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  1. Book: Biomedical nanosensors

    Irudayaraj, Joseph

    (Pan Stanford series on biomedical nanotechnology ; 3)

    2013  

    Author's details Joseph Irudayaraj ed
    Series title Pan Stanford series on biomedical nanotechnology ; 3
    Collection
    Keywords Nanotechnologie ; Biomedizinische Technik
    Subject BMT ; Biomedical engineering ; Biomedizintechnik ; Submikrometertechnik ; Submikron-Technologie ; Nanotechnik ; Nanostrukturtechnik
    Language English
    Size XII, 384 S., S. C2 - C12 : Ill., graph. Darst.
    Publisher Pan Stanford Publ
    Publishing place Singapore
    Publishing country Singapore
    Document type Book
    HBZ-ID HT016951079
    ISBN 978-981-4303-03-3 ; 981-4303-03-8 ; 9789814303040 ; 9814303046
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 5945 order for loan Magazin

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  2. Book: Nondestructive testing of food quality

    Irudayaraj, Joseph

    (IFT Press series)

    2008  

    Author's details ed.: Joseph Irudayaraj
    Series title IFT Press series
    Keywords Food industry and trade/Quality control ; Food adulteration and inspection ; Food/Nondestructive testing
    Subject code 664.07
    Language English
    Size XIII, 364 S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Blackwell u.a.
    Publishing place Ames, Iowa u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014899742
    ISBN 0-8138-2885-6 ; 978-0-8138-2885-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    078/1882 available for loan (reading room) Freihandmagazin (U1)

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  3. Book: Food processing operations modeling

    Irudayaraj, Joseph

    design and analysis

    (Food science and technology ; 107)

    2001  

    Author's details ed. by Joseph Irudayaraj
    Series title Food science and technology ; 107
    Collection
    Keywords Lebensmittelverarbeitung ; Modell
    Subject Lebensmittel
    Language English
    Size VIII, 347 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT012971997
    ISBN 0-8247-0488-6 ; 978-0-8247-0488-9
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    008/3043 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Hierarchical encapsulation of bacteria in functional hydrogel beads for inter- and intra- species communication.

    Jeong, Yoon / Irudayaraj, Joseph

    Acta biomaterialia

    2023  Volume 158, Page(s) 203–215

    Abstract: To sequester prokaryotic cells in a biofilm-like niche, the creation of a pertinent and reliable microenvironment that reflects the heterogeneous nature of biological systems is vital for sustenance. Design of a microenvironment that is conducive for ... ...

    Abstract To sequester prokaryotic cells in a biofilm-like niche, the creation of a pertinent and reliable microenvironment that reflects the heterogeneous nature of biological systems is vital for sustenance. Design of a microenvironment that is conducive for growth and survival of organisms, should account for factors such as mass transport, porosity, stability, elasticity, size, functionality, and biochemical characteristics of the organisms in the confined architecture. In this work we present an artificial long-term confinement model fabricated by natural alginate hydrogels that are structurally stable and can host organisms for over 10 days in physiologically relevant conditions. A unique feature of the confinement platform is the development of stratified habitats wherein bacterial cells can be entrapped in the core as well as in the shell layers, wherein the thickness and the number of shell layers are tunable at fabrication. We show that the hydrogel microenvironment in the beads can host complex subpopulations of organisms similar to that in a biofilm. Dynamic interaction of bacterial colonies encapsulated in different beads or within the core and stratified layers of single beads was demonstrated to show intra- species communication. Inter- species communication between probiotic bacteria and human colorectal carcinoma cells was also demonstrated to highlight a possible bidirectional communication between the organisms in the beads and the environment. STATEMENT OF SIGNIFICANCE: Bacteria confinement in a natural soft hydrogel structure has always been a challenge due to the collapse of hydrogel architectures. Alternative methods have been attempted to encapsulate microorganisms by employing various processes to avoid/minimize rupturing of hydrogel structures. However, most of the past approaches have been unfavorable in balancing cell proliferation and functionality upon confinement. Our study addresses the fundamental gap in knowledge necessary to create favorable and complex 3D biofilm mimics utilizing natural hydrogel for microbial colonization for long-term studies. Our approach represents a cornerstone in the development of 3D functional architectures not only to advance studies in microbial communication, host-microbe interaction but also to address basic and fundamental questions in biology.
    MeSH term(s) Humans ; Hydrogels/chemistry ; Alginates/chemistry ; Bacteria ; Elasticity
    Chemical Substances Hydrogels ; Alginates
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2023.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article ; Online: Dynamic Effect of β-Lactam Antibiotic Inactivation Due to the Inter- and Intraspecies Interaction of Drug-Resistant Microbes.

    Jeong, Yoon / Ahmad, Saeed / Irudayaraj, Joseph

    ACS biomaterials science & engineering

    2024  Volume 10, Issue 3, Page(s) 1461–1472

    Abstract: The presence of β-lactamase positive microorganisms imparts a pharmacological effect on a variety of organisms that can impact drug efficacy by influencing the function or composition of bacteria. Although studies to assess dynamic intra- and ... ...

    Abstract The presence of β-lactamase positive microorganisms imparts a pharmacological effect on a variety of organisms that can impact drug efficacy by influencing the function or composition of bacteria. Although studies to assess dynamic intra- and interspecies communication with bacterial communities exist, the efficacy of drug treatment and quantitative assessment of multiorganism response is not well understood due to the lack of technological advances that can be used to study coculture interactions in a dynamic format. In this study, we investigate how β-lactamase positive microorganisms can neutralize the effect of β-lactam antibiotics in a dynamic format at the inter- and intraspecies level using microbial bead technology. Three interactive models for the biological compartmentalization of organisms were demonstrated to evaluate the effect of β-lactam antibiotics on coculture systems. Our model at the intraspecies level attempts to mimic the biofilm matrix more closely as a community-level feature of microorganisms, which acknowledges the impact of nondrug-resistant species in shaping the dynamic response. In particular, the results of intraspecies studies are highly supportive of the biofilm mode of bacterial growth, which can provide structural support and protect the bacteria from an assault on host or environmental factors. Our findings also indicate that β-lactamase positive bacteria can neutralize the cytotoxic effect of β-lactam antibiotics at the interspecies level when cocultured with cancer cells. Results were validated using β-lactamase positive bacteria isolated from environmental niches, which can trigger phenotypical alteration of β-lactams when cocultured with other organisms. Our compartmentalization strategy acts as an independent ecosystem and provides a new avenue for multiscale studies to assess intra- and interspecies interactions.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Ecosystem ; beta-Lactamases/chemistry ; beta-Lactams/pharmacology ; beta-Lactams/chemistry ; Monobactams ; Bacteria ; beta Lactam Antibiotics
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6) ; beta-Lactams ; Monobactams ; beta Lactam Antibiotics
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.3c01678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Magnetic Control-Enhanced Lateral Flow Technique for Ultrasensitive Nucleic Acid Target Detection.

    Ren, Wen / Irudayaraj, Joseph

    ACS omega

    2022  Volume 7, Issue 33, Page(s) 29204–29210

    Abstract: In this work, a lateral flow (LF)-based detection strategy termed magnetic control-enhanced LFA (MCLF) was proposed to detect nucleic acid sequences at attomolar sensitivity. In the proposed MCLF method, magnetic controllers which are magnetic ... ...

    Abstract In this work, a lateral flow (LF)-based detection strategy termed magnetic control-enhanced LFA (MCLF) was proposed to detect nucleic acid sequences at attomolar sensitivity. In the proposed MCLF method, magnetic controllers which are magnetic nanoparticles modified with antibodies against the labels on capture sequences were used to interact with the unreacted labeled capture sequence (CS-label) to improve the detection limit. By regulating the movement of magnetic probes (magnetic controllers) with a simple magnet under the lateral flow strip, the movement of magnetic probes bounded with unreacted CS-label in the sample flow could be reduced. Therefore, the target sequence-containing sandwich structures will arrive at the test zone prior, to interact with the recognition ligands, whereby the capture efficiency of the sandwich structures could be increased because the unreacted capture sequences at the test zone will be reduced. With the colorimetric signal from gold nanoparticle-based probes, the proposed MCLF technique could recognize as low as 100 aM of DNA target sequences by naked eyes, and the responding range of MCLF is from 100 aM to 10 pM.
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c03276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Multi-layered alginate hydrogel structures and bacteria encapsulation.

    Jeong, Yoon / Irudayaraj, Joseph

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 61, Page(s) 8584–8587

    Abstract: We show the design and fabrication of finely tuned alginate core-shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while ...

    Abstract We show the design and fabrication of finely tuned alginate core-shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while maintaining morphology and mechanical stability of the bead without rupturing and cell leakage.
    MeSH term(s) Alginates/chemistry ; Bacteria ; Capsules/chemistry ; Hydrogels
    Chemical Substances Alginates ; Capsules ; Hydrogels
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01187e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Multi-layered alginate hydrogel structures and bacteria encapsulation

    Jeong, Yoon / Irudayaraj, Joseph

    Chemical communications. 2022 July 28, v. 58, no. 61

    2022  

    Abstract: We show the design and fabrication of finely tuned alginate core–shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while ...

    Abstract We show the design and fabrication of finely tuned alginate core–shell capsules with precisely controllable core and hierarchical shell thickness at micron scale for scaleup for mass production. The method developed was used to encapsulate bacteria while maintaining morphology and mechanical stability of the bead without rupturing and cell leakage.
    Keywords alginates ; encapsulation ; hydrogels
    Language English
    Dates of publication 2022-0728
    Size p. 8584-8587.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc01187e
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: In vitro toxicity of Lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) on Human Renal and Hepatoma Cells.

    Zhang, Xing / Sands, Mia / Lin, Mindy / Guelfo, Jennifer / Irudayaraj, Joseph

    Toxicology reports

    2024  Volume 12, Page(s) 280–288

    Abstract: We evaluate the cytotoxicity, intracellular redox conditions, apoptosis, and methylation ... ...

    Abstract We evaluate the cytotoxicity, intracellular redox conditions, apoptosis, and methylation of
    Language English
    Publishing date 2024-03-01
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2805786-7
    ISSN 2214-7500 ; 2214-7500
    ISSN (online) 2214-7500
    ISSN 2214-7500
    DOI 10.1016/j.toxrep.2024.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterizing Spray-Dried Powders through NIR Spectroscopy: Effect of Two Preparation Strategies for Calibration Samples and Comparison of Two Types of NIR Spectrometers

    Tu, Zhiyang (Stan) / Irudayaraj, Joseph / Lee, Youngsoo

    Foods. 2023 Jan. 19, v. 12, no. 3

    2023  

    Abstract: Emerging portable near infrared (NIR) spectroscopic approaches coupled with data analysis and chemometric techniques provide opportunities for the rapid characterization of spray-dried products and process optimization. This study aimed to enhance the ... ...

    Abstract Emerging portable near infrared (NIR) spectroscopic approaches coupled with data analysis and chemometric techniques provide opportunities for the rapid characterization of spray-dried products and process optimization. This study aimed to enhance the understanding of applying NIR spectroscopy in spray-dried samples by comparing two sample preparation strategies and two spectrometers. Two sets of whey protein–maltodextrin matrixes, one with a protein content gradient and one with a consistent protein content, were spray-dried, and the effect of the two preparation strategies on NIR calibration model development was studied. Secondly, a portable NIR spectrometer (PEAK) was compared with a benchtop NIR spectrometer (CARY) for the moisture analysis of prepared samples. When validating models with the samples with focused protein contents, the best PLS protein models established from the two sample sets had similar performances. When comparing two spectrometers, although CARY outperformed PEAK, PEAK still demonstrated reliable performance for moisture analysis, indicating that it is capable as an inline sensor.
    Keywords chemometrics ; near-infrared spectroscopy ; protein content ; spectrometers ; spray drying ; whey
    Language English
    Dates of publication 2023-0119
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12030467
    Database NAL-Catalogue (AGRICOLA)

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