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Article ; Online: Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration.

Mahbub, Nasir Uddin / Islam, Md Minarul / Hong, Seong-Tshool / Chung, Hea-Jong

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1348279

Abstract: Abnormal behavior of α-synuclein and prion proteins is the hallmark of Parkinson's disease (PD) and prion illnesses, respectively, being complex neurological disorders. A primary cause of protein aggregation, brain injury, and cognitive loss in prion ... ...

Abstract	Abnormal behavior of α-synuclein and prion proteins is the hallmark of Parkinson's disease (PD) and prion illnesses, respectively, being complex neurological disorders. A primary cause of protein aggregation, brain injury, and cognitive loss in prion illnesses is the misfolding of normal cellular prion proteins (PrP
MeSH term(s)	Humans ; alpha-Synuclein ; Dysbiosis ; Gastrointestinal Microbiome ; Neuroinflammatory Diseases ; Parkinson Disease ; Prion Proteins ; Prions
Chemical Substances	alpha-Synuclein ; Prion Proteins ; Prions ; SNCA protein, human
Language	English
Publishing date	2024-02-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1348279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The gut microbe pair of

Wang, Mingda / Lkhagva, Enkhchimeg / Kim, Sura / Zhai, Chongkai / Islam, Md Minarul / Kim, Hyeon J / Hong, Seong-Tshool

Gut microbes

2024 Volume 16, Issue 1, Page(s) 2342497

Abstract: Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify and validate gut microbes at the species level that provide ...

Abstract	Despite the potential protective role of the gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed to identify and validate gut microbes at the species level that provide protection against SARS-CoV-2 infection. To identify gut microbes conferring protection against COVID-19, we conducted a fecal microbiota transplantation (FMT) from an individual with no history of COVID-19 infection or immunization into a lethal COVID-19 hamster model. FMT from this COVID-19-resistant donor resulted in significant phenotypic changes related to COVID-19 sensitivity in the hamsters. Metagenomic analysis revealed distinct differences in the gut microbiome composition among the hamster groups, leading to the identification of two previously unknown bacterial species:
MeSH term(s)	Animals ; Cricetinae ; Ruminococcus ; Gastrointestinal Microbiome ; COVID-19 ; SARS-CoV-2 ; Clostridiales ; CD8-Positive T-Lymphocytes ; Immunity, Cellular
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2024.2342497
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Article: Comparative Analysis of Original and Replaced Gut Microbiomes within Same Individuals Identified the Intestinal Microbes Associated with Weight Gaining.

Zhai, Chongkai / Ahn, Ji-Seon / Islam, Md Minarul / Lkhagva, Enkhchimeg / Chung, Hea-Jong / Hong, Seong-Tshool

Microorganisms

2022 Volume 10, Issue 5

Abstract: The precise mechanisms of action of the host's gut microbiome at the level of its constituting bacteria are obscure in most cases despite its definitive role. To study the precise role of the gut microbiome on the phenotypes of a host by excluding host ... ...

Abstract	The precise mechanisms of action of the host's gut microbiome at the level of its constituting bacteria are obscure in most cases despite its definitive role. To study the precise role of the gut microbiome on the phenotypes of a host by excluding host factors, we analyzed two different gut microbiomes within the same individual mouse after replacing the gut microbiome with a new one to exclude the host factors. The gut microbiome of conventional C57BL/6 mice was randomly reestablished by feeding fecal samples from obese humans to the mice, and depleting their original gut microbiome with an antibiotic and antifungal treatment. Comparison of body weight changes before and 3 months after the replacement of the gut microbiome showed that the gut microbiome replacement affected the body weight gain in three different ways: positive, medium, and negative. The differences in body weight gain were associated with establishment of a different kind of gut microbiome in each of the mice. In addition, body weight gaining was negatively associated with the Firmicutes/Bacteroidetes ratio, which is consistent with previous recent findings. Thorough statistical analysis at low taxonomic levels showed that uncultured bacteria NR_074436.1, NR_144750.1, and NR_0421101.1 were positively associated with body weight gain, while
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10051062
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Article: Chemical, Pharmacological and Computerized Molecular Analysis of Stem’s Extracts of Bauhinia scandens L. Provide Insights into the Management of Diarrheal and Microbial Infections

Islam, Md Minarul / Alam, Rashedul / Chung, Hea-Jong / Emon, Nazim Uddin / Fazlul Kabir, Mohammad / Rudra, Sajib / Alam, Safaet / Ullah, Ahsan / Hong, Seong-Tshool / Aktar Sayeed, Mohammed

Nutrients. 2022 Jan. 09, v. 14, no. 2

2022

Abstract: Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine ...

Abstract	Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in silico study was also implemented to elucidate the binding affinity and drug capability of the selected phytochemicals. In vivo anti diarrheal activity was investigated in mice models. In vitro, antibacterial and antifungal properties of MEBS against several pathogenic strains were evaluated using the disc diffusion method. In addition, in silico study has been employed using Discovery studio 2020, UCFS Chimera, PyRx autodock vina, and online tools. In the anti-diarrheal investigation, MEBS showed a significant dose-dependent inhibition rate in all three methods. The antibacterial and antifungal screening showed a remarkable zone of inhibition, of the diameter 14–26 mm and 12–28 mm, by MEBS. The present study revealed that MEBS has remarkable anti-diarrheal potential and is highly effective in wide-spectrum bacterial and fungal strains. Moreover, the in silico study validated the results of biological screenings. To conclude, MEBS is presumed to be a good source in treating diarrhea, bacterial and fungal infections.
Keywords	Bauhinia ; asthma ; cholera ; computer simulation ; diabetes ; diarrhea ; dose response ; drugs ; fungi ; medicine ; phytochemicals
Language	English
Dates of publication	2022-0109
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14020265
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Polysubstituted Hexa-cata-hexabenzocoronenes: Syntheses, Characterization, and Their Potential as Semiconducting Materials in Transistor Applications.

Kumar, Sushil / Pola, Someshwar / Huang, Chih-Wei / Islam, Md Minarul / Venkateswarlu, Samala / Tao, Yu-Tai

The Journal of organic chemistry

2019 Volume 84, Issue 13, Page(s) 8562–8570

Abstract: A series of tetra- and octa-substituted hexa-cata-hexabenzocoronenes (cata-HBCs) were synthesized from tetraryl olefins via iodine- and iron chloride-catalyzed oxidative cyclodehydrogenation reactions. The substitutions on the periphery of the parent HBC ...

Abstract	A series of tetra- and octa-substituted hexa-cata-hexabenzocoronenes (cata-HBCs) were synthesized from tetraryl olefins via iodine- and iron chloride-catalyzed oxidative cyclodehydrogenation reactions. The substitutions on the periphery of the parent HBC serve to modify the photophysical properties, highest occupied molecular orbital-lowest unoccupied molecular orbital gaps, and thermal stabilities of the respective derivatives. The crystal structures were determined to display multiple twists in the framework, resulting in different packing motifs depending on the position, type, and number of functional groups on the hexabenzocoronene framework. Nearly perfect co-facial packing to marginally or extensively shifted co-facial stacks were obtained due to substitution. The single crystals of parent HBC were used to fabricate single-crystal field-effect transistors, from which the highest p-channel mobility of 0.51 cm
Language	English
Publishing date	2019-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.9b00802
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Article ; Online: Chemico-Pharmacological Screening of the Methanol Extract of

Chakrabarty, Nishan / Chung, Hea-Jong / Alam, Rashedul / Emon, Nazim Uddin / Alam, Safaet / Kabir, Mohammed Fazlul / Islam, Md Minarul / Hong, Seong-Tshool / Sarkar, Tapas / Sarker, Md Moklesur Rahman / Rahman, Mohammad Manjur

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 11

Abstract: Gynura nepalensis D.C. (family: Asteraceae) has abundant uses in the alternative medicinal practice, and this species is commonly used in the treatment of diabetes, rheumatism, cuts or wounds, asthma, kidney stones, cough, urinary tract bleeding, gall ... ...

Abstract	Gynura nepalensis D.C. (family: Asteraceae) has abundant uses in the alternative medicinal practice, and this species is commonly used in the treatment of diabetes, rheumatism, cuts or wounds, asthma, kidney stones, cough, urinary tract bleeding, gall bladder stones, hepatitis, diarrhea, hemorrhoids, constipation, vomiting, fertility problems, blood poisoning, septicemia, skin allergy, indigestion, high cholesterol levels, and so on. This study aims to investigate the hepatoprotective and antioxidant potential of the methanol extract of the Gynura nepalensis D.C. (GNME) along with chemical profiling with phytochemical screening. Moreover, prospective phytocompounds have been screened virtually to present the binding affinity of the bioactive components to the hepatic and oxidative receptors. In the hepatoprotective study, alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein (TP), and lipid peroxidation (LP) and total bilirubin (TB) have been assessed, and in the antioxidant study, the DPPH free radical scavenging, total antioxidant flavonoid, and phenolic contents were determined. Moreover, the molecular binding affinity of the bioactive component of the plant has been analyzed using PyRx AutoDock Vina, Chimera, and Discovery Studio software. The plant extract showed dose-dependent hepatoprotective potential (p < 0.05, 0.01, 0.001) as well as strong antioxidant properties. Moreover, hepatoprotective and antioxidant molecular docking studies revealed a result varying from −2.90 kcal/mol to −10.1 kcal/mol. 4,5-dicaffeoylquinic acid and chlorogenic acid revealed the highest binding affinity among the selected molecules. However, the plant showed portent antioxidant and hepatoprotective properties in the in vitro, in vivo, and in silico models, and it is presumed that the hepatoprotective properties of the plant extract have occurred due to the presence of the vast bioactive chemical compounds as well as their antioxidant properties. Therefore, advanced studies are recommended to elucidate the pharmacological properties of the plant extracts.
MeSH term(s)	Antioxidants/chemistry ; Asteraceae ; Chemical and Drug Induced Liver Injury/metabolism ; Computers ; Liver ; Methanol/pharmacology ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Prospective Studies
Chemical Substances	Antioxidants ; Plant Extracts ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2022-05-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27113474
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Article ; Online: Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation.

Taniya, Masuma Afrin / Chung, Hea-Jong / Al Mamun, Abdullah / Alam, Safaet / Aziz, Md Abdul / Emon, Nazim Uddin / Islam, Md Minarul / Hong, Seong-T Shool / Podder, Bristy Rani / Ara Mimi, Anjuman / Aktar Suchi, Suzia / Xiao, Jian

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 915701

Abstract: Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain development. The recent finding of the microbiota-gut-brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can ... ...

Abstract	Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain development. The recent finding of the microbiota-gut-brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can influence many neurological disorders such as autism. Most autistic patients suffer from gastrointestinal (GI) symptoms. Many studies have shown that early colonization, mode of delivery, and antibiotic usage significantly affect the gut microbiome and the onset of autism. Microbial fermentation of plant-based fiber can produce different types of short-chain fatty acid (SCFA) that may have a beneficial or detrimental effect on the gut and neurological development of autistic patients. Several comprehensive studies of the gut microbiome and microbiota-gut-brain axis help to understand the mechanism that leads to the onset of neurological disorders and find possible treatments for autism. This review integrates the findings of recent years on the gut microbiota and ASD association, mainly focusing on the characterization of specific microbiota that leads to ASD and addressing potential therapeutic interventions to restore a healthy balance of gut microbiome composition that can treat autism-associated symptoms.
MeSH term(s)	Autism Spectrum Disorder ; Fatty Acids, Volatile ; Gastrointestinal Diseases ; Gastrointestinal Microbiome/physiology ; Humans ; Microbiota
Chemical Substances	Fatty Acids, Volatile
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.915701
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Article ; Online: Chemical, Pharmacological and Computerized Molecular Analysis of Stem's Extracts of

Islam, Md Minarul / Alam, Rashedul / Chung, Hea-Jong / Emon, Nazim Uddin / Fazlul Kabir, Mohammad / Rudra, Sajib / Alam, Safaet / Ullah, Ahsan / Hong, Seong-Tshool / Aktar Sayeed, Mohammed

Nutrients

2022 Volume 14, Issue 2

Abstract: ... Bauhinia ... ...

Abstract	Bauhinia scandens
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Antidiarrheals/pharmacology ; Antifungal Agents/pharmacology ; Bacteria/drug effects ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Bauhinia/chemistry ; Diarrhea/chemically induced ; Diarrhea/drug therapy ; Diarrhea/microbiology ; Disease Models, Animal ; Fungi/drug effects ; Mice ; Mycoses/drug therapy ; Mycoses/microbiology ; Phytochemicals/pharmacology ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Stems/chemistry
Chemical Substances	Anti-Bacterial Agents ; Antidiarrheals ; Antifungal Agents ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2022-01-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14020265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polysubstituted Hexa-cata-hexabenzocoronenes: Syntheses, Characterization, and Their Potential as Semiconducting Materials in Transistor Applications

Kumar, Sushil / Huang, Chih-Wei / Islam, Md. Minarul / Pola, Someshwar / Tao, Yu-Tai / Venkateswarlu, Samala

Journal of organic chemistry. 2019 June 10, v. 84, no. 13

2019

Abstract	A series of tetra- and octa-substituted hexa-cata-hexabenzocoronenes (cata-HBCs) were synthesized from tetraryl olefins via iodine- and iron chloride-catalyzed oxidative cyclodehydrogenation reactions. The substitutions on the periphery of the parent HBC serve to modify the photophysical properties, highest occupied molecular orbital–lowest unoccupied molecular orbital gaps, and thermal stabilities of the respective derivatives. The crystal structures were determined to display multiple twists in the framework, resulting in different packing motifs depending on the position, type, and number of functional groups on the hexabenzocoronene framework. Nearly perfect co-facial packing to marginally or extensively shifted co-facial stacks were obtained due to substitution. The single crystals of parent HBC were used to fabricate single-crystal field-effect transistors, from which the highest p-channel mobility of 0.51 cm2 V–1 s–1 was measured. Thin-film transistors of selected HBCs were also prepared, and 0.61 cm2 V–1 s–1 was obtained for MeHBC-2. These results attest the potential of these materials as semiconducting materials.
Keywords	alkenes ; catalytic activity ; chemical reactions ; crystal structure ; crystals ; iodine ; iron ; moieties ; organic chemistry ; transistors
Language	English
Dates of publication	2019-0610
Size	p. 8562-8570.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.9b00802
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: High mobility n-channel single-crystal field-effect transistors based on 5,7,12,14-tetrachloro-6,13-diazapentacene.

Islam, Md Minarul / Pola, Someshwar / Tao, Yu-Tai

Chemical communications (Cambridge, England)

2011 Volume 47, Issue 22, Page(s) 6356–6358

Abstract: Heteroaromatic oligomer 5,7,12,14-tetrachloro-6,13-diazapentacene (TCDAP) was characterized and assessed as n-channel material in field-effect transistor applications. A single-crystal transistor based on TCDAP as the channel material exhibits a very ... ...

Abstract	Heteroaromatic oligomer 5,7,12,14-tetrachloro-6,13-diazapentacene (TCDAP) was characterized and assessed as n-channel material in field-effect transistor applications. A single-crystal transistor based on TCDAP as the channel material exhibits a very high electron mobility of 3.39 cm(2) V(-1) s(-1) and an on/off ratio of ∼1.08 × 10(4) respectively.
Language	English
Publishing date	2011-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/c1cc11762a
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