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Article: Imaging of intracellular rearrangement of photosynthetic proteins in Chlamydomonas cells upon state transition

Fujita, Yuki / Ito, Wakana / Shibata, Yutaka / Washiyama, Kento

Journal of photochemistry and photobiology. 2018 Aug., v. 185

2018

Abstract: Oxygenic photosynthesis is conducted by two photoactive units, photosystem I (PSI) and photosystem II (PSII), that utilize light energy to generate the electron flow from water to NADPH. Photosynthetic organisms have developed a mechanism called state ... ...

Abstract	Oxygenic photosynthesis is conducted by two photoactive units, photosystem I (PSI) and photosystem II (PSII), that utilize light energy to generate the electron flow from water to NADPH. Photosynthetic organisms have developed a mechanism called state transition (ST) to regulate the excitation balance between the two units, since the balance is constantly disturbed by fluctuation in light quality. The traditional ST model assumes shuttling of a light-harvesting complex called LHCII between the two PSs. However, there has been no direct observation of the intracellular rearrangements of LHCII upon ST, which is crucial in order to evaluate the validity of the traditional ST model. Here, the intracellular distributions of the two PSs and LHCII are visualized by using a novel cryogenic optical microscope. The calculated Pearson's correlation coefficient between the relative fluorescence intensity of LHCII and the fluorescence intensity ratio of PSII to PSI provided information about the degree of co-localization of these components. The analysis indicated that the relative emission intensity from LHCII is stronger in the PSII-abundant region than in the PSI-abundant one in both states. On the other hand, a statistical analysis by Welch's test indicated that Pearson's correlation coefficient is significantly higher in state1 than state2, probably reflecting the movement of LHCII from PSII to PSI upon state transition. The study also found an independent cell group in which degree of ST was between those observed for fully converted cells. These cells tended to show lower correlation coefficients than the fully converted ones. This was explained by assuming the existence of free LHCII, which moves to but remains unconnected to PSI in state2.
Keywords	autotrophs ; Chlamydomonas ; correlation ; emissions factor ; energy ; fluorescence ; image analysis ; light harvesting complex ; light quality ; models ; NADP (coenzyme) ; photosystem I ; photosystem II
Language	English
Dates of publication	2018-08
Size	p. 111-116.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2018.05.029
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Article ; Online: Imaging of intracellular rearrangement of photosynthetic proteins in Chlamydomonas cells upon state transition.

Fujita, Yuki / Ito, Wakana / Washiyama, Kento / Shibata, Yutaka

Journal of photochemistry and photobiology. B, Biology

2018 Volume 185, Page(s) 111–116

Abstract	Oxygenic photosynthesis is conducted by two photoactive units, photosystem I (PSI) and photosystem II (PSII), that utilize light energy to generate the electron flow from water to NADPH. Photosynthetic organisms have developed a mechanism called state transition (ST) to regulate the excitation balance between the two units, since the balance is constantly disturbed by fluctuation in light quality. The traditional ST model assumes shuttling of a light-harvesting complex called LHCII between the two PSs. However, there has been no direct observation of the intracellular rearrangements of LHCII upon ST, which is crucial in order to evaluate the validity of the traditional ST model. Here, the intracellular distributions of the two PSs and LHCII are visualized by using a novel cryogenic optical microscope. The calculated Pearson's correlation coefficient between the relative fluorescence intensity of LHCII and the fluorescence intensity ratio of PSII to PSI provided information about the degree of co-localization of these components. The analysis indicated that the relative emission intensity from LHCII is stronger in the PSII-abundant region than in the PSI-abundant one in both states. On the other hand, a statistical analysis by Welch's test indicated that Pearson's correlation coefficient is significantly higher in state1 than state2, probably reflecting the movement of LHCII from PSII to PSI upon state transition. The study also found an independent cell group in which degree of ST was between those observed for fully converted cells. These cells tended to show lower correlation coefficients than the fully converted ones. This was explained by assuming the existence of free LHCII, which moves to but remains unconnected to PSI in state2.
MeSH term(s)	Chlamydomonas/growth & development ; Chlamydomonas/metabolism ; Light-Harvesting Protein Complexes/chemistry ; Light-Harvesting Protein Complexes/metabolism ; Microscopy, Fluorescence ; Photosynthesis ; Photosystem I Protein Complex/chemistry ; Photosystem I Protein Complex/metabolism ; Photosystem II Protein Complex/chemistry ; Photosystem II Protein Complex/metabolism ; Spectrometry, Fluorescence ; Temperature
Chemical Substances	Light-Harvesting Protein Complexes ; Photosystem I Protein Complex ; Photosystem II Protein Complex
Language	English
Publishing date	2018-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	623022-2
ISSN	1873-2682 ; 1011-1344
ISSN (online)	1873-2682
ISSN	1011-1344
DOI	10.1016/j.jphotobiol.2018.05.029
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Article ; Online: Relationship between maximum occlusal force and gastrointestinal cancer in community-dwelling older Japanese adults.

Komiyama, Takamasa / Ohi, Takashi / Ito, Wakana / Miyoshi, Yoshitada / Hiratsuka, Takako / Matsuyama, Sanae / Tsuji, Ichiro / Watanabe, Makoto / Hattori, Yoshinori

Scientific reports

2022 Volume 12, Issue 1, Page(s) 440

Abstract: Globally, the cancer burden is expected to increase as populations are ageing. Therefore, cancer prevention among older age groups is important. This prospective cohort study examined the relationship between the number of remaining teeth, maximum ... ...

Abstract	Globally, the cancer burden is expected to increase as populations are ageing. Therefore, cancer prevention among older age groups is important. This prospective cohort study examined the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer in community-dwelling older Japanese individuals using data from the Tsurugaya project; 847 participants were included. The exposure variables were the number of remaining teeth and the maximum occlusal force, with the outcome being the incidence of gastrointestinal cancer. Covariates were age, sex, medical history, smoking, alcohol consumption, educational attainment, and physical function. The Cox proportional hazard model was used to examine the relationship between the number of remaining teeth, maximum occlusal force, and incidence of gastrointestinal cancer. With a median follow-up of 7.6 years, 63 participants were confirmed to have gastrointestinal cancer. The risk of gastrointestinal cancer was significantly higher in those with an occlusal force lower than the median (hazard ratio, 2.80; 95% confidence interval, 1.54-5.10). No significant risk difference was found according to the number of remaining teeth. Low maximum occlusal force was associated with the incidence of gastrointestinal cancer in community-dwelling older Japanese adults.
MeSH term(s)	Aged ; Aged, 80 and over ; Asians/statistics & numerical data ; Bite Force ; Female ; Gastrointestinal Neoplasms/epidemiology ; Humans ; Incidence ; Japan/epidemiology ; Male ; Prospective Studies
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04158-y
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Article ; Online: Noradrenaline activation of hippocampal dopamine D

Kobayashi, Katsunori / Shikano, Kisako / Kuroiwa, Mahomi / Horikawa, Mio / Ito, Wakana / Nishi, Akinori / Segi-Nishida, Eri / Suzuki, Hidenori

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 33, Page(s) e2117903119

Abstract: ... Dopamine ... ...

Abstract	Dopamine D
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Dentate Gyrus/metabolism ; Depressive Disorder/metabolism ; Dopamine/metabolism ; Dopaminergic Neurons/metabolism ; Mice ; Norepinephrine/metabolism ; Norepinephrine/pharmacology ; Receptors, Dopamine D1/metabolism
Chemical Substances	Antidepressive Agents ; Receptors, Dopamine D1 ; Dopamine (VTD58H1Z2X) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2117903119
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Article ; Online: Preliminary exploration for evaluating acuity of oral texture perception.

Furukawa, Nao / Ito, Yoshihiko / Tanaka, Yasue / Ito, Wakana / Hattori, Yoshinori

Journal of texture studies

2019 Volume 50, Issue 3, Page(s) 217–223

Abstract: Despite the important role of oral texture perception in feeding and nutritional homeostasis, its impairment has not been of particular clinical interest, and no clinical protocol is available to evaluate its acuity. This preliminary study aimed to ... ...

Abstract	Despite the important role of oral texture perception in feeding and nutritional homeostasis, its impairment has not been of particular clinical interest, and no clinical protocol is available to evaluate its acuity. This preliminary study aimed to establish a method to evaluate the acuity of oral texture perception. Because texture perception is regarded as reflecting integrity of the sensorimotor system of the jaw and mouth, we hypothesized that the ability to perceive various aspects of food texture would correlate with each other, and tested our hypothesis in 11 healthy adults. First, we prepared three types of test foods with different dominant textures, each of which comprised a series of stimuli with different ingredient concentrations; we used these test foods in discrimination tests involving pairwise comparison. Tests performed using the up-down staircase method revealed significant correlation among the discrimination thresholds for three test foods, suggesting that acuities of texture perception correlated with each other across different textural attributes. Second, we examined the associations between the acuity of texture perception and some aspects of mechanical sensation of the tongue: tactile and two-point discrimination thresholds, as well as the graininess recognition threshold. The acuity of texture perception of the subjects whose sensitivity was low for at least one of these aspects of mechanical sensation (n = 5) was significantly lower than that exhibited by the other subjects (Wilcoxon rank-sum test, p = 0.0417). We concluded that oral texture perception ability can be evaluated by discrimination tests for specific aspects of texture, using appropriate test foods.
MeSH term(s)	Adult ; Female ; Food ; Humans ; Male ; Mouth ; Taste/physiology ; Taste Perception/physiology ; Taste Threshold ; Tongue
Language	English
Publishing date	2019-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	242507-5
ISSN	1745-4603 ; 0022-4901
ISSN (online)	1745-4603
ISSN	0022-4901
DOI	10.1111/jtxs.12400
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Article ; Online: Relationship between the Rod complex and peptidoglycan structure in Escherichia coli.

Ago, Risa / Tahara, Yuhei O / Yamaguchi, Honoka / Saito, Motoya / Ito, Wakana / Yamasaki, Kaito / Kasai, Taishi / Okamoto, Sho / Chikada, Taiki / Oshima, Taku / Osaka, Issey / Miyata, Makoto / Niki, Hironori / Shiomi, Daisuke

MicrobiologyOpen

2023 Volume 12, Issue 5, Page(s) e1385

Abstract: Peptidoglycan for elongation in Escherichia coli is synthesized by the Rod complex, which includes RodZ. Although various mutant strains of the Rod complex have been isolated, the relationship between the activity of the Rod complex and the overall ... ...

Abstract	Peptidoglycan for elongation in Escherichia coli is synthesized by the Rod complex, which includes RodZ. Although various mutant strains of the Rod complex have been isolated, the relationship between the activity of the Rod complex and the overall physical and chemical structures of the peptidoglycan have not been reported. We constructed a RodZ mutant, termed RMR, and analyzed the growth rate, morphology, and other characteristics of cells producing the Rod complexes containing RMR. The growth and morphology of RMR cells were abnormal, and we isolated suppressor mutants from RMR cells. Most of the suppressor mutations were found in components of the Rod complex, suggesting that these suppressor mutations increase the integrity and/or the activity of the Rod complex. We purified peptidoglycan from wild-type, RMR, and suppressor mutant cells and observed their structures in detail. We found that the peptidoglycan purified from RMR cells had many large holes and different compositions of muropeptides from those of WT cells. The Rod complex may be a determinant not only for the whole shape of peptidoglycan but also for its highly dense structure to support the mechanical strength of the cell wall.
MeSH term(s)	Escherichia coli/genetics ; Escherichia coli Proteins/genetics ; Peptidoglycan ; Cytoskeletal Proteins/genetics ; Cell Wall
Chemical Substances	Escherichia coli Proteins ; Peptidoglycan ; Cytoskeletal Proteins ; RodZ protein, E coli
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661368-2
ISSN	2045-8827 ; 2045-8827
ISSN (online)	2045-8827
ISSN	2045-8827
DOI	10.1002/mbo3.1385
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Article: Preliminary exploration for evaluating acuity of oral texture perception

Furukawa, Nao / Ito, Yoshihiko / Tanaka, Yasue / Ito, Wakana / Hattori, Yoshinori

Journal of texture studies. 2019 June, v. 50, no. 3

2019

Abstract	Despite the important role of oral texture perception in feeding and nutritional homeostasis, its impairment has not been of particular clinical interest, and no clinical protocol is available to evaluate its acuity. This preliminary study aimed to establish a method to evaluate the acuity of oral texture perception. Because texture perception is regarded as reflecting integrity of the sensorimotor system of the jaw and mouth, we hypothesized that the ability to perceive various aspects of food texture would correlate with each other, and tested our hypothesis in 11 healthy adults. First, we prepared three types of test foods with different dominant textures, each of which comprised a series of stimuli with different ingredient concentrations; we used these test foods in discrimination tests involving pairwise comparison. Tests performed using the up‐down staircase method revealed significant correlation among the discrimination thresholds for three test foods, suggesting that acuities of texture perception correlated with each other across different textural attributes. Second, we examined the associations between the acuity of texture perception and some aspects of mechanical sensation of the tongue: tactile and two‐point discrimination thresholds, as well as the graininess recognition threshold. The acuity of texture perception of the subjects whose sensitivity was low for at least one of these aspects of mechanical sensation (n = 5) was significantly lower than that exhibited by the other subjects (Wilcoxon rank‐sum test, p = 0.0417). We concluded that oral texture perception ability can be evaluated by discrimination tests for specific aspects of texture, using appropriate test foods.
Keywords	adults ; homeostasis ; ingredients ; sensation ; sensory system ; test meals ; texture ; tongue
Language	English
Dates of publication	2019-06
Size	p. 217-223.
Publishing place	John Wiley & Sons, Inc.
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	242507-5
ISSN	1745-4603 ; 0022-4901
ISSN (online)	1745-4603
ISSN	0022-4901
DOI	10.1111/jtxs.12400
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Article ; Online: Relationship Between Oral Health and Fractures in Community-Dwelling Older Japanese Adults.

Ito, Wakana / Komiyama, Takamasa / Ohi, Takashi / Hiratsuka, Takako / Matsuyama, Sanae / Sone, Toshimasa / Tsuji, Ichiro / Watanabe, Makoto / Hattori, Yoshinori

Journal of the American Medical Directors Association

2021 Volume 22, Issue 6, Page(s) 1184–1189.e1

Abstract: Objective: To investigate the relationship between poor oral health and the incidence of fall-related fractures in older Japanese individuals.: Design: A 9-year prospective cohort study.: Setting and participants: Participants comprised 937 ... ...

Abstract	Objective: To investigate the relationship between poor oral health and the incidence of fall-related fractures in older Japanese individuals. Design: A 9-year prospective cohort study. Setting and participants: Participants comprised 937 community-dwelling older Japanese adults aged 70 years or older. They all lived in the Tsurugaya district, a suburban area of Sendai city, and underwent comprehensive geriatric assessment, including an oral examination, in a public facility. Measurements: The exposure variables were related to oral health status (posterior occlusal support, number of remaining teeth, and occlusal force). The outcome measure was the incidence of fall-related fractures, which was determined by National Health Insurance data. Analyzed covariates included age, sex, medical history, smoking, alcohol drinking, educational level, depressive symptoms, cognitive impairment, physical function, body mass index, and history of falls. Statistical relationships were examined by calculating hazard ratios (HRs) at 95% confidence intervals (CIs) using the Cox proportional hazard model. Results: In the multivariate analysis, the HRs of fall-related fractures were significantly higher in those with unilateral posterior occlusal support (HR, 2.72; 95% CI, 1.13-6.55) and no posterior occlusal support (HR, 2.58; 95% CI, 1.29-5.15) than in those with bilateral posterior occlusal support. The HRs (95% CIs) of fall-related fractures in individuals with 10-19 and 1-9 teeth and edentulous individuals were 1.77 (0.81-3.89), 2.67 (1.24-5.75), and 2.31 (1.01-5.28), respectively, compared to those with ≥20 teeth. Conclusions and implications: Poor oral health status is a risk factor for the incidence of fall-related fractures in community-dwelling older Japanese individuals. The findings suggest that attention should be focused on oral health status to further understand the risk of fall-related fractures among community-dwelling older adults.
MeSH term(s)	Accidental Falls ; Aged ; Geriatric Assessment ; Humans ; Independent Living ; Japan/epidemiology ; Oral Health ; Prospective Studies
Language	English
Publishing date	2021-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2021.01.058
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Zs.A 5971: Show issues

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Article ; Online: Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.

Ito, Wakana / Yokoi, Masayuki / Sakayoshi, Nobutaka / Sakurai, Yasutaka / Akagi, Jun-Ichi / Mitani, Hiroshi / Hanaoka, Fumio

Genes to cells : devoted to molecular & cellular mechanisms

2012 Volume 17, Issue 2, Page(s) 98–108

Abstract: DNA polymerase η (Polη), whose gene mutation is responsible for the inherited disorder xeroderma pigmentosum variant (XP-V), carries out accurate and efficient translesion synthesis (TLS) across cyclobutane pyrimidine dimer (CPD). As Polη interacts with ... ...

Abstract	DNA polymerase η (Polη), whose gene mutation is responsible for the inherited disorder xeroderma pigmentosum variant (XP-V), carries out accurate and efficient translesion synthesis (TLS) across cyclobutane pyrimidine dimer (CPD). As Polη interacts with REV1, and REV1 interacts with other TLS polymerases including Polι, Polκ and Polζ, Polη may play a role in recruitment of these TLS polymerases at lesion site. But it is unclear whether UV sensitivity of XP-V patients is caused not only by defect of Polη activity but also by dysfunction of network between Polη and other TLS polymerases. Here, we examined whether the TLS polymerase network via Polη is important for replicative bypass of CPDs and DNA damage tolerance induced by UV in mouse cells. We observed that UV sensitivity of Polη-deficient mouse cells was moderately rescued by the expression of a catalytically inactive Polη. Moreover, this recovery of cellular UV sensitivity was mediated by the interaction between Polη and REV1. However, expression of the inactive mutant Polη was not able to suppress the incidence of UV-induced mutation observed in Polη-deficient cells. We propose the model that REV1 and Polκ are involved in DNA damage tolerance via Polη-REV1 interaction when Polη fails to bypass its cognate substrates.
MeSH term(s)	Animals ; Cell Line ; DNA Replication/physiology ; DNA-Directed DNA Polymerase/deficiency ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Enzyme Activation/radiation effects ; Mice ; Nucleotidyltransferases/metabolism ; Protein Binding ; Substrate Specificity ; Ultraviolet Rays ; Xeroderma Pigmentosum/genetics ; Xeroderma Pigmentosum/metabolism
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Polk protein, mouse (EC 2.7.7.7) ; Rad30 protein (EC 2.7.7.7) ; Rev1 protein, mouse (EC 2.7.7.7)
Language	English
Publishing date	2012-01-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1330000-3
ISSN	1365-2443 ; 1356-9597
ISSN (online)	1365-2443
ISSN	1356-9597
DOI	10.1111/j.1365-2443.2011.01576.x
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Article: 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole Induces Apoptosis and Necrosis with Activation of Different Caspases in Rat Splenocytes

HASHIMOTO, Takashi / SANO, Takashi / ITO, Wakana / KANAZAWA, Kazuki / DANNO, Gen-ichi / ASHIDA, Hitoshi

Bioscience, biotechnology, and biochemistry. 2004 Jan. 1, v. 68, no. 4

2004

Abstract: A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 μM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 μM Trp-P-1 induced necrosis with activation of caspase-3- ...

Abstract	A dietary carcinogen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) at 20 μM activates caspase-3-like proteases as an apoptotic marker in rat splenocytes. The present study demonstrated 100 μM Trp-P-1 induced necrosis with activation of caspase-3-like proteases. The activation in necrosis and apoptosis resulted from the activation of caspase-9 and caspase-8, respectively. Thus, Trp-P-1 induces apoptosis and necrosis with the activation of different caspases.
Keywords	apoptosis ; biotechnology ; carcinogens ; caspase-8 ; caspase-9 ; indoles ; necrosis ; rats ; splenocytes
Language	English
Dates of publication	2004-0101
Size	p. 964-967.
Publishing place	Japan Society for Bioscience, Biotechnology, and Agrochemistry
Document type	Article
Note	NAL-light
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1271/bbb.68.964
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