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  1. Article ; Online: The Significance of Lipoproteins in the Development of Obesity.

    Blagov, Alexander / Rufanov, Konstantin / Irina, Khokhlova / Sukhorukov, Vasily / Goncharov, Andrey / Pleshko, Elizaveta / Orekhov, Alexander

    Frontiers in bioscience (Scholar edition)

    2024  Volume 16, Issue 1, Page(s) 8

    Abstract: Disruption of lipoprotein metabolism plays an important role in the development of several cardiovascular, inflammatory, and metabolic diseases. This review examines the importance of different types of lipoproteins and the role they play in the ... ...

    Abstract Disruption of lipoprotein metabolism plays an important role in the development of several cardiovascular, inflammatory, and metabolic diseases. This review examines the importance of different types of lipoproteins and the role they play in the development of dyslipidemia in obesity. The causes and consequences associated with the disruption of lipid metabolism and its significance in the pathogenesis of obesity are considered. The relationship between such pathological processes, which occur alongside obesity as dyslipidemia and inflammation, is determined. In view of the current efficacy and toxicity limitations of currently approved drugs, natural compounds as potential therapeutic agents in the treatment of obesity are considered in the review. The complex mechanisms of lipid metabolism normalization in obesity found for these compounds can serve as one of the confirmations of their potential efficacy in treating obesity. Nanoparticles can serve as carriers for the considered drugs, which can improve their pharmacokinetic properties.
    MeSH term(s) Humans ; Lipoproteins/metabolism ; Lipoproteins/therapeutic use ; Obesity/drug therapy ; Obesity/complications ; Dyslipidemias/drug therapy ; Dyslipidemias/metabolism ; Cardiovascular System/metabolism ; Cardiovascular System/pathology ; Inflammation/drug therapy
    Chemical Substances Lipoproteins
    Language English
    Publishing date 2024-03-27
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565100-6
    ISSN 1945-0524 ; 1945-0516
    ISSN (online) 1945-0524
    ISSN 1945-0516
    DOI 10.31083/j.fbs1601008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Haemoplasmas in wild rodents: Routes of transmission and infection dynamics

    Cohen, Carmit / Hadas Hawlena / Irina Khokhlova / Irit Messika / Mario Garrido / Merav Shemesh / Monica Einav / Séverine Tasker

    Molecular ecology. 2018 Sept., v. 27, no. 18

    2018  

    Abstract: The way that some parasites and pathogens persist in the hostile environment of their host for long periods remains to be resolved. Here, longitudinal field surveys were combined with laboratory experiments to investigate the routes of transmission and ... ...

    Abstract The way that some parasites and pathogens persist in the hostile environment of their host for long periods remains to be resolved. Here, longitudinal field surveys were combined with laboratory experiments to investigate the routes of transmission and infection dynamics of such a pathogen—a wild rodent haemotropic bacterium, specifically a Mycoplasma haemomuris‐like bacterium. Fleaborne transmission, direct rodent‐to‐rodent transmission and vertical transmission from fleas or rodents to their offspring were experimentally quantified, and indications were found that the main route of bacterial transmission is direct, although its rate of successful transmission is low (~20%). The bacterium's temporal dynamics was then compared in the field to that observed under a controlled infection experiment in field‐infected and laboratory‐infected rodents, and indications were found, under all conditions, that the bacterium reached its peak infection level after 25–45 days and then decreased to low bacterial loads, which persist for the rodent's lifetime. These findings suggest that the bacterium relies on persistency with low bacterial loads for long‐term coexistence with its rodent host, having both conceptual and applied implications.
    Keywords bacteria ; laboratory experimentation ; microbial load ; Mycoplasma ; parasites ; pathogens ; progeny ; rodents ; Siphonaptera ; surveys ; temporal variation
    Language English
    Dates of publication 2018-09
    Size p. 3714-3726.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1126687-9
    ISSN 1365-294X ; 0962-1083
    ISSN (online) 1365-294X
    ISSN 0962-1083
    DOI 10.1111/mec.14826
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/723: Show issues

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  3. Article: The effect of host density on ectoparasite distribution: an example of a rodent parasitized by fleas

    Krasnov, Boris / Georgy Shenbrot / Irina Khokhlova

    Ecology. 2002 Jan., v. 83, no. 1

    2002  

    Abstract: The pattern of parasitism of the flea species Xenopsylla dipodilli and Nosopsyllus iranus theodori on the desert rodent species Gerbillus dasyurus was studied to test the hypothesis that the relationships between flea abundance and host density conform ... ...

    Abstract The pattern of parasitism of the flea species Xenopsylla dipodilli and Nosopsyllus iranus theodori on the desert rodent species Gerbillus dasyurus was studied to test the hypothesis that the relationships between flea abundance and host density conform to pre‐existing models of R. M. Anderson and R. M. May, with the correction that the density of those host individuals that possess permanent burrows (residents) is substituted for the overall host density. It was predicted that: (1) the intensity of flea infestation would increase in curvilinear fashion with increase of host density to a plateau that would be attained at a lower level of host density than would be expected from the basic model, and (2) the prevalence of flea infestation plotted against host density would be hump‐shaped. The results indicated that intensity of flea infestation increased in either curvilinear fashion to an asymptote (for X. dipodilli) or linearly (for N. i. theodori) with increase of host density. As host density increased, the prevalence of infestation changed either unimodally (X. dipodilli) or logarithmically (N. i. theodori). In addition, there was a positive relationship between the mean number of fleas per host and the percentage of hosts infested. Both basic and corrected models describing the relationships between flea burden and host density fit the observational data well. However, simulations of the fraction of resident hosts demonstrated that this parameter influences the relationship between host density and flea burden only when residents comprise ≤50% of all host individuals.
    Keywords burrows ; ectoparasites ; Gerbillus ; hosts ; insect infestations ; models ; Nosopsyllus ; parasitism ; rodents ; Xenopsylla
    Language English
    Dates of publication 2002-01
    Size p. 164-175.
    Publishing place Ecological Society of America
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1797-8
    ISSN 0012-9658
    ISSN 0012-9658
    DOI 10.1890/0012-9658(2002)083%5B0164:TEOHDO%5D2.0.CO;2
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/37: Show issues
    Z 7543: Show issues

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