. Survival, only possible in the absence of renal agenesis, is extremely rare. In view of the extremely poor prognosis, early diagnosis allows for earlier counseling and less traumatic therapeutic termination of pregnancy.
MeSH term(s)	Adult ; Ectromelia/diagnostic imaging ; Ectromelia/pathology ; Female ; Humans ; Hysteroscopy ; Ultrasonography, Prenatal
Language	English
Publishing date	2010
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000309552
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Article ; Online: MiR-27a-3p and miR-124-3p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity.

Di Pietro, Cinzia / Caruso, Salvatore / Battaglia, Rosalia / Iraci Sareri, Marco / La Ferlita, Alessandro / Strino, Fabrizio / Bonaventura, Gabriele / Di Mauro, Maurizio / Barcellona, Maria Luisa / Perciavalle, Vincenzo / Purrello, Michele / Cianci, Antonio

American journal of reproductive immunology (New York, N.Y. : 1989)

2018 Volume 80, Issue 3, Page(s) e12858

Abstract: Problem: Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein-encoding genes in CE has been demonstrated, but no evidence about the ...

Abstract	Problem: Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein-encoding genes in CE has been demonstrated, but no evidence about the involvement of microRNAs in the pathology is present in literature. Method of study: In the endometrium from 15 women with CE and 15 healthy women, by RT-qPCR single assays, we investigated some microRNAs targeting IL11, CCL4, IGF1, and IGFBP1, which mRNAs had been found differentially expressed in endometrium of women affected by CE. The expression of IGF1 and IL11, targets of the deregulated microRNAs, has been analyzed in the same endometrium samples. We assessed the expression profiles of the deregulated microRNAs in the serum of the same patients validating their ability as biomarkers by statistical analysis. Results: We demonstrated the upregulation of miR-27a-3p and miR-124-3p in the endometrium and serum from women with CE and found an anticorrelation relationship between miR-27a-3p and IGF1 in endometrium. ROC curve analysis suggested that miRNA investigation in endometrium and serum could discriminate women with CE. Conclusion: MiR-27a-3p and miR-124-3p could represent non-invasive markers of CE and, in a near future, could be used to assess the endometrial quality in IVF.
MeSH term(s)	Abortion, Spontaneous/genetics ; Adult ; Chronic Disease ; Endometritis/genetics ; Endometrium/physiology ; Female ; Genetic Markers/genetics ; Humans ; Infertility/genetics ; Insulin-Like Growth Factor I/genetics ; MicroRNAs/genetics ; Pathology, Molecular ; Pregnancy ; Up-Regulation
Chemical Substances	Genetic Markers ; IGF1 protein, human ; MIRN1243 microRNA, human ; MIRN27 microRNA, human ; MicroRNAs ; Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2018-04-16
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604542-x
ISSN	1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
ISSN (online)	1600-0897
ISSN	0271-7352 ; 8755-8920 ; 1046-7408
DOI	10.1111/aji.12858
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Article: Sirenomelia with Oligodactylia: Early Ultrasonographic and Hysteroscopic Embryoscopic Diagnosis during the First Trimester of Gestation

Clemente, Claudia Maria / Farina, Marco / Cianci, Antonio / Iraci Sareri, Marco

Fetal Diagnosis and Therapy

2010 Volume 28, Issue 1, Page(s) 43–45

Institution	Azienda Ospedaliera-Universitaria Policlinico-Vittorio Emanuele, Dipartimento di Ginecologa e Ostetricia, University of Catania, and Centro GMR, Catania ASP 8, P.O. Umberto I, U.O.C. Ginecologia ed Ostetricia, Siracusa, Italy
Abstract	The case we describe reports the early sonographic findings of sirenomelia with oligodactylia at 9 weeks of gestation by transvaginal two-dimensional color Doppler ultrasonography imaging and its confirmation by hysteroscopic embryoscopy at 12 weeks to further characterize the findings. The embryo showed increased nuchal translucency and fused lower limbs with a large intra-abdominal vessel and two-vessel umbilical cords. The pregnancy was terminated by medical abortion induction after the patient viewed the embryoscopic images. Diagnosis is commonly made later in the second trimester of pregnancy, oligohydramnios being a warning signal, which usually makes the diagnosis difficult. Survival, only possible in the absence of renal agenesis, is extremely rare. In view of the extremely poor prognosis, early diagnosis allows for earlier counseling and less traumatic therapeutic termination of pregnancy.
Keywords	Sirenomelia ; Oligodactylia ; Transvaginal sonography ; Embryoscopy ; Hysteroscopy ; First trimester
Language	English
Publishing date	2010-05-26
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Images in Fetal Medicine
ZDB-ID	1066460-9
ISSN	1421-9964 ; 1015-3837
ISSN (online)	1421-9964
ISSN	1015-3837
DOI	10.1159/000309552
Database	Karger publisher's database

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Article ; Online: Conventional vs. extended-cycle oral contraceptives on the quality of sexual life: comparison between two regimens containing 3 mg drospirenone and 20 µg ethinyl estradiol.

Caruso, Salvatore / Iraci Sareri, Marco / Agnello, Carmela / Romano, Mattea / Lo Presti, Lucia / Malandrino, Chiara / Cianci, Antonio

The journal of sexual medicine

2011 Volume 8, Issue 5, Page(s) 1478–1485

Abstract: Introduction: Women may use new oral contraceptives (OC) having flexible extended-cycle regimens with a reduced hormone-free interval.: Aim: To study the changes of the quality of sexual life in users of the traditional 21/7 or extended-cycle 24/4 OC ...

Abstract	Introduction: Women may use new oral contraceptives (OC) having flexible extended-cycle regimens with a reduced hormone-free interval. Aim: To study the changes of the quality of sexual life in users of the traditional 21/7 or extended-cycle 24/4 OC regimens both containing 3 mg drospirenone and 20 µg ethinyl estradiol. Methods: One hundred fifteen women (age range 18-37 years) were enrolled. Fifty-four women were randomly placed on traditional OC standard regimen, administered for 21 days, followed by a 7-day hormone-free interval (group A); and 61 women were placed on extended-cycle OC regimen covering 24 days of the cycle with a 4-day hormone-free interval (group B). The Short Form-36 (SF-36) validate questionnaire to assess quality of life (QoL) and the Short Personal Experience Questionnaire (SPEQ) to measure the changes of sexual behavior were administered before starting OC intake and at the 3rd and 6th cycle follow-ups. Main outcome measure: The SF-36 and the SPEQ questionnaires. Results: Group A women reported QoL improvement during the 6th cycle on all the scales (P < 0.05). Group B women reported QoL improvement during the 3rd and 6th cycle (P < 0.05). Satisfaction with sexual activity, arousal, orgasm, and desire increased during the 3rd cycle in women on the group B (P < 0.05). Group A women did not report any change in all SPEQ items. At the 6th cycle, group B women reported better sexual experience than baseline in all SPEQ items (P < 0.05). All subjects who were affected by dyspareunia before OC intake reported decreased genital pain associated with intercourse at the 3rd and 6th cycle of both OC regimens (P < 0.05). Conclusion: Women could use OCs in a subjective flexible modality. The extended-cycle OC might produce positive effects on the quality of sexual life, enforcing the concept of tailoring an OC to a woman.
MeSH term(s)	Adolescent ; Adult ; Androstenes/administration & dosage ; Contraceptives, Oral, Combined/administration & dosage ; Delayed-Action Preparations ; Ethinyl Estradiol/administration & dosage ; Female ; Humans ; Personal Satisfaction ; Psychological Tests ; Quality of Life ; Sexual Behavior/psychology ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Androstenes ; Contraceptives, Oral, Combined ; Delayed-Action Preparations ; Ethinyl Estradiol (423D2T571U) ; drospirenone (N295J34A25)
Language	English
Publishing date	2011-05
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1111/j.1743-6109.2011.02208.x
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