Article ; Online: Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K.
Molecules (Basel, Switzerland)
2023 Volume 28, Issue 10
Abstract: Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been ... ...
| Abstract | Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been attracting attention for use in new medicines. Methods: Cathepsin K inhibitors were isolated from the methanol extract of Results: Two types of cathepsin K inhibitors were identified in the methanol extract of Conclusions: Different allosteric inhibitors that bind to different sites in combination, as shown in this study, may be useful for designing new allosteric inhibitory drugs with high specificity and few side effects. |
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| MeSH term(s) | Humans ; Cathepsin K/metabolism ; Allosteric Site ; Kinetics ; Methanol ; Bone Resorption ; Cathepsins/metabolism | |||||
| Chemical Substances | Cathepsin K (EC 3.4.22.38) ; Methanol (Y4S76JWI15) ; Cathepsins (EC 3.4.-) | |||||
| Language | English | |||||
| Publishing date | 2023-05-19 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1413402-0 | |||||
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 | |||||
| ISSN (online) | 1420-3049 | |||||
| ISSN | 1431-5165 ; 1420-3049 | |||||
| DOI | 10.3390/molecules28104197 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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