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  1. Article: The Wild Carrot (

    Ismail, Jana / Shebaby, Wassim N / Daher, Joey / Boulos, Joelle C / Taleb, Robin / Daher, Costantine F / Mroueh, Mohamad

    Plants (Basel, Switzerland)

    2023  Volume 13, Issue 1

    Abstract: ... Daucus ... ...

    Abstract Daucus carota
    Language English
    Publishing date 2023-12-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13010093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: PEG-Lipid-PLGA Hybrid Particles for Targeted Delivery of Anti-Inflammatory Drugs.

    Ismail, Jana / Klepsch, Lea C / Dahlke, Philipp / Tsarenko, Ekaterina / Vollrath, Antje / Pretzel, David / Jordan, Paul M / Rezaei, Kourosh / Czaplewska, Justyna A / Stumpf, Steffi / Beringer-Siemers, Baerbel / Nischang, Ivo / Hoeppener, Stephanie / Werz, Oliver / Schubert, Ulrich S

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG-Lipid conjugates with various functionalities (-RGD, -cRGD, - ... ...

    Abstract Hybrid nanoparticles (HNPs) were designed by combining a PLGA core with a lipid shell that incorporated PEG-Lipid conjugates with various functionalities (-RGD, -cRGD, -NH
    Language English
    Publishing date 2024-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: In vivo and in vitro anti-inflammatory activity evaluation of Lebanese Cannabis sativa L. ssp. indica (Lam.)

    Shebaby, Wassim / Saliba, Jane / Faour, Wissam H / Ismail, Jana / El Hage, Marissa / Daher, Costantine F / Taleb, Robin I / Nehmeh, Bilal / Dagher, Carol / Chrabieh, Edwin / Mroueh, Mohamad

    Journal of ethnopharmacology. 2021 Apr. 24, v. 270

    2021  

    Abstract: Cannabis sativa L. is an aromatic annual herb belonging to the family Cannabaceae and it is widely distributed worldwide. Cultivation, selling, and consumption of cannabis and cannabis related products, regardless of its use, was prohibited in Lebanon ... ...

    Abstract Cannabis sativa L. is an aromatic annual herb belonging to the family Cannabaceae and it is widely distributed worldwide. Cultivation, selling, and consumption of cannabis and cannabis related products, regardless of its use, was prohibited in Lebanon until April 22, 2020. Nevertheless, cannabis oil has been traditionally used unlawfully for many years in Lebanon to treat diseases such as arthritis, diabetes, cancer and few neurological disorders.The present study aims to evaluate the phytochemical and anti-inflammatory properties of a cannabis oil preparation that is analogous to the illegally used cannabis oil in Lebanon.Dried Cannabis flowers were extracted with ethanol without any purification procedures to simulate the extracts sold by underground dealers in Lebanon. GC/MS was performed to identify chemical components of the cannabis oil extract (COE). In vivo anti-inflammatory effect of COE was evaluated by using carageenan- and formalin-induced paw edema rat models. TNF-α production were determined by using LPS-activated rat monocytes. Anti-inflammatory markers were quantified using Western blot.Chemical analysis of COE revealed that cannabidiol (CBD; 59.1%) and tetrahydrocannabinol (THC; 20.2%) were found to be the most abundant cannabinoids.Various monoterpenes (α-Pinene, Camphene, β-Myrecene and D-Limonene) and sesquiterpenes (β-Caryophyllene, α-Bergamotene, α-Humelene, Humulene epoxide II, and Caryophyllene oxide) were identified in the extract. Results showed that COE markedly suppressed the release of TNF-α in LPS-stimulated rat monocytes. Western blot analysis revealed that COE significantly inhibited LPS-induced COX-2 and i-NOS protein expressions and blocked the phosphorylation of MAPKs, specifically that of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK) and p38 MAPK. COE displayed a significant inhibition of paw edema in both rat models. Histopathological examination revealed that COE reduced inflammation and edema in chronic paw edema model.The current findings demonstrate that COE possesses remarkable in vivo and in vitro anti-inflammatory activities which support the traditional use of the Lebanese cannabis oil extract in the treatment of various inflammatory diseases including arthritis.
    Keywords Cannabis sativa ; Western blotting ; anti-inflammatory activity ; arthritis ; camphene ; cannabidiol ; diabetes ; edema ; ethanol ; histopathology ; humulene ; inflammation ; limonene ; mitogen-activated protein kinase ; monocytes ; oils ; phosphorylation ; phytochemicals ; rats ; tetrahydrocannabinol ; traditional medicine ; Lebanon
    Language English
    Dates of publication 2021-0424
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2020.113743
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  4. Article ; Online: In vivo and in vitro anti-inflammatory activity evaluation of Lebanese Cannabis sativa L. ssp. indica (Lam.).

    Shebaby, Wassim / Saliba, Jane / Faour, Wissam H / Ismail, Jana / El Hage, Marissa / Daher, Costantine F / Taleb, Robin I / Nehmeh, Bilal / Dagher, Carol / Chrabieh, Edwin / Mroueh, Mohamad

    Journal of ethnopharmacology

    2020  Volume 270, Page(s) 113743

    Abstract: Ethnopharmacological relevance: Cannabis sativa L. is an aromatic annual herb belonging to the family Cannabaceae and it is widely distributed worldwide. Cultivation, selling, and consumption of cannabis and cannabis related products, regardless of its ... ...

    Abstract Ethnopharmacological relevance: Cannabis sativa L. is an aromatic annual herb belonging to the family Cannabaceae and it is widely distributed worldwide. Cultivation, selling, and consumption of cannabis and cannabis related products, regardless of its use, was prohibited in Lebanon until April 22, 2020. Nevertheless, cannabis oil has been traditionally used unlawfully for many years in Lebanon to treat diseases such as arthritis, diabetes, cancer and few neurological disorders.
    Aim of the study: The present study aims to evaluate the phytochemical and anti-inflammatory properties of a cannabis oil preparation that is analogous to the illegally used cannabis oil in Lebanon.
    Materials and methods: Dried Cannabis flowers were extracted with ethanol without any purification procedures to simulate the extracts sold by underground dealers in Lebanon. GC/MS was performed to identify chemical components of the cannabis oil extract (COE). In vivo anti-inflammatory effect of COE was evaluated by using carageenan- and formalin-induced paw edema rat models. TNF-α production were determined by using LPS-activated rat monocytes. Anti-inflammatory markers were quantified using Western blot.
    Results: Chemical analysis of COE revealed that cannabidiol (CBD; 59.1%) and tetrahydrocannabinol (THC; 20.2%) were found to be the most abundant cannabinoids.Various monoterpenes (α-Pinene, Camphene, β-Myrecene and D-Limonene) and sesquiterpenes (β-Caryophyllene, α-Bergamotene, α-Humelene, Humulene epoxide II, and Caryophyllene oxide) were identified in the extract. Results showed that COE markedly suppressed the release of TNF-α in LPS-stimulated rat monocytes. Western blot analysis revealed that COE significantly inhibited LPS-induced COX-2 and i-NOS protein expressions and blocked the phosphorylation of MAPKs, specifically that of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK) and p38 MAPK. COE displayed a significant inhibition of paw edema in both rat models. Histopathological examination revealed that COE reduced inflammation and edema in chronic paw edema model.
    Conclusion: The current findings demonstrate that COE possesses remarkable in vivo and in vitro anti-inflammatory activities which support the traditional use of the Lebanese cannabis oil extract in the treatment of various inflammatory diseases including arthritis.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Cannabis/chemistry ; Carrageenan/toxicity ; Disease Models, Animal ; Edema/blood ; Edema/chemically induced ; Edema/drug therapy ; Edema/pathology ; Flowers/chemistry ; Formaldehyde/toxicity ; Inflammation/blood ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/pathology ; Lebanon ; Lipopolysaccharides/toxicity ; MAP Kinase Signaling System/drug effects ; Male ; Monocytes/drug effects ; Monocytes/metabolism ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Primary Cell Culture ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/metabolism ; Rats
    Chemical Substances Anti-Inflammatory Agents ; Lipopolysaccharides ; Phytochemicals ; Plant Extracts ; Tumor Necrosis Factor-alpha ; Formaldehyde (1HG84L3525) ; Carrageenan (9000-07-1)
    Language English
    Publishing date 2020-12-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2020.113743
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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