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  1. Article ; Online: Perioperative Care in Patients with Chronic Liver Disease: What Can We Do More?

    Droc, Gabriela / Isac, Sebastian

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Chronic liver diseases represent a prevalent pathology that exerts considerable pressure on healthcare providers and various healthcare systems worldwide [ ... ]. ...

    Abstract Chronic liver diseases represent a prevalent pathology that exerts considerable pressure on healthcare providers and various healthcare systems worldwide [...].
    MeSH term(s) Humans ; Health Personnel ; Perioperative Care ; Liver Diseases
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Orthotopic Liver Transplantation of a SARS-CoV-2 Negative Recipient from a Positive Donor: The Border between Uncertainty and Necessity in a Pandemic Era- Case Report and Overview of the Literature.

    Droc, Gabriela / Martac, Cristina / Buzatu, Cristina Georgiana / Jipa, Miruna / Punga, Maria Daniela / Isac, Sebastian

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 5

    Abstract: 1) ...

    Abstract (1)
    MeSH term(s) Adult ; Female ; Humans ; Young Adult ; Antibodies, Neutralizing ; COVID-19 ; Liver Transplantation ; Pandemics/prevention & control ; SARS-CoV-2 ; Uncertainty
    Chemical Substances Antibodies, Neutralizing
    Language English
    Publishing date 2023-04-26
    Publishing country Switzerland
    Document type Case Reports ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Epigenetics in inflammatory liver diseases: A clinical perspective (Review).

    Isac, Teodora / Isac, Sebastian / Rababoc, Razvan / Cotorogea, Mihail / Iliescu, Laura

    Experimental and therapeutic medicine

    2022  Volume 23, Issue 5, Page(s) 366

    Abstract: Inflammatory liver diseases are, nowadays, multifactorial and wide-spread, thus having an important socio-economic impact. Although the therapeutic algorithms are well-known in hepatitis, regardless of etiology, strategies to identify inflammatory ... ...

    Abstract Inflammatory liver diseases are, nowadays, multifactorial and wide-spread, thus having an important socio-economic impact. Although the therapeutic algorithms are well-known in hepatitis, regardless of etiology, strategies to identify inflammatory hepatic lesions in early stages and to develop new epigenetic therapies should be prioritized. The main entities of inflammatory liver disease are: alcoholic and non-alcoholic fatty liver disease, autoimmune hepatitis, viral hepatitis and Wilson disease. The main epigenetic processes include: DNA methylation/demethylation, which imply changes in DNA tertiary structure; post-translational histone covalent changes (methylation/demethylation, acetylation/deacetylation, ubiquitination), that cause DNA-histone instability; synthesis of small, non-coding RNA molecules, called microRNAs, that modulate translational potential of transcripts (mRNAs) and post-translational modification of polypeptide chains. Consequently, the epigenetic interactions aforementioned, play an important modulatory role in disease progression and response to conventional therapies The present review focused on the main epigenetic changes in inflammatory liver conditions, considering a new perspective: Epigenetic therapy. This approach is more than welcomed, taking into consideration that conventional therapeutic strategies are almost exhausted.
    Language English
    Publishing date 2022-04-04
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2022.11293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biodetoxification Using Intravenous Lipid Emulsion, a Rescue Therapy in Life-Threatening Quetiapine and Venlafaxine Poisoning: A Case Report.

    Cobilinschi, Cristian / Mirea, Liliana / Andrei, Cosmin-Andrei / Ungureanu, Raluca / Cotae, Ana-Maria / Avram, Oana / Isac, Sebastian / Grințescu, Ioana Marina / Țincu, Radu

    Toxics

    2023  Volume 11, Issue 11

    Abstract: The administration of intravenous lipid emulsion (ILE) is a proven antidote used to reverse local anesthetic-related systemic toxicity. Although the capacity of ILE to generate blood tissue partitioning of lipophilic drugs has been previously ... ...

    Abstract The administration of intravenous lipid emulsion (ILE) is a proven antidote used to reverse local anesthetic-related systemic toxicity. Although the capacity of ILE to generate blood tissue partitioning of lipophilic drugs has been previously demonstrated, a clear recommendation for its use as an antidote for other lipophilic drugs is still under debate. Venlafaxine (an antidepressant acting as a serotonin-norepinephrine reuptake inhibitor (SNRI)) and quetiapine (a second-generation atypical antipsychotic) are widely used in the treatment of psychotic disorders. Both are lipophilic drugs known to induce cardiotoxicity and central nervous depression. We report the case of a 33-year-old man with a medical history of schizoaffective disorder who was admitted to the emergency department (ED) after having been found unconscious due to a voluntary ingestion of 12 g of quetiapine and 4.5 g of venlafaxine. Initial assessment revealed a cardiorespiratory stable patient but unresponsive with a GCS of 4 (M2 E1 V1). In the ED, he was intubated, and gastric lavage was performed. Immediately after the admission to the intensive care unit (ICU), his condition quickly deteriorated, developing cardiovascular collapse refractory to crystalloids and vasopressor infusion. Junctional bradycardia occurred, followed by spontaneous conversion to sinus rhythm. Subsequently, frequent ventricular extrasystoles, as well as patterns of bigeminy, trigeminy, and even episodes of non-sustained ventricular tachycardia, occurred. Additionally, generalized tonic-clonic seizures were observed. Alongside supportive therapy, antiarrhythmic and anticonvulsant therapy, intravenous lipid emulsion bolus, and continuous infusion were administered. His condition progressively improved over the following hours, and 24 h later, he was tapered off the vasopressor. On day 2, the patient repeated the cardiovascular collapse and a second dose of ILE was administered. Over the next few days, the patient's clinical condition improved, and he was successfully weaned off ventilator and vasopressor support. ILE has the potential to become a form of rescue therapy in cases of severe lipophilic drug poisoning and should be considered a viable treatment for severe cardiovascular instability that is refractory to supportive therapy.
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11110917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Omics Complexity in Sepsis: The Limits of the Personalized Medicine Approach.

    Isac, Sebastian / Isac, Teodora / Tanasescu, Maria Daniela / Pavel, Bogdan / Andreescu, Cristina Veronica / Badea, Andrada-Georgiana / Ojog, Damiana / Teodorescu, Geani-Danut / Laceanu, Anca / Trifan, Cristian-Bogdan / Droc, Gabriela

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the remarkable advances in modern medicine throughout the last century, the mortality rates associated with sepsis have remained significantly elevated, both in high- ... ...

    Abstract Sepsis is one of the most common causes of morbidity and mortality worldwide. Despite the remarkable advances in modern medicine throughout the last century, the mortality rates associated with sepsis have remained significantly elevated, both in high- and low-income countries. The main difficulty in the diagnosis and treatment of septic patients is the tremendous heterogeneity of this condition. The vast heterogeneity that characterizes sepsis ranges from the clinical presentation to the biological aspects of the disease. Evidence-based medicine approaches sepsis as a homogenous syndrome and does not consider the individual discrepancies between septic patients. This approach may contribute to the poor outcomes of septic patients. In recent years, personalized medicine has gained significant interest. This novel form of medicine underlines the importance of understanding the genetic, epigenetic, and molecular basis of a disease in order to provide a more tailored approach for the patient. The study of "omics", such as cytomics, genomics, epigenomics, transcriptomics, proteomics, and metabolomics, provides a deeper comprehension of the complex interactions between the host, the disease, and the environment. The aim of this review is to summarize the potential role of a personalized approach in sepsis management, considering the interactions between various "omics".
    Language English
    Publishing date 2024-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Toxic-Induced Nonthyroidal Illness Syndrome Induced by Acute Low-Dose Pesticides Exposure-Preliminary In Vivo Study.

    Cobilinschi, Cristian / Țincu, Radu / Ungureanu, Raluca / Dumitru, Ioana / Băetu, Alexandru / Isac, Sebastian / Cobilinschi, Claudia Oana / Grințescu, Ioana Marina / Mirea, Liliana

    Toxics

    2022  Volume 10, Issue 9

    Abstract: Background and objectives: Conditions such as trauma, burns, sepsis, or acute intoxications have considerable consequences on the endocrine status, causing "sick euthyroid syndrome". Organophosphate exposure may induce an increase in acetylcholine ... ...

    Abstract Background and objectives: Conditions such as trauma, burns, sepsis, or acute intoxications have considerable consequences on the endocrine status, causing "sick euthyroid syndrome". Organophosphate exposure may induce an increase in acetylcholine levels, thus altering the thyroid's hormonal status. The present study aims to identify the effects of acetylcholinesterase inhibition on thyroid hormones.
    Material and methods: A prospective experimental study was conducted on twenty Wistar rats. Blood samples were drawn to set baseline values for thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). Chlorpyrifos 0.1 mg/kg was administered by oral gavage to induce acetyl-cholinesterase inhibition. After exhibiting cholinergic symptoms, blood samples were collected to assess levels of cholinesterase and thyroid hormones using ELISA.
    Results: Butyrylcholinesterase levels confirmed major inhibition immediately after intoxication compared to the baseline, certifying the intoxication. A significant increase in T4 levels was noted (
    Conclusions: This study demonstrated that cholinesterase inhibition caused major alterations in thyroid hormone levels, which may be characterized by a transient hypothyroidism status with an impact on survival prognosis.
    Language English
    Publishing date 2022-08-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10090511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What Is Different in Acute Hematologic Malignancy-Associated ARDS? An Overview of the Literature.

    Cotorogea-Simion, Mihail / Pavel, Bogdan / Isac, Sebastian / Telecan, Teodora / Matache, Irina-Mihaela / Bobirca, Anca / Bobirca, Florin-Teodor / Rababoc, Razvan / Droc, Gabriela

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 9

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Hematologic Neoplasms/complications ; Humans ; Leukemic Infiltration/complications ; Leukemic Infiltration/pathology ; Leukostasis/complications ; Leukostasis/pathology ; Lung/pathology ; Lung Diseases ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-09-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58091215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opioid-Sparing Analgesia Impacts the Perioperative Anesthetic Management in Major Abdominal Surgery.

    Jipa, Miruna / Isac, Sebastian / Klimko, Artsiom / Simion-Cotorogea, Mihail / Martac, Cristina / Cobilinschi, Cristian / Droc, Gabriela

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Analgesia, Epidural/methods ; Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use ; Anesthetics, Local/therapeutic use ; Fentanyl/therapeutic use ; Humans ; Ketamine/therapeutic use ; Lidocaine/therapeutic use ; Morphine/therapeutic use ; Pain, Postoperative/drug therapy ; Postoperative Nausea and Vomiting/chemically induced ; Sevoflurane
    Chemical Substances Analgesics ; Analgesics, Opioid ; Anesthetics, Local ; Sevoflurane (38LVP0K73A) ; Ketamine (690G0D6V8H) ; Morphine (76I7G6D29C) ; Lidocaine (98PI200987) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Acute Promyelocytic Leukemia and Severe Differentiation Syndrome in Pregnancy-A Management Challenge.

    Droc, Gabriela / Stancioaica, Maria Camelia / Soare, Corina Gabriela / Stefan, Mihai-Gabriel / Ingustu, Daiana / Martac, Cristina / Coriu, Daniel / Isac, Sebastian / Suciu, Nicolae / Andrei, Stefan

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Acute promyelocytic leukemia (APL) is generated by the PML-RARA fusion gene. In patients suffering from APL, the early diagnosis and treatment are essential in the successful management. We reported a case of a 27-year-old 17th-week pregnant patient ... ...

    Abstract Acute promyelocytic leukemia (APL) is generated by the PML-RARA fusion gene. In patients suffering from APL, the early diagnosis and treatment are essential in the successful management. We reported a case of a 27-year-old 17th-week pregnant patient diagnosed with APL. After an extensive hematological diagnostic panel, the acute promyelocytic leukemia was confirmed, and the patient received all-
    Language English
    Publishing date 2023-05-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Management of Postoperative Cognitive Dysfunction in Cirrhotic Patients: An Overview of the Literature.

    Ingustu, Daiana-Georgiana / Pavel, Bogdan / Paltineanu, Silvia-Ioana / Mihai, Diana-Irene / Cotorogea-Simion, Mihail / Martac, Cristina / Florescu, Madalina-Marieta / Cobilinschi, Cristian / Isac, Sebastian / Droc, Gabriela

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 3

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Humans ; Postoperative Cognitive Complications/etiology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Hepatic Encephalopathy/complications ; Anesthesia, General/adverse effects ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59030465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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