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  1. Article ; Online: Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug.

    Isgrò, Camilla / Sardanelli, Anna Maria / Palese, Luigi Leonardo

    Viruses

    2021  Volume 13, Issue 1

    Abstract: In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to ... ...

    Abstract In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Catalytic Domain ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Databases, Factual ; Drug Repositioning ; Ethacrynic Acid/chemistry ; Ethacrynic Acid/pharmacology ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacokinetics ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology
    Chemical Substances Antiviral Agents ; Protease Inhibitors ; Coronavirus 3C Proteases (EC 3.4.22.28) ; Ethacrynic Acid (M5DP350VZV)
    Language English
    Publishing date 2021-01-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13010106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome.

    Sardanelli, Anna Maria / Isgrò, Camilla / Palese, Luigi Leonardo

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 5

    Abstract: In late 2019, a global pandemic occurred. The causative agent was identified as a member of ... ...

    Abstract In late 2019, a global pandemic occurred. The causative agent was identified as a member of the
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; Catalytic Domain/drug effects ; Computer Simulation ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Databases, Chemical ; Drug Discovery ; Enzyme Assays ; Humans ; Ligands ; Metabolome ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; Protease Inhibitors/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Silymarin/chemistry ; Silymarin/metabolism ; Silymarin/pharmacology ; Software ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Ligands ; Protease Inhibitors ; Silymarin ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2021-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26051409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Oxidative Damage and Post-COVID Syndrome: A Cross-Sectional Study in a Cohort of Italian Workers.

    Stufano, Angela / Isgrò, Camilla / Palese, Luigi Leonardo / Caretta, Paolo / De Maria, Luigi / Lovreglio, Piero / Sardanelli, Anna Maria

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: In addition to the acute symptoms after infection, patients and society are also being challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as a pivotal point in the pathophysiology of COVID-19, could potentially be ... ...

    Abstract In addition to the acute symptoms after infection, patients and society are also being challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as a pivotal point in the pathophysiology of COVID-19, could potentially be also involved in the development of the post-COVID syndrome. The aim of the present study was to evaluate the relationship between changes in oxidative status and the persistence of long-COVID symptoms in workers with a previous mild COVID-19 infection. A cross-sectional study was conducted among 127 employees of an Italian university (80 with a previous COVID-19 infection, and 47 healthy subjects). The TBARS assay was used to detect malondialdehyde serum levels (MDA), while total hydroperoxide (TH) production was measured by a d-ROMs kit. A significant difference in mean serum MDA values was found between previously infected subjects and healthy controls and (4.9 µm vs. 2.8 µm, respectively). Receiver-operating characteristic (ROC) curves showed high specificity and good sensibility (78.7% and 67.5%, respectively) for MDA serum levels. A random forest classifier identified the hematocrit value, MDA serum levels, and IgG titer against SARS-CoV-2 as features with the highest predictive value in distinguishing 34 long-COVID from 46 asymptomatic post-COVID subjects. Oxidative damage persists in subjects with previous COVID-19 infection, suggesting a possible role of oxidative stress mediators in the pathogenesis of long COVID.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; Cross-Sectional Studies ; Oxidative Stress/physiology ; Italy/epidemiology
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rhus Coriaria

    Isgrò, Camilla / Spagnuolo, Ludovica / Pannucci, Elisa / Mondello, Luigi / Santi, Luca / Dugo, Laura / Sardanelli, Anna Maria

    International journal of molecular sciences

    2022  Volume 23, Issue 21

    Abstract: Sumac, ...

    Abstract Sumac,
    MeSH term(s) Rhus ; Antioxidants/pharmacology ; Parkinson Disease/drug therapy ; Hydrogen Peroxide ; Plant Extracts/pharmacology ; Fibroblasts ; Macrophages ; Energy Metabolism ; Adenosine Triphosphate
    Chemical Substances Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Plant Extracts ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-10-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232112774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Oxidative Stress in Postmenopausal Women with or without Obesity.

    Leanza, Giulia / Conte, Caterina / Cannata, Francesca / Isgrò, Camilla / Piccoli, Alessandra / Strollo, Rocky / Quattrocchi, Carlo Cosimo / Papalia, Rocco / Denaro, Vincenzo / Maccarrone, Mauro / Napoli, Nicola / Sardanelli, Anna Maria

    Cells

    2023  Volume 12, Issue 8

    Abstract: Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly ... ...

    Abstract Oxidative stress, a key mediator of cardiovascular disease, metabolic alterations, and cancer, is independently associated with menopause and obesity. Yet, among postmenopausal women, the correlation between obesity and oxidative stress is poorly examined. Thus, in this study, we compared oxidative stress states in postmenopausal women with or without obesity. Body composition was assessed via DXA, while lipid peroxidation and total hydroperoxides were measured in patient's serum samples via thiobarbituric-acid-reactive substances (TBARS) and derivate-reactive oxygen metabolites (d-ROMs) assays, respectively. Accordingly, 31 postmenopausal women were enrolled: 12 with obesity and 19 of normal weight (mean (SD) age 71.0 (5.7) years). Doubled levels of serum markers of oxidative stress were observed in women with obesity in women with obesity compared to those of normal weight (H
    MeSH term(s) Humans ; Female ; Aged ; Postmenopause ; Hydrogen Peroxide ; Obesity/metabolism ; Oxidative Stress ; Body Mass Index
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12081137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prevaccination Glucose Time in Range Correlates With Antibody Response to SARS-CoV-2 Vaccine in Type 1 Diabetes.

    Alhamar, Ghadeer / Briganti, Silvia / Maggi, Daria / Viola, Viola / Faraj, Malak / Zannella, Carla / Galdiero, Massimiliano / Franci, Gianluigi / Fusco, Clorinda / Isgrò, Camilla / Leanza, Giulia / Malandrucco, Ilaria / Spinelli, Andrea / Tramontana, Flavia / Iaria, Domenico / Tortoriello, Rachele / Pieralice, Silvia / Rosati, Milena / Matarese, Giuseppe /
    Pozzilli, Paolo / Galgani, Mario / Strollo, Rocky

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 7, Page(s) e474–e479

    Abstract: Context: Poor glucose control has been associated with increased mortality in COVID-19 patients with type 1 diabetes (T1D).: Objective: This work aimed to assess the effect of prevaccination glucose control on antibody response to the SARS-CoV-2 ... ...

    Abstract Context: Poor glucose control has been associated with increased mortality in COVID-19 patients with type 1 diabetes (T1D).
    Objective: This work aimed to assess the effect of prevaccination glucose control on antibody response to the SARS-CoV-2 vaccine BNT162b2 in T1D.
    Methods: We studied 26 patients with T1D scheduled to receive 2 doses, 21 days apart, of BNT162b2, followed prospectively for 6 months with regular evaluation of SARS-CoV-2 antibodies and glucose control. Immunoglobulin G (IgG) to spike glycoprotein were assessed by enzyme-linked immunosorbent assay, and serum neutralization by a live SARS-CoV-2 assay (Vero E6 cells system). Glycated hemoglobin A1c (HbA1c) and continuous glucose monitoring (CGM), including time in range (TIR) and above range (TAR), were collected. The primary exposure and outcome measures were prevaccination glucose control, and antibody response after vaccination, respectively.
    Results: Prevaccination HbA1c was unrelated to postvaccine spike IgG (r = -0.33; P = .14). Of note, the CGM profile collected during the 2 weeks preceding BNT162b2 administration correlated with postvaccine IgG response (TIR: r = 0.75; P = .02; TAR: r = -0.81; P = .008). Patients meeting the recommended prevaccination glucose targets of TIR (≥ 70%) and TAR (≤ 25%) developed stronger neutralizing antibody titers (P < .0001 and P = .008, respectively), regardless of HbA1c. Glucose control along the study time frame was also associated with IgG response during follow-up (TIR: r = 0.93; P < .0001; TAR: r = -0.84; P < .0001).
    Conclusion: In T1D, glucose profile during the 2 weeks preceding vaccination is associated with stronger spike antibody binding and neutralization, highlighting a role for well-controlled blood glucose in vaccination efficacy.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Glucose ; BNT162 Vaccine ; Diabetes Mellitus, Type 1 ; Blood Glucose ; Antibody Formation ; Blood Glucose Self-Monitoring ; COVID-19/prevention & control ; Glycated Hemoglobin ; SARS-CoV-2 ; Immunoglobulin G ; Antibodies, Neutralizing ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Glucose (IY9XDZ35W2) ; BNT162 Vaccine ; Blood Glucose ; Glycated Hemoglobin ; Immunoglobulin G ; Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Sclerostin Regulation, Microarchitecture, and Advanced Glycation End-Products in the Bone of Elderly Women With Type 2 Diabetes.

    Piccoli, Alessandra / Cannata, Francesca / Strollo, Rocky / Pedone, Claudio / Leanza, Giulia / Russo, Fabrizio / Greto, Valentina / Isgrò, Camilla / Quattrocchi, Carlo Cosimo / Massaroni, Carlo / Silvestri, Sergio / Vadalà, Gianluca / Bisogno, Tiziana / Denaro, Vincenzo / Pozzilli, Paolo / Tang, Simon Y / Silva, Matt J / Conte, Caterina / Papalia, Rocco /
    Maccarrone, Mauro / Napoli, Nicola

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2020  Volume 35, Issue 12, Page(s) 2415–2422

    Abstract: Increased circulating sclerostin and accumulation of advanced glycation end-products (AGEs) are two potential mechanisms underlying low bone turnover and increased fracture risk in type 2 diabetes (T2D). Whether the expression of the sclerostin-encoding ... ...

    Abstract Increased circulating sclerostin and accumulation of advanced glycation end-products (AGEs) are two potential mechanisms underlying low bone turnover and increased fracture risk in type 2 diabetes (T2D). Whether the expression of the sclerostin-encoding SOST gene is altered in T2D, and whether it is associated with AGEs accumulation or regulation of other bone formation-related genes is unknown. We hypothesized that AGEs accumulate and SOST gene expression is upregulated in bones from subjects with T2D, leading to downregulation of bone forming genes (RUNX2 and osteocalcin) and impaired bone microarchitecture and strength. We obtained bone tissue from femoral heads of 19 T2D postmenopausal women (mean glycated hemoglobin [HbA1c] 6.5%) and 73 age- and BMI-comparable nondiabetic women undergoing hip replacement surgery. Despite similar bone mineral density (BMD) and biomechanical properties, we found a significantly higher SOST (p = .006) and a parallel lower RUNX2 (p = .025) expression in T2D compared with non-diabetic subjects. Osteocalcin gene expression did not differ between T2D and non-diabetic subjects, as well as circulating osteocalcin and sclerostin levels. We found a 1.5-fold increase in total bone AGEs content in T2D compared with non-diabetic women (364.8 ± 78.2 versus 209.9 ± 34.4 μg quinine/g collagen, respectively; p < .001). AGEs bone content correlated with worse bone microarchitecture, including lower volumetric BMD (r = -0.633; p = .02), BV/TV (r = -0.59; p = .033) and increased trabecular separation/spacing (r = 0.624; p = .023). In conclusion, our data show that even in patients with good glycemic control, T2D affects the expression of genes controlling bone formation (SOST and RUNX2). We also found that accumulation of AGEs is associated with impaired bone microarchitecture. We provide novel insights that may help understand the mechanisms underlying bone fragility in T2D. © 2020 American Society for Bone and Mineral Research (ASBMR).
    MeSH term(s) Aged ; Bone Density ; Bone and Bones ; Diabetes Mellitus, Type 2 ; Female ; Fractures, Bone ; Glycated Hemoglobin A ; Humans
    Chemical Substances Glycated Hemoglobin A
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2142: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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