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  1. Article ; Online: Risk of unfavorable outcomes after penile prosthesis implantation - results from a national registry (INSIST-ED).

    Preto, Mirko / Falcone, Marco / Plamadeala, Natalia / Schifano, Nicolò / Bettocchi, Carlo / Colombo, Fulvio / Fiordelise, Stefano / Vitarelli, Antonio / Silvani, Mauro / Mondaini, Nicola / Paradiso, Matteo / Ceruti, Carlo / Varvello, Francesco / Palumbo, Fabrizio / Avolio, Antonio / Antonini, Gabriele / Corvasce, Antonio / Pozza, Diego / Franco, Giorgio /
    Bitelli, Marco / Boezio, Francesco / Conti, Enrico / Caraceni, Enrico / Negro, Carlo / Carrino, Maurizio / Vicini, Patrizio / Ghidini, Nicola / Alei, Giovanni / Italiano, Emilio / Timpano, Massimiliano / Polito, Massimo / Natali, Alessandro / Tamai, Aldo / Pescatori, Edoardo / Dehò, Federico / Gideon, Blecher / Gontero, Paolo / Palmieri, Alessandro / Capogrosso, Paolo

    International journal of impotence research

    2023  

    Abstract: Like all surgeries, penile prosthesis implantation (PPI) has the potential for both postoperative complications and suboptimal patient satisfaction. In order to assess risk factors for poor satisfaction, we reviewed patients who had been prospectively ... ...

    Abstract Like all surgeries, penile prosthesis implantation (PPI) has the potential for both postoperative complications and suboptimal patient satisfaction. In order to assess risk factors for poor satisfaction, we reviewed patients who had been prospectively recruited in a national multi-institutional registry of penile prostheses procedures (INSIST-ED) from 2014 to 20121. Patient baseline characteristics and postoperative complications were recorded. The primary endpoint of this study was unfavorable outcomes after inflatable PPI, defined as significant postoperative complications (Clavien-Dindo ≥2) and/or Sexuality with Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) scores below the 10th percentile. A total of 256 patients were included in the study. The median age was 60 years (IQR 56-67). The most common cause of erectile dysfunction (ED) was organic (42.2%), followed by pelvic surgery/radiotherapy (39.8%) and Peyronie's disease (18.0%). Postoperative complications were recorded in 9.6%. High-grade complications (Clavien ≥2) occurred in 4.7%. At 1-year follow-up, the median QoLSPP total score was 71 (IQR 65-76). In all, 14.8% of patients were classified as having experienced unfavorable outcomes because of significant postoperative complications and/or QoLSPP scores below the 10th percentile. Logistic regression analysis demonstrated patient age to be non-linearly associated with the risk of experiencing unfavorable outcomes. A U-shaped correlation showed a lower risk for younger and older patients and a higher risk for middle-aged men. ED etiology and surgical volume were not associated with PPI outcomes. Physicians should, therefore, be aware that middle-aged men may be at higher risk of being unsatisfied following PPI compared to both younger and older patients.
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-023-00784-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2910: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dietary Supplements as Surrogate of Mediterranean Diet in Healthy Smoking Subjects.

    Vasto, Sonya / Accardi, Giulia / Aiello, Anna / Di Gaudio, Francesca / Barera, Annalisa / Indelicato, Serena / Galimberti, Damiano / Italiano, Emilio / Monastero, Roberto / Rizzo, Claudia / Caruso, Calogero / Candore, Giuseppina

    Rejuvenation research

    2017  Volume 21, Issue 1, Page(s) 37–43

    Abstract: The interventions to slow aging, favoring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of aging pathologies have been identified. Between them, a healthy lifestyle seems ... ...

    Abstract The interventions to slow aging, favoring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of aging pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low-cost way to act on aging process. Mediterranean diet has received much attention since its antioxidant and anti-inflammatory effects have been consistently demonstrated. Unfortunately, many people follow a Western diet, poor in phytochemicals that represent the main source of beneficial effects of this dietary pattern. So, supplements administration should be considered, especially in subjects exposed to high level of oxidative stress and inflammation. So, we tested the properties of a commercial food supplement containing a series of plant polyphenols in combination with caffeine, bioperine (black pepper extract), and selenium in smoking healthy volunteers. Fifty participants have been recruited and hematochemical analyses and biochemistry tests have been performed, before and after 60 days of supplement intake. Thirteen subjects dropped out of the study. At the end of the intervention, the variation of inflammatory and oxidant markers has been evaluated, measuring urinary isoprostanes, serum advanced glycation end products, and oxidized low-density lipoproteins. The results showed that this supplement exhibits promising antioxidant and anti-inflammatory responses, especially in women, highlighting the role of supplementation in certain groups of subjects, for the control of oxidative stress as well as inflammatory status. So, its intake should be useful in delaying the onset of age-related diseases.
    MeSH term(s) Anthropometry ; Diet, Mediterranean ; Dietary Supplements ; Female ; Glycation End Products, Advanced/metabolism ; Health ; Humans ; Isoprostanes/metabolism ; Lipoproteins, LDL/metabolism ; Male ; Middle Aged ; Smoking
    Chemical Substances Glycation End Products, Advanced ; Isoprostanes ; Lipoproteins, LDL ; oxidized low density lipoprotein
    Language English
    Publishing date 2017-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2150779-X
    ISSN 1557-8577 ; 1549-1684
    ISSN (online) 1557-8577
    ISSN 1549-1684
    DOI 10.1089/rej.2017.1950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Inflammation and prostate cancer.

    Vasto, Sonya / Carruba, Giuseppe / Candore, Giuseppina / Italiano, Emilio / Di Bona, Danilo / Caruso, Calogero

    Future oncology (London, England)

    2008  Volume 4, Issue 5, Page(s) 637–645

    Abstract: Prostate cancer remains a major health concern for the male population throughout the Western world. It is today widely accepted that inflammation has a role in many human cancers. In fact, inflammation is thought to incite carcinogenesis by causing cell ...

    Abstract Prostate cancer remains a major health concern for the male population throughout the Western world. It is today widely accepted that inflammation has a role in many human cancers. In fact, inflammation is thought to incite carcinogenesis by causing cell and genome damage, promoting cellular turnover and creating a tissue microenvironment that can enhance cell replication, angiogenesis and tissue repair. Accordingly, there is a body of literature suggesting a link between chronic inflammation and prostate cancer, in which prostate inflammation may contribute to the promotion of prostate cancer development. On the other hand, high levels of endogenous gonadal steroids are considered as risk factors for prostate cancer. Interestingly, it is clear that elevation of estrogens in the presence of testosterone results in a prostate-specific inflammatory response. Thus, it is possible that early inflammatory events stimulated by sex hormones serve as a prerequisite for the onset of prostate cancer.
    MeSH term(s) Animals ; Gonadal Steroid Hormones/metabolism ; Humans ; Inflammation/epidemiology ; Inflammation/genetics ; Inflammation/pathology ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology
    Chemical Substances Gonadal Steroid Hormones
    Language English
    Publishing date 2008-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2184533-5
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/14796694.4.5.637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: INSIST-ED: Italian Society of Andrology registry on penile prosthesis surgery. First data analysis.

    Pescatori, Edoardo / Alei, Giovanni / Antonini, Gabriele / Avolio, Antonio / Bettocchi, Carlo / Bitelli, Marco / Boezio, Francesco / Cai, Tommaso / Caraceni, Enrico / Carrino, Maurizio / Colombo, Fulvio / Conti, Enrico / Corvasce, Antonio / Dehò, Federico / Fiordelise, Stefano / Ghidini, Nicola / Italiano, Emilio / La Pera, Giuseppe / Liguori, Giovanni /
    Maretti, Carlo / Mondaini, Nicola / Natali, Alessandro / Negro, Carlo / Palmieri, Alessandro / Palumbo, Fabrizio / Paradiso, Matteo / Polito, Massimo / Pozza, Diego / Silvani, Mauro / Tamai, Aldo / Timpano, Massimiliano / Utizi, Lilia / Varvello, Francesco / Vicini, Patrizio / Vitarelli, Antonio / Franco, Giorgio

    Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica

    2016  Volume 88, Issue 2, Page(s) 122–127

    Abstract: Objectives: The Italian Society of Andrology, i.e. "Società Italiana di Andrologia" (S.I.A.), launched on December 2014 a prospective, multicenter, monitored and internal review board approved Registry for penile implants, the "INSIST-ED" (Italian ... ...

    Abstract Objectives: The Italian Society of Andrology, i.e. "Società Italiana di Andrologia" (S.I.A.), launched on December 2014 a prospective, multicenter, monitored and internal review board approved Registry for penile implants, the "INSIST-ED" (Italian Nationwide Systematic Inventarisation of Surgical Treatment for ED) Registry. Purpose of this first report is to present a baseline data analysis of the characteristics of penile implant surgery in Italy.
    Material and methods: The INSIST-ED Registry is open to all surgeons implanting penile prostheses (all brands, all models) in Italy, providing anonymous patient, device, surgical procedure, outcome, follow-up data, for both first and revision surgeries. A Registry project Board overviews all the steps of the project, and a Registry Monitor interacts with the Registry implanting surgeons.
    Results: As by April 8, 2016, 31 implanting surgeons actively joined the Registry, entering 367 surgical procedures in its database, that comprise: 310 first implants, 43 prosthesis substitutions, 14 device explants without substitution. Implanted devices account for: 288 three-component devices (81,3%), 20 two-component devices (5,4%), 45 non-hydraulic devices (12,3%). Leading primary ED etiologies in first implant surgeries resulted: former radical pelvic surgery in 111 cases (35,8%), Peyronie's disease in 66 cases (21,3%), diabetes in 39 cases (12,6%). Two intraoperative complications have been recorded. Main reasons for 57 revision surgeries were: device failure (52,6%), erosion (19,3%), infection (12,3%), patient dissatisfaction (10,5%). Surgical settings for patients undergoing a first penile implant were: public hospitals in 251 cases (81%), private environments in 59 cases (19%).
    Conclusions: The INSIST-ED Registry represents the first European experience of penile prosthesis Registry. This baseline data analysis shows that: three-pieces inflatable prosthesis is the most implanted device, leading etiology of erectile dysfunction (ED) in patient receiving a prosthesis is former radical pelvic surgery, primary reason for revision surgery is device failure, primary settings for first penile implant surgery are public hospitals. Evaluation of penile implant impact on recipients quality of life is presently ongoing.
    MeSH term(s) Erectile Dysfunction/surgery ; Follow-Up Studies ; Humans ; Intraoperative Complications/epidemiology ; Italy ; Male ; Penile Implantation/methods ; Penile Prosthesis ; Prospective Studies ; Quality of Life ; Registries ; Reoperation/statistics & numerical data
    Language English
    Publishing date 2016-07-04
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1153526-x
    ISSN 2282-4197 ; 1124-3562 ; 1120-8538
    ISSN (online) 2282-4197
    ISSN 1124-3562 ; 1120-8538
    DOI 10.4081/aiua.2016.2.122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.182: Show issues Location:
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