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Article ; Online: Changes in spinal alignment one month post abdominal surgery: A prospective cohort study.

Ito, Akihiro / Iijima, Shinno

2023 Volume 102, Issue 17, Page(s) e33674

Abstract: Following abdominal surgery, many patients assume a bending or stooping posture to protect the surgical wound. Such postural changes are known to induce side effects, but the improvement and persistence of these effects are unknown. Therefore, the ... ...

Abstract	Following abdominal surgery, many patients assume a bending or stooping posture to protect the surgical wound. Such postural changes are known to induce side effects, but the improvement and persistence of these effects are unknown. Therefore, the purpose of this study was to clarify the nature of postural changes in patients undergoing abdominal surgery. In this prospective cohort study, we enrolled 25 patients who underwent abdominal surgery from February 2019 to January 2020. Measurements were obtained during the preoperative, pre-discharge, and first outpatient stages. The sacral tilt, lumbar lordotic, thoracic kyphosis, and overall tilt angles were measured in the static standing position in a private room. Wound pain was measured using a Visual Analogue Scale. Repeated measures analysis of variance was applied to compare spine measurements for each measurement period, followed by the Bonferroni method for each level. Pearson's product-moment correlation coefficient was performed to examine the relationship between wound pain and spinal column angle. The lumbar kyphosis angle was lower before discharge (-7.2 ± 7.4°) compared to preoperatively (-11.1 ± 7.5°) (95% CI 0.76, 7.08; P < .01, η2 = 0.21). Regarding the overall tilt angle, the anterior tilt angle increased before discharge (3.4 ± 3.9°) compared to preoperatively (1.1 ± 4.1°) (95% CI 0.86, 3.78; P < .01, η2 = 0.33). No statistically significant correlation with pain was observed. Compared to the preoperative period, the patients had an anterior tilt, mainly due to lumbar spine changes, prior to discharge from the hospital. Changes in spinal alignment were not associated with wound pain.
MeSH term(s)	Humans ; Prospective Studies ; Lordosis/surgery ; Kyphosis/surgery ; Lumbar Vertebrae/surgery ; Pain
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033674
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Ua VI Zs.171: Show issues

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Article: Postoperative C-reactive protein levels correlate with reduced spinal column mobility after median sternotomy: a prospective cohort study.

Ito, Akihiro / Hara, Tsuyoshi / Irie, Hiroshi

Journal of thoracic disease

2024 Volume 16, Issue 1, Page(s) 469–478

Abstract: Background: The sternum is connected to the spinal column via the ribs, forming the thorax. Therefore, it is necessary to consider the effect of a midline sternotomy on the spinal column, but no : Methods: The participants were patients who had ... ...

Abstract	Background: The sternum is connected to the spinal column via the ribs, forming the thorax. Therefore, it is necessary to consider the effect of a midline sternotomy on the spinal column, but no Methods: The participants were patients who had undergone cardiac surgery through a standby midline sternotomy. Spinal range of motion in forward flexion was measured before and after surgery. The following perioperative factors were investigated: operating time, days to postoperative measurement, C-reactive protein (CRP) measurement on the third postoperative day, the day of the start of bed release, and the stage of bed release progression on the second postoperative day. Statistics were compared between the two groups before and after surgery for each factor. Multiple regression analysis (forced entry method) was then performed with the change in spinal range of motion, which showed statistical differences between the preoperative and postoperative groups, as the dependent variable and each perioperative factor as the independent variable. Results: The study included 93 patients. Postoperatively, there was a significant decrease in thoracic spine range of motion. Multiple regression analysis showed that an increase in CRP on the third postoperative day was responsible for the decrease in thoracic range of motion (β=-0.30, P<0.01). Conclusions: After median sternotomy, thoracic spine range of motion was decreased and correlated with postoperative inflammation.
Language	English
Publishing date	2024-01-12
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1439
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Article ; Online: Severe Legionella Pneumonia in Which Serial Testing by Ribotest

Motokura, Yumi / Ito, Akihiro / Ishida, Tadashi

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 20, Page(s) 2989–2993

Abstract: A 79-year-old man presented with chest pain, and urinary antigen tests for Legionella pneumophila ( ... ...

Abstract	A 79-year-old man presented with chest pain, and urinary antigen tests for Legionella pneumophila (ImmunoCatch
MeSH term(s)	Male ; Humans ; Aged ; Legionella ; Legionnaires' Disease/diagnosis ; Legionella pneumophila ; Pneumonia ; Steroids
Chemical Substances	Steroids
Language	English
Publishing date	2023-03-08
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0766-22
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Zs.A 240: Show issues

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Article ; Online: Identification rate of

Ito, Akihiro / Ishida, Tadashi / Tachibana, Hiromasa / Nakanishi, Yosuke / Kawataki, Masanori / Yamazaki, Akio / Washio, Yasuyoshi

Journal of clinical microbiology

2024 Volume 62, Issue 4, Page(s) e0166523

Abstract: ... ...

Abstract	Many
MeSH term(s)	Humans ; Legionella ; Sputum ; Legionnaires' Disease/diagnosis ; Legionella pneumophila ; Pneumonia
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/jcm.01665-23
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Zs.A 1188: Show issues

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Article ; Online: Statin administration ameliorates ischemia-induced overactive bladder with improvement of blood flow and anti-inflammatory effects in rats.

Ishizuka, Yuichi / Satake, Yohei / Kimura, Shingo / Yamashita, Shinichi / Kawamorita, Naoki / Ito, Akihiro

Neurourology and urodynamics

2024 Volume 43, Issue 4, Page(s) 991–1002

Abstract: Aims: Statins are widely used to treat dyslipidemia and have been shown to reduce the risk of ischemic heart disease and cerebrovascular disease. The effects of statins on ischemia-induced overactive bladder (OAB) and the associated mechanisms were ... ...

Abstract	Aims: Statins are widely used to treat dyslipidemia and have been shown to reduce the risk of ischemic heart disease and cerebrovascular disease. The effects of statins on ischemia-induced overactive bladder (OAB) and the associated mechanisms were investigated in a rat model of chronic pelvic ischemia. Methods: A pelvic ischemia model was created by iliac arterial injury (AI) and a high-fat diet using male Sprague-Dawley rats. Rats were assigned to 3 groups: control group, AI group, and AI + statin group. The control group underwent sham operation and was fed a normal diet. The AI group underwent AI surgery and was fed a high-cholesterol diet. The AI + statin group was administered a statin for 4 weeks. Cystometry was performed for 8 weeks after surgery. Blood flow was evaluated by laser meter. Thickness of the iliac arteries was measured, and microvascular density in the lamina propria was evaluated by immunostaining for CD31. Expressions of inflammatory cytokines in the bladder were measured by real-time PCR. Results: Cystometry showed a significantly shorter voiding interval and lower bladder capacity in the AI group than in the control group. The AI + statin group showed improvement of these findings. The AI group showed decreased bladder blood flow, increased iliac arterial wall thickening, and decreased microvascular density compared to the control group. Statin administration improved blood flow. Iliac arterial wall thickening was suppressed, and microvascular density was increased by statin administration, though not significantly. Real-time PCR showed significantly higher expressions of inflammatory cytokines (IL-6, IL-8, and TNF-α) in the AI group than in the control group, and IL-6 and IL-8 expressions were lower in the AI + statin group than in the AI group. Conclusions: The present results suggest that statins are effective in OAB caused by arteriosclerosis and ischemia. The mechanism of their effects involves improved bladder blood flow and decreased bladder inflammation.
MeSH term(s)	Rats ; Male ; Animals ; Urinary Bladder, Overactive ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Rats, Sprague-Dawley ; Interleukin-8/therapeutic use ; Interleukin-6 ; Ischemia ; Cytokines ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Interleukin-8 ; Interleukin-6 ; Cytokines ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.25433
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Zs.A 1828: Show issues

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Article ; Online: Wide-Targeted Semi-Quantitative Analysis of Acidic Glycosphingolipids in Cell Lines and Urine to Develop Potential Screening Biomarkers for Renal Cell Carcinoma.

Maekawa, Masamitsu / Sato, Tomonori / Kanno, Chika / Sakamoto, Izumi / Kawasaki, Yoshihide / Ito, Akihiro / Mano, Nariyasu

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Glycosphingolipids (GSLs), mainly located in the cell membrane, play various roles in cancer cell function. GSLs have potential as renal cell carcinoma (RCC) biomarkers; however, their analysis in body fluids is challenging because of the complexity of ... ...

Abstract	Glycosphingolipids (GSLs), mainly located in the cell membrane, play various roles in cancer cell function. GSLs have potential as renal cell carcinoma (RCC) biomarkers; however, their analysis in body fluids is challenging because of the complexity of numerous glycans and ceramides. Therefore, we applied wide-targeted lipidomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with selected reaction monitoring (SRM) based on theoretical mass to perform a comprehensive measurement of GSLs and evaluate their potency as urinary biomarkers. In semi-quantitative lipidomics, 240 SRM transitions were set based on the reported/speculated structures. We verified the feasibility of measuring GSLs in cells and medium and found that disialosyl globopentaosylceramide (DSGb5 (d18:1/16:0)) increased GSL in the ACHN medium. LC-MS/MS analysis of urine samples from clear cell RCC (ccRCC) patients and healthy controls showed a significant increase in the peak intensity of urinary DSGb5 (d18:1/16:0) in the ccRCC group compared with that in the control group. Receiver operating characteristic analysis indicated that urinary DSGb5 could serve as a sensitive and specific marker for RCC screening, with an AUC of 0.89. This study demonstrated the possibility of urinary screening using DSGb5 (d18:1/16:0). In conclusion, urinary DSGb5 (d18:1/16:0) was a potential biomarker for cancer screening, which could contribute to the treatment of RCC patients.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/diagnosis ; Acidic Glycosphingolipids ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Body Fluids ; Biomarkers ; Cell Line ; Kidney Neoplasms/diagnosis
Chemical Substances	Acidic Glycosphingolipids ; Biomarkers
Language	English
Publishing date	2024-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25074098
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Article: Students' level of satisfaction with graduation research during the COVID-19 pandemic.

Kubo, Akira / Onoda, Ko / Yakabi, Akihiro / Hara, Tsuyoshi / Ito, Akihiro

Journal of physical therapy science

2023 Volume 35, Issue 3, Page(s) 182–184

Abstract: Purpose] We investigated the effects of the state of emergency declared following the spread of coronavirus disease on the level of satisfaction with graduation research. [Participants and Methods] The study included 320 students who graduated from a ... ...

Abstract	[Purpose] We investigated the effects of the state of emergency declared following the spread of coronavirus disease on the level of satisfaction with graduation research. [Participants and Methods] The study included 320 students who graduated from a university in northern Tochigi Prefecture between March 2019 and 2022. Participants were categorized into the non-coronavirus group (graduation in 2019 and 2020) and the coronavirus group (graduation in 2021 and 2022). Levels of satisfaction with the content and rewards of graduation research were assessed using a visual analog scale. [Results] Levels of satisfaction with the content and rewards of graduation research were >70 mm in both groups and were significantly higher in females in the coronavirus group than in the non-coronavirus group. [Conclusion] The study highlights that despite the pandemic, educational engagement can improve students' satisfaction with graduation research.
Language	English
Publishing date	2023-03-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.35.182
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Article ; Online: Eosinopenia is associated with adverse outcomes after COVID-19 infection: A perspective from Japan.

Ito, Akihiro / Ishida, Tadashi / Nakanishi, Yosuke / Kobe, Hiroshi / Tokioka, Fumiaki

Respirology (Carlton, Vic.)

2023 Volume 28, Issue 7, Page(s) 677–680

MeSH term(s)	Humans ; COVID-19/epidemiology ; Japan/epidemiology ; Leukocyte Count ; Eosinophils
Language	English
Publishing date	2023-04-27
Publishing country	Australia
Document type	Letter
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14509
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Zs.A 4957: Show issues

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Article ; Online: Relationship between Total Kihon Checklist Score and Age-Specific Deaths among Late-Stage Older Adults in Otawara City (Aged 75 and Older) over a 15-Year Period.

Ito, Akihiro / Igawa, Tatsuya / Ishizaka, Masahiro / Hashimoto, Naori / Hara, Tsuyoshi

Gerontology

2023 Volume 69, Issue 9, Page(s) 1095–1103

Abstract: Introduction: While the Japanese long-term care insurance system supports an ageing society, there are concerns about the shortage of financial resources and labour force. Further, extending healthy life expectancy and narrowing the gap with the average ...

Abstract	Introduction: While the Japanese long-term care insurance system supports an ageing society, there are concerns about the shortage of financial resources and labour force. Further, extending healthy life expectancy and narrowing the gap with the average life expectancy are important issues. In this study, we aimed to examine, over a 15-year period, the relationship between the total Kihon Checklist (t-KCL) score and age-specific deaths among late-stage older adults aged 75 and older who were not certified for long-term care insurance. Methods: The participants were older adults residing in Otawara City, Tochigi Prefecture, who were aged 75 years or older as of 2006. The participants, who were not certified by the long-term care insurance system, were asked to complete the KCL by a community welfare committee member. Based on their t-KCL scores, the participants were classified as robust (0-3 points), pre-frail (4-7 points), and frail (≥8 points). The deaths of those aged 75-89 years who had completed the KCL were investigated. Information on deaths was obtained from local authorities. Statistics were examined for the risk of robust, pre-frail, and frail mortality using a Cox proportional hazards model with age and gender as covariates for the 75-79, 80-84, and 85-89 age groups. Results: Of the 7,924 participants, 3,423 (75-79 years: 1,990, 80-84 years: 1,059, 85-89 years: 374) were ultimately eligible for the study. Of these, 2,450 (75-79 years: 1,238, 80-84 years: 861, 85-89 years: 351) died over the 15-year study period. Hazard ratios for death in frailty as determined by the t-KCL score were 1.337 (95% confidence interval [CI], 1.162-1.540) for the pre-frail group and 2.012 (95% CI, 1.7756-2.305) for the frail group at 75-79 years, respectively, compared with the robust group; 1.511 (95% CI, 1.271-1.797) at 80-84 years only in the frail group; and 1.567 (95% CI, 1.140-2.154) at 85-89 years, also in the frail group. Discussion: The relationship between frailty and mortality weakens after age 80. The results suggest that factors other than frailty may have a stronger influence on mortality risk after the age of 80.
MeSH term(s)	Aged ; Humans ; Frailty ; Checklist/methods ; Geriatric Assessment/methods ; Age Factors ; Frail Elderly ; Japan
Language	English
Publishing date	2023-07-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193798-4
ISSN	1423-0003 ; 0304-324X
ISSN (online)	1423-0003
ISSN	0304-324X
DOI	10.1159/000532061
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Ud II Zs.201: Show issues

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Article ; Online: Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site.

Ito, Akihiro / Wang, Lei / Notomi, Ryotaro / Sasaki, Shigeki / Taniguchi, Yosuke

Chemical & pharmaceutical bulletin

2023 Volume 72, Issue 1, Page(s) 16–20

Abstract: Triplex DNA formation has generated much interest as a genomic targeting tool that directly targets duplex DNA. However, fundamental limitations in the base pairs of target duplex DNA sequences that can form stable triplex DNA have limited the ... ...

Abstract	Triplex DNA formation has generated much interest as a genomic targeting tool that directly targets duplex DNA. However, fundamental limitations in the base pairs of target duplex DNA sequences that can form stable triplex DNA have limited the application. Recently, we have reported on the recognition of CG and
MeSH term(s)	Nucleic Acids ; DNA ; Oligonucleotides ; Benzimidazoles
Chemical Substances	triplex DNA ; Nucleic Acids ; DNA (9007-49-2) ; Oligonucleotides ; Benzimidazoles
Language	English
Publishing date	2023-12-14
Publishing country	Japan
Document type	Journal Article
ZDB-ID	213307-6
ISSN	1347-5223 ; 0009-2363
ISSN (online)	1347-5223
ISSN	0009-2363
DOI	10.1248/cpb.c23-00666
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