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  1. Article ; Online: Linear dichroism reveals the perpendicular orientation of DNA bases in the RecA and Rad51 recombinase filaments: A possible mechanism for the strand exchange reaction.

    Takahashi, Masayuki / Ito, Kentaro / Iwasaki, Hiroshi / Norden, Bengt

    Chirality

    2024  Volume 36, Issue 4, Page(s) e23664

    Abstract: Linear dichroism spectroscopy is used to investigate the structure of RecA family recombinase filaments (RecA and Rad51 proteins) with DNA for clarifying the molecular mechanism of DNA strand exchange promoted by these proteins and its activation. The ... ...

    Abstract Linear dichroism spectroscopy is used to investigate the structure of RecA family recombinase filaments (RecA and Rad51 proteins) with DNA for clarifying the molecular mechanism of DNA strand exchange promoted by these proteins and its activation. The measurements show that the recombinases promote the perpendicular base orientation of single-stranded DNA only in the presence of activators, indicating the importance of base orientation in the reaction. We summarize the results and discuss the role of DNA base orientation.
    MeSH term(s) Rad51 Recombinase/chemistry ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Stereoisomerism ; DNA/chemistry ; DNA, Single-Stranded
    Chemical Substances Rad51 Recombinase (EC 2.7.7.-) ; DNA (9007-49-2) ; DNA, Single-Stranded
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1011639-4
    ISSN 1520-636X ; 0899-0042
    ISSN (online) 1520-636X
    ISSN 0899-0042
    DOI 10.1002/chir.23664
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2594: Show issues Location:
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  2. Article ; Online: Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity.

    Setsu, Genzui / Goto, Megumi / Ito, Kentaro / Taira, Tomoe / Miyamoto, Masaya / Watanabe, Tomohiro / Higuchi, Saito

    Biochemical and biophysical research communications

    2024  Volume 715, Page(s) 149995

    Abstract: Immune checkpoint inhibitors have significantly transformed the landscape of cancer therapy. Nevertheless, while these inhibitors are highly effective for certain patient groups, many do not benefit due to primary or acquired resistance. Specifically, ... ...

    Abstract Immune checkpoint inhibitors have significantly transformed the landscape of cancer therapy. Nevertheless, while these inhibitors are highly effective for certain patient groups, many do not benefit due to primary or acquired resistance. Specifically, these treatments often lack sufficient therapeutic efficacy against cancers with low antigenicity. Thus, the development of an effective strategy to overcome cancers with low antigenicity is imperative for advancing next-generation cancer immunotherapy. Here, we show that small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) combined with programmed cell death ligand 1 (PD-L1) blockade can enhance T-cell response to tumor with low antigenicity. We found that treatment of OT-1 splenocytes with HPK1 inhibitor enhanced the activation of signaling molecules downstream of T-cell receptor provoked by low-affinity-antigen stimulation. Using an in vivo OT-1 T-cell transfer model, we demonstrated that combining the HPK1 inhibitor with the anti-PD-L1 antibody significantly suppressed the growth of tumors expressing low-affinity altered peptide ligand of chicken ovalbumin, while anti-PD-L1 antibody monotherapy was ineffective. Our findings offer crucial insights into the potential for overcoming tumors with low antigenicity by combining conventional immune checkpoint inhibitors with HPK1 inhibitor.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2024.149995
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    Zs.A 116: Show issues Location:
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  3. Article ; Online: Effect of Flavanol-Rich Cacao Extract on the Profile of Mood State in Healthy Middle-Aged Japanese Women: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

    Murakami, Rika / Natsume, Midori / Ito, Kentaro / Ebihara, Shukuko / Terauchi, Masakazu

    Nutrients

    2023  Volume 15, Issue 17

    Abstract: To investigate the effects of flavanol-rich cacao extract on healthy middle-aged women's fatigue and mood conditions, we conducted a randomized, double-blind, placebo-controlled study in women aged 40-60 years who had reported fatigue and had shown high ... ...

    Abstract To investigate the effects of flavanol-rich cacao extract on healthy middle-aged women's fatigue and mood conditions, we conducted a randomized, double-blind, placebo-controlled study in women aged 40-60 years who had reported fatigue and had shown high levels of a serum oxidative stress marker. We randomized the participants (
    MeSH term(s) Female ; Humans ; Middle Aged ; Cacao ; East Asian People ; Fatigue ; Pilot Projects ; Plant Extracts/pharmacology
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2023-09-03
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15173843
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  4. Article ; Online: Highly Sensitive Electrochemical Immunoassay Using Signal Amplification of the Coagulation Cascade.

    Ito, Kentaro / Inoue, Kumi Y / Ino, Kosuke / Shiku, Hitoshi

    Analytical chemistry

    2022  Volume 94, Issue 36, Page(s) 12427–12434

    Abstract: Here, we report a highly sensitive immunoassay for human immunoglobulin G (IgG) that uses signal amplification of the coagulation cascade. Z-Phe-Pro-Lys- ...

    Abstract Here, we report a highly sensitive immunoassay for human immunoglobulin G (IgG) that uses signal amplification of the coagulation cascade. Z-Phe-Pro-Lys-
    MeSH term(s) Blood Coagulation ; Electrodes ; Humans ; Immunoassay ; Immunoglobulin G ; Thrombin
    Chemical Substances Immunoglobulin G ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c02241
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    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: High-Sensitivity Amperometric Dual Immunoassay Using Two Cascade Reactions with Signal Amplification of Redox Cycling in Nanoscale Gap.

    Ito, Kentaro / Y Inoue, Kumi / Ino, Kosuke / Shiku, Hitoshi

    Analytical chemistry

    2022  Volume 94, Issue 47, Page(s) 16451–16460

    Abstract: Here, we report a high-sensitivity dual immunoassay ... ...

    Abstract Here, we report a high-sensitivity dual immunoassay using
    MeSH term(s) Humans ; Factor XIa ; Immunoassay/methods ; Electrodes ; Oxidation-Reduction ; Endotoxins
    Chemical Substances Factor XIa (EC 3.4.21.27) ; Endotoxins
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c03921
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    Zs.A 4033: Show issues Location:
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  6. Article ; Online: Physical Activity Using a Wearable Device as an Alternative to Performance Status in Patients With Advanced Lung Cancer.

    Ito, Kentaro / Suzuki, Yuta / Sakaguchi, Tadashi / Fujiwara, Kentaro / Nishii, Yoichi / Yasui, Hiroki / Taguchi, Osamu / Hataji, Osamu

    JAMA oncology

    2024  

    Abstract: Importance: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among ... ...

    Abstract Importance: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among observers.
    Objective: To investigate the association between measured physical activity and ECOG PS, as well as the potential prognostic value of physical activity measurements in patients with advanced lung cancer.
    Design, setting, and participants: This single-institution, prospective observational study enrolled 119 patients with advanced lung cancer scheduled to receive systemic therapy as outpatients at Matsusaka Municipal Hospital in Mie, Japan. Participants wore the wearable device amuelink (Sony) for up to 14 days to measure physical activity, including metabolic equivalent tasks, distance walked, and number of steps taken. ECOG PS was assessed at enrollment, which took place from December 2021 to August 2022.
    Main outcomes and measures: The primary end point was estimating the area under the curve (AUC) for classification into ECOG PS of 2 or higher using physical activity measurements. An analysis of the association with survival was also conducted.
    Results: Among the 119 patients (median [range] age, 72 (32-88) years; 71 [59.7%] male), mean distance walked (MDW) had the highest diagnostic value for classifying an ECOG PS of 2 or greater, with an AUC of 0.818 (95% CI, 0.703-0.934). Moreover, MDW was also associated with 6-month survival, with an AUC of 0.806 (95% CI, 0.694-0.918). Survival curves significantly diverged based on the MDW threshold, indicating a potential association with survival outcome (hazard ratio, 0.17; 95% CI, 0.05-0.57).
    Conclusions and relevance: The cohort study suggests that MDW, as measured by a wearable device, was associated with ECOG PS and may serve as a predictor of health status alongside ECOG PS categories. It demonstrates the potential of objectively measured physical activity in complementing subjective ECOG PS assessments in patients with advanced lung cancer. Further research is needed to confirm the prognostic value of physical activity measurements.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2024.0023
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  7. Article ; Online: Free-Standing Molecularly Thin Amorphous Silica Nanosheets.

    Yamamoto, Eisuke / Fujihara, Kosuke / Takezaki, Yuma / Ito, Kentaro / Shi, Yue / Kobayashi, Makoto / Osada, Minoru

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 22, Page(s) e2300022

    Abstract: Recent progress in 2D materials has initiated new fields of molecularly thin amorphous materials with mysterious properties and structures. However, designed synthesis of molecularly thin amorphous silica still remains a challenge; whether free-standing ... ...

    Abstract Recent progress in 2D materials has initiated new fields of molecularly thin amorphous materials with mysterious properties and structures. However, designed synthesis of molecularly thin amorphous silica still remains a challenge; whether free-standing molecularly thin amorphous silica nanosheets can exist is unclear. Here, this issue is addressed by using a new chemical protocol; solid-state surfactant lamellae with ordered alkyl-chain arrangements can serve as superior templates guiding free-standing amorphous silica nanosheets. Simple sonication of the lamellar hybrids allows exfoliation into monolayer amorphous silica nanosheets with 0.9 nm thickness. In addition, the nanosheets show the distinctive feature of high colloidal stability that enables atomic layer engineering of silica nanocoatings and dielectric nanofilms. The approach may shed new light on the properties and applications of old silica.
    Language English
    Publishing date 2023-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202300022
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  8. Article ; Online: Refractory response to entrectinib for ROS-1 rearranged NSCLC with concurrent de novo TP53 mutation showing good response to CNS lesion, but poor duration of response: A case report.

    Ito, Kentaro / Nishio, Miho / Fujiwara, Kentaro / Nishii, Yoichi / Ushiro, Kengo / Yasui, Hiroki / Hataji, Osamu

    Thoracic cancer

    2023  Volume 14, Issue 25, Page(s) 2622–2626

    Abstract: Entrectinib, a ROS-1 inhibitor, has been shown to be effective for patients with ROS-1 fused NSCLC, and has been established as the standard of care for this population. Entrectinib has been shown to achieve a better response to brain metastasis due to ... ...

    Abstract Entrectinib, a ROS-1 inhibitor, has been shown to be effective for patients with ROS-1 fused NSCLC, and has been established as the standard of care for this population. Entrectinib has been shown to achieve a better response to brain metastasis due to the characteristic of the drug having a weak interaction with P-glycoprotein and, even in prospective studies, the intracranial response is higher. Patients have been known to acquire resistance to molecularly targeted drugs such as EGF-TKIs or ALK-TKIs during targeted therapy. Similarly, the mechanisms of resistance to entrectinib have been reported, but information about the effects of TP53 mutation with entrectinib are still limited. Here, we experienced a case of a patient with ROS-1 fusion and concurrent TP53 mutation who was treated with entrectinib, resulting in a response to brain metastasis but rapid resistance to entrectinib. Our case demonstrates both the intracranial activity of entrectinib and the potential for resistance to entrectinib due to TP53 mutation.
    MeSH term(s) Humans ; Reactive Oxygen Species ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/pathology ; Brain Neoplasms/drug therapy ; Mutation ; Lung Neoplasms/pathology ; Protein Kinase Inhibitors/therapeutic use ; Tumor Suppressor Protein p53/genetics
    Chemical Substances entrectinib (L5ORF0AN1I) ; Reactive Oxygen Species ; Protein Kinase Inhibitors ; TP53 protein, human ; Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-08-06
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15044
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    Zs.A 6921: Show issues Location:
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  9. Article ; Online: Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange.

    Renodon-Corniere, Axelle / Mikawa, Tsutomu / Kuwabara, Naoyuki / Ito, Kentaro / Levitsky, Dmitri / Iwasaki, Hiroshi / Takahashi, Masayuki

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Human Rad51 protein (HsRad51)-promoted DNA strand exchange, a crucial step in homologous recombination, is regulated by proteins and calcium ions. Both the activator protein Swi5/Sfr1 and ... ...

    Abstract Human Rad51 protein (HsRad51)-promoted DNA strand exchange, a crucial step in homologous recombination, is regulated by proteins and calcium ions. Both the activator protein Swi5/Sfr1 and Ca
    MeSH term(s) Humans ; Oligonucleotides ; Rad51 Recombinase ; Calcium ; Ions ; DNA
    Chemical Substances Oligonucleotides ; Rad51 Recombinase (EC 2.7.7.-) ; Calcium (SY7Q814VUP) ; Ions ; DNA (9007-49-2)
    Language English
    Publishing date 2024-03-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073633
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  10. Article: Osimertinib therapy as first-line treatment before acquiring T790M mutation: from AURA1 trial.

    Ito, Kentaro / Hataji, Osamu

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 26, Page(s) S3071–S3077

    Language English
    Publishing date 2018-02-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.07.52
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