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  1. Article: BA.5 and Monkeypox: A wakeup call for public health in Pakistan.

    Islam, Muhammad Bilal / Jawed, Shizra / Zeeshan, Muhammad Hamayl

    Annals of medicine and surgery (2012)

    2022  Volume 81, Page(s) 104413

    Language English
    Publishing date 2022-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1016/j.amsu.2022.104413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cholera outbreak in Balochistan amidst flash floods: an impending public health crisis.

    Jawed, Shizra / Islam, Muhammad Bilal / Awan, Hashir Ali / Ullah, Irfan / Asghar, Muhammad Sohaib

    International journal of surgery (London, England)

    2023  Volume 109, Issue 2, Page(s) 107–108

    Abstract: Despite being the largest province in Pakistan due to inadequate and underdeveloped infrastructure, Balochistan has been the worst-inflicted region with biblical floods. Following these disastrous flash floods, a sudden rise in cholera cases was seen in ... ...

    Abstract Despite being the largest province in Pakistan due to inadequate and underdeveloped infrastructure, Balochistan has been the worst-inflicted region with biblical floods. Following these disastrous flash floods, a sudden rise in cholera cases was seen in the affected province. To overcome this public health crisis, the authorities must put in place a system to ensure food safety, an adequate supply of clean drinking water, and the provision of proper sanitation facilities for the locals.
    MeSH term(s) Humans ; Public Health ; Cholera/epidemiology ; Floods ; Disease Outbreaks ; Sanitation
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Re-Emergence of Polio in Pakistan: Another Public Health Failure?

    Jawed, Shizra / Islam, Muhammad Bilal / Butt, Muhammad Hammad / Ullah, Irfan

    Disaster medicine and public health preparedness

    2022  Volume 17, Page(s) e262

    MeSH term(s) Humans ; Public Health ; Pakistan/epidemiology ; Disease Eradication ; Poliomyelitis/epidemiology ; Immunization Programs ; Vaccination
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Letter
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2022.236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluating the safety and efficacy of daprodustat for anemia of chronic kidney disease: a meta-analysis of randomized clinical trials.

    Fatima, Kaneez / Ahmed, Warda / Fatimi, Asad Saulat / Mahmud, Omar / Mahar, Muhammad Umar / Ali, Ayesha / Aamir, Syed Roohan / Nasim, Muhammad Taha / Islam, Muhammad Bilal / Maniya, Muhammad Talha / Azim, Dua / Marsia, Shayan / Almas, Talal

    European journal of clinical pharmacology

    2022  Volume 78, Issue 12, Page(s) 1867–1875

    Abstract: Purpose: Anemia of chronic kidney disease (CKD) has traditionally been treated with recombinant human erythropoietin (rhEPO). Recently, daprodustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor, has also been shown to increase hematocrit. It ... ...

    Abstract Purpose: Anemia of chronic kidney disease (CKD) has traditionally been treated with recombinant human erythropoietin (rhEPO). Recently, daprodustat, a hypoxia-inducible factor prolyl-hydroxylase inhibitor, has also been shown to increase hematocrit. It remains unclear whether daprodustat or rhEPO should be the treatment of choice for anemia of CKD. We aimed to assess the efficacy and cardiovascular safety of daprodustat versus rhEPO in CKD patients.
    Methods: Online databases were queried in April 2022 for articles comparing the efficacy and safety of daprodustat in DD-CKD and NDD-CKD subgroups. Results from trials were pooled using a random-effects model.
    Results: Data on 8245 CKD patients from eight clinical trials were included. Our results show that in comparison to rhEPO, daprodustat maintained the same efficacy in increasing hemoglobin levels in both the DD-CKD (MD: 0.10; 95% CI [- 0.13,0.34]; p = 0.50) and NDD-CKD (MD: - 0.01; 95% CI [- 0.38,0.35]; p = 0.95) subgroups. Daprodustat significantly lowered hepcidin levels and significantly increased TIBC in both subgroups. Additionally, daprodustat significantly reduced the incidence of major adverse cardiovascular events (MACE) (RR: 0.89; 95% CI: 0.89-0.98; p = 0.02) and its myocardial infarction (MI) component (RR: 0.74; 95% CI: 0.59-0.92; p = 0.006) in the DD-CKD subgroup.
    Conclusion: Daprodustat has similar efficacy compared to rhEPO for the treatment of anemia of CKD. On treatment, the reduced experience of MACE was reported in DD-CKD patients as compared to rhEPO. Furthermore, effects on iron metabolism varied by parameter, with daprodustat being superior to rhEPO in some cases and inferior in others.
    MeSH term(s) Humans ; Anemia/drug therapy ; Anemia/etiology ; Erythropoietin/therapeutic use ; Hypoxia-Inducible Factor-Proline Dioxygenases ; Randomized Controlled Trials as Topic ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Barbiturates/therapeutic use
    Chemical Substances Erythropoietin (11096-26-7) ; GSK1278863 ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29) ; Barbiturates
    Language English
    Publishing date 2022-10-05
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-022-03395-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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