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  1. AU="Irigoin, Victoria"
  2. AU="Kim, Joo-Yun"
  3. AU="Albu, Simona Elena"
  4. AU="Monalisa Feliciano Figueiredo"
  5. AU="Zhao, Houhua"
  6. AU="Kern, Bastian Johannes"
  7. AU="Antonio Vitobello"
  8. AU="Paulus Rahardjo"
  9. AU="Geier, Martina"
  10. AU="Kwon, Tae-Hwan"
  11. AU="Christos Barboutis, "
  12. AU="Fayaz, U"
  13. AU="Ba, Yabo"
  14. AU="Stevens, Valerie A"
  15. AU="Kahouli, Sophia"
  16. AU="Sun, Chuanrui"
  17. AU="Carrera, Carlo Giovanni"
  18. AU="Secrieru, Oana Manuela"
  19. AU="Wang, Lanzhong"

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  1. Artikel ; Online: Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma.

    Irigoín, Victoria / Oliver, Carolina / López, Stefanía / Landoni, Ana Inés / Gabús, Raúl / Díaz, Lilián

    Revista medica de Chile

    2020  Band 147, Heft 12, Seite(n) 1553–1560

    Abstract: Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International ... ...

    Abstract Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols ; Female ; Humans ; Immunotherapy ; Leukocyte Count ; Lymphoma, Large B-Cell, Diffuse/blood ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Middle Aged ; Monocytes ; Prognosis ; Retrospective Studies ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-03-18
    Erscheinungsland Chile
    Dokumenttyp Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872019001201553
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: TGF-β/SMAD Pathway Is Modulated by miR-26b-5p: Another Piece in the Puzzle of Chronic Lymphocytic Leukemia Progression.

    Marquez, Maria Elena / Sernbo, Sandra / Payque, Eugenia / Uria, Rita / Tosar, Juan Pablo / Querol, Juliana / Berca, Catalina / Uriepero, Angimar / Prieto, Daniel / Alvarez-Saravia, Diego / Oliver, Carolina / Irigoin, Victoria / Dos Santos, Gimena / Guillermo, Cecilia / Landoni, Ana Inés / Navarrete, Marcelo / Palacios, Florencia / Oppezzo, Pablo

    Cancers

    2022  Band 14, Heft 7

    Abstract: Clinical and molecular heterogeneity are hallmarks of chronic lymphocytic leukemia (CLL), a neoplasm characterized by accumulation of mature and clonal long-lived CD5 + B-lymphocytes. Mutational status of the IgHV gene of leukemic clones is a powerful ... ...

    Abstract Clinical and molecular heterogeneity are hallmarks of chronic lymphocytic leukemia (CLL), a neoplasm characterized by accumulation of mature and clonal long-lived CD5 + B-lymphocytes. Mutational status of the IgHV gene of leukemic clones is a powerful prognostic tool in CLL, and it is well established that unmutated CLLs (U-CLLs) have worse evolution than mutated cases. Nevertheless, progression and treatment requirement of patients can evolve independently from the mutational status. Microenvironment signaling or epigenetic changes partially explain this different behavior. Thus, we think that detailed characterization of the miRNAs landscape from patients with different clinical evolution could facilitate the understanding of this heterogeneity. Since miRNAs are key players in leukemia pathogenesis and evolution, we aim to better characterize different CLL behaviors by comparing the miRNome of clinically progressive U-CLLs vs. stable U-CLLs. Our data show up-regulation of miR-26b-5p, miR-106b-5p, and miR-142-5p in progressive cases and indicate a key role for miR-26b-5p during CLL progression. Specifically, up-regulation of miR-26b-5p in CLL cells blocks TGF-β/SMAD pathway by down-modulation of SMAD-4, resulting in lower expression of p21
    Sprache Englisch
    Erscheinungsdatum 2022-03-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071676
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Resonancia magnética como screening inicial de diagnóstico de compromiso secundario del sistema nervioso central en LNH difuso de grandes Células B.

    Oliver, Ana Carolina / Irigoin, Victoria / Sgarbi, Nicolas / Peixoto, Adriana / Turcatti, Paola / Diaz, Lilian / Zunino, Juan

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2018  Band 75, Heft 2, Seite(n) 67–71

    Abstract: Background: Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to ... ...

    Titelübersetzung Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
    Abstract Background: Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to evaluate the role of magnetic resonance imaging (MR) at diagnosis to detect early SNC compromise.
    Methods: Prospective longitudinal cohort’s study in DGCB patients treated at Hospital de Clínicas between 2013 and 2015. Skull MRI was performed in all patients at diagnosis and lumbar puncture was done according to predefined risk factors.
    Results: 35 patients were analyzed. Median age: 68 years (24-85 years). Stage III-IV: 62%, 57% good prognosis according to RIPI score and 43% poor prognosis. MRI was performed in all patients, with no pathological findings in any of them. Twenty-one patients fullfilled criteria for cerebrospinal fluid study. Twenty-two patients were studied and received intrathecal methotrexate prophylaxis. Meningeal relapse was observed in a single patient who had negative studies at diagnosis and had received complete prophylaxis at the end of the 6 R-CHOP series.
    Conclusions: Only one of the 35 patients relapsed in the CNS. This patient had a noral MRI and CSF study at diagnosis and had received prophylaxis with intrathecal chemotherapy. This results lead us to believe that the value of MRI to detect early infiltration in asymptomatic patients at diagnosis is low.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/therapeutic use ; Central Nervous System Neoplasms/cerebrospinal fluid ; Central Nervous System Neoplasms/diagnostic imaging ; Central Nervous System Neoplasms/drug therapy ; Early Detection of Cancer/methods ; Female ; Humans ; Longitudinal Studies ; Lymphoma, Large B-Cell, Diffuse/cerebrospinal fluid ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prospective Studies ; Rituximab/therapeutic use ; Skull Base/diagnostic imaging
    Chemische Substanzen Antineoplastic Agents, Immunological ; Rituximab (4F4X42SYQ6)
    Sprache Spanisch
    Erscheinungsdatum 2018-06-10
    Erscheinungsland Argentina
    Dokumenttyp Journal Article
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v75.n2.17517
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Citarabina y reacciones cutáneas en leucemia aguda mieloide.

    Grille, Sofía / Guadagna, Regina / Boada, Matilde / Irigoin, Victoria / Stevenazzi, Mariana / Guillermo, Cecilia / Díaz, Lilián

    Medicina

    2013  Band 73, Heft 6, Seite(n) 535–538

    Abstract: Cytarabine is an antimetabolite used in the treatment of acute myeloid leukemia (AML). It has many adverse effects as: myelosuppression, toxic reactions involving central nervous system, liver, gastrointestinal tract, eyes or skin. Dermatologic toxicity ... ...

    Titelübersetzung Cytarabine and skin reactions in acute myeloid leukemia.
    Abstract Cytarabine is an antimetabolite used in the treatment of acute myeloid leukemia (AML). It has many adverse effects as: myelosuppression, toxic reactions involving central nervous system, liver, gastrointestinal tract, eyes or skin. Dermatologic toxicity is often described as rare; nevertheless there are differences in the reported frequency. We performed a retrospective study including all AML treated with chemotherapy that involved cytarabine between 1st July of 2006 and 1st July of 2012; 46 patients were included with a median age of 55 years. The overall incidence of skin reactions was 39% (n = 18). Sex, age, history of atopy, history of drug reactions, or dose of cytarabine used, were not associated with them. Skin reactions were observed from 2 to 8 days after treatment started. Considering injury degree: 27.8% had grade 1, 38.9% grade 2 and 33.3% grade 3. We did not find any injury grade 4 or death associated with skin toxicity. As for the type of injury: 55.6% presented macules, 22.2% papules and 22.2% erythema. Lesions distribution was diffuse in 52% of patients, acral in 39.3%, and at flexural level in 8.7%. Adverse cutaneous reactions secondary to the administration of cytarabine are frequent in our service and include some cases with severe involvement. Although these reactions usually resolve spontaneously, they determine an increased risk of infection and a compromise of the patient quality of life.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/adverse effects ; Cytarabine/adverse effects ; Drug Eruptions/etiology ; Drug Eruptions/pathology ; Female ; Humans ; Incidence ; Leukemia, Myeloid, Acute/classification ; Leukemia, Myeloid, Acute/drug therapy ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Statistics, Nonparametric ; Young Adult
    Chemische Substanzen Antimetabolites, Antineoplastic ; Cytarabine (04079A1RDZ)
    Sprache Spanisch
    Erscheinungsdatum 2013
    Erscheinungsland Argentina
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL.

    Prieto, Daniel / Seija, Noé / Uriepero, Angimar / Souto-Padron, Thais / Oliver, Carolina / Irigoin, Victoria / Guillermo, Cecilia / Navarrete, Marcelo A / Inés Landoni, Ana / Dighiero, Guillermo / Gabus, Raúl / Giordano, Mirta / Oppezzo, Pablo

    British journal of haematology

    2018  Band 182, Heft 4, Seite(n) 521–525

    Abstract: Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not ... ...

    Abstract Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL.
    Mesh-Begriff(e) Aged ; Biomarkers, Tumor/biosynthesis ; Female ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Leukemic ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/enzymology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lipoprotein Lipase/biosynthesis ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Prognosis ; RNA, Messenger/biosynthesis ; RNA, Neoplasm/biosynthesis
    Chemische Substanzen Biomarkers, Tumor ; Neoplasm Proteins ; RNA, Messenger ; RNA, Neoplasm ; LPL protein, human (EC 3.1.1.34) ; Lipoprotein Lipase (EC 3.1.1.34)
    Sprache Englisch
    Erscheinungsdatum 2018-06-28
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.15427
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression.

    Prieto, Daniel / Sotelo, Natalia / Seija, Noé / Sernbo, Sandra / Abreu, Cecilia / Durán, Rosario / Gil, Magdalena / Sicco, Estefanía / Irigoin, Victoria / Oliver, Carolina / Landoni, Ana Inés / Gabus, Raúl / Dighiero, Guillermo / Oppezzo, Pablo

    Blood

    2017  Band 130, Heft 6, Seite(n) 777–788

    Abstract: Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clonal B lymphocytes, resulting from a complex balance between cell proliferation and apoptotic death. Continuous crosstalk between cancer cells and local/distant ...

    Abstract Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clonal B lymphocytes, resulting from a complex balance between cell proliferation and apoptotic death. Continuous crosstalk between cancer cells and local/distant host environment is required for effective tumor growth. Among the main actors of this dynamic interplay between tumoral cells and their microenvironment are the nano-sized vesicles called exosomes. Emerging evidence indicates that secretion, composition, and functional capacity of exosomes are altered as tumors progress to an aggressive phenotype. In CLL, no data exist exploring the specific changes in the proteomic profile of plasma-derived exosomes from patients during disease evolution. We hereby report for the first time different proteomic profiles of plasma exosomes, both between indolent and progressive CLLs as well as within the individual patients at the onset of disease and during its progression. Next, we focus on the changes of the exosome protein cargoes, which are found exclusively in patients with progressive CLL after disease progression. The alterations in the proteomic cargoes underline different networks specific for leukemia progression related to inflammation, oxidative stress, and NF-κB and phosphatidylinositol 3-kinase/AKT pathway activation. Finally, our results suggest a preponderant role for the protein S100-A9 as an activator of the NFκB pathway during CLL progression and suggest that the leukemic clone can generate an autoactivation loop through S100-A9 expression, NF-κB activation, and exosome secretion. Collectively, our data propose a new pathway for NF-κB activation in CLL and highlight the importance of exosomes as extracellular mediators promoting tumor progression in CLL.
    Mesh-Begriff(e) Basigin/analysis ; Basigin/immunology ; Calgranulin B/analysis ; Calgranulin B/immunology ; Disease Progression ; Exosomes/immunology ; Exosomes/pathology ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/blood ; Leukemia, Lymphocytic, Chronic, B-Cell/immunology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; NF-kappa B/analysis ; NF-kappa B/immunology ; Proteome/analysis ; Proteome/immunology
    Chemische Substanzen Calgranulin B ; NF-kappa B ; Proteome ; Basigin (136894-56-9)
    Sprache Englisch
    Erscheinungsdatum 2017-06-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-02-769851
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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