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Article ; Online: Pharmacological evaluation of carvacrol anti-migraine potential.

Anwar, Spogmay / Khan, Arif-Ullah / Irshad, Nadeem

Naunyn-Schmiedeberg's archives of pharmacology

2023 Volume 396, Issue 6, Page(s) 1309–1324

Abstract: Migraine is a devitalizing neurovascular disorder that affects millions of people worldwide. This study was directed against the determination of the effectiveness of carvacrol against migraine. In silico results revealed that carvacrol possesses ... ...

Abstract	Migraine is a devitalizing neurovascular disorder that affects millions of people worldwide. This study was directed against the determination of the effectiveness of carvacrol against migraine. In silico results revealed that carvacrol possesses specific scoring values of - 4.4 to - 6 against selected targets. In vivo studies showed that carvacrol (25-50 mg/Kg) decreased migraine pain by reversing thermal allodynia, mechanical allodynia, number of head-scratching, and light phobicity in rats. Levels of glutathione, glutathione-s-transferase, and catalase enhanced in the cortex and trigeminal nucleus caudalis of the animal's brain tissues, i.e., cortex and trigeminal nucleus caudalis with the use of carvacrol, while a significant decrease in lipid peroxide level was seen. Histopathological evaluation showed improvement in cellular architecture and a decrease in expression of certain inflammatory markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interleukin-18, and prostaglandin E2 validated by enzyme-linked immune sorbent assay, immunohistochemistry, and western blot analysis. This study indicates that carvacrol exhibits binding affinities against different targets involved in migraine pathology and possesses anti-migraine action, mediated through anti-inflammatory and anti-oxidant pathways.
MeSH term(s)	Rats ; Animals ; Cymenes ; Migraine Disorders/drug therapy ; Hyperalgesia ; Glutathione
Chemical Substances	carvacrol (9B1J4V995Q) ; Cymenes ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121471-8
ISSN	1432-1912 ; 0028-1298
ISSN (online)	1432-1912
ISSN	0028-1298
DOI	10.1007/s00210-023-02412-w
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Article: Blood pressure lowering effect of selected pyrimidine derivatives mediated through inhibition of calcium channel: A computational approach.

Irshad, Nadeem / Khan, Arif-Ullah / Kamal, Yousaf / Iqbal, Muhammad Nasir

Pakistan journal of pharmaceutical sciences

2023 Volume 35, Issue 6, Page(s) 1513–1522

Abstract: Pyrimidine 2, 4, 6-trione derivatives are known to have L-type calcium channel blockade activity due to which they are quite effective in cardiovascular diseases along with cancer, epilepsy and inflammatory disorders. The chemoinformatics prediction for ... ...

Abstract	Pyrimidine 2, 4, 6-trione derivatives are known to have L-type calcium channel blockade activity due to which they are quite effective in cardiovascular diseases along with cancer, epilepsy and inflammatory disorders. The chemoinformatics prediction for test compounds: 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) was investigated. The drug likeliness and pharmacokinetic properties (PKs) of test compounds calculated using Molinspiration & Swiss ADME online servers. These test drugs subjected to molecular docking analysis and molecular dynamic (MD) simulation to calculate their binding energies with hypertensive and platelet aggregatory proteinaceous targets and their stability against calcium channel. The druggability and PKs of selected compounds exhibited that these compounds could be represented as potential candidates for further development into antihypertensive-like agents. The docking results indicated that binding energies ranged between -5 and -8.8 kcal/mol. Compounds showed good binding energies against calcium channels (CC) and subjected to molecular dynamic simulation to assess the stability of protein-ligand complex. The results showed that all the ligands form stable complexes with the CC, though SR-9 and SR-10 had enhanced stability when compared to SR-5 and SR-8.
MeSH term(s)	Calcium Channels ; Antihypertensive Agents/pharmacology ; Molecular Docking Simulation ; Blood Pressure ; Pyrimidines/pharmacology
Chemical Substances	Calcium Channels ; Antihypertensive Agents ; Pyrimidines
Language	English
Publishing date	2023-02-15
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article: Design, synthesis and screening of indole acetic acid-based tri-azo moieties as antioxidants, anti-microbial and cytotoxic agents.

Javaid, Maryam / Haq, Ihsan-Ul / Nadeem, Humaira / Fatima, Humaira / Khan, Arif-Ullah / Irshad, Nadeem

Frontiers in pharmacology

2023 Volume 14, Page(s) 1084181

Abstract: Multidrug resistance and infectious disease have enormous spread despite drug discovery and development advancements. 1, 2, 4 -triazoles have been extensively studied, playing an imperative role in many pathologic conditions. A series of Schiff base ... ...

Abstract	Multidrug resistance and infectious disease have enormous spread despite drug discovery and development advancements. 1, 2, 4 -triazoles have been extensively studied, playing an imperative role in many pathologic conditions. A series of Schiff base triazoles; derived from Indole -3- acetic acid with substituted Benzaldehydes (5a-5g) were designed, synthesized, and evaluated through various Spectroanalytical techniques. SwissADME was used to assess physicochemical properties and pharmacokinetic drug-likeliness behavior. (5a-5g) were evaluated for their varied biological potential through antioxidant, antimicrobial, enzyme inhibition, and cytotoxic evaluation. Schiff bases express drug-like nature as they follow Lipinski's rule of five.
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1084181
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Article ; Online: Pharmacological evaluation of newly synthesized organotin IV complex for antiulcer potential.

Azmatullah, Syed / Khan, Arif-Ullah / Qazi, Neelam Gul / Nadeem, Humaira / Irshad, Nadeem

BMC pharmacology & toxicology

2022 Volume 23, Issue 1, Page(s) 58

Abstract: The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2'E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characterization performed by carbon nuclear magnetic ... ...

Abstract	The present study aims to investigate the newly synthesized organotin (IV) complex (2E, 2'E) dibutylstannanediyl bis (4-(4-nitrophenyl) amino)-4-oxobut-2-enoate (DTN) for its anti-ulcer potential. Characterization performed by carbon nuclear magnetic resonance spectroscopy proved that all values are in the expected ranges of the new compound. Gastroprotective activity of DTN was evaluated through in-silico, anti-H. pylori, in-vitro, in-vivo, and ex-vivo proteomic analysis. In-silico analysis shows that DTN possess stable binding with protein targets involved in gastric ulcer pathophysiology. DTN exhibited an inhibitory effect against 2,2-diphenyl-1-picrylhydrazyl, H. pylori and hydrogen potassium ATPase (H
MeSH term(s)	Animals ; Anti-Ulcer Agents/pharmacology ; Anti-Ulcer Agents/therapeutic use ; Antioxidants/pharmacology ; H(+)-K(+)-Exchanging ATPase/metabolism ; Helicobacter pylori/metabolism ; Proteomics ; Proton Pump Inhibitors/pharmacology ; Proton Pump Inhibitors/therapeutic use ; Rats ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/pathology
Chemical Substances	Anti-Ulcer Agents ; Antioxidants ; Proton Pump Inhibitors ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10)
Language	English
Publishing date	2022-07-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-022-00596-0
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Article ; Online: Pharmacological evaluation of newly synthesized benzimidazole derivative for anti-Alzheimer potential.

Ahmed, Aleeza / Khan, Arif-Ullah / Nadeem, Humaira / Imran, Muhammad / Irshad, Nadeem

The International journal of neuroscience

2022 , Page(s) 1–17

Abstract: Backgound: ...

Abstract	Backgound:
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3061-2
ISSN	1563-5279 ; 1543-5245 ; 0020-7454
ISSN (online)	1563-5279 ; 1543-5245
ISSN	0020-7454
DOI	10.1080/00207454.2022.2138382
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Article: Characterization and comparative evaluation of wound healing potential of Ajugarin I and

Wasti, Yusra / Muntaqua, Durdana / Majid, Muhammad / Naz, Iffat / Zafar, Aroosa / Khan, Safir Ullah / Kazmi, Syeda Tayyaba Batool / Rehman, Tofeeq Ur / Irshad, Nadeem / Fatima, Humaira

Frontiers in chemistry

2024 Volume 11, Page(s) 1325578

Abstract: ... Ajuga ... ...

Abstract	Ajuga bracteosa
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1325578
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Article ; Online: Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways.

Irshad, Nadeem / Khan, Arif-Ullah / Alamgeer / Khan, Salah-Ud-Din / Iqbal, Muhammad Shahid

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 139, Page(s) 111567

Abstract: This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)- ... ...

Abstract	This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hypertension. In deoxycorticosterone acetate-salt rats, SR-5, SR-8, SR-9, and SR-10 reduced blood pressure and normalized renal functions. In isolated rat aortic rings, SR-5, SR-8, SR-9, and SR-10 relaxed phenylephrine (PE) and K
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Antioxidants/pharmacology ; Aorta/drug effects ; Calcium/pharmacology ; Desoxycorticosterone ; Female ; Guinea Pigs ; Humans ; Hypertension/chemically induced ; Hypertension/drug therapy ; Kidney Function Tests ; Male ; Mice ; Muscle Contraction/drug effects ; Muscle, Smooth, Vascular/drug effects ; Myocardial Contraction/drug effects ; Phenylephrine/pharmacology ; Platelet Aggregation/drug effects ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Vasodilator Agents/pharmacology
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Antihypertensive Agents ; Antioxidants ; Pyrimidines ; Vasodilator Agents ; Phenylephrine (1WS297W6MV) ; Desoxycorticosterone (40GP35YQ49) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-04-10
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.111567
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Article ; Online: Comparative appraisal of in vitro biological profile and in vivo wound healing attributes of bergenin and Bergenia ciliata (Haw.) Sternb.

Faiz, Sidra / Waseem, Durdana / Haq, Ihsan-Ul / Taqi, Malik Mumtaz / Mohsin, Syeda Aroosa / Irshad, Nadeem / Phull, Abdul Rehman / Fatima, Humaira

Journal of ethnopharmacology

2022 Volume 304, Page(s) 115993

Abstract: Ethnopharmacological relevance: People of all ages experience injuries, whether mild or severe. The most available option to treat wounds as an alternative to allopathic care in both urban and rural populations is traditional medicine, which is mostly ... ...

Abstract	Ethnopharmacological relevance: People of all ages experience injuries, whether mild or severe. The most available option to treat wounds as an alternative to allopathic care in both urban and rural populations is traditional medicine, which is mostly target inflammation. Bergenia ciliata (Haw.) Sternb rhizome and leaf powder are used in Ayurveda and local communities for various ailments including healing of wounds and burns. Owing to this property it is traditionally known as "Zakham-e-hayat" (wound healer). Aim of the study: In the present study, we compared biological activity and wound healing potential of B. ciliata rhizome (R) extract and bergenin, a glycoside isolated from B. ciliata. Materials and methods: Reverse-phase high performance liquid chromatography (RP-HPLC) was performed to analyze polyphenols and bergenin in B. ciliata R extract. Samples were subjected to in vitro antioxidant assays including free radical scavenging, ferric chloride reducing power and total antioxidant capacity. Micro-broth dilution method, brine shrimp lethality assay and isolated RBC hemolysis assay were conducted to assess in vitro antibacterial and cytotoxic activities. Moreover, in vivo wound healing potential was determined by an excision wound model in mice. Results: RP-HPLC showed significant content of polyphenols and bergenin (6.05 ± 0.12 μg/mg) in B. ciliata R extract. Crude extract possesses higher overall antioxidant and antibacterial capacities than bergenin due to presence of multiple phytoconstituents in extract. Both samples showed low hemolytic activity indicating their safe profile. Furthermore, mice treated with B. ciliata R extract depicted substantial decrease in wound area (99.3%; p < 0.05) as compared to bergenin, which showed 88.8% of wound closure after 12 days of treatment. Additionally, both treatments reduced epithelization duration by 1.6- and 1.4-fold in B. ciliata R extract (12.0 ± 0.6 days) and bergenin (14.2 ± 0.8 days) treated mice, respectively. This was supported by histopathological examination that showed greater epithelization, fibroblast proliferation, collagen synthesis, and revascularization in mice treated with B. ciliata R. Conclusion: Concisely, it is evident that B. ciliata R contains phytoconstituents in addition to bergenin, which potentiated wound healing activity of the extract. Hence, B. ciliata R is good source of compounds for treating wounds.
MeSH term(s)	Mice ; Animals ; Antioxidants/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Benzopyrans/pharmacology ; Benzopyrans/therapeutic use ; Saxifragaceae/chemistry ; Polyphenols ; Anti-Bacterial Agents/pharmacology
Chemical Substances	bergenin (L84RBE4IDC) ; Antioxidants ; Plant Extracts ; Benzopyrans ; Polyphenols ; Anti-Bacterial Agents
Language	English
Publishing date	2022-12-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115993
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Article ; Online: Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury.

Khan, Adnan / Shal, Bushra / Naveed, Muhammad / Nasir, Bakht / Irshad, Nadeem / Ali, Hussain / Khan, Salman

Psychopharmacology

2020 Volume 237, Issue 8, Page(s) 2327–2343

Abstract: Rationale: The c-Jun N-terminal kinase (JNK) pathway and neurotrophic factor dysregulation play a critical role in the pathogenesis of neurobehavioral disorders (anxiety and depression). Targeting the JNK pathway and BDNF/VEGF signaling may signify a ... ...

Abstract	Rationale: The c-Jun N-terminal kinase (JNK) pathway and neurotrophic factor dysregulation play a critical role in the pathogenesis of neurobehavioral disorders (anxiety and depression). Targeting the JNK pathway and BDNF/VEGF signaling may signify a new avenue for the treatment of neurobehavioral disorders. Objectives: The present study investigated the effect of matrine (Mat) against anxiety- and depressive-like emotional status in an acute mouse model of burn injury and explores its underlying mechanism. Methods: In the mouse model of thermal injury, anxiety- and depression-related behaviors were evaluated using the elevated plus-maze test, the light-dark box test, the open-field test, the forced swimming test, and the tail suspension test. The JNK/caspase-3 and BDNF/VEGF proteins were determined by immunohistochemistry. Additionally, proinflammatory cytokine, antioxidant, nitric oxide, and corticosterone levels were also measured. Results: The results showed that treatment with Mat significantly improves anxiety- and depressive-like behaviors. It remarkably reduced the levels of proinflammatory cytokines, malondialdehyde, and nitric oxide in the hippocampus and prefrontal cortex of a mouse brain. It considerably improved burn-induced alteration in the antioxidant status, corticosterone, and BDNF/VEGF. It also inhibited burn-induced apoptotic signaling by downregulating the expression of JNK/caspase-3. Similarly, it prevented DNA damage and histopathological changes in the dentate gyrus of the hippocampus. Furthermore, molecular docking results showed that Mat possess better binding affinity for JNK/caspase-3 and BDNF/VEGF proteins. Conclusions: These findings provide convincing evidence that Mat improves anxiety- and depressive-like emotional status through modulation of JNK-mediated inflammatory, oxidative stress, apoptotic, and BDNF/VEGF signaling in an acute mouse model of burn injury.
MeSH term(s)	Alkaloids/metabolism ; Alkaloids/pharmacology ; Alkaloids/therapeutic use ; Animals ; Anti-Anxiety Agents/metabolism ; Anti-Anxiety Agents/pharmacology ; Anti-Anxiety Agents/therapeutic use ; Anxiety/drug therapy ; Anxiety/metabolism ; Brain-Derived Neurotrophic Factor/antagonists & inhibitors ; Brain-Derived Neurotrophic Factor/metabolism ; Burns/drug therapy ; Burns/metabolism ; Caspase 3/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Mice ; Molecular Docking Simulation/methods ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Quinolizines/metabolism ; Quinolizines/pharmacology ; Quinolizines/therapeutic use ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Alkaloids ; Anti-Anxiety Agents ; Bdnf protein, mouse ; Brain-Derived Neurotrophic Factor ; Quinolizines ; Vascular Endothelial Growth Factor A ; vascular endothelial growth factor A, mouse ; Caspase 3 (EC 3.4.22.-) ; matrine (N390W430AC)
Language	English
Publishing date	2020-05-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-020-05537-5
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Article ; Online: Thymus linearis

Younatan, Yamema / Majid, Muhammad / Phull, Abdul Rehman / Baig, Muhammad Waleed / Irshad, Nadeem / Fatima, Humaira / Nasir, Bakht / Zafar, Aroosa / Majid, Abdul / Parveen, Amna / Haq, Ihsan-Ul

Oxidative medicine and cellular longevity

2023 Volume 2023, Page(s) 5648837

Abstract: Materials and methods: The extract library (n-hexane (NH), ethyl acetate (EA), methanol (M), distilled water (DW), and combined extract (CE)) was standardized using : Results: Phytochemical analysis including RP-HPLC analysis of the extracts showed ... ...

Abstract	Materials and methods: The extract library (n-hexane (NH), ethyl acetate (EA), methanol (M), distilled water (DW), and combined extract (CE)) was standardized using Results: Phytochemical analysis including RP-HPLC analysis of the extracts showed that flavonoids and phenolics (myricetin, kaempferol, and apigenin), previously known to be effective against obesity and diabetes, are present in the extracts. Antioxidant studies revealed that the plant possesses a highly significant ( Conclusion: In principle, the current study's findings scientifically validate the implication of
MeSH term(s)	Rats ; Animals ; Antioxidants/metabolism ; Rats, Sprague-Dawley ; Metabolic Syndrome/metabolism ; Insulin Resistance ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Oxidative Stress ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytochemicals/metabolism ; alpha-Amylases/metabolism ; Liver/metabolism
Chemical Substances	Antioxidants ; Plant Extracts ; Phytochemicals ; alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2023/5648837
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