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Article ; Online: Clinical application of MAO-B PET using

Ishibashi, Kenji

2023 Volume 24 Suppl 1, Page(s) 31–43

Abstract: Monoamine oxidase B (MAO-B) is an enzyme localized to the outer mitochondrial membrane and highly concentrated in astrocytes. Temporal changes in regional MAO-B levels can be used as an index of astrocytic proliferation, known as activated astrocytes or ... ...

Abstract	Monoamine oxidase B (MAO-B) is an enzyme localized to the outer mitochondrial membrane and highly concentrated in astrocytes. Temporal changes in regional MAO-B levels can be used as an index of astrocytic proliferation, known as activated astrocytes or astrogliosis. MAO-B is a marker to evaluate the degree of astrogliosis. Therefore, MAO-B positron emission tomography (PET) is a powerful imaging technique for visualizing and quantifying ongoing astrogliosis through the estimate of regional MAO-B levels. Each neurodegenerative disorder generally has a characteristic distribution pattern of astrogliosis secondary to neuronal loss and pathological protein aggregation. Therefore, by imaging astrogliosis, MAO-B PET can be used as a neurodegeneration marker for identifying degenerative lesions. Any inflammation in the brain usually accompanies astrogliosis starting from an acute phase to a chronic phase. Therefore, by imaging astrogliosis, MAO-B PET can be used as a neuroinflammation marker for identifying inflammatory lesions. MAO-B levels are high in gliomas originating from astrocytes but low in lymphoid tumors. Therefore, MAO-B PET can be used as a brain tumor marker for identifying astrocytic gliomas by imaging MAO-B levels and distinguishing between astrocytic and lymphoid tumors. This review summarizes the clinical application of MAO-B PET using
MeSH term(s)	Humans ; Monoamine Oxidase/metabolism ; Gliosis/metabolism ; Gliosis/pathology ; Neuroinflammatory Diseases ; Positron-Emission Tomography ; Nervous System Diseases/metabolism ; Nervous System Diseases/pathology ; Brain/metabolism ; Neoplasms ; Aminopyridines ; Quinolines
Chemical Substances	Monoamine Oxidase (EC 1.4.3.4) ; THK5351 ; Aminopyridines ; Quinolines
Language	English
Publishing date	2023-11-16
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14729
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Article ; Online: Pitfalls of Amyloid-Beta PET: Comparisons With 18 F-MK-6240 and 18 F-THK5351 PET.

Ishibashi, Kenji / Kurihara, Masanori / Toyohara, Jun / Ishii, Kenji / Iwata, Atsushi

Clinical nuclear medicine

2024 Volume 49, Issue 4, Page(s) 319–321

Abstract: Abstract: We present 3 patients as pitfalls of amyloid-beta (Aβ) PET, who underwent 11 C-PiB (Aβ), 18 F-MK-6240 (Alzheimer disease [AD]-tau), and 18 F-THK5351 (astrogliosis) PET examinations. Despite negligible or tiny Aβ pathology, patients 1 and 2 ... ...

Abstract	Abstract: We present 3 patients as pitfalls of amyloid-beta (Aβ) PET, who underwent 11 C-PiB (Aβ), 18 F-MK-6240 (Alzheimer disease [AD]-tau), and 18 F-THK5351 (astrogliosis) PET examinations. Despite negligible or tiny Aβ pathology, patients 1 and 2 were diagnosed with AD as the cause of symptoms. Despite widespread Aβ pathology, patient 3 was not diagnosed with AD as the cause of symptoms. However, if we had only conducted Aβ PET, patients 1 and 2 might not have been diagnosed with AD, whereas patient 3 might have been diagnosed with AD. Hence, both Aβ and AD-tau assessments are necessary to relate clinical symptoms to AD pathology.
MeSH term(s)	Humans ; Amyloid beta-Peptides ; Alzheimer Disease/diagnostic imaging ; Aminopyridines ; Isoquinolines ; Quinolines
Chemical Substances	MK-6240 ; THK5351 ; Amyloid beta-Peptides ; Aminopyridines ; Isoquinolines ; Quinolines
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000005097
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Article ; Online: Diagnostic performance of the cingulate island sign ratio for differentiating dementia with Lewy bodies from Alzheimer's disease changes depending on the mini-mental state examination score.

Asahara, Yuki / Kameyama, Masashi / Ishii, Kenji / Ishibashi, Kenji

Journal of the neurological sciences

2023 Volume 455, Page(s) 122782

Abstract: Background: The cingulate island sign (CIS) ratio is a diagnostic adjunct for differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). A recent study showed that the CIS ratio in DLB changed depending on the Mini-Mental State ... ...

Abstract	Background: The cingulate island sign (CIS) ratio is a diagnostic adjunct for differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). A recent study showed that the CIS ratio in DLB changed depending on the Mini-Mental State Examination (MMSE) score. We aimed to evaluate whether the diagnostic performance (sensitivity and specificity) of the CIS ratio for differentiating DLB from AD changes depending on the MMSE score. Methods: Twenty-two patients with DLB and 26 amyloid-positive patients with AD, who underwent Results: Within Group B, the CIS ratio in DLB was significantly higher than that in AD (p = 0.0005), but not within Groups A (p = 0.5117) and C (p = 0.8671). ROC curve analyses showed that the sensitivities and specificities of the CIS ratio for differentiating DLB from AD were 66.7% and 77.8% in Group A, 91.7% and 100.0% in Group B, and 75.0% and 66.7% in Group C, respectively. Conclusions: The present study suggests that the diagnostic performance of the CIS ratio for differentiating DLB from AD changes depending on the MMSE score, with higher sensitivity and specificity at MMSE scores of 20-24.
MeSH term(s)	Humans ; Alzheimer Disease/diagnostic imaging ; Lewy Body Disease/diagnostic imaging ; Sensitivity and Specificity ; ROC Curve ; Fluorodeoxyglucose F18 ; Diagnosis, Differential
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2023-11-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80160-4
ISSN	1878-5883 ; 0022-510X ; 0374-8642
ISSN (online)	1878-5883
ISSN	0022-510X ; 0374-8642
DOI	10.1016/j.jns.2023.122782
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Article ; Online: Clinical Application of 18F-THK5351 PET to Identify Inflammatory Lesions Through Imaging Astrogliosis in a Case of Cytomegalovirus Ventriculoencephalitis.

Hatano, Keiko / Ishibashi, Kenji / Yamada, Kazuki / Ishii, Kenji / Iwata, Atsushi

Clinical nuclear medicine

2023 Volume 48, Issue 10, Page(s) e489–e490

Abstract: Abstract: 18F-THK5351 PET is used to estimate the degree of astrogliosis. Because inflammatory lesions usually accompany astrogliosis, 18F-THK5351 PET is potentially worthy of clinical application in inflammatory disorders. Here, we report a case of ... ...

Abstract	Abstract: 18F-THK5351 PET is used to estimate the degree of astrogliosis. Because inflammatory lesions usually accompany astrogliosis, 18F-THK5351 PET is potentially worthy of clinical application in inflammatory disorders. Here, we report a case of cytomegalovirus ventriculoencephalitis in an immunocompromised 75-year-old woman who underwent 18F-THK5351 PET and conventional neuroimaging modalities, including 11C-methionine, 18F-FDG, and MRI. 18F-THK5351 PET was clearly superior to the other modalities in identifying inflammatory lesions and can therefore be a useful marker for identifying inflammatory lesions through imaging astrogliosis. This feature of 18F-THK5351 may contribute to the early diagnosis of cytomegalovirus ventriculoencephalitis.
MeSH term(s)	Female ; Humans ; Aged ; Gliosis ; Cytomegalovirus ; Aminopyridines ; Positron-Emission Tomography
Chemical Substances	THK5351 ; Aminopyridines
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004809
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Article ; Online: 18 F-THK5351 PET Can Evaluate Tumor Extension in Intravascular Large B-Cell Lymphoma : Comparison With 11C-Methionine PET and 18F-FDG PET.

Hatano, Keiko / Ishibashi, Kenji / Kondo, Soichiro / Ishii, Kenji / Iwata, Atsushi

Clinical nuclear medicine

2023 Volume 48, Issue 4, Page(s) e204–e206

Abstract: Abstract: A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11 C-methionine, 18 F- ...

Abstract	Abstract: A 79-year-old man presenting with gait disturbance and cognitive decline was diagnosed with intravascular large B-cell lymphoma (IVLBCL) by random skin biopsy. Some IVLBCL lesions were identified by PET examinations using 11 C-methionine, 18 F-FDG, and 18 F-THK5351. 11 C-methionine and 18 F-FDG uptake, which likely reflects the presence of the lymphoma cells themselves, increased clearly in the left putamen but weakly in the left deep white matter. 18 F-THK5351 uptake increased in all lesions, likely reflecting perivascular astrogliosis caused by IVLBCL. Hence, 18 F-THK5351 PET can evaluate tumor extension in IVLBCL lesions where 11 C-methionine and 18 F-FDG PET may fail in its visualization.
MeSH term(s)	Male ; Humans ; Aged ; Fluorodeoxyglucose F18 ; Carbon Radioisotopes ; Radiopharmaceuticals ; Positron-Emission Tomography ; Methionine ; Lymphoma, Large B-Cell, Diffuse
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; THK5351 ; Carbon-11 ; Carbon Radioisotopes ; Radiopharmaceuticals ; carbon-11 methionine (58576-49-1) ; Methionine (AE28F7PNPL)
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004568
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Article: A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure - A Theoretical Approach Using Fluid Dynamics.

Kameyama, Masashi / Momose, Toshimitsu / Ishibashi, Kenji / Ishii, Kenji

Frontiers in neurology

2022 Volume 12, Page(s) 765463

Abstract: Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [ ...

Abstract	Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [
Language	English
Publishing date	2022-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.765463
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Article ; Online: Detailed Assessment of 18F-THK5351 Distribution Pattern in the Midbrain: Comparison With Progressive Supranuclear Palsy and Corticobasal Syndrome.

Ishibashi, Kenji / Kurihara, Masanori / Ihara, Ryoko / Higashihara, Mana / Iwata, Atsushi / Ishii, Kenji

Clinical nuclear medicine

2023 Volume 48, Issue 10, Page(s) 841–846

Abstract: Background: 18F-THK5351 PET is used to image ongoing astrogliosis by estimating monoamine oxidase B levels. 18F-THK5351 preferentially accumulates around the substantia nigra (SN) and periaqueductal gray (PG) in the midbrain under healthy conditions and ...

Abstract	Background: 18F-THK5351 PET is used to image ongoing astrogliosis by estimating monoamine oxidase B levels. 18F-THK5351 preferentially accumulates around the substantia nigra (SN) and periaqueductal gray (PG) in the midbrain under healthy conditions and exhibits a "trimodal pattern." In progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), the midbrain 18F-THK5351 uptake can be increased by astrogliosis, collapsing the "trimodal pattern." We aimed to elucidate cases in which the "trimodal pattern" collapses in PSP and CBS. Patients and methods: Participants in the PSP (n = 11), CBS (n = 17), Alzheimer disease (n = 11), and healthy control (n = 8) groups underwent 18F-THK5351 PET. Volumes of interest (VOIs) were placed on the SN, PG, and their midpoints. The midbrain uptake ratio (MUR) was calculated to assess the trimodal pattern as follows: MUR = (VOI value on the midpoint)/(VOI value on the SN and PG). Approximately, the trimodal pattern can be identified at MUR <1 but not at MUR >1. Results: Compared with the healthy control group, MUR significantly increased in the PSP (P < 0.01) and CBS (P < 0.01) groups, but was unchanged in the Alzheimer disease group (P = 0.10). In the PSP group, all patients, including 2 with mild symptoms and a short disease duration, showed MUR >1. In the CBS group, MUR varied widely. Conclusions: In PSP, the trimodal pattern can collapse even in the early phase when symptoms are mild. In CBS, the trimodal pattern may or may not collapse depending on the underlying pathology.
MeSH term(s)	Humans ; Supranuclear Palsy, Progressive/diagnostic imaging ; Alzheimer Disease ; Corticobasal Degeneration ; Gliosis ; Mesencephalon/diagnostic imaging
Chemical Substances	THK5351
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000004815
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Article ; Online: Ventral Variant Posterior Cortical Atrophy with Occipito-temporal Accumulation of Tau Proteins/Astrocyte Gliosis.

Shiio, Mihoko / Maeda, Nobuya / Iwata, Atsushi / Ishibashi, Kenji / Ishii, Kenji / Takuma, Hiroshi / Ishizaka, Yuko / Sakurai, Yasuhisa

Internal medicine (Tokyo, Japan)

2024

Abstract: A 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these ... ...

Abstract	A 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these symptoms were attributed to damage to the bilateral occipito-temporal cortices, consistent with ventral variant PCA. While the Pittsburgh compound B uptake was extensively distributed throughout the occipito-parietal (dorsal) and occipito-temporal (ventral) areas, the THK5351 (ligand binding to tau aggregates/astrocyte gliosis) accumulation was limited to the ventral area. These findings suggest that local accumulation of tau proteins and/or astrocyte gliosis over the occipito-temporal cortices can result in ventral variant PCA.
Language	English
Publishing date	2024-02-19
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2844-23
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Article: [Cross-validation of Quantitative Analytical Software Using 18F-florbetapir PET Imaging].

Wagatsuma, Kei / Miwa, Kenta / Sakata, Muneyuki / Ishibashi, Kenji / Ishii, Kenji

Nihon Hoshasen Gijutsu Gakkai zasshi

2021 Volume 77, Issue 1, Page(s) 32–40

Abstract: Background: 18: Methods: We injected 40 individuals with : Results: A cSUVR>1.10 was determined by Amygo neuro and MIMneuro in 15 of the 40 individuals. The rSUVR in the posterior cingulate, parietal lobe, precuneus, and temporal lobe ... ...

Abstract	Background: 18 Methods: We injected 40 individuals with Results: A cSUVR>1.10 was determined by Amygo neuro and MIMneuro in 15 of the 40 individuals. The rSUVR in the posterior cingulate, parietal lobe, precuneus, and temporal lobe significantly differed between Amygo neuro and MIMneuro, whereas the cSUVR did not. The SUVR calculated by the two types of software closely correlated to each other (R=0.89-0.96, P<0.05). Conclusions: The cSUVR was not different between Amygo neuro and MIMneuro. We suggest that Amygo neuro is comparable to MIMneuro in quantitative analysis using SUVR for
MeSH term(s)	Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/metabolism ; Aniline Compounds ; Brain/diagnostic imaging ; Brain/metabolism ; Ethylene Glycols ; Humans ; Positron-Emission Tomography ; Software
Chemical Substances	Amyloid beta-Peptides ; Aniline Compounds ; Ethylene Glycols ; florbetapir (6867Q6IKOD)
Language	Japanese
Publishing date	2021-01-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2269092-X
ISSN	1881-4883 ; 0369-4305
ISSN (online)	1881-4883
ISSN	0369-4305
DOI	10.6009/jjrt.2021_JSRT_77.1.32
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Article ; Online: Brain

Ishibashi, Kenji / Miura, Yoshiharu / Wagatsuma, Kei / Kameyama, Masashi / Ishii, Kenji

Journal of neuroimaging : official journal of the American Society of Neuroimaging

2021 Volume 31, Issue 5, Page(s) 864–868

Abstract: Background and purpose: Little evidence exists on the role of type 1 metabotropic glutamate receptor (mGluR1) in the pathophysiology of Alzheimer's disease (AD), although mGluR1 may be involved in the regulation of neuronal excitability and synaptic ... ...

Abstract	Background and purpose: Little evidence exists on the role of type 1 metabotropic glutamate receptor (mGluR1) in the pathophysiology of Alzheimer's disease (AD), although mGluR1 may be involved in the regulation of neuronal excitability and synaptic plasticity. We have recently reported that mGluR1 availability in the early stage of AD is equivalent to that in healthy subjects. This study aimed to address whether mGluR1 availability changes with the progression of AD. Methods: Eight patients with AD (79.1 ± 4.6 years) underwent a total of two positron emission tomography (PET) examinations using the mGluR1 radioligand during the early-to-middle stages of AD. The mean interval was 2.8 years. Volumes-of-interest were placed on the frontal, parietal, and temporal cortices, hippocampus, anterior and posterior lobes, and vermis in the cerebellum. The binding potential (BP Results: No significant difference was observed in BP Conclusion: This study suggests that mGluR1 availability is unchanged in the follow-up period of a few years during the early-to-middle stages of AD.
MeSH term(s)	Alzheimer Disease/diagnostic imaging ; Brain/diagnostic imaging ; Brain/metabolism ; Humans ; Positron-Emission Tomography ; Receptors, Metabotropic Glutamate/metabolism
Chemical Substances	Receptors, Metabotropic Glutamate
Language	English
Publishing date	2021-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1071724-9
ISSN	1552-6569 ; 1051-2284
ISSN (online)	1552-6569
ISSN	1051-2284
DOI	10.1111/jon.12895
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