Artikel ; Online: Correlation of the vancomycin 24-h area under the concentration-time curve (AUC
2020 Band 92, Seite(n) 151–159
Abstract: Background: Vancomycin is a common drug used in children with severe infection. In adults, at least 15 mg/L of the optimal vancomycin trough concentration (C: Objectives: To determine vancomycin PK in children with severe infection and to explore the ...
Abstract | Background: Vancomycin is a common drug used in children with severe infection. In adults, at least 15 mg/L of the optimal vancomycin trough concentration (C Objectives: To determine vancomycin PK in children with severe infection and to explore the correlation between vancomycin C Materials and methods: Children aged 2-18 years who were admitted to Chiang Mai University Hospital and received intravenous vancomycin for severe infection were included in the study. Serum samples for vancomycin PK were obtained before and serially after the administration of the first dose according to the protocol. Pharmacokinetic analyses were performed using Phoenix WinNonlin® 7.0 and NLME™7.0. Results: Fourteen children with 64% males and age range from 2 to 13 years were included in this study. Non-compartmental analysis revealed the median volume of distribution, clearance, and elimination half-life of 0.58 L/kg, 2.82 mL/kg/min and 2.33 h, respectively. Vancomycin serum concentrations were best described by a two-compartmental model with first-order elimination.The observed C Conclusion: Correlation between vancomycin C |
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Mesh-Begriff(e) | Administration, Intravenous ; Adolescent ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/therapeutic use ; Area Under Curve ; Child ; Child, Preschool ; Female ; Hospitals, University ; Humans ; Infections/drug therapy ; Infections/metabolism ; Male ; Microbial Sensitivity Tests ; Monte Carlo Method ; Vancomycin/administration & dosage ; Vancomycin/pharmacokinetics ; Vancomycin/therapeutic use |
Chemische Substanzen | Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) |
Sprache | Englisch |
Erscheinungsdatum | 2020-01-11 |
Erscheinungsland | Canada |
Dokumenttyp | Journal Article |
ZDB-ID | 1331197-9 |
ISSN | 1878-3511 ; 1201-9712 |
ISSN (online) | 1878-3511 |
ISSN | 1201-9712 |
DOI | 10.1016/j.ijid.2019.12.036 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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