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Article: Blue light potentiates safety and bactericidal activity of p-Toluquinone

Wang, Shen / Wong, Ka Ioi / Li, Yongli / Ishii, Momoko / Li, Xin / Wei, Li / Lu, Min / Wu, Mei X.

Journal of photochemistry and photobiology. 2022 May, v. 230

2022

Abstract: Fewer antibiotics are available for effective management of bacterial infections to date owing to increasing multiple-drug resistance (MDR). Here, we expand our early success in combination of 405 nm blue light irradiation with phenolic compounds to ... ...

Abstract	Fewer antibiotics are available for effective management of bacterial infections to date owing to increasing multiple-drug resistance (MDR). Here, we expand our early success in combination of 405 nm blue light irradiation with phenolic compounds to sufficiently kill blue light-refractory MDR Escherichia coli (E. coli). p-Toluquinone (p-TQ) alongside blue light inactivated 7.3 log₁₀E. coli within 6 min, whereas either alone was totally ineffective. A similar killing efficacy was attained with four other pathogens commonly seen in hospital-acquired infections and Enterococcus faecalis (Ef) that don't produce porphyrins-like molecules. The combinatory therapy prevented recurrence of E. coli infection in skin scratch wounds of murine. The bactericidal activity was ascribed to reactive oxygen species (ROS) generation triggered by blue light-mediated excitation of p-TQ, which is less likely to induce resistance because of multi-targeted and non-specific nature of ROS. Remarkably, toxic p-TQ became harmless to mammalian cells after brief exposure to blue light while retaining its bactericidal activity. The opposite effect of blue light on p-TQ activity unravels a novel, simple strategy to detoxify p-TQ and its combination with blue light as a safe and efficacious bactericidal modality for managing MDR bacterial infections.
Keywords	Enterococcus faecalis ; Escherichia coli ; antibacterial properties ; blue light ; irradiation ; mice ; multiple drug resistance ; photobiology ; photochemistry ; reactive oxygen species ; therapeutics ; toxicity
Language	English
Dates of publication	2022-05
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2022.112427
Database	NAL-Catalogue (AGRICOLA)

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Article: Tuning Exchange Coupling in a New Family of Nanocrystal-Based Granular Multiferroics Using an Applied Electric Field

Sasaki, Stephen S. / Udalov, Oleg G. / Kurish, Jeffrey A. / Ishii, Momoko / Beloborodov, Igor S. / Tolbert, Sarah H.

ACS applied materials & interfaces. 2022 Mar. 30, v. 14, no. 14

2022

Abstract: In this work, we demonstrate an experimental realization of a granular multiferroic composite, where the magnetic state of a nanocrystal array is modified by tuning the interparticle exchange coupling using an applied electric field. Previous theoretical ...

Abstract	In this work, we demonstrate an experimental realization of a granular multiferroic composite, where the magnetic state of a nanocrystal array is modified by tuning the interparticle exchange coupling using an applied electric field. Previous theoretical models of a granular multiferroic composite predicted a unique magnetoelectric coupling mechanism, in which the magnetic spins of the ensemble are governed by interparticle exchange. The extent of these exchange interactions can be controlled by varying the local dielectric environment between grains. We specifically utilize the strong dielectric dependence of ferroelectric materials to modify the interparticle coupling of closely spaced magnetic nanoparticles using either a change in temperature or an electric field. This coupling modifies the ensemble magnetic coercivity and thus the superparamagnetic-to-ferromagnetic phase transition temperature. Through the use of two different ferroelectrics, our results suggest that this magnetoelectric coupling mechanism could be generalized as a new class of multiferroic material, applicable to a broad range of ferroelectric/magnetic nanocrystal composites.
Keywords	electric field ; magnetism ; nanocrystals ; new family ; phase transition ; temperature
Language	English
Dates of publication	2022-0330
Size	p. 16505-16514.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c20599
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Article ; Online: Blue light potentiates safety and bactericidal activity of p-Toluquinone.

Wang, Shen / Wong, Ka Ioi / Li, Yongli / Ishii, Momoko / Li, Xin / Wei, Li / Lu, Min / Wu, Mei X

Journal of photochemistry and photobiology. B, Biology

2022 Volume 230, Page(s) 112427

Abstract	Fewer antibiotics are available for effective management of bacterial infections to date owing to increasing multiple-drug resistance (MDR). Here, we expand our early success in combination of 405 nm blue light irradiation with phenolic compounds to sufficiently kill blue light-refractory MDR Escherichia coli (E. coli). p-Toluquinone (p-TQ) alongside blue light inactivated 7.3 log
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Infections ; Benzoquinones ; Escherichia coli ; Light ; Mammals ; Mice ; Reactive Oxygen Species/pharmacology
Chemical Substances	Anti-Bacterial Agents ; Benzoquinones ; Reactive Oxygen Species ; 2-methyl-1,4-benzoquinone (VF06HB6AZN)
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2022.112427
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Article ; Online: Biocement from the ocean: Hybrid microbial-electrochemical mineralization of CO

Kludze, Atsu / Solanki, Devan / Lejeune, Marcelo / Yanagi, Rito / Ishii, Momoko / Raychaudhuri, Neera / Anastas, Paul / Boyle, Nanette / Hu, Shu

iScience

2022 Volume 25, Issue 10, Page(s) 105156

Abstract: Increasing concentrations of atmospheric ... ...

Abstract	Increasing concentrations of atmospheric CO
Language	English
Publishing date	2022-09-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2022.105156
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tuning Exchange Coupling in a New Family of Nanocrystal-Based Granular Multiferroics Using an Applied Electric Field.

Sasaki, Stephen S / Udalov, Oleg G / Kurish, Jeffrey A / Ishii, Momoko / Beloborodov, Igor S / Tolbert, Sarah H

ACS applied materials & interfaces

2022 Volume 14, Issue 14, Page(s) 16505–16514

Abstract	In this work, we demonstrate an experimental realization of a granular multiferroic composite, where the magnetic state of a nanocrystal array is modified by tuning the interparticle exchange coupling using an applied electric field. Previous theoretical models of a granular multiferroic composite predicted a unique magnetoelectric coupling mechanism, in which the magnetic spins of the ensemble are governed by interparticle exchange. The extent of these exchange interactions can be controlled by varying the local dielectric environment between grains. We specifically utilize the strong dielectric dependence of ferroelectric materials to modify the interparticle coupling of closely spaced magnetic nanoparticles using either a change in temperature or an electric field. This coupling modifies the ensemble magnetic coercivity and thus the superparamagnetic-to-ferromagnetic phase transition temperature. Through the use of two different ferroelectrics, our results suggest that this magnetoelectric coupling mechanism could be generalized as a new class of multiferroic material, applicable to a broad range of ferroelectric/magnetic nanocrystal composites.
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c20599
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis.

Johnson, Caroline H / Golla, Jaya Prakash / Dioletis, Evangelos / Singh, Surendra / Ishii, Momoko / Charkoftaki, Georgia / Thompson, David C / Vasiliou, Vasilis

Cancers

2021 Volume 13, Issue 17

Abstract: The etiology of colorectal cancer (CRC) is complex. Approximately, 10% of individuals with CRC have predisposing germline mutations that lead to familial cancer syndromes, whereas most CRC patients have sporadic cancer resulting from a combination of ... ...

Abstract	The etiology of colorectal cancer (CRC) is complex. Approximately, 10% of individuals with CRC have predisposing germline mutations that lead to familial cancer syndromes, whereas most CRC patients have sporadic cancer resulting from a combination of environmental and genetic risk factors. It has become increasingly clear that chronic alcohol consumption is associated with the development of sporadic CRC; however, the exact mechanisms by which alcohol contributes to colorectal carcinogenesis are largely unknown. Several proposed mechanisms from studies in CRC models suggest that alcohol metabolites and/or enzymes associated with alcohol metabolism alter cellular redox balance, cause DNA damage, and epigenetic dysregulation. In addition, alcohol metabolites can cause a dysbiotic colorectal microbiome and intestinal permeability, resulting in bacterial translocation, inflammation, and immunosuppression. All of these effects can increase the risk of developing CRC. This review aims to outline some of the most significant and recent findings on the mechanisms of alcohol in colorectal carcinogenesis. We examine the effect of alcohol on the generation of reactive oxygen species, the development of genotoxic stress, modulation of one-carbon metabolism, disruption of the microbiome, and immunosuppression.
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13174404
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increase in muscle endurance in mice by dietary Yamabushitake mushroom (Hericium erinaceus) possibly via activation of PPARδ.

Komiya, Yusuke / Nakamura, Toshiya / Ishii, Momoko / Shimizu, Kuniyoshi / Hiraki, Eri / Kawabata, Fuminori / Nakamura, Mako / Tatsumi, Ryuichi / Ikeuchi, Yoshihide / Mizunoya, Wataru

Animal science journal = Nihon chikusan Gakkaiho

2019 Volume 90, Issue 6, Page(s) 781–789

Abstract: Skeletal muscle fiber is largely classified into two types: type 1 (slow-twitch) and type 2 (fast-twitch) fibers. Meat quality and composition of fiber types are thought to be closely related. Previous research showed that overexpression of ... ...

Abstract	Skeletal muscle fiber is largely classified into two types: type 1 (slow-twitch) and type 2 (fast-twitch) fibers. Meat quality and composition of fiber types are thought to be closely related. Previous research showed that overexpression of constitutively active peroxisome proliferator-activated receptor (PPAR)δ, a nuclear receptor present in skeletal muscle, increased type 1 fibers in mice. In this study, we found that hexane extracts of Yamabushitake mushroom (Hericium erinaceus) showed PPARδ agonistic activity in vitro. Eight-week-old C57BL/6J mice were fed a diet supplemented with 5% (w/w) freeze-dried Yamabushitake mushroom for 24 hr. After the treatment period, the extensor digitorum longus (EDL) muscles were excised. The Yamabushitake-supplemented diet up-regulated the PPARδ target genes Pdk4 and Ucp3 in mouse skeletal muscles in vivo. Furthermore, feeding the Yamabushitake-supplemented diet to mice for 8 weeks resulted in a significant increase in muscle endurance. These results indicate that Yamabushitake mushroom contains PPARδ agonistic ligands and that dietary intake of Yamabushitake mushroom could activate PPARδ in skeletal muscle of mice. Unexpectedly, we observed no significant alterations in composition of muscle fiber types between the mice fed control and Yamabushitake-supplemented diets.
MeSH term(s)	Agaricales/chemistry ; Animals ; Dietary Supplements ; Hexanes ; Ligands ; Male ; Mice, Inbred C57BL ; Muscle Fibers, Fast-Twitch/metabolism ; Muscle Fibers, Slow-Twitch/metabolism ; Muscle Strength ; Muscle, Skeletal/metabolism ; PPAR delta/agonists ; PPAR delta/genetics ; Plant Extracts/pharmacology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Time Factors ; Uncoupling Protein 3/genetics ; Uncoupling Protein 3/metabolism ; Up-Regulation/drug effects
Chemical Substances	Hexanes ; Ligands ; PPAR delta ; Pdk4 protein, mouse ; Plant Extracts ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase ; Ucp3 protein, mouse ; Uncoupling Protein 3 ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2019-04-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13199
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacteria-specific phototoxic reactions triggered by blue light and phytochemical carvacrol.

Lu, Min / Wang, Shen / Wang, Tao / Hu, Sisi / Bhayana, Brijesh / Ishii, Momoko / Kong, Yifei / Cai, Yuchen / Dai, Tianhong / Cui, Wenguo / Wu, Mei X

Science translational medicine

2021 Volume 13, Issue 575

Abstract: Development of alternatives to antibiotics is one of the top priorities in the battle against multidrug-resistant (MDR) bacterial infections. Here, we report that two naturally occurring nonantibiotic modalities, blue light and phytochemical carvacrol, ... ...

Abstract	Development of alternatives to antibiotics is one of the top priorities in the battle against multidrug-resistant (MDR) bacterial infections. Here, we report that two naturally occurring nonantibiotic modalities, blue light and phytochemical carvacrol, synergistically kill an array of bacteria including their planktonic forms, mature biofilms, and persisters, irrespective of their antibiotic susceptibility. Combination but not single treatment completely or substantially cured acute and established biofilm-associated
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.aba3571
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Article: Increase in muscle endurance in mice by dietary Yamabushitake mushroom (Hericium erinaceus) possibly via activation of PPARδ

Komiya, Yusuke / Nakamura, Toshiya / Ishii, Momoko / Shimizu, Kuniyoshi / Hiraki, Eri / Kawabata, Fuminori / Nakamura, Mako / Tatsumi, Ryuichi / Ikeuchi, Yoshihide / Mizunoya, Wataru

Animal science journal =. 2019 June, v. 90, no. 6

2019

Abstract: Skeletal muscle fiber is largely classified into two types: type 1 (slow‐twitch) and type 2 (fast‐twitch) fibers. Meat quality and composition of fiber types are thought to be closely related. Previous research showed that overexpression of ... ...

Abstract	Skeletal muscle fiber is largely classified into two types: type 1 (slow‐twitch) and type 2 (fast‐twitch) fibers. Meat quality and composition of fiber types are thought to be closely related. Previous research showed that overexpression of constitutively active peroxisome proliferator‐activated receptor (PPAR)δ, a nuclear receptor present in skeletal muscle, increased type 1 fibers in mice. In this study, we found that hexane extracts of Yamabushitake mushroom (Hericium erinaceus) showed PPARδ agonistic activity in vitro. Eight‐week‐old C57BL/6J mice were fed a diet supplemented with 5% (w/w) freeze‐dried Yamabushitake mushroom for 24 hr. After the treatment period, the extensor digitorum longus (EDL) muscles were excised. The Yamabushitake‐supplemented diet up‐regulated the PPARδ target genes Pdk4 and Ucp3 in mouse skeletal muscles in vivo. Furthermore, feeding the Yamabushitake‐supplemented diet to mice for 8 weeks resulted in a significant increase in muscle endurance. These results indicate that Yamabushitake mushroom contains PPARδ agonistic ligands and that dietary intake of Yamabushitake mushroom could activate PPARδ in skeletal muscle of mice. Unexpectedly, we observed no significant alterations in composition of muscle fiber types between the mice fed control and Yamabushitake‐supplemented diets.
Keywords	Hericium ; food intake ; freeze drying ; gene expression regulation ; genes ; hexane ; ligands ; meat quality ; mice ; muscle fibers ; muscles ; mushrooms ; peroxisome proliferator-activated receptors ; skeletal muscle
Language	English
Dates of publication	2019-06
Size	p. 781-789.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13199
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Using Web-Based Social Media to Recruit Heavy-Drinking Young Adults for Sleep Intervention: Prospective Observational Study.

Ash, Garrett I / Robledo, David S / Ishii, Momoko / Pittman, Brian / DeMartini, Kelly S / O'Malley, Stephanie S / Redeker, Nancy S / Fucito, Lisa M

Journal of medical Internet research

2020 Volume 22, Issue 8, Page(s) e17449

Abstract: Background: Novel alcohol prevention strategies are needed for heavy-drinking young adults. Sleep problems are common among young adults who drink heavily and are a risk factor for developing an alcohol use disorder (AUD). Young adults, interested in ... ...

Abstract	Background: Novel alcohol prevention strategies are needed for heavy-drinking young adults. Sleep problems are common among young adults who drink heavily and are a risk factor for developing an alcohol use disorder (AUD). Young adults, interested in the connection between sleep and alcohol, are open to getting help with their sleep. Therefore, sleep interventions may offer an innovative solution. This study evaluates social media advertising for reaching young adults and recruiting them for a new alcohol prevention program focused on sleep. Objective: This study aims to evaluate the effectiveness and cost of using Facebook, Instagram, and Snapchat advertising to reach young adults who drink heavily for a sleep intervention; characterize responders' sleep, alcohol use, and related concerns and interests; and identify the most appealing advertising content. Methods: In study 1, advertisements targeting young adults with sleep concerns, heavy alcohol use, or interest in participating in a sleep program ran over 3 months. Advertisements directed volunteers to a brief web-based survey to determine initial sleep program eligibility and characterize the concerns or interests that attracted them to click the advertisement. In study 2, three advertisements ran simultaneously for 2 days to enable us to compare the effectiveness of specific advertising themes. Results: In study 1, advertisements generated 13,638 clicks, 909 surveys, and 27 enrolled volunteers in 3 months across the social media platforms. Fees averaged US $0.27 per click, US $3.99 per completed survey, US $11.43 per volunteer meeting initial screening eligibility, and US $106.59 per study enrollee. On average, those who completed the web-based survey were 21.1 (SD 2.3) years of age, and 69.4% (631/909) were female. Most reported sleep concerns (725/909, 79.8%) and an interest in the connection between sleep and alcohol use (547/909, 60.2%), but few had drinking concerns (49/909, 5.4%). About one-third (317/909, 34.9%) were identified as being at risk for developing an AUD based on a validated alcohol screener. Among this subsample, 8.5% (27/317) met the final criteria and were enrolled in the trial. Some volunteers also referred additional volunteers by word of mouth. In study 2, advertisements targeting sleep yielded a higher response rate than advertisements targeting alcohol use (0.91% vs 0.56% click rate, respectively; P<.001). Conclusions: Social media advertisements designed to target young adults with sleep concerns reached those who also drank alcohol heavily, despite few being concerned about their drinking. Moreover, advertisements focused on sleep were more effective than those focused on drinking. Compared with previous studies, cost-effectiveness was moderate for engagement (impressions to clicks), excellent for conversion (clicks to survey completion), and reasonable for enrollment. These data demonstrate the utility of social media advertising focused on sleep to reach young adults who drink heavily and recruit them for intervention.
MeSH term(s)	Adolescent ; Adult ; Alcohol Drinking/prevention & control ; Alcoholism/therapy ; Female ; Humans ; Male ; Prospective Studies ; Sleep Wake Disorders/etiology ; Social Media/standards ; Surveys and Questionnaires ; Volunteers ; Young Adult
Language	English
Publishing date	2020-08-11
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/17449
Database	MEDical Literature Analysis and Retrieval System OnLINE

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