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  1. AU="Isaku Okamoto"
  2. AU="Mebis, Jeroen"
  3. AU="Nathan P. Manes"
  4. AU="Forcillo, Jessica"
  5. AU="Santos, Daniel Wagner de Castro Lima"
  6. AU="Dong, Yujie"
  7. AU="Cnockaert, Margo"
  8. AU="Hong, Fan"
  9. AU="Zhao, Shiteng"
  10. AU="Zimmermann, Lisa"
  11. AU="Malone, Daniel C"
  12. AU="Kuo, Sheree"
  13. AU="Leonard, Warren J"
  14. AU=Hawthorne Dawn M
  15. AU=Zein Ahmad Fariz Malvi Zamzam
  16. AU="Delgado, Fernanda"
  17. AU="André Scherag"
  18. AU="Simring, Steven"
  19. AU="Gowdy, John M."
  20. AU="Yeldandi, Anjana"
  21. AU="Mierdel, Katrin"
  22. AU="Karaaslan, Ayse"
  23. AU="Fuchs, Ch"
  24. AU="Toro, Diana"
  25. AU="Lindner, Robert"
  26. AU="Meshkat, Shakila"
  27. AU="Geist, Felix"
  28. AU="Xiong, Yinyi"
  29. AU="Larciprete, R"
  30. AU="Camila Mugnai Vieira"
  31. AU="Michael Sjöström"
  32. AU="Bouchau, Robin"
  33. AU="Shahabi Rabori, Venus"
  34. AU="Jeronimo, Matthew"
  35. AU="Misra, Maitreyi"
  36. AU="Liu, Xuping"
  37. AU="Corinna Lüneburg"
  38. AU="Clement, Lionel C"
  39. AU="Parkhill, Julian"
  40. AU="Wiita, Arun P"
  41. AU=Lubrano Riccardo
  42. AU=Biggs Andrew
  43. AU="Lian, Kejian"
  44. AU="Almutairi, Abdulrahman"
  45. AU="Cosculluela-Pueyo, Rafaél"
  46. AU="Gehrs, Teresa"
  47. AU="Munir, Atif"
  48. AU="Ou, Ya-Nan"
  49. AU=Brown James E AU=Brown James E
  50. AU="Wang, Zhongmin"
  51. AU="Lemieux, Audrée"
  52. AU="Abdelhameed, Mohamed F"
  53. AU="Schaible, Lonnie M"
  54. AU="Yazie, Taklo Simeneh Yazie"
  55. AU="Jude Orumuah Agbugui"
  56. AU="Kruse, Robert L"
  57. AU="Shyama Nandakumar"
  58. AU="Gelb, M"
  59. AU="Gasparini, L"
  60. AU="Ulvila, J"
  61. AU="Länsimies, Helena"

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  1. Artikel ; Online: Single-center prospective study on the efficacy of nivolumab against platinum-sensitive recurrent or metastatic head and neck squamous cell carcinoma

    Isaku Okamoto / Kiyoaki Tsukahara / Hiroki Sato

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Band 10

    Abstract: Abstract Nivolumab, an immune checkpoint inhibitor, is beneficial to patients with platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). However, platinum-sensitive R/M-HNSCC has not yet been studied. Hence, in ... ...

    Abstract Abstract Nivolumab, an immune checkpoint inhibitor, is beneficial to patients with platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC). However, platinum-sensitive R/M-HNSCC has not yet been studied. Hence, in this prospective study, we evaluated the efficacy and safety of nivolumab in patients with platinum-sensitive R/M-HNSCC. This prospective single-arm study was conducted in a single institution in Japan. Patients with platinum-sensitive R/M-HNSCC (defined as head and neck cancer that recurred or metastasized at least 6 months after platinum-based chemotherapy or chemoradiotherapy) were enrolled. The primary endpoint was overall survival (OS). The secondary endpoints were progression-free survival (PFS), overall response rate (ORR), immune-related adverse events (irAEs), and quality of life (QOL). This study was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN000031324). Twenty-two patients with platinum-sensitive R/M-HNSCC were enrolled. The median OS was 17.4 months, and the 1-year OS rate was 73%. The median PFS was 9.6 months, 1-year PFS rate was 48%, and ORR was 36%. Sixteen irAEs were recorded in 12 patients; however, no grade 4 or 5 irAEs were observed. The QOL assessments revealed that nivolumab did not decrease the QOL of patients. Nivolumab is effective against platinum-sensitive R/M-HNSCC with acceptable safety.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Postoperative Complications and Swallowing Function after Jejunal and Skin Flap Reconstruction for Hypopharyngeal Carcinoma—A Multicenter Retrospective Study

    Kunihiko Tokashiki / Isaku Okamoto / Takuro Okada / Hiroki Sato / Taku Yamashita / Takashi Matsuki / Takahito Kondo / Chihiro Fushimi / Tatsuo Masubuchi / Kouki Miura / Go Omura / Kiyoaki Tsukahara

    Journal of Clinical Medicine, Vol 11, Iss 1464, p

    2022  Band 1464

    Abstract: This study compared the incidence of perioperative complications and swallowing function between free jejunal flap reconstruction and cutaneous free tissue flap construction. We included 223 patients who underwent hypopharyngeal reconstruction using free ...

    Abstract This study compared the incidence of perioperative complications and swallowing function between free jejunal flap reconstruction and cutaneous free tissue flap construction. We included 223 patients who underwent hypopharyngeal reconstruction using free flap. At discharge, +the free jejunal flap was associated with a Functional Oral Intake Scale (FOIS) score of 1–6 in 132 cases (70%) and a score of 7 in 56 cases (30%). Regarding the cutaneous free tissue flaps, FOIS scores of 1–6 were observed in 18 cases (51%), and a score of 7 was noted in 17 cases (49%). Donor site complications occurred in 12% of the patients who underwent free jejunal flap procedures and in none of the patients who underwent cutaneous free tissue flap procedures. We found that the free jejunal flap had a regular dietary intake rate in 56 patients (30%), whereas cutaneous free tissue flaps had a regular dietary intake rate in 17 patients (49%). Cutaneous free tissue flaps had a significantly higher regular dietary intake rate at discharge and a significantly lower incidence of donor site complications than free jejunal flaps. In conclusion, free-flap reconstruction may be a better method than free jejunal flap reconstruction for the treatment of hypopharyngeal cancer.
    Schlagwörter free jejunal flap ; cutaneous free tissue flaps ; hypopharyngeal carcinoma ; total pharyngolaryngectomy ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux

    Ryoji Tokashiki / Isaku Okamoto / Nobutoshi Funato / Mamoru Suzuki

    World Journal of Gastroenterology, Vol 19, Iss 31, Pp 5118-

    2013  Band 5124

    Abstract: AIM: To investigate the effect of rikkunshito on laryngopharyngeal reflux (LPR) symptoms and gastric emptying in patients with proton-pump inhibitor (PPI)-refractory LPR. METHODS: In total, 22 patients with LPR were enrolled. Following a 2-wk treatment ... ...

    Abstract AIM: To investigate the effect of rikkunshito on laryngopharyngeal reflux (LPR) symptoms and gastric emptying in patients with proton-pump inhibitor (PPI)-refractory LPR. METHODS: In total, 22 patients with LPR were enrolled. Following a 2-wk treatment with PPI monotherapy, PPI-refractory LPR patients were randomly divided into two treatment groups (rikkunshito alone or rikkunshito plus the PPI, lansoprazole). LPR symptoms were assessed using a visual analog scale (VAS) score, gastrointestinal symptoms were assessed using the gastrointestinal symptom rating scale (GSRS), and gastric emptying was assessed using the radio-opaque marker method prior to and 4 wk following treatments. RESULTS: The 4-wk treatment with rikkunshito alone and with rikkunshito plus the PPI significantly decreased the globus sensation VAS scores. The VAS score for sore throat was significantly decreased following treatment with rikkunshito plus PPI but not by rikkunshito alone. Neither treatment significantly changed the GSRS scores. Rikkunshito improved delayed gastric emptying. We found a significant positive correlation between improvements in globus sensation and in gastric emptying (r2 = 0.4582, P < 0.05). CONCLUSION: Rikkunshito improved globus sensation in patients with PPI-refractory LPR, in part, because of stimulation of gastric emptying. Thus, rikkunshito is an effective treatment for PPI-refractory LPR.
    Schlagwörter Laryngopharyngeal reflux ; Gastroesophageal reflux disease ; Globus sensation ; Gastric emptying ; Rikkunshito ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Sprache Englisch
    Erscheinungsdatum 2013-01-01T00:00:00Z
    Verlag Baishideng Publishing Group Co., Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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