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  1. Article ; Online: Seroprevalence surveys in blood donors population and complexity of immunization patterns.

    Gallian, Pierre / Brisbarre, Nadége / Isnard, Christine / Morel, Pascal / de Lamballerie, Xavier

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine

    2022  Volume 30, Issue 1, Page(s) 21

    MeSH term(s) Humans ; Blood Donors ; Seroepidemiologic Studies ; Immunization ; Vaccination ; Surveys and Questionnaires ; Antibodies, Viral
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-09-05
    Publishing country France
    Document type Letter
    ZDB-ID 1204698-x
    ISSN 1953-8022 ; 1246-7820
    ISSN (online) 1953-8022
    ISSN 1246-7820
    DOI 10.1016/j.tracli.2022.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4097: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 308: Show issues

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  2. Article ; Online: SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021.

    Gallian, Pierre / Hozé, Nathanaël / Brisbarre, Nadège / Saba Villarroel, Paola Mariela / Nurtop, Elif / Isnard, Christine / Pastorino, Boris / Richard, Pascale / Morel, Pascal / Cauchemez, Simon / de Lamballerie, Xavier

    iScience

    2023  Volume 26, Issue 4, Page(s) 106222

    Abstract: We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n = 32605), from March-2020 to January-2021. A mathematical model combined seroprevalence with a daily number of hospital admissions to estimate the ... ...

    Abstract We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n = 32605), from March-2020 to January-2021. A mathematical model combined seroprevalence with a daily number of hospital admissions to estimate the probability of hospitalization upon infection and determine the number of infections while correcting for antibody decay. There was an overall seroprevalence increase over the study period and we estimate that ∼15% of the French population had been infected by SARS-CoV-2 by January-2021. The infection/hospitalization ratio increased with age, from 0.31% (18-30yo) to 4.5% (61-70yo). Half of the IgG-S1 positive individuals had no detectable antibodies 4 to 5 months after infection. The seroprevalence in group O donors (7.43%) was lower (p = 0.003) than in A, B, and AB donors (8.90%). We conclude, based on seroprevalence data and mathematical modeling, that a large proportion of the French population was unprotected against severe disease prior to the vaccination campaign.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low neutralization capacity against SARS-CoV-2 Omicron BQ.1.1 of convalescent plasma collected during circulation of Omicron BA.1.

    Gallian, Pierre / Brisbarre, Nadége / Nurtop, Elif / Le Cam, Sophie / Franck, Touret / Isnard, Christine / Malard, Lucile / Laperche, Syria / Richard, Pascale / Morel, Pascal / Tiberghien, Pierre / de Lamballerie, Xavier

    Vox sanguinis

    2023  Volume 118, Issue 5, Page(s) 407–408

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/therapy ; COVID-19 Serotherapy ; Plasma ; Antibodies, Viral ; Antibodies, Neutralizing ; Neutralization Tests
    Chemical Substances Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 74: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Reduced neutralizing antibody potency of COVID-19 convalescent vaccinated plasma against SARS-CoV-2 Omicron variant.

    Gallian, Pierre / Amroun, Abdennour / Laperche, Syria / Le Cam, Sophie / Brisbarre, Nadège / Malard, Lucile / Nurtop, Elif / Isnard, Christine / Richard, Pascale / Morel, Pascal / Tiberghien, Pierre / de Lamballerie, Xavier

    Vox sanguinis

    2022  Volume 117, Issue 7, Page(s) 971–975

    Abstract: Background and objective: The SARS-CoV-2 Omicron variant displays increased infectiveness as well as mutations resulting in reduced neutralizing activity of antibodies acquired after vaccination or infection involving earlier strains. To assess the ... ...

    Abstract Background and objective: The SARS-CoV-2 Omicron variant displays increased infectiveness as well as mutations resulting in reduced neutralizing activity of antibodies acquired after vaccination or infection involving earlier strains. To assess the ability of vaccinated COVID-19 convalescent plasma (CCP-V) collected before November 2021 to seroneutralize Omicron, we compared neutralizing antibody (nAb) titres of 63 samples against Omicron and earlier B.1 (D614G) strains.
    Methods and findings: Relationship between anti-Omicron titres and IgG anti-S1 levels (binding arbitrary unit: BAU/ml) was studied. Although correlated, anti-Omicron titres were significantly lower than anti-B.1 titres (median = 80 [10-1280] vs. 1280 [160-10,240], p < 0.0001). Omicron nAb titres and IgG anti-S1 levels were correlated (Spearman's rank correlation coefficient = 0.67). Anti-S1 IgG threshold at 7000 BAU/ml may allow to discard CCP-V without anti-Omicron activity (nAb titre <40). Conversely, only those with highest titres (≥160) had systematically anti-S1 IgG levels >7000 BAU/ml.
    Conclusion: A fraction of CCP-V collected before November 2021 retains anti-Omicron seroneutralizing activity that may be selected by quantitative anti-IgG assays, but such assays do not easily allow the identification of 'high-titre' CCP-V. However, collecting plasma from vaccinated donors recently infected with Omicron may be the best option to provide optimal CCP-V for immunocompromised patients infected with this variant.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/therapy ; Humans ; Immunization, Passive ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2022-05-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.13279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 74: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Seroprevalence Study of Anti-HEV IgG among Different Adult Populations in Corsica, France, 2019

    Capai, Lisandru / Masse, Shirley / Gallian, Pierre / Souty, Cécile / Isnard, Christine / Blanchon, Thierry / Peres, Brigitte / de Lamballerie, Xavier / Charrel, Rémi / Falchi, Alessandra

    Microorganisms. 2019 Oct. 16, v. 7, no. 10

    2019  

    Abstract: Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%. The aim of this study was to determine the seroprevalence of anti- ... ...

    Abstract Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%. The aim of this study was to determine the seroprevalence of anti-HEV IgG in three adult populations in Corsica and the risk factors associated with antibody detection. Between 2017 and 2019, a total of 930 individuals, including 467 blood donors, 393 students or university staff members and 70 patients from general practice, were tested for the presence of anti-HEV IgG using the Wantai HEV IgG enzyme immunoassay kit and filled a questionnaire. The association between seropositivity and potential risk factors was tested with univariate and multivariate analyses. Out of the 930 samples, 52.3% (486/930) were seropositive—54.4% (254/467) among blood donors, 47.6% (187/393) among university students and 64.3% (45/70) among patients of general practice. Three main risk factors were identified: (i) skinning and butchering (Adjusted Odds Ratio aOR = 2.76, 95% confidence interval [95% CI] [1.51–5.37]; p-value < 10−3), (ii) consumption of a local pork live raw sausage (fittonu) (aOR = 1.95 95% CI [1.45–2.64]; p-value = 10−5), and (iii) increasing age (p-value = 0.003). Seropositivity rates between the different populations were homogeneous after age stratification. This cross-sectional study indicates a high anti-HEV IgG seroprevalence in the Corsican adult population, not significantly different between women and men and increasing with age. This serosurvey also showed homogeneity regarding the exposure to HEV among three different types of populations. Finally, we confirmed the endemicity of Corsica with respect to HEV and identified a strong association between consumption of figatellu/fittonu and the practice of skinning and butchering with the detection of anti-HEV IgG.
    Keywords Orthohepevirus A ; adults ; antibody detection ; blood donors ; butchering ; college students ; confidence interval ; cross-sectional studies ; endemic diseases ; enzyme immunoassays ; hepatitis ; immunoglobulin G ; indigenous species ; men ; multivariate analysis ; odds ratio ; patients ; pork ; questionnaires ; risk factors ; sausages ; seroprevalence ; skinning ; women ; Corsica ; France
    Language English
    Dates of publication 2019-1016
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7100460
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: SARS-CoV-2 IgG seroprevalence surveys in blood donors before the vaccination campaign, France 2020-2021

    Gallian, Pierre / Hozé, Nathanaël / Brisbarre, Nadège / Mariela Saba Villarroel, Paola / Nurtop, Elif / Isnard, Christine / Pastorino, Boris / Richard, Pascale / Morel, Pascal / Cauchemez, Simon / de Lamballerie, Xavier

    medRxiv

    Abstract: We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n=32605), from May-2020 to January-2021. A mathematical model combined seroprevalence with daily number of hospital admissions to estimate the probability ... ...

    Abstract We conducted a cross-sectional study for SARS-CoV-2 anti-S1 IgG prevalence in French blood donors (n=32605), from May-2020 to January-2021. A mathematical model combined seroprevalence with daily number of hospital admissions to estimate the probability of hospitalization upon infection and determine the number of infections while correcting for antibody decay. There was an overall seroprevalence increase over the study period and we estimate that ~15% of the French population had been infected by SARS-CoV-2 by January-2021. The infection/hospitalization ratio increased with age, from 0.56% (18-30yo) to 6.75% (61-70yo). Half of the IgG-S1 positive individuals had no detectable antibodies 4 to 5 months after infection. The seroprevalence in group O donors (7.43%) was lower (p=0.003) than in A, B and AB donors (8.90%). We conclude, based on seroprevalence data and mathematical modelling, that the overall immunity in the French population before the vaccination campaign started was too low to achieve herd immunity.
    Keywords covid19
    Language English
    Publishing date 2022-07-31
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.07.29.22278190
    Database COVID19

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  7. Article: Seroprevalence Study of Anti-HEV IgG among Different Adult Populations in Corsica, France, 2019.

    Capai, Lisandru / Masse, Shirley / Gallian, Pierre / Souty, Cécile / Isnard, Christine / Blanchon, Thierry / Peres, Brigitte / de Lamballerie, Xavier / Charrel, Rémi / Falchi, Alessandra

    Microorganisms

    2019  Volume 7, Issue 10

    Abstract: Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%. The aim of this study was to determine the seroprevalence of anti- ... ...

    Abstract Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%. The aim of this study was to determine the seroprevalence of anti-HEV IgG in three adult populations in Corsica and the risk factors associated with antibody detection. Between 2017 and 2019, a total of 930 individuals, including 467 blood donors, 393 students or university staff members and 70 patients from general practice, were tested for the presence of anti-HEV IgG using the Wantai HEV IgG enzyme immunoassay kit and filled a questionnaire. The association between seropositivity and potential risk factors was tested with univariate and multivariate analyses. Out of the 930 samples, 52.3% (486/930) were seropositive-54.4% (254/467) among blood donors, 47.6% (187/393) among university students and 64.3% (45/70) among patients of general practice. Three main risk factors were identified: (i) skinning and butchering (Adjusted Odds Ratio aOR = 2.76, 95% confidence interval [95% CI] [1.51-5.37];
    Language English
    Publishing date 2019-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7100460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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