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Article ; Online: Locating the interatrial septal vein.

Ito, Yoko / Sato, Yuriko / Yazaki, Yoshinao

European heart journal. Cardiovascular Imaging

2022 Volume 23, Issue 12, Page(s) e540

MeSH term(s)	Humans ; Heart Septal Defects, Atrial/diagnostic imaging ; Heart Septal Defects, Atrial/surgery ; Echocardiography, Transesophageal
Language	English
Publishing date	2022-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeac180
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Article: Differentiation of Trafficking Pathways at Golgi Entry Core Compartments and Post-Golgi Subdomains.

Ito, Yoko / Boutté, Yohann

Frontiers in plant science

2020 Volume 11, Page(s) 609516

Abstract: Eukaryotic cells have developed specialized membrane structures called organelles, which compartmentalize cellular functions and chemical reactions. Recent improvements in microscopy and membrane compartment isolation techniques are now sophisticating ... ...

Abstract	Eukaryotic cells have developed specialized membrane structures called organelles, which compartmentalize cellular functions and chemical reactions. Recent improvements in microscopy and membrane compartment isolation techniques are now sophisticating our view. Emerging evidences support that there are distinct sub-populations or subdomains, which are spatially and/or temporally segregated within one type of organelle, contributing to specify differential sorting of various cargos to distinct destinations of the cell. In plant cells, the Golgi apparatus represents a main trafficking hub in which entry occurs through a Golgi Entry Core Compartment (GECCO), that remains to be further characterized, and sorting of cargos is mediated through multiple transport pathways with different sets of regulator proteins at the post-Golgi compartment
Language	English
Publishing date	2020-12-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.609516
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Article ; Online: Bilateral Hilar and Mediastinal Lymphadenopathy as an Initial Manifestation of Amyloidosis.

Urata, Mika / Ito, Yoko / Ogiya, Daisuke / Kutsuzawa, Naokata / Ogura, Go / Ueda, Mitsuharu / Hayama, Naoki / Oguma, Tsuyoshi / Asano, Koichiro

The Tokai journal of experimental and clinical medicine

2024 Volume 49, Issue 1, Page(s) 12–16

Abstract: A 75-year-old male visited our hospital with bilateral hilar lymph node swelling detected on chest radiography during an annual medical checkup. Chest computed tomography revealed swelling of multiple hilar mediastinal lymph nodes. Histopathological and ... ...

Abstract	A 75-year-old male visited our hospital with bilateral hilar lymph node swelling detected on chest radiography during an annual medical checkup. Chest computed tomography revealed swelling of multiple hilar mediastinal lymph nodes. Histopathological and immunohistochemical examinations of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens from the hilar lymph nodes revealed amyloid deposition. Bilateral hilar and mediastinal lymphadenopathies can be the first manifestations of amyloidosis diagnosed using EBUS-TBNA.
MeSH term(s)	Male ; Humans ; Aged ; Lung Neoplasms/diagnosis ; Lymphadenopathy/etiology ; Lymphadenopathy/pathology ; Mediastinum/pathology ; Lymph Nodes/pathology ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Bronchoscopy/methods
Language	English
Publishing date	2024-04-20
Publishing country	Japan
Document type	Case Reports
ZDB-ID	431622-8
ISSN	2185-2243 ; 0385-0005
ISSN (online)	2185-2243
ISSN	0385-0005
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Article ; Online: Dexamethasone restores TNFα-induced epithelial barrier dysfunction in primary rat alveolar epithelial cells.

Kutsuzawa, Naokata / Ito, Yoko / Kagawa, Shizuko / Kohno, Chinatsu / Takiguchi, Hiroto / Asano, Koichiro

PloS one

2023 Volume 18, Issue 12, Page(s) e0295684

Abstract: Alveolar barrier dysfunction is one of the major pathophysiological changes in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In ALI/ARDS, tumor necrosis factor-alpha (TNFα) disrupts the barriers of alveolar epithelium and ... ...

Abstract	Alveolar barrier dysfunction is one of the major pathophysiological changes in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). In ALI/ARDS, tumor necrosis factor-alpha (TNFα) disrupts the barriers of alveolar epithelium and endothelium. Glucocorticoids (GCs) exert anti-inflammatory effects and ameliorate pulmonary edema in ALI/ARDS. However, the involvement of GCs in the restoration of alveolar epithelial barrier dysfunction has not been extensively studied. Here, we elucidated that dexamethasone (Dex) restored TNFα-induced alveolar epithelial barrier dysfunction in vitro using primary rat alveolar epithelial cells isolated from Sprague-Dawley rats. Moreover, Dex promoted the alveolar epithelial cell barrier integrity by initiating GC receptor-mediated signaling via the downregulation of myosin light chain kinase (MLCK) expression and the dephosphorylation of myosin light chain (MLC) 2. Further investigation revealed that Dex enhanced the expression of zonula occludens-1 (ZO-1), a tight junction-related protein, at intercellular junction sites. These findings suggest that GCs strengthen the integrity of the alveolar epithelial barrier in ALI/ARDS via the GR-MLCK-pMLC2 axis.
MeSH term(s)	Rats ; Animals ; Alveolar Epithelial Cells/metabolism ; Tumor Necrosis Factor-alpha ; Rats, Sprague-Dawley ; Tight Junction Proteins/metabolism ; Respiratory Distress Syndrome ; Dexamethasone/pharmacology ; Epithelial Cells/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha ; Tight Junction Proteins ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0295684
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Article ; Online: T1-T2 Mismatch Sign as a Predictor of Ipsilateral Ischemic Change After Carotid Artery Stenting.

Onishi, Shumpei / Ohba, Shinji / Isobe, Naoyuki / Ito, Yoko / Takano, Motoki / Maeda, Yugo / Horie, Nobutaka

World neurosurgery

2023 Volume 179, Page(s) e450–e457

Abstract: Background: Magnetic resonance (MR)-plaque imaging reflects the characteristics of carotid plaque. We evaluated the relationship between MR-plaque images and ischemic change after carotid artery stenting (CAS).: Methods: MR-plaque images were ... ...

Abstract	Background: Magnetic resonance (MR)-plaque imaging reflects the characteristics of carotid plaque. We evaluated the relationship between MR-plaque images and ischemic change after carotid artery stenting (CAS). Methods: MR-plaque images were acquired from patients with carotid artery stenosis before CAS treatment. We calculated the relative signal intensity of plaque components compared with that of the sternocleidomastoid muscle and evaluated the presence/absence of T1-T2 mismatch and match sign. We then assessed the appearance of new ischemic lesions after CAS on diffusion-weighted imaging (DWI). Factors associated with the appearance of a high-intensity lesion on DWI were retrospectively analyzed. Results: A total of 64 patients with carotid artery stenoses treated with CAS were included in this study. In univariate analysis, T1-T2 mismatch sign was associated with the appearance of high-intensity lesions on DWI after CAS (odds ratio [OR], 12.00; 95% confidence interval [CI], 3.593-40.072; P < 0.0001), whereas T1-T2 match sign and high intensity on T2-weighted imaging were negatively associated (OR, 0.061, 95% CI, 0.007-0.502, P = 0.009 and OR, 0.085; 95% CI, 0.022-0.334, P = 0.0004, respectively). In multivariate logistic regression analysis, T1-T2 mismatch sign was independently associated with the appearance of a high-intensity lesion on DWI after CAS (OR, 16.695; 95% CI, 1.324-210.52; P = 0.0295). Conclusions: T1-T2 mismatch sign on MR-plaque imaging is significantly associated with the appearance of new ischemic lesions after CAS. T1-T2 mismatch sign may be useful in considering treatment strategies for carotid artery stenosis.
MeSH term(s)	Humans ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Carotid Stenosis/complications ; Retrospective Studies ; Risk Factors ; Stents/adverse effects ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/surgery ; Carotid Arteries/pathology ; Diffusion Magnetic Resonance Imaging
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.08.117
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Book ; Online: Initiatives to expand the introduction of renewable energy in various APEC economies : examples of RPS in Japan, Korea, and California in the US

Ito, Yoko

2015

Author's details	Yoko Ito (Senior Researcher, Coal & Gas Subunit, Fossil Fuels & Electric Power Industry Unit, New and Renewable Energy Group, New and Renewable Energy & International Cooperation Unit, Asia Pacific Energy Research Centre (APERC))
Keywords	Förderung erneuerbarer Energien ; Energiepreis ; Japan ; Südkorea ; Kalifornien
Language	English
Size	1 Online-Ressource (circa 74 Seiten), Illustrationen
Publisher	Asia Pacific Energy Research Centre (APERC)
Publishing place	Tokyo
Document type	Book ; Online
Note	IMD-Felder maschinell generiert
ISBN	9784931482487 ; 4931482481
Database	ECONomics Information System

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Article ; Online: Mechanistic Insights into the Pathogenesis of Proliferative and Nonproliferative Vitreomacular Traction.

Ito, Yoko / Takatsudo, Yuki / Gehlbach, Peter L / Mori, Keisuke

American journal of ophthalmology

2021 Volume 238, Page(s) 1–9

Abstract: Purpose: To describe the vitreoretinal interface in vitreomacular traction (VMT) by using novel optical coherence tomography (OCT) methods; wide-angle montage, and pseudomotion OCT imaging systems.: Design: Observational case series.: Methods: ... ...

Abstract	Purpose: To describe the vitreoretinal interface in vitreomacular traction (VMT) by using novel optical coherence tomography (OCT) methods; wide-angle montage, and pseudomotion OCT imaging systems. Design: Observational case series. Methods: Wide-angle montage OCT images of horizontal and vertical scans through the fovea were acquired in 50 eyes of 46 consecutive patients with VMT. Baseline fundus scans were obtained. These were followed by scans acquired with an eye-tracking system performed immediately after vertical and horizontal eye movements. Three scans were then superimposed to compare changes in the contour and position of the posterior vitreous. Results: The subjects were classified as VMT with ("proliferative"; 48.0%) and without ("nonproliferative"; 52.0%) thickened posterior vitreous. Epiretinal membrane was observed in 26.9% of nonproliferative and 95.8% of proliferative VMT eyes (P = 3.6 × 10 Conclusions: By dynamically evaluating the vitreoretinal interface of patients with VMT, the static contraction forces of a thickened posterior vitreous at the macula are implicated in proliferative VMT. This contractile force is not strongly implicated in the majority of VMT eyes with nontaut and more mobile vitreous (nonproliferative VMT). VMT and its associated complications are determined by at least 2 different pathophysiological mechanisms.
MeSH term(s)	Humans ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Traction ; Vision Disorders ; Visual Acuity ; Vitreous Body/diagnostic imaging ; Vitreous Body/pathology ; Vitreous Detachment/diagnosis
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2021.11.026
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Article ; Online: Can MASCC and CISNE scores predict delays of lung cancer chemotherapy after febrile neutropenia?

Ono, Yoshitaka / Hayama, Naoki / Hattori, Shigeaki / Ito, Yoko / Oguma, Tsuyoshi / Sakamaki, Fumio / Asano, Koichiro

Thoracic cancer

2022

Abstract: Background: Febrile neutropenia (FN) during cancer chemotherapy can lead to morbidity and mortality. The Multinational Association of Supportive Care in Cancer (MASCC) and clinical index of stable febrile neutropenia (CISNE) scores have been widely used ...

Abstract	Background: Febrile neutropenia (FN) during cancer chemotherapy can lead to morbidity and mortality. The Multinational Association of Supportive Care in Cancer (MASCC) and clinical index of stable febrile neutropenia (CISNE) scores have been widely used to predict the risk of severe medical complications in patients with FN; however, there are few tools for predicting chemotherapy delays or discontinuation after FN. Methods: Patients admitted to two university hospitals between 2014 and 2018 with a FN diagnosis during the first cycle of chemotherapy for lung cancer were reviewed retrospectively. Results: Among 539 patients who received 813 courses of chemotherapy for lung cancer, 49 (9%) developed FN during the first treatment cycle. Although all the patients recovered from their primary infection, 19 patients (38.8%) developed serious medical complications, 11 (22.4%) were unable to resume chemotherapy and one (2.0%) declined to resume chemotherapy, and nine (18.4%) died within 90 days. Patients who failed to resume chemotherapy had a lower MASCC score (median 8.5 vs. 17, p < 0.01) and a higher CISNE score (median 3 vs. 1, p < 0.01) at the onset of FN. The specificity to predict the patient who failed to resume chemotherapy was 90% or more with MASCC score ≤9 or CISNE score ≥3, with the sensitivity of 61%. MASCC score ≤ 16 can also be a sensitive indicator with the sensitivity and specificity of 89 and 52%, respectively. Conclusion: The MASCC and CISNE scores are useful in identifying lung cancer patients who are unable to resume chemotherapy as scheduled after the onset of FN.
Language	English
Publishing date	2022-11-04
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.14720
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Article ; Online: Combination of computed tomography imaging pattern and severity of respiratory failure as factors associated with prognosis for acute exacerbation of idiopathic chronic fibrosing interstitial pneumonia.

Enokida, Keito / Takihara, Takahisa / Horio, Yukihiro / Nakamura, Noriko / Kutsuzawa, Naotaka / Takahashi, Mari / Takahashi, Fuminari / Tajiri, Sakurako / Ito, Yoko / Asano, Koichiro

PloS one

2023 Volume 18, Issue 2, Page(s) e0279878

Abstract: Background and objectives: The prognosis of idiopathic chronic fibrotic interstitial pneumonitis (CFIP) in patients with acute exacerbation (AE) is variable. We examined whether the imaging pattern on thoracic computed tomography (CT) or the severity of ...

Abstract	Background and objectives: The prognosis of idiopathic chronic fibrotic interstitial pneumonitis (CFIP) in patients with acute exacerbation (AE) is variable. We examined whether the imaging pattern on thoracic computed tomography (CT) or the severity of respiratory failure with AE-CFIP is associated with short-term prognosis. Methods: Patients admitted to two university hospitals were retrospectively analyzed and divided into derivation and validation cohorts. The distribution of newly appearing parenchymal abnormalities on thoracic CT was classified into peripheral, multifocal, and diffuse patterns. Respiratory failure was defined as severe if a fraction of inspired oxygen ≥ 0.5 was required to maintain percutaneous oxygen saturation ≥ 90% on admission. Factors associated with 90 day-mortality were analyzed using univariate and Cox proportional hazard regression. Results: In 59 patients with AE-CFIP of the derivation cohort, diffuse pattern on CT was associated with higher mortality within 90 days (43%) than peripheral/multifocal pattern (17%, p = 0.03). Additionally, compared with non-severe failure, severe respiratory failure was associated with higher mortality (47% vs. 21%, p = 0.06). Cox proportional hazard regression analysis demonstrated that a combination of diffuse pattern on CT and severe respiratory failure was associated with the poorest prognosis (hazard ratio [HR] 3.51 [interquartile range 1.26-9.80], p = 0.016) in the derivation cohort, which was confirmed in the validation cohort (n = 31, HR 4.30 [interquartile range 1.51-12.2], p = 0.006). Conclusion: The combination of imaging pattern on thoracic CT and severity of respiratory failure was associated with the prognosis of idiopathic AE-CFIP.
MeSH term(s)	Humans ; Retrospective Studies ; Lung Diseases, Interstitial ; Idiopathic Interstitial Pneumonias ; Prognosis ; Respiratory Insufficiency ; Tomography, X-Ray Computed/methods ; Idiopathic Pulmonary Fibrosis ; Disease Progression
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279878
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Article ; Online: Retroperitoneal Hematoma During Prophylactic Dose of Heparin Therapy for Coronavirus Disease 2019.

Okada, Naoki / Niimi, Kyoko / Asami, Yoshino / Hattori, Shigeaki / Takiguchi, Hiroto / Hayama, Naoki / Ito, Yoko / Oguma, Tsuyoshi / Ono, Shun / Asano, Koichiro

The Tokai journal of experimental and clinical medicine

2023 Volume 48, Issue 1, Page(s) 47–51

Abstract: We report a case of retroperitoneal hematoma during prophylactic heparin therapy for coronavirus disease 2019 (COVID-19). A 79-year-old man was diagnosed with COVID-19 pneumonia with possible exacerbation of fibrotic hypersensitivity pneumonia. He ... ...

Abstract	We report a case of retroperitoneal hematoma during prophylactic heparin therapy for coronavirus disease 2019 (COVID-19). A 79-year-old man was diagnosed with COVID-19 pneumonia with possible exacerbation of fibrotic hypersensitivity pneumonia. He received a prophylactic dose of subcutaneous heparin therapy, methylprednisolone pulse therapy and Intravenous remdesivir but developed a spontaneous iliopsoas muscle hematoma, and transcatheter arterial embolization was performed. Even with a prophylactic dose of subcutaneous heparin therapy, the course should be carefully monitored, especially in patients with preexisting risk factors for hemorrhagic complications. Once retroperitoneal hematoma develops, aggressive procedures, such as transcatheter arterial embolization, should be considered to avoid fatal outcomes.
MeSH term(s)	Male ; Humans ; Aged ; COVID-19 ; Anticoagulants/adverse effects ; Heparin/adverse effects ; Hematoma/chemically induced ; Hematoma/drug therapy ; Gastrointestinal Hemorrhage
Chemical Substances	Anticoagulants ; Heparin (9005-49-6)
Language	English
Publishing date	2023-04-20
Publishing country	Japan
Document type	Case Reports
ZDB-ID	431622-8
ISSN	2185-2243 ; 0385-0005
ISSN (online)	2185-2243
ISSN	0385-0005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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