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  1. AU="Isaia, Giancarlo"
  2. AU=Gudowska-Sawczuk Monika
  3. AU="Huang, Wenjin"
  4. AU="Dinh, Huyenlan"
  5. AU="Osei, Silas Acheampong" AU="Osei, Silas Acheampong"
  6. AU="Michener, Hayley"
  7. AU="Bachman, Victoria F"
  8. AU="Jean-Michel Luccarini"
  9. AU="Resch, R."
  10. AU="Olaf Booy"
  11. AU=Skorski Tomasz
  12. AU="Sanayeh, Elie Bou"
  13. AU="Echeverría, J.L."
  14. AU="Balasubramanian, Ramnath"
  15. AU="Adam Orłowski"
  16. AU="Tumanov A"
  17. AU="Hsu, Rafael M C S"
  18. AU=Perfect John R
  19. AU="Francini, Saverio"
  20. AU="Hurley, David"
  21. AU=Thomas L
  22. AU="French, M S"
  23. AU=Bonek Krzysztof
  24. AU="Noviello, Colleen M"
  25. AU="Jill A. Hollenbach"
  26. AU="Bansal, Ramesh C."
  27. AU="Huang, Xuhua"
  28. AU="Latorre, Víctor"
  29. AU="Simon J. Waddell"
  30. AU="Luo, Yueming"

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  1. Artikel ; Online: Associations between hypovitaminosis D and COVID-19: a narrative review.

    Isaia, Giancarlo / Medico, Enzo

    Aging clinical and experimental research

    2020  Band 32, Heft 9, Seite(n) 1879–1881

    Abstract: In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could ...

    Abstract In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could not yet provide a convincing demonstration of a cause-effect relationship. In this editorial, the authors describe the scientific evidence underlying a possible role of vitamin D in the prevention and development of the pandemic, considering its immunomodulatory role and antiviral effects. They conclude that further studies are needed to (1) better explore possible associations between vitamin D deficiency and COVID-19 morbidity and lethality, and (2) assess if compensating such deficiency could avoid or mitigate the worst manifestations of COVID-19. They highlight the need for public health campaigns to promote consumption of vitamin D-rich foods and proper sunlight exposition or, when this is not possible, controlled pharmaceutical supplementation, especially in countries with high prevalence of hypovitaminosis D.
    Mesh-Begriff(e) Humans ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/prevention & control ; Dietary Supplements ; Immunologic Factors/immunology ; Immunologic Factors/pharmacology ; Pandemics/prevention & control ; Prevalence ; SARS-CoV-2 ; Vitamin D/administration & dosage ; Vitamin D/immunology ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/immunology ; Vitamin D Deficiency/therapy
    Chemische Substanzen Immunologic Factors ; Vitamin D (1406-16-2)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-07-23
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-020-01650-9
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  2. Artikel: Associations between hypovitaminosis D and COVID-19: a narrative review

    Isaia, Giancarlo / Medico, Enzo

    Aging Clin Exp Res

    Abstract: In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could ...

    Abstract In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most cases based on cross-sectional analyses, could not yet provide a convincing demonstration of a cause-effect relationship. In this editorial, the authors describe the scientific evidence underlying a possible role of vitamin D in the prevention and development of the pandemic, considering its immunomodulatory role and antiviral effects. They conclude that further studies are needed to (1) better explore possible associations between vitamin D deficiency and COVID-19 morbidity and lethality, and (2) assess if compensating such deficiency could avoid or mitigate the worst manifestations of COVID-19. They highlight the need for public health campaigns to promote consumption of vitamin D-rich foods and proper sunlight exposition or, when this is not possible, controlled pharmaceutical supplementation, especially in countries with high prevalence of hypovitaminosis D.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #670638
    Datenquelle COVID19

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  3. Artikel ; Online: Associations between hypovitaminosis D and COVID-19

    Isaia, Giancarlo / Medico, Enzo

    Aging Clinical and Experimental Research

    a narrative review

    2020  Band 32, Heft 9, Seite(n) 1879–1881

    Schlagwörter Ageing ; Geriatrics and Gerontology ; covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-020-01650-9
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy

    Isaia, Giancarlo / Diémoz, Henri / Maluta, Francesco / Fountoulakis, Ilias / Ceccon, Daniela / di Sarra, Alcide / Facta, Stefania / Fedele, Francesca / Lorenzetto, Giuseppe / Siani, Anna Maria / Isaia, Gianluca

    Science of the Total Environment. 2021 Feb., v. 757 p.143757-

    2021  

    Abstract: A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective ... ...

    Abstract A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. To this purpose, in this environmental ecological study a mixed-effect exponential regression was built to explain the incidence of COVID-19 based on the environmental conditions, and demographic and pathophysiologic factors. Observations and estimates of the cumulative solar UV exposure have been included to quantify the amount of radiation available e.g., for pre-vitamin D3 synthesis or SARS-CoV-2 inactivation by sunlight. The analysis shows a significant correlation (p-value <5 × 10⁻²) between the response variables (death percentage, incidence of infections and positive tests) and biologically effective solar UV radiation, residents in nursing homes per inhabitant (NHR), air temperature, death percentage due to the most frequent comorbidities. Among all factors, the amount of solar UV radiation is the variable contributing the most to the observed correlation, explaining up to 83.2% of the variance of the COVID-19 affected cases per population. While the statistical outcomes of the study do not directly entail a specific cause-effect relationship, our results are consistent with the hypothesis that solar UV radiation impacted on the development of the infection and on its complications, e.g. through the effect of vitamin D on the immune system or virus inactivation by sunlight. The analytical framework used in this study, based on commonly available data, can be easily replicated in other countries and geographical domains to identify possible correlations between exposure to solar UV radiation and the spread of the pandemic.
    Schlagwörter COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; air temperature ; death ; ecological studies ; environment ; immune system ; morbidity ; mortality ; pandemic ; pathophysiology ; ultraviolet radiation ; variance ; viruses ; Italy ; COVID-19 ; Tropospheric Emission Monitoring Internet Service (TEMIS) ; Clinical outcomes in Italy ; Hypovitaminosis D
    Sprache Englisch
    Erscheinungsverlauf 2021-02
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.143757
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Circulating MicroRNAs as Biomarkers of Osteoporosis and Fragility Fractures.

    Ciuffi, Simone / Marini, Francesca / Fossi, Caterina / Donati, Simone / Giusti, Francesca / Botta, Annalisa / Masi, Laura / Isaia, Giancarlo / Marcocci, Claudio / Migliaccio, Silvia / Minisola, Salvatore / Nuti, Ranuccio / Tarantino, Umberto / Iantomasi, Teresa / Brandi, Maria Luisa

    The Journal of clinical endocrinology and metabolism

    2022  Band 107, Heft 8, Seite(n) 2267–2285

    Abstract: Context: Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility fracture risk has recently become a subject of investigation.: Objective: Measure by next-generation sequencing (NGS), global miRNA expression in serum ... ...

    Abstract Context: Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility fracture risk has recently become a subject of investigation.
    Objective: Measure by next-generation sequencing (NGS), global miRNA expression in serum samples of osteoporotic subjects vs individuals with normal bone mineral density (BMD).
    Design: Samples were collected from patients with different bone phenotypes and/or fragility fractures who did not receive any antiresorptive and/or bone-forming drug at the time of blood collection.
    Setting: Samples and data were collected at 7 medical centers in Italy.
    Patients: NGS prescreening: 50 osteoporotic patients vs 30 individuals with normal BMD. Droplet digital polymerase chain reaction (ddPCR) validation: 213 patients with different bone phenotypes, including the NGS-analyzed cohort.
    Results: NGS identified 5 miRNAs (miR-8085, miR-320a-3p, miR-23a-3p, miR-4497, miR-145-5p) differentially expressed in osteoporosis cases without fractures vs controls. ddPCR validation confirmed lower c-miR-23a-3p expression in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects and increased c-miR-320a-3p expression in osteoporotic patients with fracture and lower expression in osteoporotic patients without fracture. ddPCR analysis showed a significantly increased expression of miR-21-5p in osteoporotic patients, with or without fracture, than in osteopenic and normal subjects, not evidenced by the NGS prescreening.
    Discussion: Our study confirmed levels of c-miR-23a-3p and c-miR-21-5p as able to distinguish osteoporotic patients and subjects with normal BMD. Increased levels of c-miR-320a-3p specifically associated with fractures, independently by BMD, suggesting c-miR-320a-3p as a prognostic indicator of fracture risk in osteoporotic patients, to be confirmed in prospective studies on incident fractures.
    Mesh-Begriff(e) Circulating MicroRNA/blood ; Circulating MicroRNA/genetics ; Genetic Markers ; Humans ; Osteoporosis/blood ; Osteoporosis/genetics ; Osteoporotic Fractures/blood ; Osteoporotic Fractures/genetics ; Prospective Studies
    Chemische Substanzen Circulating MicroRNA ; Genetic Markers ; MIRN145 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2022-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac293
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Buch: Le malattie del metabolismo minerale

    Isaia, Giancarlo

    guida pratica alla gestione operativa

    2000  

    Verfasserangabe [a cura di] Giancarlo Isaia
    Mesh-Begriff(e) Bone Diseases, Metabolic ; Metabolic Diseases ; Minerals
    Sprache Italienisch
    Umfang xiv, 296 p. :, ill.
    Verlag Centro scientifico editore
    Erscheinungsort Torino
    Dokumenttyp Buch
    ISBN 9788876405099 ; 8876405097
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  7. Artikel ; Online: Circulating Long Non-Coding RNA GAS5 Is Overexpressed in Serum from Osteoporotic Patients and Is Associated with Increased Risk of Bone Fragility.

    Visconti, Virginia Veronica / Fittipaldi, Simona / Ciuffi, Simone / Marini, Francesca / Isaia, Giancarlo / D'Amelio, Patrizia / Migliaccio, Silvia / Marcocci, Claudio / Minisola, Salvatore / Nuti, Ranuccio / Novelli, Giuseppe / Brandi, Maria Luisa / Botta, Annalisa / Tarantino, Umberto

    International journal of molecular sciences

    2020  Band 21, Heft 18

    Abstract: Osteoporosis (OP) is a multifactorial disorder in which environmental factors along with genetic variants and epigenetic mechanisms have been implicated. Long non-coding RNAs (lncRNAs) have recently emerged as important regulators of bone metabolism and ... ...

    Abstract Osteoporosis (OP) is a multifactorial disorder in which environmental factors along with genetic variants and epigenetic mechanisms have been implicated. Long non-coding RNAs (lncRNAs) have recently emerged as important regulators of bone metabolism and OP aetiology. In this study, we analyzed the expression level and the genetic association of lncRNA GAS5 in OP patients compared to controls. Quantitative RT-PCR analysis of GAS5 was performed on the serum of 56 OP patients and 28 healthy individuals. OP subjects were divided into three groups of analysis: 29 with fragility fractures of lumbar spine (OP_VF), 14 with fragility fractures of femoral neck (OP_FF) and 13 without fractures (OP_WF). Genotyping of the rs145204276 insertion/deletion polymorphism has also been performed by Restriction fragment length polymorphism (RFLP) and direct sequencing analyses. Expression of circulating GAS5 is significantly increased in OP patients compared to controls (
    Mesh-Begriff(e) Aged ; Cell-Free Nucleic Acids/blood ; Female ; Gene Expression Regulation ; Humans ; Male ; Middle Aged ; Osteoporosis/blood ; Osteoporotic Fractures/blood ; RNA, Long Noncoding/blood ; Risk Factors
    Chemische Substanzen Cell-Free Nucleic Acids ; GAS5 long non-coding RNA, human ; RNA, Long Noncoding
    Sprache Englisch
    Erscheinungsdatum 2020-09-21
    Erscheinungsland Switzerland
    Dokumenttyp Clinical Trial ; Journal Article ; Multicenter Study
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21186930
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  8. Artikel ; Online: Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy.

    Isaia, Giancarlo / Diémoz, Henri / Maluta, Francesco / Fountoulakis, Ilias / Ceccon, Daniela / di Sarra, Alcide / Facta, Stefania / Fedele, Francesca / Lorenzetto, Giuseppe / Siani, Anna Maria / Isaia, Gianluca

    The Science of the total environment

    2020  Band 757, Seite(n) 143757

    Abstract: A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective ... ...

    Abstract A significantly stronger impact in mortality and morbidity by COVID-19 has been observed in the northern Italian regions compared to the southern ones. The reasons of this geographical pattern might involve several concurrent factors. The main objective of this work is to investigate whether any correlations exist between the spatial distribution of COVID-19 cases and deaths in the different Italian regions and the amount of solar ultraviolet (UV) radiation at the Earth's surface. To this purpose, in this environmental ecological study a mixed-effect exponential regression was built to explain the incidence of COVID-19 based on the environmental conditions, and demographic and pathophysiologic factors. Observations and estimates of the cumulative solar UV exposure have been included to quantify the amount of radiation available e.g., for pre-vitamin D3 synthesis or SARS-CoV-2 inactivation by sunlight. The analysis shows a significant correlation (p-value <5 × 10
    Mesh-Begriff(e) COVID-19 ; Humans ; Italy/epidemiology ; Pandemics ; SARS-CoV-2 ; Ultraviolet Rays
    Sprache Englisch
    Erscheinungsdatum 2020-11-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.143757
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: L'innovazione tecnologica e l'ospedalizzazione a domicilio.

    Tibaldi, Vittoria / Aimonino Ricauda, Nicoletta / Rocco, Maurizio / Bertone, Paola / Fanton, Giordano / Isaia, Giancarlo

    Recenti progressi in medicina

    2013  Band 104, Heft 5, Seite(n) 181–188

    Abstract: Advances in the miniaturization and portability of diagnostic technologies, information technologies, remote monitoring, and long-distance care have increased the viability of home-based care, even for patients with serious conditions. Telemedicine and ... ...

    Titelübersetzung Technological advances and hospital-at-home care.
    Abstract Advances in the miniaturization and portability of diagnostic technologies, information technologies, remote monitoring, and long-distance care have increased the viability of home-based care, even for patients with serious conditions. Telemedicine and teleradiology projects are active at the Hospital at Home Service of Torino.
    Mesh-Begriff(e) Academies and Institutes/organization & administration ; Cell Phone ; Home Care Services, Hospital-Based/organization & administration ; Home Care Services, Hospital-Based/trends ; Hospitals, Public/organization & administration ; Humans ; Internet ; Inventions ; Italy ; Microcomputers ; Monitoring, Physiologic/instrumentation ; Monitoring, Physiologic/methods ; Remote Consultation/instrumentation ; Remote Consultation/organization & administration ; Telemedicine/instrumentation ; Telemedicine/methods ; Telemedicine/organization & administration ; Teleradiology/instrumentation ; Teleradiology/organization & administration
    Sprache Italienisch
    Erscheinungsdatum 2013-05
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Review
    ZDB-ID 138266-4
    ISSN 0034-1193
    ISSN 0034-1193
    DOI 10.1701/1291.14274
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Health-related quality of life in severe osteoporosis.

    D'Amelio, Patrizia / Di Stefano, Marco / Isaia, Giancarlo

    Aging clinical and experimental research

    2007  Band 19, Heft 3 Suppl, Seite(n) 28–30

    Abstract: Osteoporotic fractures are associated with significant morbidity and mortality. In addition, the declines in physical function and the changes in appearance due to fractures contribute to the severe reduction in patients' quality of life (HRQOL). It has ... ...

    Abstract Osteoporotic fractures are associated with significant morbidity and mortality. In addition, the declines in physical function and the changes in appearance due to fractures contribute to the severe reduction in patients' quality of life (HRQOL). It has been demonstrated that patients suffering subclinical fractures experience a reduction in their HRQOL. Some studies have also suggested that osteoporotic patients without fractures perceive a reduction in their quality of life. It has been suggested that anti- osteoporotic therapy is effective in increasing patients' HRQOL. In our clinical experience, treatment with teriparatide is effective in reducing back pain and in enhancing patients' activities of daily living.
    Mesh-Begriff(e) Chronic Disease ; Humans ; Osteoporosis/complications ; Osteoporosis/psychology ; Quality of Life ; Severity of Illness Index ; Spinal Fractures/etiology ; Spinal Fractures/psychology
    Sprache Englisch
    Erscheinungsdatum 2007-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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