Article ; Online: Role of African Swine Fever Virus Proteins EP153R and EP402R in Reducing Viral Persistence in Blood and Virulence in Pigs Infected with BeninΔDP148R.
2021 Volume 96, Issue 1, Page(s) e0134021
Abstract: The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress toward vaccine development. Previously, the DP148R gene was deleted from the genome of genotype I virulent Benin 97/1 ... ...
| Abstract | The limited knowledge on the role of many of the approximately 170 proteins encoded by African swine fever virus restricts progress toward vaccine development. Previously, the DP148R gene was deleted from the genome of genotype I virulent Benin 97/1 isolate. This virus, BeninΔDP148R, induced transient moderate clinical signs after immunization and high levels of protection against challenge. However, the BeninΔDP148R virus and genome persisted in blood over a prolonged period. In the current study, deletion of either EP402R or EP153R genes individually or in combination from BeninΔDP148R genome was shown not to reduce virus replication in macrophages |
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| MeSH term(s) | African Swine Fever/immunology ; African Swine Fever/metabolism ; African Swine Fever/virology ; African Swine Fever Virus/physiology ; Animals ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Antigens, Viral/genetics ; Antigens, Viral/immunology ; Antigens, Viral/metabolism ; Biomarkers ; Cells, Cultured ; Genetic Engineering ; Genotype ; Host-Pathogen Interactions ; Immunization ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/virology ; Sequence Deletion ; Swine ; Viral Proteins/genetics ; Viral Proteins/immunology ; Viral Proteins/metabolism ; Viral Vaccines/immunology ; Viremia/virology ; Virulence ; Virus Replication | |||||
| Chemical Substances | Antibodies, Viral ; Antigens, Viral ; Biomarkers ; Viral Proteins ; Viral Vaccines | |||||
| Language | English | |||||
| Publishing date | 2021-10-13 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/JVI.01340-21 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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