LIVIVO - Search results -

Search results

Result 1 - 10 of total 357

Search options

Article ; Online: Invited Commentary: The Efficacy of VAMMFT Compared to "Bogota Bag" in Achieving Sheath Closure Following Temporary Abdominal Closure at Index Laparotomy for Trauma.

Isik, Arda / Memis, Ufuk

2023 Volume 47, Issue 6, Page(s) 1442–1443

MeSH term(s)	Humans ; Laparotomy ; Colombia ; Abdomen/surgery ; Abdominal Muscles ; Abdominal Injuries/surgery ; Retrospective Studies ; Abdominal Wound Closure Techniques
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-023-06931-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1336: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Synergistic effect of mesoporous silica nanocarrier-assisted photodynamic therapy and anticancer agent activity on lung cancer cells.

Güleryüz, Burcu / Işık, Ayşe / Gülsoy, Murat

Lasers in medical science

2024 Volume 39, Issue 1, Page(s) 91

Abstract: Investigating combined treatment methodologies is crucial for addressing the complex nature of cancer. As an emerging strategy, nano-biotechnology encourages the design of unique nanocarriers possessing simultaneous therapeutic application properties. ... ...

Abstract	Investigating combined treatment methodologies is crucial for addressing the complex nature of cancer. As an emerging strategy, nano-biotechnology encourages the design of unique nanocarriers possessing simultaneous therapeutic application properties. This study aims to explore the combined effects of photodynamic and anticancer treatments using a multifunctional nanocarrier system co-administering the photosensitizer IR780 and the anticancer agent curcumin (Cur) on lung cancer cells. Nanocarriers were prepared by encapsulation IR780 and Cur inside polyethylene glycol-capped mesoporous silica nanoparticles (Cur&IR780@MSN). Various concentrations of nanocarriers were evaluated on A549 cells following 5 min NIR laser light (continuous wave, 785 nm, 500 mW/cm
MeSH term(s)	Humans ; Lung Neoplasms/drug therapy ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Silicon Dioxide/chemistry ; Drug Carriers/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Nanoparticles/chemistry ; Photochemotherapy
Chemical Substances	Curcumin (IT942ZTH98) ; Silicon Dioxide (7631-86-9) ; Drug Carriers ; Antineoplastic Agents
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-023-03969-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The prognostic and predictive role of class III β-Tubulin and hENT1 expression in patients with advanced pancreatic ductal adenocarcinoma.

Sahin, T K / Isik, A / Guven, D C / Ceylan, F / Babaoglu, B / Akyol, A / Yalcin, S / Dizdar, O

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

2024 Volume 24, Issue 2, Page(s) 279–288

Abstract: Background: FOLFIRINOX and gemcitabine-nabpaclitaxel (GnP) are standard first-line treatment regimens for advanced pancreatic ductal adenocarcinoma (PDAC). However, currently, there is a lack of predictive biomarkers to aid in the treatment selection. ... ...

Abstract	Background: FOLFIRINOX and gemcitabine-nabpaclitaxel (GnP) are standard first-line treatment regimens for advanced pancreatic ductal adenocarcinoma (PDAC). However, currently, there is a lack of predictive biomarkers to aid in the treatment selection. We aimed to explore the prognostic and predictive value of class III β-Tubulin (TUBB3) and human equilibrative nucleoside transporter 1 (hENT1) expression, which have previously been shown to be associated with taxane and gemcitabine resistance in advanced PDAC. Methods: We conducted a retrospective analysis of 106 patients with advanced PDAC treated with GnP and/or FOLFIRINOX at our institution. TUBB3 and hENT1 immunohistochemical staining was performed on tumor specimens and subsequently evaluated based on the intensity and percentage of expression. Results: In patients who received the GnP regimen, a high combined score (TUBB3 Conclusion: Our findings indicate that tumor TUBB3 and hENT1 expression may predict the efficacy of the GnP regimen, and low TUBB3 and high hENT1 expression (TUBB3
MeSH term(s)	Humans ; Adenocarcinoma/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/therapeutic use ; Equilibrative Nucleoside Transporter 1/genetics ; Equilibrative Nucleoside Transporter 1/analysis ; Gemcitabine ; Pancreatic Neoplasms/pathology ; Prognosis ; Retrospective Studies ; Tubulin/genetics ; Tubulin/metabolism ; Tubulin/therapeutic use
Chemical Substances	Deoxycytidine (0W860991D6) ; Equilibrative Nucleoside Transporter 1 ; Gemcitabine ; Tubulin ; SLC29A1 protein, human
Language	English
Publishing date	2024-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2056680-3
ISSN	1424-3911 ; 1424-3903
ISSN (online)	1424-3911
ISSN	1424-3903
DOI	10.1016/j.pan.2024.01.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5553: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Letter to the editor concerning "Most cited 100 articles from Turkey on abdominal wall hernias: a bibliometric study".

Işık, Arda / Fırat, Deniz

Turkish journal of surgery

2021 Volume 37, Issue 2, Page(s) 193–194

Language	English
Publishing date	2021-06-30
Publishing country	Turkey
Document type	Journal Article
ISSN	2564-6850
ISSN	2564-6850
DOI	10.47717/turkjsurg.2021.4973
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Impact of Intranasal Splint Removal Time on Postoperative Complications after Septoplasty.

Arslan, S / Yıldırım, H / Çobanoğlu, B / Işık, A Ü / Bahadır, O

Nigerian journal of clinical practice

2024 Volume 27, Issue 4, Page(s) 430–434

Abstract: Background: Various types of nasal tampons are used for packing after septoplasty. Intranasal splints are widely used as they are more advantageous than other materials regarding the lower complication rates of synechia, and lesser pain during removal. ... ...

Abstract	Background: Various types of nasal tampons are used for packing after septoplasty. Intranasal splints are widely used as they are more advantageous than other materials regarding the lower complication rates of synechia, and lesser pain during removal. However, there is no consensus on the timing of intranasal splint removal after septoplasty operations. Aim: In this study, we aimed to investigate the effects of removal time of intranasal splints on postoperative complications after septoplasty. Methods: One hundred patients who had septoplasty were randomly divided into two groups according to splint removal time. In group I, the splints were removed on the third postoperative day and in group II, splints were removed on the seventh postoperative day. Pain during splint removal was evaluated by visual analog scale (VAS). Complications of hemorrhage, septal hematoma, crusting, mucosal injury, and infection were recorded during splint removal and compared. In the first postoperative month, hemorrhage, crusting, mucosal injury, infection, synechia, and in the second postoperative month, synechia and perforation rates were compared between two groups. Results: Mucosal crusting was significantly higher in group II during splint removal. There was no statistically significant difference between the two groups regarding the complication rates and pain scores. Our findings showed no significant difference in pain scores during splint removal and postoperative complications between the two groups except for mucosal crusting. Conclusion: Based on our findings, although there is no consensus on the optimal time for splint removal, earlier removal of splints can be considered a favorable option after septoplasty operations.
MeSH term(s)	Humans ; Female ; Male ; Adult ; Nasal Septum/surgery ; Splints ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Rhinoplasty/adverse effects ; Rhinoplasty/methods ; Time Factors ; Middle Aged ; Young Adult ; Tampons, Surgical ; Device Removal ; Pain, Postoperative/etiology ; Pain, Postoperative/epidemiology ; Adolescent ; Pain Measurement
Language	English
Publishing date	2024-04-29
Publishing country	India
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_381_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4975: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Characterization of the Subcellular Distribution of Phospho-β-catenin in Colorectal Cancer.

Uzun, Sarp / Isik, Aynur / Katipoglu, Kubra / Guner, Gunes / Akyol, Aytekin

In vivo (Athens, Greece)

2023 Volume 37, Issue 4, Page(s) 1576–1583

Abstract: Background/aim: β-Catenin is a multifunctional protein, which is localized to different subcellular compartments of the normal colon epithelium. The hyperactivation of Wnt pathway results in the nuclear accumulation of β-catenin and induction of ... ...

Abstract	Background/aim: β-Catenin is a multifunctional protein, which is localized to different subcellular compartments of the normal colon epithelium. The hyperactivation of Wnt pathway results in the nuclear accumulation of β-catenin and induction of colorectal carcinogenesis. Although N-terminally hypo-phosphorylated β-catenin (active β-catenin) is known as the transcriptionally active form, phospho-S33/S37/T41-β-catenin (phospho-β-catenin) can also accumulate in the nucleus. In this study, we aimed to characterize the subcellular distribution of phospho-β-catenin and the other forms of β-catenin in normal colon epithelium and colorectal cancer (CRC). Materials and methods: Phosphorylated, hypo-phosphorylated, and the total pool of β-catenin were evaluated in colon epithelium and CRC using immunohistochemistry, immunofluorescence staining, and western blotting. Tissue microarrays were used to determine the expression pattern of phospho-β-catenin in CRC samples. Results: Almost 11% (49/452) of CRCs expressed moderate to high levels of phospho-β-catenin in the nucleus. In addition, hypo-phosphorylated and phosphorylated forms of β-catenin localized to different subcellular regions in normal colon epithelium and CRC. Immunoblotting experiments suggested that truncated phospho-β-catenin forms can be found in CRCs. Conclusion: Phospho-β-catenin accumulates in the nucleus and different molecular weight β-catenin proteins are present in colon cancer cells. To elaborate on the functional significance of nuclear phospho-β-catenin, further studies should be performed.
MeSH term(s)	Humans ; beta Catenin ; Carcinogenesis/metabolism ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Colonic Neoplasms ; Colorectal Neoplasms/metabolism ; Wnt Signaling Pathway
Chemical Substances	beta Catenin ; CTNNB1 protein, human
Language	English
Publishing date	2023-06-25
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13242
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2288: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Tyrosine Kinase Inhibitor Therapies in Chronic Myeloid Leukemia: Effects on Clinical Characteristics and Triglyceride-to-High Density Lipoprotein Cholesterol Ratio.

Erkek, E T / Isik, A C / Ipek, Y / Kul, A N

Nigerian journal of clinical practice

2023 Volume 26, Issue 6, Page(s) 802–809

Abstract: Background and aim: Tyrosine kinase inhibitors (TKIs) have dramatically improved chronic myeloid leukemia (CML) prognosis. However, TKIs are associated with dyslipidemia and impaired glucosehomeostasis. Triglyceride-to-high-density lipoprotein ... ...

Abstract	Background and aim: Tyrosine kinase inhibitors (TKIs) have dramatically improved chronic myeloid leukemia (CML) prognosis. However, TKIs are associated with dyslipidemia and impaired glucosehomeostasis. Triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) is proposed to be an indicator of insulin resistance and atherogenic index, but there is no research on TG/HDL-C alterations in patients receiving TKIs for CML. We aimed to evaluate relationships between TKI type/count, clinical characteristics, and laboratory results (particularly TG/HDL-C) in CML patients. Patients and methods: A total of 104 patients with chronic phase CML were enrolled in the study. All patients received initial imatinib therapy at 400 mg daily, the type or dose of TKI was then changed according to treatment response and clinical outcomes. Patients were compared with respect to TG/HDL-C categorization (>2.5 versus <2.5), number of TKIs used, and use of imatinib as the only TKI. Results: The median TG/HDL-C was 2.82 (1.03-17.33) and this ratio was higher than 2.5 in 59 (56.7%) patients. Patients with high TG/HDL-C had a significantly higher age than patients with low values (P < 0.001). Recipients of more than one TKI had higher EUTOS risk score and white blood cell (WBC) count (P < 0.05). Recipients of imatinib as the only TKI had higher age, low EOTUS risk score, low WBC, and low neutrophil count (all, P < 0.05). Conclusion: TG/HDL-C values were not associated with the number of different TKIs used or the use of imatinib only in chronic-phase patients with CML. Further large-scale prospective studies are needed to determine whether TG/HDL-C can be used for diagnostic or prognostic purposes in TKI recipients.
MeSH term(s)	Humans ; Cholesterol, HDL ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Tyrosine Kinase Inhibitors/therapeutic use
Chemical Substances	Cholesterol, HDL ; Imatinib Mesylate (8A1O1M485B) ; Tyrosine Kinase Inhibitors
Language	English
Publishing date	2023-07-20
Publishing country	India
Document type	Journal Article
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_755_22
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4975: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synthesis of new benzimidazole derivatives containing 1,3,4-thiadiazole: their in vitro antimicrobial, in silico molecular docking and molecular dynamic simulations studies.

Acar Çevik, U / Işık, A / Evren, A E / Kapusız, Ö / Gül, Ü D / Özkay, Y / Kaplancıklı, Z A

SAR and QSAR in environmental research

2022 Volume 33, Issue 11, Page(s) 899–914

Abstract: A series of some new benzimidazole-1,3,4-thiadiazoles was synthesized. The structures of target substances were confirmed by ... ...

Abstract	A series of some new benzimidazole-1,3,4-thiadiazoles was synthesized. The structures of target substances were confirmed by using
MeSH term(s)	Microbial Sensitivity Tests ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Escherichia coli ; Quantitative Structure-Activity Relationship ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents ; Thiadiazoles/pharmacology ; Benzimidazoles/pharmacology ; Candida albicans
Chemical Substances	1,3,4-thiadiazole (14IAC3GH7G) ; Anti-Infective Agents ; Anti-Bacterial Agents ; Thiadiazoles ; Benzimidazoles
Language	English
Publishing date	2022-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2023559-8
ISSN	1029-046X ; 1062-936X
ISSN (online)	1029-046X
ISSN	1062-936X
DOI	10.1080/1062936X.2022.2149620
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities.

Işık, A / Acar Çevik, U / Karayel, A / Celik, I / Erçetin, T / Koçak, A / Özkay, Y / Kaplancıklı, Z A

SAR and QSAR in environmental research

2022 Volume 33, Issue 3, Page(s) 193–214

Abstract: Some novel substituted thiazolylhydrazine derivatives were designed, synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes and antioxidant activities were investigated. The structures of the ... ...

Abstract	Some novel substituted thiazolylhydrazine derivatives were designed, synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes and antioxidant activities were investigated. The structures of the synthesized compounds were determined using different spectroscopic techniques such as
MeSH term(s)	Acetylcholinesterase/metabolism ; Alzheimer Disease ; Butyrylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Humans ; Hydrazones/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Quantitative Structure-Activity Relationship ; Structure-Activity Relationship
Chemical Substances	Cholinesterase Inhibitors ; Hydrazones ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2023559-8
ISSN	1029-046X ; 1062-936X
ISSN (online)	1029-046X
ISSN	1062-936X
DOI	10.1080/1062936X.2022.2041723
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Approaches to the treatment of pilonidal sinus disease, clinical practice in 2019.

Isik, Arda / Ramanathan, Rajesh

International wound journal

2019 Volume 17, Issue 2, Page(s) 508–509

MeSH term(s)	Endoscopy/standards ; Pilonidal Sinus/surgery ; Practice Guidelines as Topic ; Sacrococcygeal Region ; Skin Diseases/surgery
Language	English
Publishing date	2019-11-11
Publishing country	England
Document type	Letter
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.13265
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6006: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito